36 results on '"Walldius, Goran"'
Search Results
2. Chronic inflammation markers are associated with risk of pancreatic cancer in the Swedish AMORIS cohort study
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Sollie, Sam, Michaud, Dominique S., Sarker, Debashis, Karagiannis, Sophia N., Josephs, Debra H., Hammar, Niklas, Santaolalla, Aida, Walldius, Goran, Garmo, Hans, Holmberg, Lars, Jungner, Ingmar, and Van Hemelrijck, Mieke
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- 2019
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3. Association of Inflammatory Markers and Blood Cell Counts and the Risk of Leukemia in the Swedish Amoris Cohort
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Sami, Mohammad Abdus, primary, Feychting, Maria, additional, Hammar, Niklas, additional, Walldius, Goran, additional, Van Hemelrijck, Mieke, additional, Kordasti, Shahram, additional, and Santaolalla, Aida, additional
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- 2021
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4. Serum Total Bilirubin and Risk of Cancer: A Swedish Cohort Study and Meta-Analysis
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Monroy-Iglesias, Maria J., primary, Moss, Charlotte, additional, Beckmann, Kerri, additional, Hammar, Niklas, additional, Walldius, Goran, additional, Bosco, Cecilia, additional, Hemelrijck, Mieke Van, additional, and Santaolalla, Aida, additional
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- 2021
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5. Additional file 1 of Association between serum markers of the humoral immune system and inflammation in the Swedish AMORIS study
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Santaolalla, Aida, Sollie, Sam, Rislan, Ali, Josephs, Debra H., Hammar, Niklas, Walldius, Goran, Garmo, Hans, Karagiannis, Sophia N., and Van Hemelrijck, Mieke
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Additional file 1. Supplementary information describing the interactions among biomarkers.
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- 2021
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6. Long-term risk of a major cardiovascular event by apoB, apoA-1, and the apoB/apoA-1 ratio-Experience from the Swedish AMORIS cohort : A cohort study
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Walldius, Goran, de Faire, Ulf, Alfredsson, Lars, Leander, Karin, Westerholm, Peter, Malmstrom, Hakan, Ivert, Torbjorn, Hammar, Niklas, Walldius, Goran, de Faire, Ulf, Alfredsson, Lars, Leander, Karin, Westerholm, Peter, Malmstrom, Hakan, Ivert, Torbjorn, and Hammar, Niklas
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Background Elevated apolipoprotein B (apoB) and elevated apoB/apoA-1 ratio increase the risk of myocardial infarction (MI) and stroke, whereas high apoA-1 is protective. We study how these apolipoproteins are associated with major adverse cardiovascular events (MACEs), whether apoA-1 contributes to this association, and whether abnormal values occur decades before such events develop. Methods and findings In the Swedish AMORIS (Apolipoprotein-related MOrtality RISk) cohort study, 137,100 men and women aged 25-84 years were followed an average 17.8 years. ApoB, apoA-1, and the apoB/apoA-1 ratio were analysed in relation to MACEs (non-fatal MI, stroke, and cardiovascular [CV] mortality), yielding 22,473 events. Hazard ratios (HRs) were estimated using Cox regression. Kaplan-Meier estimates were used to investigate the relationship of MACEs with increasing quintiles of the apoB/apoA-1 ratio in all age groups for both sexes. In nested case-control analyses, cases were randomly matched to age- and sex-matched controls, yielding population trajectories for apolipoproteins. Increased level of apoB and increased apoB/apoA-1 ratio were associated with risk of MACE and all clinical sub-components in both men and women across all ages (10th versus first decile in both sexes combined: HR 1.7 for MACE and 2.7 for non-fatal MI). Decreased values of apoA-1 potentiated the impact of apoB at all levels of apoB (on average across apoB range: 40% increase in HR for MACE and 72% increase in HR for non-fatal MI), indicating that the apoB/apoA-1 ratio covers a broader range of persons with dyslipidaemia at risk than apoB alone. In both men and women, MACEs occurred earlier on average for each increasing quintile of the apoB/apoA-1 ratio. Individuals with the highest levels of apoB/apoA-1 ratio experienced CV events on average several years earlier than those with lower ratios. Higher apoB/apoA-1 ratio in cases of MACE versus controls was seen already about 20 years before the event. A li
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- 2021
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7. Relation of Age, the Apolipoprotein B/Apolipoprotein A-I Ratio, and the Risk of Fatal Myocardial Infarction and Implications for the Primary Prevention of Cardiovascular Disease
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Sniderman, Allan D., Holme, Ingar, Aastveit, Are, Furberg, Curt, Walldius, Goran, and Jungner, Ingmar
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- 2007
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8. Association between serum markers of the humoral immune system and inflammation in the Swedish AMORIS study
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santaolalla, aida, primary, Sollie, Sam, additional, Rislan, Ali, additional, Josephs, Debra H., additional, Hammar, Niklas, additional, Walldius, Goran, additional, Jungner, Ingmar, additional, Garmo, Hans, additional, Karagiannis, Sophia N., additional, and Hemelrijck, Mieke Van, additional
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- 2020
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9. Does Low-Density Lipoprotein Size Add to Atherogenic Particle Number in Predicting the Risk of Fatal Myocardial Infarction?
