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The article discusses the importance of reproductive healthcare advocacy and policy-making in the field of reproductive immunology. It highlights the role of the American Society for Reproductive Immunology (ASRI) in advancing research and fostering collaboration among diverse professionals. The text also addresses concerns about restrictive reproductive healthcare laws and their impact on healthcare providers, researchers, and patients, emphasizing the need for advocacy and political engagement. The authors call for proactive action, urging the scientific community to participate in elections, engage with legislators, and advocate for reproductive health rights. [Extracted from the article]

This study sought to develop a user-friendly decision-making tool to explore country-specific estimates for costs and economic consequences of different options for scaling screening and psychosocial interventions for women with common perinatal mental health problems in Malawi. We developed a simple simulation model using a structure and parameter estimates that were established iteratively with experts, based on published trials, international databases and resources, statistical data, best practice guidance and intervention manuals. The model projects annual costs and returns to investment from 2022 to 2026. The study perspective is societal, including health expenditure and productivity losses. Outcomes in the form of health-related quality of life are measured in Disability Adjusted Life Years, which were converted into monetary values. Economic consequences include those that occur in the year in which the intervention takes place. Results suggest that the net benefit is relatively small at the beginning but increases over time as learning effects lead to a higher number of women being identified and receiving (cost‑)effective treatment. For a scenario in which screening is first provided by health professionals (such as midwives) and a second screening and the intervention are provided by trained and supervised volunteers to equal proportions in group and individual sessions, as well as in clinic versus community setting, total costs in 2022 amount to US$ 0.66 million and health benefits to US$ 0.36 million. Costs increase to US$ 1.03 million and health benefits to US$ 0.93 million in 2026. Net benefits increase from US$ 35,000 in 2022 to US$ 0.52 million in 2026, and return-on-investment ratios from 1.05 to 1.45. Results from sensitivity analysis suggest that positive net benefit results are highly sensitive to an increase in staff salaries. This study demonstrates the feasibility of developing an economic decision-making tool that can be used by local policy makers and influencers to inform investments in maternal mental health. [ABSTRACT FROM AUTHOR]

1. Understand the foundation of DT and the utilization of virtual platform to provide DT to patients with advanced cancer. 2. Identify lessons learned, pros and cons of vDT and strategies to implement into clinical practice. Patients experiencing serious illness often have existential and psychosocial distress contributing to their pain and suffering. Addressing existential distress can be challenging and finding new approaches to make this available to patients is important. Dignity therapy (DT) has been shown to relieve existential distress. We will present results of our pilot study of feasibility and acceptability of virtual DT (vDT). Patients with advanced cancer often experience distress related to their disease, treatment, and impending mortality. Dignity therapy (DT) an individualized psychotherapy that aims to relieve psycho emotional and existential distress and improve the experiences of patients whose lives are impacted by serious illness. DT involves the production of a generativity document (GD) for the patient and their loved ones. During the pandemic, utilization of virtual visits increased and became standard of practice, therefore it was important to determine the feasibility and acceptability of virtual DT (vDT) into to provide this intervention to seriously ill patients. This pilot study at Mayo Clinic Rochester recruited adult patients with advanced cancer and expected prognosis >6 months. Prior to DT intervention, baseline measures were collected followed by DT interviews which consisted of a total of 2-3 sessions of interviews focused on life review, discussion and editing of the GD, and an exit interview focused on the acceptability and feasibility of virtual DT. Twenty-nine patients from the Mayo Clinic Palliative Care Clinic were referred to the study with twenty-four eligible patients. Fourteen patients consented. In completed program evaluation surveys, acceptability of the virtual component (4.6/5 rating) and satisfaction with the DT process (4.4/5 rating) were high (n=5). Post DT intervention interviews were also conducted. Results support to the feasibility and acceptability of vDT. For patients that are too sick DT can be high effort not allowing for completion of the GD. Transcribing and editing the document can be time intensive for the interviewer. Finding ways to move vDT into clinical practice is important. Existential / Humanities / Spirituality / ReligionInnovative Technologies [ABSTRACT FROM AUTHOR]

A total synthesis of the enantiopure syn,syn‐tosyl‐samroiyotmycin A, a C2‐symmetric 20‐membered antimalarial macrodiolide with syn,syn‐configuration of the 8,24‐dihydroxy‐9,25‐dimethyl units and it's enantiopure anti,anti‐derivative is described. The synthesis was accomplished utilizing a linear approach in 7 steps and 3 % overall yield via a sequence of diastereoselective methylation of SuperQuat oxazolidinone auxiliary, cross metathesis and Yamaguchi macrolactonization of fully functionalized seco‐acids. By a similar approach we gained access to several samroiyotmycin analogues and precursors. Antimalarial activity was tested on multi‐resistant (K1) and sensitive (Nf54) P. falciparum strains providing insight into structure activity relationships. Both tosyl‐oxazol unit as well as the syn‐configuration of the two contiguous stereogenic centers turned out to be beneficial for antiplasmodial activity. For instance, syn,syn‐tosyl‐samroiyotmycin A showed 3.4 times higher activities than the “tosyl‐free” natural product. [ABSTRACT FROM AUTHOR]