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1. Lack of detection of SARS-CoV-2 in British wildlife 2020-21 and first description of a stoat (Mustela erminea) Minacovirus

Author

Ternenge Apaa, Amy J. Withers, Laura McKenzie, Ceri Staley, Adam Blanchard, Malcolm Bennett, Samantha Bremner-Harrison, Elizabeth A. Chadwick, Frank Hailer, Stephen W.R. Harrison, Xavier Lambin, Mathew Loose, Fiona Mathews, and Rachael Tarlinton

Abstract

2.AbstractRepeat spill over of SARS-CoV-2 into new hosts has highlighted the critical role of cross species transmission of coronaviruses and establishment of new reservoirs of virus in pandemic and epizootic spread of coronaviruses. Species particularly susceptible to SARS-CoV-2 spill-over include Mustelidae (mink, ferrets and related animals) and cricetid rodents (hamsters and related animals). These predispositions led us to screen British wildlife with sarbecovirus specific qPCR and pan coronavirus PCR assays for SARS-CoV-2 using samples collected during the human pandemic to establish if widespread spill-over was occurring. Fourteen wildlife species (n=402) were tested, including : 2 Red Foxes (Vulpes vulpes), 101 Badgers (Meles meles), 2 wild American Mink (Neovison vison), 41 Pine Marten (Martes martes), 2 Weasels (Mustela nivalis), 7 Stoats (Mustela erminea), 108 Water Voles (Arvicola amphibius), 39 Bank voles (Myodes glareolous), 10 Field Voles (Microtus agrestis), 15 Wood Mice (Apodemus sylvaticus), 1 Common Shrew (Sorex aranaeus), 2 Pygmy Shrews (Sorex minutus), 2 Hedgehogs(Erinaceus europaeus) and 75 Eurasian Otters (Lutra lutra). No cases of SARS-CoV-2 were detected in any animals, however a novel minacovirus related to mink and ferret alphacoronaviruses was detected in stoats recently introduced to the Orkney Islands. This group of viruses is of interest due to pathogenicity in ferrets. The impact of this virus on the health of stoat populations remains to be established.

Published
2023
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2. Sarbecoviruses of British Horseshoe Bats; Sequence Variation and Epidemiology

Author

Ternenge Apaa, Amy J. Withers, Ceri Staley, Adam Blanchard, Malcolm Bennett, Samantha Bremner-Harrison, Elizabeth A. Chadwick, Frank Hailer, Stephen W.R. Harrison, Mathew Loose, Fiona Mathews, and Rachael Tarlinton

Abstract

Horseshoe bats are the natural hosts of theSarbecovirussubgenus that includes SARS-CoV-1 and 2. Despite the devastating impacts of the COVID-19 pandemic, there is still little known about the underlying epidemiology and virology of sarbecoviruses in their natural hosts, leaving large gaps in our pandemic preparedness. Here we describe the results of PCR testing for sarbecoviruses in the two horseshoe bat species (Rhinolophus hipposiderosandR. ferrumequinum) present in Great Britain, collected in 2021-22 during the peak of COVID-19 pandemic. One hundred and ninety sevenR. hipposiderossamples from 33 roost sites and 277R. ferremequinumsamples from 20 roost sites were tested. No coronaviruses were detected in any samples fromR. ferrumequinumwhereas 44% and 56% of individual and pooled (respectively) faecal samples fromR. hipposiderosacross multiple roost sites tested positive in a sarbecovirus-specific qPCR. Full genome sequences were generated from three of the positive samples (and partial genomes from two more) using Illumina RNAseq on unenriched samples. Phylogenetic analyses showed that the obtained sequences belong to the same monophyletic clade, with >95% similarity, as previously reported European isolates fromR. hipposideros. The sequences differed in the presence or absence of accessory genes ORF 7b, 9b and 10. All lacked the furin cleavage site of SARS-CoV-2 spike gene and are therefore unlikely to be infective for humans. These results demonstrate a lack, or at least low incidence, of SARS-CoV-2 spill over from humans to susceptible GB bats, and confirm that sarbecovirus infection is widespread inR. hipposideros. Despite frequently sharing roost sites withR. ferrumequinum, no evidence of cross-species transmission was found.