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Jungner, Ingmar, Sniderman, Allan D., Furberg, Curt, Aastveit, Are H., Holme, Ingar, and Walldius, Goran
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- 2006
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10. High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fatal myocardial infarction (AMORIS study): a prospective study
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Walldius, GoRan, Jungner, Ingmar, Holme, Ingar, Aastveit, Are H., Kolar, Werner, and Steiner, Eugen
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- 2001
11. Serum Immunoglobulin G Is Associated With Decreased Risk of Pancreatic Cancer in the Swedish AMORIS Study
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Sollie, Sam, primary, Santaolalla, Aida, additional, Michaud, Dominique S., additional, Sarker, Debashis, additional, Karagiannis, Sophia N., additional, Josephs, Debra H., additional, Hammar, Niklas, additional, Walldius, Goran, additional, Garmo, Hans, additional, Holmberg, Lars, additional, Jungner, Ingmar, additional, and Van Hemelrijck, Mieke, additional
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- 2020
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12. Immune mediator expression signatures are associated with improved outcome in ovarian carcinoma
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Nakamura, Mano, Bax, Heather J., Scotto, Daniele, Souri, Elmira Amiri, Sollie, Sam, Harris, Robert J., Hammar, Niklas, Walldius, Goran, Winship, Anna, Ghosh, Sharmistha, Montes, Ana, Spicer, James F., Van Hemelrijck, Mieke, Josephs, Debra H., Lacy, Katie E., Tsoka, Sophia, and Karagiannis, Sophia N.
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lcsh:Immunologic diseases. Allergy ,Immune activation ,ovarian cancer ,immune mediators ,inflammation ,M1/M2 ,biomarkers ,Th1/Th2/Th17 ,lcsh:RC581-607 ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,lcsh:RC254-282 ,Original Research - Abstract
Immune and inflammatory cascades may play multiple roles in ovarian cancer. We aimed to identify relationships between expression of immune and inflammatory mediators and patient outcomes. We interrogated differential gene expression of 44 markers and marker combinations (n = 1,978) in 1,656 ovarian carcinoma patient tumors, alongside matched 5-year overall survival (OS) data in silico. Using machine learning methods, we investigated whether genomic expression of these 44 mediators can discriminate between malignant and non-malignant tissues in 839 ovarian cancer and 115 non-malignant ovary samples. We furthermore assessed inflammation markers in 289 ovarian cancer patients’ sera in the Swedish Apolipoprotein MOrtality-related RISk (AMORIS) cohort. Expression of the 44 mediators could discriminate between malignant and non-malignant tissues with at least 96% accuracy. Higher expression of classical Th1, Th2, Th17, anti-parasitic/infection and M1 macrophage mediator signatures were associated with better OS. Contrastingly, inflammatory and angiogenic mediators, CXCL-12, C-reactive protein (CRP) and platelet-derived growth factor subunit A (PDGFA) were negatively associated with OS. Of the serum inflammatory markers in the AMORIS cohort, women with ovarian cancer who had elevated levels of haptoglobin (≥1.4 g/L) had a higher risk of dying from ovarian cancer compared to those with haptoglobin levels
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- 2019
13. Serum IgG Is Associated With Risk of Melanoma in the Swedish AMORIS Study
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Kessler, Anna, primary, Sollie, Sam, additional, Karagiannis, Sophia N., additional, Walldius, Goran, additional, Hammar, Niklas, additional, and Van Hemelrijck, Mieke, additional
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- 2019
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14. The effect of probucol on femoral atherosclerosis: the Probucol Quantitative Regression Swedish Trial (PQRST)
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Walldius, Goran, Erikson, Uno, Olsson, Anders G., Bergstrand, Lott, Hadell, Karin, Johansson, Jan, Kaijser, Lennart, Lassvik, Claes, Molgaard, Jorgen, Nilsson, Sven, Schafer-Elinder, Liselotte, Stenport, Goran, and Holme, Ingar
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Hypercholesterolemia -- Drug therapy ,Probucol -- Evaluation ,Femoral artery ,Atherosclerosis ,Health - Abstract
The Probucol Quantitative Regression Swedish Trial tested whether treatment of hypercholesterolemic persons with probucol for 3 years affected femoral atherosclerosis. The primary end point was the change in atheroma volume estimated as change in lumen volume of the femoral artery assessed by quantitative arteriography. Three hundred three patients with visible atherosclerosis were randomized to probucol 0.5 g, twice daily, or to placebo. All patients were given diet and cholestyramine, 8 to 16 g/day. Twenty-nine patients were excluded because of inadequate primary end point measurements. The mean age of the remaining 274 subjects (158 were men) was 55 years. Seventeen percent had intermittent claudication and 24% had angina pectoris. After 3 years, the probucol-treated patients had 17% lower serum cholesterol, 12% lower low-density lipoprotein cholesterol, 24% lower total high-density lipoprotein cholesterol, and 34% lower high-density [lipoprotein.sub.2] cholesterol levels than control subjects. All lipoprotein differences between the treatment groups remained highly significant during the trial. There was no statistically significant change in lumen volume between the probucol and the control group. Furthermore, there was no difference between the treatment groups with regard to change in arterial edge roughness or amount of aorto-femoral atherosclerosis; neither were there any differences between the treatment groups with regard to change in ST-segment depressions on exercise tests or ankle/arm blood pressure (secondary end points). In the control group, lumen volume increased (p [less than] 0.001) and roughness of the femoral artery decreased (p [less than] 0.05). It is concluded that the addition of probucol to diet and cholestyramine did not result in any significant regression of atherosclerosis compared with that found in patients treated only with diet and cholestyramine. However, in this control group there was statistically significant evidence of improvement. (Am J Cardiol 1994;74:875-883)
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- 1994
15. The role of lipids and antioxidative factors for development of atherosclerosis: The Probucol Quantitative Regression Swedish Trial (PQRST)
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Walldius, Goran, Regnstrom, J., Nilsson, J., Johansson, J., Schafer-Elinder, L., Moelgaard, J., Hadell, K., Olsson, A.G., and Carlson, L.A.
