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Self-evolution problem of an aircraft-engine assembly workshop with uncertain number of assembly times in knowledgeable manufacturing environment is studied in this article. The whole dynamic self-evolution process is decomposed into a series of static ones by using the rolling horizon procedure. A rolling rule, which is employed to select operations into rolling windows, is designed on the basis of the level priority of each operation. An algorithm for the self-evolution algorithm is then proposed. Due to the deterministic production information, a static decision sub-problem is needed to be solved at each decision point. A general mathematical model of sub-problems is built to minimize the production cost. For solving it, a bi-level genetic algorithm is proposed. In the lower level genetic algorithm, an improved decoding method is also designed by considering production features. Finally, simulation results demonstrate the feasibility and validity of the model and algorithms. Then, computational data indicate that the system with self-evolution capability pays lower costs for production. [ABSTRACT FROM AUTHOR]

An adaptive scheduling strategy based on state-action uncertainty bias based Q-learning (SAUBQ-learning) is proposed for adaptive scheduling in knowledgeable manufacturing environment. Aiming at the problem of slow convergence and long training time in conventional Q-learning process, a state-action uncertainty measure is defined by information entropy, on the basis of which a Q-learning action bias information function is defined. The bias information is integrated into Q-learning system by designing heuristic Q-learning reward function, and the optimal strategy invariance and convergence of SAUBQ-learning are proved. In learning process, search space is adjusted by bias information, the effective state-action number explored by Q-learning is reduced. Furthermore, the bias information is also continually updated by Q-learning results, and misleading Q-learning process is avoided. Simulation experiment results indicate that the strategy has better adaptive feature in dynamic environment and the feature of converging quickly in large state space, and improves the efficiency of scheduling. [ABSTRACT FROM AUTHOR]

Objective To understand the differences in the demand,preference,and tendency for elderly care services between urban and rural areas in the Pearl River Delta (PRD),and to provide reference for the planning and balanced allocation of elderly care resources in urban and rural areas. Methods Using the multi-stage stratified random sampling method,we selected 7 community health service centers in 2 prefecture-level cities in the PRD and conducted a questionnaire survey on the elderly care service demand,preference,and tendency among 1919 regular residents aged 60 years and above who attended the centers. Results A total of 641 urban elderly residents (33.4%) and 1278 rural elderly residents (66.6%) were surveyed in the PRD.The urban and rural elderly residents showed differences in the child number ( χ 2 =43.379, P <0.001),willingness to purchase socialized elderly care services ( χ 2 =104.141, P <0.001),and attitudes to the concept of raising child to avoid elderly hardship ( χ 2 =65.632, P <0.001).The proportion (71.8%) of rural elderly residents who prefer family-based elderly care was higher than that (57.1%) of urban elderly residents ( χ 2 =41.373, P <0.001).The proportion (62.2%) of urban elderly residents clearly expressing their willingness to choose institutions for elderly care was higher than that (44.0%) of rural elderly residents ( χ 2 =57.007, P <0.001).Compared with family-based elderly care,the willingness to choose institutional or community-based in-house elderly care was low among the urban elderly residents with surplus monthly household income or balanced income and expenditure;urban males,those with college education background or above,and those who purchased socialized elderly care services tended to prefer community-based in-house elderly care.In rural areas,the elderly residents who had local household registry were prone to choose institutional or community-based in-house elderly care,while those who had more than one child and those who were satisfied with the current living conditions were less willing to choose community-based in-house elderly care. Conclusions It is suggested that the urban-rural differences in the elderly care service demand,preference and tendency should be fully considered in the planning and allocation of urban and rural elderly care resources.Efforts remain to be made to develop diversified social elderly care services tailored to the characteristics of urban and rural areas.

