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Your search keyword '"Wohlstadter, Jacob N."' showing total 29 results
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29 results on '"Wohlstadter, Jacob N."'

2. Exploratory factor analysis yields grouping of brain injury biomarkers significantly associated with outcomes in neonatal and pediatric ECMO

Author

Huang, Victoria, primary, Roem, Jennifer, additional, Ng, Derek K., additional, McElrath Schwartz, Jamie, additional, Everett, Allen D., additional, Padmanabhan, Nikhil, additional, Romero, Daniel, additional, Joe, Jessica, additional, Campbell, Christopher, additional, Sigal, George B., additional, Wohlstadter, Jacob N., additional, and Bembea, Melania M., additional

Published
2024
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5. Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination

Author

Röltgen, Katharina, primary, Nielsen, Sandra C.A., additional, Silva, Oscar, additional, Younes, Sheren F., additional, Zaslavsky, Maxim, additional, Costales, Cristina, additional, Yang, Fan, additional, Wirz, Oliver F., additional, Solis, Daniel, additional, Hoh, Ramona A., additional, Wang, Aihui, additional, Arunachalam, Prabhu S., additional, Colburg, Deana, additional, Zhao, Shuchun, additional, Haraguchi, Emily, additional, Lee, Alexandra S., additional, Shah, Mihir M., additional, Manohar, Monali, additional, Chang, Iris, additional, Gao, Fei, additional, Mallajosyula, Vamsee, additional, Li, Chunfeng, additional, Liu, James, additional, Shoura, Massa J., additional, Sindher, Sayantani B., additional, Parsons, Ella, additional, Dashdorj, Naranjargal J., additional, Dashdorj, Naranbaatar D., additional, Monroe, Robert, additional, Serrano, Geidy E., additional, Beach, Thomas G., additional, Chinthrajah, R. Sharon, additional, Charville, Gregory W., additional, Wilbur, James L., additional, Wohlstadter, Jacob N., additional, Davis, Mark M., additional, Pulendran, Bali, additional, Troxell, Megan L., additional, Sigal, George B., additional, Natkunam, Yasodha, additional, Pinsky, Benjamin A., additional, Nadeau, Kari C., additional, and Boyd, Scott D., additional

Published
2022
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6. Direct comparison of antibody responses to four SARS-CoV-2 vaccines in Mongolia

Author

Dashdorj, Naranjargal J., primary, Wirz, Oliver F., additional, Röltgen, Katharina, additional, Haraguchi, Emily, additional, Buzzanco, Anthony S., additional, Sibai, Mamdouh, additional, Wang, Hannah, additional, Miller, Jacob A., additional, Solis, Daniel, additional, Sahoo, Malaya K., additional, Arunachalam, Prabhu S., additional, Lee, Alexandra S., additional, Shah, Mihir M., additional, Liu, James, additional, Byambabaatar, Sumiya, additional, Bat-Ulzii, Purevjargal, additional, Enkhbat, Anir, additional, Batbold, Enkhtuul, additional, Zulkhuu, Delgersaikhan, additional, Ochirsum, Byambasuren, additional, Khurelsukh, Tungalag, additional, Dalantai, Ganbold, additional, Burged, Natsagdorj, additional, Baatarsuren, Uurtsaikh, additional, Ariungerel, Nomin, additional, Oidovsambuu, Odgerel, additional, Bungert, Andreas S., additional, Genden, Zulkhuu, additional, Yagaanbuyant, Dahgwahdorj, additional, Mordorj, Altankhuu, additional, Pulendran, Bali, additional, Chinthrajah, Sharon, additional, Nadeau, Kari C., additional, Jardetzky, Theodore, additional, Wilbur, James L., additional, Wohlstadter, Jacob N., additional, Sigal, George B., additional, Pinsky, Benjamin A., additional, Boyd, Scott D., additional, and Dashdorj, Naranbaatar D., additional

Published
2021
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7. mRNA vaccination compared to infection elicits an IgG-predominant response with greater SARS-CoV-2 specificity and similar decrease in variant spike recognition

Author

Röltgen, Katharina, primary, Nielsen, Sandra C. A., additional, Arunachalam, Prabhu S., additional, Yang, Fan, additional, Hoh, Ramona A., additional, Wirz, Oliver F., additional, Lee, Alexandra S., additional, Gao, Fei, additional, Mallajosyula, Vamsee, additional, Li, Chunfeng, additional, Haraguchi, Emily, additional, Shoura, Massa J., additional, Wilbur, James L., additional, Wohlstadter, Jacob N., additional, Davis, Mark M., additional, Pinsky, Benjamin A., additional, Sigal, George B., additional, Pulendran, Bali, additional, Nadeau, Kari C., additional, and Boyd, Scott D., additional