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Atherosclerosis -- Drug therapy ,Low density lipoproteins -- Physiological aspects ,Oxidation, Physiological -- Physiological aspects ,Antioxidants -- Physiological aspects ,Probucol -- Physiological aspects ,Health - Abstract
The effect of prebucol on the development of atherascleresis is being Investigated in the Probucol Quantitative Regression Swedish Trial (PQRST). Hypercholosterolemic patients are randomIzed to receive either probucol 0.5 g twice daily or placebo in a double-blind manner, in combination with dietary therapy and choleatyramine 8-:1.6 g daily for a 3-year period. The primary endpoint of the trial is the change in atheroma volume, asseseecl by annual quantitative angiography involving 20-cm segments of the femoral artery. Data from the open diet and prerandomization phase indicate that probucol added to dietary intervention plus cholestyramine produced highly significant reductions in total (-17%), low-donslty lipopratein (LDL; -10%), and high-donsity lipopratein (-30%) cholesterol. From a subpopulatlon, LDL levels were isolated during different stages of the prerandomization phase. LDL was exposed to the oxidant Cu2+ and binding to fibroblasts as well as degradation by macrophages was measured. The generation of thlobarbRuric acid-reactive substances (TBARS) was also moasered. Probucol prevented degradation of copper-exposed LDL by macrophages and also reducad the formation of TBARS, indicating that probucol protected LDL from oxidation. After the tdal concludes in December 1992, statistical models will he used to investigate how much of the change in atheresclerosis is explained by changes in lipoprotein concentrations and how much is explained by probucors antioxidative effects. Thus, other matabolic factors such as dietary intake and circulating levels of lipid soluble vitamins and fatty acids that may modify the possible antioxldative effects of probucal are also measured and will he related to change in atheresclerosis. (Am J Cardiol 1993;71:15B-19B)
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- 1993
16. Serum inflammatory markers in relation to prostate cancer severity and death
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Crawley, Danielle, primary, Williams, Robert, additional, Garmo, Hans, additional, Holmberg, Lars, additional, Stattin, Par, additional, Malmstrom, Hakan, additional, Lambe, Mats, additional, Hammar, Niklas, additional, Walldius, Goran, additional, Robinson, David, additional, Jungner, Ingmar, additional, and Van Hemelrijck, Mieke, additional
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- 2018
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17. Serum inflammatory markers in relation to prostate cancer severity and death
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Crawley, Danielle, primary, Williams, Robert, additional, Garmo, Hans, additional, Holmberg, Lars, additional, Stattin, Par, additional, Malmstrom, Hakan, additional, Lambe, Mats, additional, Hammar, Niklas, additional, Walldius, Goran, additional, Robinson, David, additional, Jungner, Ingmar, additional, and Van Hemelrijck, Mieke, additional
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- 2017
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18. Associations between prediagnostic blood glucose levels, diabetes, and glioma
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Schwartzbaum, Judith, Edlinger, Michael, Zigmont, Victoria, Stattin, Pär, Rempala, Grzegorz A., Nagel, Gabriele, Hammar, Niklas, Ulmer, Hanno, Foeger, Bernhard, Walldius, Goran, Manjer, Jonas, Malmstrom, Hakan, Feychting, Maria, Schwartzbaum, Judith, Edlinger, Michael, Zigmont, Victoria, Stattin, Pär, Rempala, Grzegorz A., Nagel, Gabriele, Hammar, Niklas, Ulmer, Hanno, Foeger, Bernhard, Walldius, Goran, Manjer, Jonas, Malmstrom, Hakan, and Feychting, Maria
- Abstract
Previous literature indicates that pre-diagnostic diabetes and blood glucose levels are inversely related to glioma risk. To replicate these findings and determine whether they could be attributed to excess glucose consumption by the preclinical tumour, we used data from the Apolipoprotein MOrtality RISk (AMORIS) (n = 528,580) and the Metabolic syndrome and Cancer project (Me-Can) cohorts (n = 269,365). We identified individuals who were followed for a maximum of 15 years after their first blood glucose test until glioma diagnosis, death, emigration or the end of follow-up. Hazard ratios (HRs), 95% confidence intervals (CIs) and their interactions with time were estimated using Cox time-dependent regression. As expected, pre-diagnostic blood glucose levels were inversely related to glioma risk (AMORIS, P-trend = 0.002; Me-Can, P-trend = 0.04) and pre-diagnostic diabetes (AMORIS, HR = 0.30, 95% CI 0.17 to 0.53). During the year before diagnosis, blood glucose was inversely associated with glioma in the AMORIS (HR = 0.78, 95% CI 0.66 to 0.93) but not the Me-Can cohort (HR = 0.99, 95% CI 0.63 to 1.56). This AMORIS result is consistent with our hypothesis that excess glucose consumption by the preclinical tumour accounts for the inverse association between blood glucose and glioma. We discuss additional hypothetical mechanisms that may explain our paradoxical findings.