Objective To compare the functional status of diabetic patients with and without nephropathy and identify the items that diabetic patients with nephropathy are more likely to develop dysfunction than diabetic patients without nephropathy based on the international classification of functioning,disability and health rehabilitation set(ICF-RS).Methods A cross-sectional study was conducted.A total of 320 diabetic patients hospitalized in Guangdong Provincial Hospital of Chinese Medicine from August 2021 to February 2022 were selected and assigned into a group with nephropathy and a group without nephropathy.The general characteristics,clinical examination,and laboratory findings were compared by the t test,rank sum test,and Chi-squared test.The functional status of the patients was compared between the two groups by the t test based on the ICF-RS.Logistic regression was employed to control interferential factors between the two groups and identify the association between nephropathy and ICF-RS problematic items among diabetic patients.Results The diabetic patients with nephropathy had more problematic items in ICF-RS( P <0.001),the body function dimension( P =0.003),the activity dimension( P <0.001),and the participation dimension( P <0.001)than those without nephropathy.Moreover,the diabetic patients with nephropathy experienced severer problems in 5 body function items(energy and drive functions,sleep functions,sexual functions,exercise tolerance functions,and muscle power functions),10 activity items(transferring oneself,walking,moving around using equipment,moving around,washing oneself,caring for body parts,toileting,dressing,doing housework,and looking after one's health),and 4 participation items(using transportation,assisting others,basic interpersonal interactions,and recreation and leisure)(all P <0.05).The Logistic regression results showed that compared with the diabetic patients without nephropathy,the diabetic patients with nephropathy were more likely to develop problems in energy and drive functions( aOR =4.35,95% CI =1.28-14.79, P =0.019),emotional functions( aOR =1.88,95% CI =1.06-3.34, P =0.031),sexual functions( aOR =3.39,95% CI =1.82-6.34, P <0.001),moving around( aOR =3.11,95% CI =1.76-5.52, P <0.001),doing housework( aOR =17.48,95% CI =3.57-85.60, P <0.001),looking after one's health( aOR =1.97,95% CI =1.13-3.43, P =0.017),using transportation( aOR =2.59,95% CI =1.38-4.88, P =0.003),and recreation and leisure( aOR =2.52,95% CI =1.46-4.35, P <0.001).Conclusion Compared with the diabetic patients without nephropathy,the patients with nephropathy suffer more ICF-RS problematic items and are more likely to develop dysfunction in certain items in all the three dimensions.

Pyroptosis plays an important role in hemorrhagic stroke. Excessive endoplasmic reticulum stress can cause endoplasmic reticulum dysfunction and cellular pyroptosis by regulating the nucleotide-binding oligomerization domain and leucine-rich repeat pyrin domain-containing protein 3 (NLRP3) pathway. However, the relationship between pyroptosis and endoplasmic reticulum stress after intraventricular hemorrhage is unclear. In this study, we established a mouse model of intraventricular hemorrhage and found pyroptosis and endoplasmic reticulum stress in brain tissue. Intraperitoneal injection of the selective GPR120 agonist TUG-891 inhibited endoplasmic reticulum stress, pyroptosis, and inflammation and protected neurons. The neuroprotective effect of TUG-891 appears related to inhibition of endoplasmic reticulum stress and pyroptosis activation., Competing Interests: None

Necrostatin-1, an inhibitor of necroptosis, can effectively inhibit necrotic apoptosis in neurological diseases, which results in the inhibition of inflammation, endoplasmic reticulum stress, and reactive oxygen species production and substantial improvement of neurological function. However, the effects of necrostatin-1 on intraventricular hemorrhage (IVH) remain unknown. In this study, we established a mouse model of IVH by injecting autologous blood into the lateral ventricle of the brain. We also injected necrostatin-1 into the lateral ventricle one hour prior to IVH induction. We found that necrostatin-1 effectively reduced the expression levels of the necroptosis markers receptor-interacting protein kinase (RIP)1, RIP3, mixed lineage kinase domain-like protein (MLKL), phosphorylated (p)-RIP3, and p-MLKL and the levels of interleukin-1β , interleukin-6, and tumor necrosis factor-α in the surrounding areas of the lateral ventricle. However, necrostatin-1 did not reduce ependymal ciliary injury or brain water content. These findings suggest that necrostatin-1 can prevent local inflammation and microglial activation induced by IVH but does not greatly improve prognosis., Competing Interests: None