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Your search keyword '"Wei-Wei Jing"' showing total 13 results
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13 results on '"Wei-Wei Jing"'

1. An artificial intelligence algorithm for the detection of pulmonary ground-glass nodules on spectral detector CT: performance on virtual monochromatic images

Author

Zhong-Yan Ma, Hai-lin Zhang, Fa-jin Lv, Wei Zhao, Dan Han, Li-chang Lei, Qin Song, Wei-wei Jing, Hui Duan, and Shao-Lei Kang

Subjects
Pulmonary ground-glass nodule, Artificial intelligence, Deep learning, Dual-layer detector spectral, Computed tomography, Virtual monochromatic images, Medical technology, R855-855.5
Abstract

Abstract Background This study aims to assess the performance of an established an AI algorithm trained on conventional polychromatic computed tomography (CT) images (CPIs) to detect pulmonary ground-glass nodules (GGNs) on virtual monochromatic images (VMIs), and to screen the optimal virtual monochromatic energy for the clinical evaluation of GGNs. Methods Non-enhanced chest SDCT images of patients with pulmonary GGNs in our clinic from January 2022 to December 2022 were continuously collected: adenocarcinoma in situ (AIS, n = 40); minimally invasive adenocarcinoma (MIA, n = 44) and invasive adenocarcinoma (IAC, n = 46). A commercial CAD system based on deep convolutional neural networks (DL-CAD) was used to process the CPIs, 40, 50, 60, 70, and 80 keV monochromatic images of 130 spectral CT images. AI-based histogram parameters by logistic regression analysis. The diagnostic performance was evaluated by the receiver operating characteristic (ROC) curves, and Delong’s test was used to compare the CPIs group with the VMIs group. Results When distinguishing IAC from MIA, the diagnostic efficiency of total mass was obtained at 80 keV, which was superior to those of other energy levels (P 0.05). Conclusion The AI algorithm trained on CPIs showed consistent diagnostic performance on VMIs. When pulmonary GGNs are encountered in clinical practice, 80 keV could be the optimal virtual monochromatic energy for the identification of preoperative IAC on a non-enhanced chest CT.

Published
2024
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2. Pathologic responses and surgical outcomes after neoadjuvant immunochemotherapy versus neoadjuvant chemoradiotherapy in patients with locally advanced esophageal squamous cell carcinoma

Author

Lei Xu, Xiu-feng Wei, Can-jun Li, Zhao-yang Yang, Yong-kui Yu, Hao-miao Li, Hou-nai Xie, Ya-fan Yang, Wei-wei Jing, Zhen Wang, Xiao-zheng Kang, Rui-xiang Zhang, Jian-jun Qin, Li-yan Xue, Nan Bi, Xian-kai Chen, and Yin Li

Subjects
neoadjuvant immunotherapy, immunochemotherapy, neoadjuvant chemoradiotherapy, treatment response, postoperative complications, esophageal squamous cell carcinoma, Immunologic diseases. Allergy, RC581-607
Abstract

BackgroundCurrently, the role of immunotherapy in neoadjuvant setting for patients with locally advanced esophageal squamous cell carcinoma (ESCC) is gradually attracting attention. Few studies compared the efficacy of neoadjuvant immunochemotherapy (NICT) and neoadjuvant chemoradiotherapy (NCRT). Our study aimed to compare treatment response and postoperative complications after NICT followed by surgery with that after conventional NCRT in patients with locally advanced ESCC.MethodsOf 468 patients with locally advanced ESCC, 154 received conventional NCRT, whereas 314 received NICT. Treatment response, postoperative complications and mortality between two groups were compared. Pathological response of primary tumor was evaluated using the Mandard tumor regression grade (TRG) scoring system. Pathological complete response (pCR) of metastatic lymph nodes (LNs) was defined as no viable tumor cell within all resected metastatic LNs. According to regression directionality, tumor regression pattern was summarized into four categories: type I, regression toward the lumen; type II, regression toward the invasive front; type III, concentric regression; and type IV, scattered regression. Inverse probability propensity score weighting was performed to minimize the influence of confounding factors.ResultsAfter adjusting for baseline characteristics, the R0 resection rates (90.9% vs. 89.0%, P=0.302) and pCR (ypT0N0) rates (29.8% vs. 34.0%, P=0.167) were comparable between two groups. Patients receiving NCRT showed lower TRG score (P

Published
2022
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3. Effect of ventilation strategy during cardiopulmonary bypass on postoperative pulmonary complications after cardiac surgery: a randomized clinical trial

Author

Meng-Qiu Zhang, Yu-Qi Liao, Hong Yu, Xue-Fei Li, Wei Shi, Wei-Wei Jing, Zai-Li Wang, Yi Xu, and Hai Yu