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- 2017
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19. Association between metabolic syndrome components and the risk of primary liver cancer and cirrhosis
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Nderitu, Paul, primary, Garmo, Hans, additional, Holmberg, Lars, additional, Malmstrom, Hakan, additional, Hammar, Niklas, additional, Walldius, Goran, additional, Jungner, Ingmar, additional, Lambe, Mats, additional, and Van Hemelrijck, Mieke, additional
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- 2016
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20. Association between baseline serum glucose, triglycerides and total cholesterol, and prostate cancer risk categories
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Arthur, Rhonda, Møller, Henrik, Garmo, Hans, Holmberg, Lars, Stattin, Pär, Malmstrom, Hakan, Lambe, Mats, Hammar, Niklas, Walldius, Goran, Robinson, David, Jungner, Ingmar, Van Hemelrijck, Mieke, Arthur, Rhonda, Møller, Henrik, Garmo, Hans, Holmberg, Lars, Stattin, Pär, Malmstrom, Hakan, Lambe, Mats, Hammar, Niklas, Walldius, Goran, Robinson, David, Jungner, Ingmar, and Van Hemelrijck, Mieke
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Lifestyle-related risk factors such as hyperglycemia and dyslipidemia have been associated with several cancers. However, studies exploring their link with prostate cancer (PCa) clinicopathological characteristics are sparse and inconclusive. Here, we investigated the associations between serum metabolic markers and PCa clinicopathological characteristics. The study comprised 14,294 men from the Swedish Apolipoprotein MOrtality RISk (AMORIS) cohort who were diagnosed with PCa between 1996 and 2011. Univariate and multivariable logistic regression were used to investigate the relation between glucose, triglycerides and total cholesterol and PCa risk categories, PSA, Gleason score, and T-stage. Mean age at time of PCa diagnosis was 69 years. Men with glucose levels >6.9 mmol/L tend to have PSA<4 mu g/L, while those with glucose levels of 5.6-6.9 mmol/L had a greater odds of PSA>20 mu g/L compared to PSA 4.0-9.9 mu g/L. Hypertriglyceridemia was also positively associated with PSA>20 mu g/L. Hyperglycemic men had a greater odds of intermediate-and high-grade PCa and advanced stage or metastatic PCa. Similarly, hypertriglyceridemia was positively associated with high-grade PCa. There was also a trend toward an increased odds of intermediate risk localized PCa and advanced stage PCa among men with hypertriglyceridemia. Total cholesterol did not have any statistically significant association with any of the outcomes studied. Our findings suggest that high serum levels of glucose and triglycerides may influence PCa aggressiveness and severity. Further investigation on the role of markers of glucose and lipid metabolism in influencing PCa aggressiveness and severity is needed as this may help define important targets for intervention.
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- 2016
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21. Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival
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Wulaningsih, Wahyu, Holmberg, Lars, Garmo, Hans, Karagiannis, Sophia N., Ahlstedt, Staffan, Malmstrom, Hakan, Lambe, Mats, Hammar, Niklas, Walldius, Goran, Jungner, Ingmar, Ng, Tony, Van Hemelrijck, Mieke, Wulaningsih, Wahyu, Holmberg, Lars, Garmo, Hans, Karagiannis, Sophia N., Ahlstedt, Staffan, Malmstrom, Hakan, Lambe, Mats, Hammar, Niklas, Walldius, Goran, Jungner, Ingmar, Ng, Tony, and Van Hemelrijck, Mieke
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Prior findings linking allergy and cancer have been inconsistent, which may be driven by diverse assessment methods. We used serum specific immunoglobulin E (IgE) against common inhalant allergens that was assessed prior to cancer diagnosis in studying this association. We selected 8,727 Swedish men and women who had measurements of serum allergen-specific IgE and total IgE between 1992 and 1996. Multivariable Cox regression using age as a timescale was performed to assess the associations of IgE sensitization, defined by any levels of serum specific IgE >= 35 kU/L, with risk of overall and specific cancers. A test for trend was performed by assigning scores derived from allergen-specific IgE levels at baseline as an ordinal scale. Kaplan-Meier curves and log-rank test were used to assess cancer survival by IgE sensitization status. During a mean follow-up of 16 year, 689 persons were diagnosed with cancer. We found an inverse association between IgE sensitization and cancer risk, with a hazard ratio (HR) of 0.83 and 95% confidence intervals (CI) of 0.70-0.99. A similar trend was seen with specific IgE scores overall (P-trend = 0.007) and in women (P-trend = 0.01). Although IgE sensitization was not associated with risk of common site-specific cancers, serum specific IgE scores were inversely associated with melanoma risk in men and women combined, and with risk of female breast and gynecological cancers combined. No association with survival was observed. The association between circulating IgE levels and incident cancer may point toward a role of T-helper 2 (T(H)2)-biased response in development of some cancers.
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- 2016
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22. Chronic kidney disease and 10-year risk of cardiovascular death
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Holzmann, Martin J., Carlsson, Axel C., Hammar, Niklas, Ivert, Torbjorn, Walldius, Goran, Jungner, Ingmar, Wandell, Per, Ärnlöv, Johan, Holzmann, Martin J., Carlsson, Axel C., Hammar, Niklas, Ivert, Torbjorn, Walldius, Goran, Jungner, Ingmar, Wandell, Per, and Ärnlöv, Johan
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Background In recent clinical guidelines, individuals with chronic kidney disease are considered to have a similar 10-year absolute risk of cardiovascular death as individuals with diabetes or established cardiovascular disease. There is limited evidence to support this claim. Methods We investigated the 10-year risk for cardiovascular death in individuals with moderate or severe chronic kidney disease (glomerular filtration rate of 30-60 or <30mL/min/1.73m(2), respectively) in a cohort of primary care health check-ups in Stockholm, Sweden (n=295,191, 46% women, 4290 cardiovascular deaths during 10 years follow-up). We also assessed the risk associated with diabetes or cardiovascular disease. The inclusion criteria, exposure, study outcome and follow-up period adhered strictly to the definitions of the European Society of Cardiology guidelines. Results The absolute 10-year risk of cardiovascular death was 3.9% and 14.0% in individuals with moderate and severe chronic kidney disease, respectively, but was substantially lower in women and in younger individuals. The risk in individuals with prevalent diabetes and cardiovascular disease was approximately two and three times higher compared to the risk estimate for moderate chronic kidney disease (hazard ratio (HR) 4.1, 95% confidence interval (CI) 3.8-4.5 and HR 6.2, 95% CI 5.7-6.7 vs. HR 2.3 95% CI 2.0-2.6, respectively) while the risk for individuals with severe chronic kidney disease appeared more congruent to that of diabetes and cardiovascular disease (HR 5.5, 95% CI 3.3-8.9). Conclusions Although moderate chronic kidney disease is an independent predictor for an increased 10-year risk of cardiovascular death, only those with severe chronic kidney disease had similar risk to those with diabetes or cardiovascular disease.