Published
2021
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9. Abstract 4030A: S-PLEXSMTroponin I assay with fg/mL sensitivity

Author

Aghvanyan, Anahit, primary, Gardner, Louis, additional, Shukla, Animesh, additional, Miller, Thomas, additional, Wang, Su, additional, Grove, Sheldon, additional, Chow, Andrew, additional, Suschak, Jessica, additional, Wheeler, Sarah, additional, Mathew, Anu, additional, Stengelin, Martin K., additional, and Wohlstadter, Jacob N., additional

Published
2017
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11. Detection of fg/mL Levels of IL-2, IL-4, IL-6, IL-10, and IL-17A in Serum, Plasma, and Supernatant of Established Cell Models

Author

Georlette, Daphne, primary, Wheeler, Sarah E, additional, Ranganathan, Sripriya, additional, Wang, Su, additional, Nikolenko, Galina N, additional, Shukla, Animesh, additional, Miller, Thomas C, additional, Aghvanyan, Anahit, additional, Stengelin, Martin, additional, Mathew, Anu, additional, Kuklis, Catlin, additional, Sharma, Deepak, additional, Bess, Matthew, additional, Davydov, Ilia V, additional, and Wohlstadter, Jacob N, additional

Published
2017
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12. Rapid Immunoassay Development using the U-PLEX® Assay Platform.

Author

Yatsula, Victoria, primary, Shelburne, Christopher, additional, Ning, Qian, additional, Krai, Priscilla, additional, Cheo, David, additional, Ranganathan, Sripriya, additional, Davydov, Ilia V., additional, Liu, Pu, additional, Stewart, David, additional, Oberoi, Pankaj, additional, Wilbur, James, additional, and Wohlstadter, Jacob N., additional

Published
2017
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13. Measuring fg/mL Concentrations of Cytokines in Cerebrospinal Fluid (CSF)

Author

Georlette, Daphne, primary, Suschak, Jessica, additional, Aghvanyan, Anahit, additional, Navaratnam, Manjula, additional, Lockney, Dustin, additional, Biesso, Arianna, additional, Gardner, Louis, additional, Bartlett, Dan, additional, Porter, Erica, additional, Tamot, Banita, additional, Shukla, Animesh, additional, Miller, Thomas, additional, Mathew, Anu, additional, Wheeler, Sarah E, additional, Stengelin, Martin, additional, and Wohlstadter, Jacob N, additional

Published
2017
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17. True Sensitivity of Immunoassays: Are Concentrations of Low Abundance Analytes Real or Artifacts?

Author

Oberoi, Pankaj, primary, Suschak, Jessica, additional, Stenglin, Martin, additional, Aghvanyan, Anahit, additional, Nikolenko, Galina, additional, Roy, Daisy, additional, Gardner, Louis, additional, Lockney, Dustin, additional, Shukla, Animesh, additional, Porter, Erica, additional, Miller, Thomas, additional, Biesso, Adrianna, additional, Sardesai, Laukik, additional, Sivakamasundar, Ramou, additional, Mathew, Anu, additional, Glezer, Eli N, additional, and Wohlstadter, Jacob N, additional

Published
2016
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19. Development and analytical validation of a flexible multiplexing platform for cytokine assays.

Author

Sandberg, Eric M, primary, Liu, Pu, additional, Ning, Qiang, additional, Rangwala, Sameera, additional, Shelburne, Christopher, additional, Kobayashi, Lori E, additional, Lu, Claire, additional, Stewart, David, additional, Tsionsky, Michael, additional, Plisova, Tatiana, additional, Glezer, Eli N, additional, Oberoi, Pankaj, additional, and Wohlstadter, Jacob N, additional

Published
2016
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26. Chemiluminescence, Electrogenerated

Author

Nepomnyashchii, Alexander B., primary, Bard, Allen J., additional, Leland, Jonathan K., additional, Debad, Jeff D., additional, Sigal, George B., additional, Wilbur, James L., additional, and Wohlstadter, Jacob N., additional

Published
2000
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27. Chemiluminescence, Electrogenerated

Author

Bard, Allen J., primary, Debad, Jeff D., additional, Leland, Jonathan K., additional, Sigal, George B., additional, Wilbur, James L., additional, and Wohlstadter, Jacob N., additional

Published
2000
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28. Gestational SARS-CoV-2 Infection in a Ugandan Birth Cohort: High Incidence, Mild Maternal Disease, and Evidence of Association with Transient Infant Stunting.