Subjects
Cardiac surgery, Cardiopulmonary bypass, Mechanical ventilation, Fraction of inspired oxygen, Postoperative pulmonary complications, Surgery, RD1-811, Anesthesiology, RD78.3-87.3
Abstract

Abstract Background To determine whether maintaining ventilation during cardiopulmonary bypass (CPB) with a different fraction of inspired oxygen (FiO2) had an impact on the occurrence of postoperative pulmonary complications (PPCs). Methods A total of 413 adult patients undergoing elective cardiac surgery with CPB were randomly assigned into three groups: 138 in the NoV group (received no mechanical ventilation during CPB), 138 in the LOV group (received a tidal volume (VT) of 3–4 ml/kg of ideal body weight with the respiratory rate of 10–12 bpm, and the positive end-expiratory pressure of 5–8 cmH2O during CPB; the FiO2 was 30%), and 137 in the HOV group (received the same ventilation parameters settings as the LOV group while the FiO2 was 80%). Results The primary outcomes were the incidence and severity of PPCs during hospitalization. The composite incidence of PPCs did not significantly differ between the NoV (63%), LOV (49%) and HOV (57%) groups (P = 0.069). And there was also no difference regarding the incidence of PPCs between the non-ventilation (NoV) and ventilation (the combination of LOV and HOV) groups. The LOV group was observed a lower proportion of moderate and severe pulmonary complications (grade ≥ 3) than the NoV group (23.1% vs. 44.2%, P = 0.001). Conclusion Maintaining ventilation during CPB did not reduce the incidence of PPCs in patients undergoing cardiac surgery. Trial registration: Chinese Clinical Trial Registry ChiCTR1800015261. Prospectively registered 19 March 2018. http://www.chictr.org.cn/showproj.aspx?proj=25982

Published
2021
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4. Effect of Volatile Anesthesia Versus Total Intravenous Anesthesia on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial

Author

Lei-Lei He, Xue-Fei Li, Jia-Li Jiang, Hong Yu, Shun-Hui Dai, Wei-Wei Jing, and Hai Yu

Subjects
Adult, Anesthesiology and Pain Medicine, Postoperative Complications, Anesthetics, Inhalation, Anesthesia, Intravenous, Humans, Anesthesia, General, Cardiac Surgical Procedures, Cardiology and Cardiovascular Medicine, Propofol, Anesthetics, Intravenous
Abstract

The purpose of this study was to evaluate the effect of volatile anesthesia and propofol-based total intravenous anesthesia (TIVA) on postoperative pulmonary complications (PPCs) among patients undergoing cardiac surgery.Parallel-group, randomized controlled trial.Single-center tertiary care hospital.Five hundred twenty-four patients undergoing cardiac surgery with cardiopulmonary bypass.The patients were assigned randomly (1:1) to receive anesthesia maintenance with a volatile anesthetic (sevoflurane or desflurane) or propofol-based TIVA.The primary outcome was a composite of postoperative pulmonary complications within the first 7 postoperative days. The PPCs occurred in 118 of 262 patients (45.0%) in the volatile anesthesia group compared with 105 of 262 patients (40.1%) in the propofol-based intravenous anesthesia group (relative risk: 1.17 [95% CI 0.96-1.42], p = 0.123). There were no significant differences in the severity of PPCs within 7 days postoperatively, the occurrence and severity grade of PPCs within 30 days, the incidence of hypoxia, and 30-day mortality.In adult patients undergoing cardiac surgery with cardiopulmonary bypass, general anesthesia with a volatile anesthetic compared with propofol-based TIVA had not reduced pulmonary complications within the first 7 days after surgery.

Published
2022

5. Inhibitory Effect of CCK-8 on Methamphetamine-Induced Apoptosis

Author

Wu-Hua, Zhang, Ming-Long, Zhang, Wei-Wei, Jing, Bing, Xie, Hai-Tao, Bi, Feng, Yu, Bin, Cong, Chun-Ling, Ma, and Di, Wen

Subjects
HEK293 Cells, Humans, Apoptosis, Central Nervous System Stimulants, Sincalide, Methamphetamine
Abstract