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- 2016
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23. Effects of felodipine versus nifedipine on exercise tolerance in stable angina pectoris
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Ekelund, Lars G., Ulvenstam, Goran, Walldius, Goran, and Aberg, Anders
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Felodipine -- Physiological aspects ,Nifedipine -- Physiological aspects ,Angina pectoris -- Drug therapy ,Health - Abstract
The effects of single doses of felodipine (5 and 10 mg) and nifedipine (10 and 20 mg) on chronic stable effort angina pectoris were assessed in a placebo-controlled, double-blind, crossover study of 24 patients receiving [beta] blockers and short. acting nitroglycerin. The effects were measured by repeated bicycle ergometer tests. The total work, and time until 1 mm of ST depression increased significantly by 9 to 31% after both active drugs at both dose levels in comparison with placebo. The differences were not. significant between drugs or doses. At rest, blood pressure decreased (10 to 15%) and heart rate increased (S to 10%) significantly after both active drugs. During exercise at the highest comparable work load, systolic blood pressure decreased significantly (23 to 26%), whereas heart rate was not affected after felodipine and nifedipine compared with placebo. The 2 drugs were well tolerated, and side effects were mild. Therefore, single doses of 5 and 10 mg of felodipine, and 10 and 20 mg of nifedpine have similar antiaginal and anti-ishemic properties. However, felodipine has a longer duration of action, which may improve compliance.
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- 1994
24. Association between prediagnostic glucose, triglycerides, cholesterol and meningioma, and reverse causality
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Bernardo, Brittany M, primary, Orellana, Robert C, additional, Weisband, Yiska Lowenberg, additional, Hammar, Niklas, additional, Walldius, Goran, additional, Malmstrom, Hakan, additional, Ahlbom, Anders, additional, Feychting, Maria, additional, and Schwartzbaum, Judith, additional
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- 2016
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25. Serum lactate dehydrogenase and survival following cancer diagnosis
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Wulaningsih, Wahyu, Holmberg, Lars, Garmo, Hans, Malmstrom, Hakan, Lambe, Mats, Hammar, Niklas, Walldius, Goran, Jungner, Ingmar, Ng, Tony, Van Hemelrijck, Mieke, Wulaningsih, Wahyu, Holmberg, Lars, Garmo, Hans, Malmstrom, Hakan, Lambe, Mats, Hammar, Niklas, Walldius, Goran, Jungner, Ingmar, Ng, Tony, and Van Hemelrijck, Mieke
- Abstract
Background: There is evidence that high level of serum lactate dehydrogenase (LDH) is associated with poorer overall survival in several malignancies, but its link to cancer-specific survival is unclear. Methods: A total of 7895 individuals diagnosed with cancer between 1986 and 1999 were selected for this study. Multivariable Cox proportional hazards regression was used to assess overall and cancer-specific death by the z-score and clinical categories of serum LDH prospectively collected within 3 years before diagnosis. Site-specific analysis was performed for major cancers. Analysis was repeated by different lag times between LDH measurements and diagnosis. Results: At the end of follow-up, 5799 participants were deceased. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall and cancer-specific death in the multivariable model were 1.43 (1.31-1.56) and 1.46 (1.32-1.61), respectively, for high compared with low prediagnostic LDH. Site-specific analysis showed high LDH to correlate with an increased risk of death from prostate, pulmonary, colorectal, gastro-oesophageal, gynaecological and haematological cancers. Serum LDH assessed within intervals closer to diagnosis was more strongly associated with overall and cancer-specific death. Conclusions: Our findings demonstrated an inverse association of baseline serum LDH with cancer-specific survival, corroborating its role in cancer progression.
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- 2015
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26. Prediagnostic serum glucose and lipids in relation to survival in breast cancer patients : a competing risk analysis
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Wulaningsih, Wahyu, Vahdaninia, Mariam, Rowley, Mark, Holmberg, Lars, Garmo, Hans, Malmstrom, Hakan, Lambe, Mats, Hammar, Niklas, Walldius, Goran, Jungner, Ingmar, Coolen, Anthonius C., Van Hemelrijck, Mieke, Wulaningsih, Wahyu, Vahdaninia, Mariam, Rowley, Mark, Holmberg, Lars, Garmo, Hans, Malmstrom, Hakan, Lambe, Mats, Hammar, Niklas, Walldius, Goran, Jungner, Ingmar, Coolen, Anthonius C., and Van Hemelrijck, Mieke
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Background: Abnormal glucose and lipids levels may impact survival after breast cancer (BC) diagnosis, but their association to other causes of mortality such as cardiovascular (CV) disease may result in a competing risk problem. Methods: We assessed serum glucose, triglycerides (TG) and total cholesterol (TC) measured prospectively 3 months to 3 years before diagnosis in 1798 Swedish women diagnosed with any type of BC between 1985 and 1999. In addition to using Cox regression, we employed latent class proportional hazards models to capture any heterogeneity of associations between these markers and BC death. The latter method was extended to include the primary outcome (BC death) and competing outcomes (CV death and death from other causes), allowing latent class-specific hazard estimation for cause-specific deaths. Results: A lack of association between prediagnostic glucose, TG or TC with BC death was observed with Cox regression. With latent class proportional hazards model, two latent classes (Class I and II) were suggested. Class I, comprising the majority (81.5 %) of BC patients, had an increased risk of BC death following higher TG levels (HR: 1.87, 95 % CI: 1.01-3.45 for every log TG increase). Lower overall survival was observed in Class II, but no association for BC death was found. On the other hand, TC positively corresponded to CV death in Class II, and similarly, glucose to death from other causes. Conclusion: Addressing cohort heterogeneity in relation to BC survival is important in understanding the relationship between metabolic markers and cause-specific death in presence of competing outcomes.