Author

Jacobson KB, Röltgen K, Lam B, Nayebare P, Kakuru A, Kizza J, Aguti M, Nankya F, Briggs J, Takahashi S, Greenhouse B, Rodriguez-Barraquer I, van der Ploeg K, Wohlstadter JN, Sigal GB, Roh ME, Nankabirwa JI, Cuu G, Gaw SL, Rosenthal PJ, Kamya MR, Ssewanyana I, Dorsey G, Boyd SD, and Jagannathan P

Abstract

Many questions remain about the prevalence and effects of SARS-CoV-2 infection in malaria-endemic African countries like Uganda, particularly in vulnerable groups such as pregnant women. We describe SARS-CoV-2 immunoglobulin (Ig)G and IgM antibody responses and clinical outcomes in mother-infant dyads enrolled in malaria chemoprevention trials in Uganda. From December 2020-February 2022, among 400 unvaccinated pregnant women enrolled at 12-20 weeks gestation and followed through delivery, 128 (32%) were seronegative for anti-SARS-CoV-2 IgG and IgM at enrollment and delivery, 80 (20%) were infected prior to or early in pregnancy, and 192 (48%) were infected or re-infected with SARS-CoV-2 during pregnancy. We observed preferential binding of plasma IgG to Wuhan-Hu-1-like antigens in individuals seroconverting up to early 2021, and to Delta variant antigens in a subset of individuals in mid-2021. Breadth of IgG binding to all variants improved over time, consistent with affinity maturation of the antibody response in the cohort. No women experienced severe respiratory illness during the study. SARS-CoV-2 infection in early pregnancy was associated with lower median length-for-age Z-score at age 3 months compared with no infection or late pregnancy infect (-1.54 versus -0.37 and -0.51, P = 0.009). These findings suggest that pregnant Ugandan women experienced high levels of SARS-CoV-2 infection without severe respiratory illness. Variant-specific serology testing demonstrated evidence of antibody affinity maturation at the population level. Early gestational SARS-CoV-2 infection was associated with transient shorter stature in early infancy. Further research should explore the significance of this finding and define targeted measures to prevent infection in pregnancy.

Published
2024
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29. mRNA vaccination compared to infection elicits an IgG-predominant response with greater SARS-CoV-2 specificity and similar decrease in variant spike recognition.

Author

Röltgen K, Nielsen SCA, Arunachalam PS, Yang F, Hoh RA, Wirz OF, Lee AS, Gao F, Mallajosyula V, Li C, Haraguchi E, Shoura MJ, Wilbur JL, Wohlstadter JN, Davis MM, Pinsky BA, Sigal GB, Pulendran B, Nadeau KC, and Boyd SD

Abstract

During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, new vaccine strategies including lipid nanoparticle delivery of antigen encoding RNA have been deployed globally. The BioNTech/Pfizer mRNA vaccine BNT162b2 encoding SARS-CoV-2 spike protein shows 95% efficacy in preventing disease, but it is unclear how the antibody responses to vaccination differ from those generated by infection. Here we compare the magnitude and breadth of antibodies targeting SARS-CoV-2, SARS-CoV-2 variants of concern, and endemic coronaviruses, in vaccinees and infected patients. We find that vaccination differs from infection in the dominance of IgG over IgM and IgA responses, with IgG reaching levels similar to those of severely ill COVID-19 patients and shows decreased breadth of the antibody response targeting endemic coronaviruses. Viral variants of concern from B.1.1.7 to P.1 to B.1.351 form a remarkably consistent hierarchy of progressively decreasing antibody recognition by both vaccinees and infected patients exposed to Wuhan-Hu-1 antigens., Competing Interests: Declaration of Interests S.D.B. has consulted for Regeneron, Sanofi, and Novartis on topics unrelated to this study, and owns stock in AbCellera Biologics. K.C.N. reports grants from National Institute of Allergy and Infectious Diseases (NIAID), Food Allergy Research & Education (FARE), End Allergies Together (EAT); National Heart, Lung, and Blood Institute (NHLBI), and National Institute of Environmental Health Sciences (NIEHS). K.C.N. is Director of FARE and World Allergy Organization (WAO) Center of Excellence at Stanford; Advisor at Cour Pharmaceuticals; Cofounder of Before Brands, Alladapt, Latitude, and IgGenix; National Scientific Committee member for the Immune Tolerance Network (ITN) of NIAID; recipient of a Research Sponsorship from Nestle; Consultant and Advisory Board Member at Before Brands, Alladapt, IgGenix, NHLBI, and ProBio; and Data and Safety Monitoring Board member at NHLBI.

Published
2021
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