To investigate the inhibitory effect of cholecystokinin octapeptide (CCK-8) binding to cholecystokinin 2 receptor (CCK2R) on methamphetamine (METH)-induced neuronal apoptosis, and to explore the signal transduction mechanism of β-arrestin 2 in CCK-8 inhibiting METH-induced neuronal apoptosis.SH-SY5Y cell line was cultured, and HEK293-CCK1R and HEK293-CCK2R cell line were constructed by lentivirus transfection. Small interfering RNA (siRNA) was used to knockdown the expression of β-arrestin 2. Annexin Ⅴ-FITC/PI staining and flow cytometry were used to detect the apoptotic rate of cells, and Western blotting was used to detect the expression of apoptosis-related proteins.The apoptosis of SH-SY5Y cells was induced by 1 mmol/L and 2 mmol/L METH treatment, the number of nuclear fragmentation and pyknotic cells was significantly increased, and the expression of apoptosis-related proteins Bax and cleaved caspase-3 were increased. CCK-8 pre-treatment at the dose of 0.1 mmol/L and 1 mmol/L significantly reversed METH-induced apoptosis in SH-SY5Y cells, and inhibited cell nuclear fragmentation, pyknosis and the changes of apoptosis-related proteins induced by METH. In lentivirus transfected HEK293-CCK1R and HEK293-CCK2R cells, the results revealed that CCK-8 had no significant effect on METH-induced changes of apoptosis-related proteins in HEK293-CCK1R cells, but it could inhibit the expression level of apoptosis-related proteins in HEK293-CCK2R cells induced by METH. The inhibitory effect of CCK-8 on METH-induced apoptosis was blocked by the knockdown of β-arrestin 2 expression in SH-SY5Y cells.CCK-8 can bind to CCK2R and exert an inhibitory effect on METH-induced apoptosis by activating the β-arrestin 2 signal.

Published
2022

6. Effect of ventilation strategy during cardiopulmonary bypass on postoperative pulmonary complications after cardiac surgery: a randomized clinical trial

Author

Xue-Fei Li, Yu-Qi Liao, Hai Yu, Wei Shi, Wei-Wei Jing, Meng-Qiu Zhang, Yi Xu, Zai-Li Wang, and Hong Yu

Subjects
Pulmonary and Respiratory Medicine, Adult, medicine.medical_specialty, RD1-811, medicine.medical_treatment, law.invention, Mechanical ventilation, Randomized controlled trial, law, Anesthesiology, Fraction of inspired oxygen, medicine, Cardiopulmonary bypass, Tidal Volume, Humans, RD78.3-87.3, Cardiac Surgical Procedures, Lung, Tidal volume, Cardiopulmonary Bypass, Postoperative pulmonary complications, business.industry, General Medicine, Cardiac surgery, Respiration, Artificial, Cardiothoracic surgery, Anesthesia, Breathing, Surgery, Cardiology and Cardiovascular Medicine, business, circulatory and respiratory physiology, Research Article
Abstract

Background To determine whether maintaining ventilation during cardiopulmonary bypass (CPB) with a different fraction of inspired oxygen (FiO2) had an impact on the occurrence of postoperative pulmonary complications (PPCs). Methods A total of 413 adult patients undergoing elective cardiac surgery with CPB were randomly assigned into three groups: 138 in the NoV group (received no mechanical ventilation during CPB), 138 in the LOV group (received a tidal volume (VT) of 3–4 ml/kg of ideal body weight with the respiratory rate of 10–12 bpm, and the positive end-expiratory pressure of 5–8 cmH2O during CPB; the FiO2 was 30%), and 137 in the HOV group (received the same ventilation parameters settings as the LOV group while the FiO2 was 80%). Results The primary outcomes were the incidence and severity of PPCs during hospitalization. The composite incidence of PPCs did not significantly differ between the NoV (63%), LOV (49%) and HOV (57%) groups (P = 0.069). And there was also no difference regarding the incidence of PPCs between the non-ventilation (NoV) and ventilation (the combination of LOV and HOV) groups. The LOV group was observed a lower proportion of moderate and severe pulmonary complications (grade ≥ 3) than the NoV group (23.1% vs. 44.2%, P = 0.001). Conclusion Maintaining ventilation during CPB did not reduce the incidence of PPCs in patients undergoing cardiac surgery. Trial registration: Chinese Clinical Trial Registry ChiCTR1800015261. Prospectively registered 19 March 2018. http://www.chictr.org.cn/showproj.aspx?proj=25982

Published
2021

8. The effects of intravenous lidocaine on wound pain and gastrointestinal function recovery after laparoscopic colorectal surgery.