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- 2015
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27. Inorganic phosphate and the risk of cancer in the Swedish AMORIS study
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Wulaningsih, Wahyu, Michaelsson, Karl, Garmo, Hans, Hammar, Niklas, Jungner, Ingmar, Walldius, Goran, Holmberg, Lars, Van Hemelrijck, Mieke, Wulaningsih, Wahyu, Michaelsson, Karl, Garmo, Hans, Hammar, Niklas, Jungner, Ingmar, Walldius, Goran, Holmberg, Lars, and Van Hemelrijck, Mieke
- Abstract
Background: Both dietary and serum levels of inorganic phosphate (Pi) have been linked to development of cancer in experimental studies. This is the first population-based study investigating the relation between serum Pi and risk of cancer in humans. Methods: From the Swedish Apolipoprotein Mortality Risk (AMORIS) study, we selected all participants (>20 years old) with baseline measurements of serum Pi, calcium, alkaline phosphatase, glucose, and creatinine (n = 397,292). Multivariable Cox proportional hazards regression analyses were used to assess serum Pi in relation to overall cancer risk. Similar analyses were performed for specific cancer sites. Results: We found a higher overall cancer risk with increasing Pi levels in men (HR: 1.02 (95% CI: 1.00-1.04) for every SD increase in Pi), and a negative association in women (HR: 0.97 (95% CI: 0.96-0.99) for every SD increase in Pi). Further analyses for specific cancer sites showed a positive link between Pi quartiles and the risk of cancer of the pancreas, lung, thyroid gland and bone in men, and cancer of the oesophagus, lung, and nonmelanoma skin cancer in women. Conversely, the risks for developing breast and endometrial cancer as well as other endocrine cancer in both men and women were lower in those with higher Pi levels. Conclusions: Abnormal Pi levels are related to development of cancer. Furthermore, the inverse association between Pi levels and risk of breast, endometrial and other endocrine cancers may indicate the role of hormonal factors in the relation between Pi metabolism and cancer.
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- 2013
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28. Country of birth-specific and gender differences in prevalence of diabetes in Sweden
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Carlsson, Axel C., Wandell, Per E., Hedlund, Ebba, Walldius, Goran, Nordqvist, Tobias, Jungner, Ingmar, Hammar, Niklas, Carlsson, Axel C., Wandell, Per E., Hedlund, Ebba, Walldius, Goran, Nordqvist, Tobias, Jungner, Ingmar, and Hammar, Niklas
- Abstract
Objective: The aim was to investigate country or region of birth-specific prevalence and gender differences of diabetes in residents in Sweden, using Swedish-born men and women as referent. Methods: The Apolipoprotein MOrtality RISk (AMORIS) cohort was used (184,000 men and 151,453 women) aged between 20 and 80 years, with data from the CALAB laboratory, Stockholm, 1985-1996. Diabetes was defined as fasting glucose >= 7.0 mmol/L or a hospital diagnosis of diabetes. Country of birth was obtained by linkage to Swedish Censuses 1970-1990. Standardized prevalence rate ratios (SPRR) with 95% confidence intervals (95% CI) were estimated. Results: Five groups of women and one group of men had a significantly higher prevalence than Swedish-born (based on SPRR): women born in Iraq (6.0 (95% CI 1.3-28.9)), North Africa (6.9 (95% CI 3.1-15.3)), South Asia (3.1 (95% CI 1.0-10.0)), Syria (5.3 (95% CI 1.8-16.0)), Turkey (3.7 (95% CI 1.2-10.9)) and men born in other Middle Eastern countries (2.3 (95% CI 1.0-5.5)). Swedish-born men had a higher age-standardized prevalence of diabetes (3.9%) than Swedish born women ( 2.5%). A higher prevalence among men was also seen in other Western countries. In contrast, a higher age-standardized prevalence among women was observed in immigrants from Turkey (8.9% vs. 3.1%, p < 0.001), Syria (13.1% vs. 4.0%, p = 0.002), and North Africa (16.8% vs. 6.6%, p < 0.001). Conclusion: Female immigrants to Sweden from Iraq, North Africa, South Asia, Syria, and Turkey have an increased prevalence of diabetes of substantial public health concern.
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- 2013
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29. Iron metabolism and risk of cancer in the Swedish AMORIS study
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Gaur, Anjali, Collins, Helen, Wulaningsih, Wahyu, Holmberg, Lars, Garmo, Hans, Hammar, Niklas, Walldius, Goran, Jungner, Ingmar, Van Hemelrijck, Mieke, Gaur, Anjali, Collins, Helen, Wulaningsih, Wahyu, Holmberg, Lars, Garmo, Hans, Hammar, Niklas, Walldius, Goran, Jungner, Ingmar, and Van Hemelrijck, Mieke
- Abstract
Pre-clinical studies have shown that iron can be carcinogenic, but few population-based studies investigated the association between markers of the iron metabolism and risk of cancer while taking into account inflammation. We assessed the link between serum iron (SI), total-iron binding capacity (TIBC), and risk of cancer by levels of C-reactive protein (CRP) in a large population-based study (n = 220,642). From the Swedish Apolipoprotein Mortality Risk (AMORIS) study, we selected all participants (> 20 years old) with baseline measurements of serum SI, TIBC, and CRP. Multivariate Cox proportional hazards regression was carried out for standardized and quartile values of SI and TIBC. Similar analyses were performed for specific cancers (pancreatic, colon, liver, respiratory, kidney, prostate, stomach, and breast cancer). To avoid reverse causation, we excluded those with follow-up < 3 years. We found a positive association between standardized TIBC and overall cancer [HR 1.03 (95 % CI 1.01-1.05)]. No statistically significant association was found between SI and cancer risk except for postmenopausal breast cancer [HR for standardized SI 1.09 (95 % CI 1.02-1.15)]. The association between TIBC and specific cancer was only statistically significant for colon cancer [i.e., HR for standardized TIBC: 1.17 (95 % CI 1.08-1.28)]. A borderline interaction between SI and levels of CRP was observed only in stomach cancer. As opposed to pre-clinical findings for serum iron and cancer, this population-based epidemiological study showed an inverse relation between iron metabolism and cancer risk. Minimal role of inflammatory markers observed warrants further study focusing on developments of specific cancers.
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- 2013
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30. Serum calcium and risk of gastrointestinal cancer in the Swedish AMORIS study
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Wulaningsih, Wahyu, Michaelsson, Karl, Garmo, Hans, Hammar, Niklas, Jungner, Ingmar, Walldius, Goran, Lambe, Mats, Holmberg, Lars, Van Hemelrijck, Mieke, Wulaningsih, Wahyu, Michaelsson, Karl, Garmo, Hans, Hammar, Niklas, Jungner, Ingmar, Walldius, Goran, Lambe, Mats, Holmberg, Lars, and Van Hemelrijck, Mieke
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Background: Observational studies have indicated that high calcium intake may prevent colorectal cancer, but as for randomized trials the results are inconclusive. Meanwhile, limited data on the link between serum calcium and cancer risk is available. We investigated the relation between serum calcium and risk of different gastrointestinal cancers in a prospective study. Methods: A cohort based on 492,044 subjects with baseline information on calcium (mmol/L) and albumin (g/L) was selected from the Swedish Apolipoprotein MOrtality RISk (AMORIS) study. Multivariable Cox proportional hazard models were used to analyse associations between standardised levels, quartiles and age/sex-specific categories of serum calcium and risk of oesophageal, stomach, colon, rectal cancer and also colorectal cancer combined, while taking into account serum albumin and other comorbidities. Results: During 12 years of follow-up, we identified 323 incident oesophageal cancers, 782 stomach cancers, 2519 colon cancers, and 1495 rectal cancers. A positive association was found between albumin-adjusted serum calcium and risk of oesophageal [HR: 4.82 (95% CI: 2.07 - 11.19) for high compared to normal age-specific calcium levels] and colon cancer [e.g. HR: 1.07 (95% CI: 1.00 - 1.14) for every SD increase of calcium] as well as colorectal cancer [e.g. HR: 1.06 (95% CI: 1.02-1.11) for every SD increase of calcium] in women. In men there were similar but weaker non-statistically significant trends. Conclusion: The positive relation between serum calcium, oesophageal cancer and colorectal cancer calls for further studies including calcium regulators to evaluate whether there is a true link between calcium metabolism and development of gastrointestinal cancer.
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- 2013
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31. Lipid Profiles and Risk of Breast and Ovarian Cancer in the Swedish AMORIS Study
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Melvin, Jennifer C., Seth, Divya, Holmberg, Lars, Garmo, Hans, Hammar, Niklas, Jungner, Ingmar, Walldius, Goran, Lambe, Mats, Wigertz, Annette, Van Hemelrijck, Mieke, Melvin, Jennifer C., Seth, Divya, Holmberg, Lars, Garmo, Hans, Hammar, Niklas, Jungner, Ingmar, Walldius, Goran, Lambe, Mats, Wigertz, Annette, and Van Hemelrijck, Mieke
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Background: Obesity is a risk factor for breast and ovarian cancer; the mechanisms of action are not completely understood. Perturbed lipid metabolism often accompanies obesity; we therefore ascertained the associations between lipid components and breast and ovarian cancer risk in a prospective cohort study. Methods: A total of 234,494 women with baseline measurements of triglycerides and total cholesterol and glucose were selected from the AMORIS database.A total of 27,394 had measurements of high-density lipoprotein, low-density lipoprotein, apolipoprotein (Apo) B, and A-I. Associations between quartiles and dichotomized values of lipid components and breast and ovarian cancer risk were analyzed using Cox proportional hazard models. Results: We identified 6,105 women diagnosed with breast cancer and 808 women diagnosed with ovarian cancer. A weak trend was observed between triglycerides and breast cancer (HR, 1.01, 95% Confidence Interval, 0.94-1.09; 0.93 (0.86-1.00) 0.91 (0.84-0.99), second, third, and fourth quartiles; P = 0.01). No other associations between lipid components and risk of breast cancer or ovarian cancer showed statistical significance. Conclusions: A weak protective association was found between levels of triglycerides and risk of breast cancer. Impact: An analysis including information on tumour characteristics of ovarian cancer and breast cancer may provide more insight in possible links between lipid metabolism and the risk of these cancers.