Author

Wei, Shi, Yu‐han, Zhang, Wei‐wei, Jing, and Hai, Yu

Subjects
COLON surgery, RECTAL surgery, CONVALESCENCE, GASTROINTESTINAL motility, INFORMATION storage & retrieval systems, MEDICAL databases, MEDICAL information storage & retrieval systems, INTRAVENOUS therapy, LAPAROSCOPY, LIDOCAINE, MEDLINE, META-analysis, ONLINE information services, POSTOPERATIVE pain, SYSTEMATIC reviews
Abstract

To evaluate the efficacy of intravenous lidocaine in relieving postoperative pain and promoting rehabilitation in laparoscopic colorectal surgery, we conducted this meta‐analysis. The systematic search strategy was performed on PubMed, EMBASE, Chinese databases, and Cochrane Library before September 2019. As a result, 10 randomised clinical trials were included in this meta‐analysis (n = 527 patients). Intravenous lidocaine significantly reduced pain scores at 2, 4, 12, 24, and 48 hours on movement and 2, 4, and 12 hours on resting‐state and reduced opioid requirement in first 24 hours postoperatively (weighted mean difference [WMD] = −5.02 [−9.34, −0.70]; P =.02). It also decreased the first flatus time (WMD: −10.15 [−11.20, −9.10]; P <.00001), first defecation time (WMD: −10.27 [−17.62, −2.92]; P =.006), length of hospital stay (WMD: −1.05 [−1.89, −0.21]; P =.01), and reduced the incidence of postoperative nausea and vomiting (risk ratio: 0.53 [0.30, 0.93]; P =.03) when compared with control group. However, it had no effect on pain scores at 24 and 48 hours at rest, the normal dietary time, and the level of serum C‐reactive protein. In summary, perioperative intravenous lidocaine could alleviate acute pain, reduce postoperative analgesic requirements, and accelerate recovery of gastrointestinal function in patients undergoing laparoscopic colorectal surgery. [ABSTRACT FROM AUTHOR]

Published
2020
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9. Biocompatibility assessment of porous chitosan-Nafion and chitosan-PTFE compositesin vivo

Author

Xian-Zheng Sha, Wei-Wei Jing, Juan Su, Min-Jie Wei, Bo-Ji Liu, and Li-Nan Ma

Subjects
Materials science, Polytetrafluoroethylene, Biocompatibility, Silica gel, technology, industry, and agriculture, Metals and Alloys, Biomedical Engineering, engineering.material, Biomaterials, Solvent, Chitosan, chemistry.chemical_compound, Coating, chemistry, Tissue engineering, Nafion, Ceramics and Composites, engineering, Composite material, Biomedical engineering
Abstract

Chitosan (CS) is widely used as a scaffold material in tissue engineering. The objective of this study was to test whether porous chitosan membrane (PCSM) coating for Nafion used in implantable sensor reduced fibrous capsule (FC) density and promoted superior vascularization compared with PCSM coating for polytetrafluoroethylene (PTFE). PCSM was fabricated with solvent casting/particulate leaching method using silica gel as porogen and characterized in vitro. Then, PCSM-Nafion and PCSM-PTFE composites were assembled with hydrated PCSM and implanted subcutaneously in rats. The histological analysis was performed in comparison with Nafion and PTFE. Implants were explanted 35, 65, and 100 days after the implantation. Histological assessments indicated that both composites achieved presumed effects of porous coatings on decreasing collagen deposition and promoting angiogenesis. PCSM-PTFE exerted higher collagen deposition by area ratio, both within and outside, compared with that of PCSM-Nafion. Angiogenesis within and outside the PCSM-Nafion both increased over time, but that of the PCSM-PTFE within decreased.

Published
2013
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10. Biocompatibility assessment of porous chitosan-Nafion and chitosan-PTFE composites in vivo

Author

Bo-Ji, Liu, Li-Nan, Ma, Juan, Su, Wei-Wei, Jing, Min-Jie, Wei, and Xian-Zheng, Sha

Subjects
Rats, Sprague-Dawley, Chitosan, Fluorocarbon Polymers, Tissue Scaffolds, Foreign-Body Reaction, Animals, Biocompatible Materials, Polytetrafluoroethylene, Porosity, Rats
Abstract

Chitosan (CS) is widely used as a scaffold material in tissue engineering. The objective of this study was to test whether porous chitosan membrane (PCSM) coating for Nafion used in implantable sensor reduced fibrous capsule (FC) density and promoted superior vascularization compared with PCSM coating for polytetrafluoroethylene (PTFE). PCSM was fabricated with solvent casting/particulate leaching method using silica gel as porogen and characterized in vitro. Then, PCSM-Nafion and PCSM-PTFE composites were assembled with hydrated PCSM and implanted subcutaneously in rats. The histological analysis was performed in comparison with Nafion and PTFE. Implants were explanted 35, 65, and 100 days after the implantation. Histological assessments indicated that both composites achieved presumed effects of porous coatings on decreasing collagen deposition and promoting angiogenesis. PCSM-PTFE exerted higher collagen deposition by area ratio, both within and outside, compared with that of PCSM-Nafion. Angiogenesis within and outside the PCSM-Nafion both increased over time, but that of the PCSM-PTFE within decreased.

Published
2013

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