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- 2012
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32. Serum calcium and incident and fatal prostate cancer in the Swedish AMORIS study.
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Van Hemelrijck, Mieke, primary, Hermans, Ruben, additional, Michaelsson, Karl, additional, Garmo, Hans, additional, Hammar, Niklas, additional, Jungner, Ingmar, additional, Walldius, Goran, additional, Lambe, Mats, additional, and Holmberg, Lars, additional
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- 2012
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33. Gamma-glutamyltransferase and risk of cancer in a cohort of 545,460 persons – the Swedish AMORIS study
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Van Hemelrijck, Mieke, primary, Jassem, Wayel, additional, Walldius, Goran, additional, Fentiman, Ian S., additional, Hammar, Niklas, additional, Lambe, Mats, additional, Garmo, Hans, additional, Jungner, Ingmar, additional, and Holmberg, Lars, additional
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- 2011
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34. Two-Dimensional Tortuosity of the Superficial Femoral Artery in Early Atherosclerosis
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Smedby, Örjan, primary, Högman, Nils, additional, Nilsson, Sven, additional, Erikson, Uno, additional, Olssori, Anders G., additional, and Walldius, Goran, additional
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- 1993
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35. Serum total bilirubin and risk of cancer: a Swedish cohort study and meta‐analysis
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Maria J. Monroy-Iglesias, Niklas Hammar, Charlotte Moss, Göran Walldius, Kerri Beckmann, Aida Santaolalla, Cecilia Bosco, Mieke Van Hemelrijck, Monroy Iglesias, Maria J, Moss, Charlotte, Beckmann, Kerri, Hammar, Niklas, Walldius, Goran, Bosco, Cecilia, Van Hemelrijck, Mieke, and Santaolalla, Aida
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Oncology ,Cancer Research ,medicine.medical_specialty ,hyperbilirubinemia ,Colorectal cancer ,colorectal cancer ,cancer risk ,Article ,Breast cancer ,breast cancer ,Internal medicine ,medicine ,cohort study ,melanoma ,Lung cancer ,RC254-282 ,business.industry ,Cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,gynecological cancer ,medicine.disease ,lung cancer ,Relative risk ,Cohort ,bilirubin ,Risk assessment ,business ,Cohort study - Abstract
Bilirubin has strong antioxidant properties that have been hypothesized to be preventive against the development of cancer. Thus, we aimed to investigate the association between serum total bilirubin (STB) and risk of overall and site-specific cancers in the large Swedish Apolipoprotein Mortality Risk (AMORIS) cohort. We also performed a systematic review and meta-analysis for specific cancer types (colorectal, breast and lung). We found no association between high levels of STB and risk of overall cancer. Regarding site-specific cancer, there was an inverse association between increased STB and lung cancer (Hazard Ratio (HR) for the 4th quartile (Q4) vs. Q1: 0.50, 95%CI: 0.44–0.59) and gynecological cancer (HR for Q4 vs. Q1: 0.86, 95%CI: 0.76–0.99). A positive association was found with melanoma (HR for Q4 vs. Q1: 1.25, 95%CI: 1.06–1.47) and breast cancer (HR for Q4 vs. Q1: 1.13, 95%CI: 1.01–1.25) risk. The meta-analysis showed an inverse association between high levels of STB and risk of lung cancer (Relative risk (RR): 0.69, 95%CI: 0.55–0.86). No associations were seen for colorectal and breast cancer risk. Further studies are required to establish if bilirubin can be used as a biomarker for risk assessment and/or as a novel therapeutic target.
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- 2021
36. Biomarker-based score to predict mortality in persons aged 50 years and older: a new approach in the Swedish AMORIS study.
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Van Hemelrijck M, Harari D, Garmo H, Hammar N, Walldius G, Lambe M, Jungner I, and Holmberg L
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Background: Management of frailty is the cornerstone of geriatric medicine, but there remains a need to identify biomarkers that can predict early death, and thereby lead to effective clinical interventions. We aimed to study the combination of C-reactive protein (CRP), albumin, gamma-glutamyl transferase (GGT), and HDL to predict mortality., Methods: A total of 44,457 persons aged 50+ whose levels of CRP, albumin, GGT, and HDL were measured at baseline were selected from the Swedish Apolipoprotein MOrtality RISk (AMORIS) study. A mortality score, ranging from 0 to 4, was created by adding the number of markers with abnormal values according to the clinical cut-off (CRP > 10 mg/L, albumin < 35 mg/L, GGT > 36 kU/L, HDL < 1.04 mmol/L). Mortality was studied with multivariate Cox proportional hazards models., Results: 2,245 persons died from cancer, 3,276 from circulatory disease, and 1,860 from other causes. There was a positive trend between mortality score and all-cause mortality as well as cancer and circulatory disease-specific death (e.g. HR for all-cause mortality: 1.39 (95%CI: 1.32-1.46), 2.04 (1.89-2.21), and 3.36 (2.87-3.93), for score=1, 2, and 3+, compared to score=0). Among cancer patients with no other co-morbidities (n=1,955), there was a positive trend between the score and mortality (HR: 1.24 (95%CI: 1.0.-1.49), 2.38 (95%CI: 1.76-3.22), and 5.47 (95%CI: 2.98-10.03) for score=1, 2, and 3+ compared to score=0)., Conclusions: By combining biomarkers of different mechanisms contributing to patient frailty, we found a strong marker for mortality in persons aged 50+. Elevated risks among cancer patients with no other co-morbidities prior to biomarker assessment call for validation in other cohorts and testing of different combinations and cut-offs than those used here, in order to aid decision-making in treatment of older cancer patients.
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- 2012
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