Published
2023
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3. Title Pages / Contents

Author

H.A. Wichman, A. Bardhan, D.A. Parish, M. Rábová, R. Wimmer, A. Banaszek, C.A. Redi, S. Garagna, Terence J. Robinson, D.W. Burt, T.L. Lear, C. Tease, Z. Taib, H. Neitzel, S. Henschel, B.A. Reutter, L. Granjon, W. Vogel, R.M. Jones, B. Sicard, S. Fedyk, E. Sjöstrand, Patricia C. M. O’Brien, J.S. Heslop-Harrison, H. Guedes-Pinto, P.G. Johnston, F. Ståhl, S. Santos, Polina L. Perelman, J.-F. Ducroz, N.B. Rubtsov, R. Chaves, W. Just, T. Raudsepp, H. Brünner, M. Hakhverdyan, N. Ihara, S. Röttger, W. Feichtinger, B.M.N. Wallace, Å. Sjöling, I. Nanda, N. Bogdanchikova, W.R. Harrison, P.M. Mirol, R. Visbal García, C. Mais, S.-I. Kawada, T. Sharma, M. Bahadur, T. Ashley, M. Lombard, V. Aniskin, Natalya A. Serdukova, E. Lecompte, P. Vise, J. Hausser, M.A. Hultén, P. Mariani, G. Dobigny, H. Kühl, A.P. Singh, J.A. Marshall Graves, J. Britton-Davidian, V. Volobouev, R.J. Baker, M.J. Puertas, N.V. Vorobieva, V. Kalscheuer, J.J. Bull, K.M. Mendoza, U. Arnason, L.E. Jensen, P. Gómez-Fabre, C.J. Metcalfe, M. Schmid, T.V. Karamysheva, Jan Zima, M. Morgan-Richards, G. Levan, W. Chetnicki, A. Janke, Y.M. Borissov, O.V. Andreenkova, P. Nová, H. Hameister, K.M. Reed, F. Yang, M.D. Giménez, J.B. Searle, W. Schempp, K. Klinga-Levan, E. Capanna, M.D.B. Eldridge, K. Belkhir, D.A. Martí, T. Haaf, A. Fernández Badillo, A.L. Barlow, F. Adega, Larisa S. Biltueva, B.P. Chowdhary, U. Fiedorczuk, J. Catalan, Alexander S. Graphodatsky, C.A. Everett, V.T. Volobouev, B.S. Milne, F.A. Ponce de León, R. Bellavia, K. Sperling, N.O. Bianchi, A. Behboudi, B. Schreiner, C.W. Beattie, G.L. Bennett, I. Reisert, M.A. Ferguson-Smith, N. Lugon-Moulin, V.M. Aniskin, K.A. Szałaj, C.J. Bidau, M. Corti, B. Fu, M. Zuccotti, C. Steinlein, M.N. Bochkaerev, A. Baumstark, R. Castiglia, Pavel M. Borodin, and Y. Sugimoto

Subjects
Genetics, Library science, Zoology, Biology, Molecular Biology, Genetics (clinical)
Published
2002
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4. Endothelin Antagonists Diminish Postischemic Microvascular Incompetence and Necrosis in the Heart

Author

W.R. Harrison, John B. Gavin, and Linda Maxwell

Subjects
Endothelin Receptor Antagonists, medicine.hormone, medicine.medical_specialty, Endothelium, Heart Ventricles, Drug Evaluation, Preclinical, Ischemia, Peptides, Cyclic, Rats, Inbred WKY, Biochemistry, Microcirculation, Endothelins, Necrosis, Internal medicine, medicine, Animals, Myocardial Stunning, Myocardial stunning, Ion Transport, Receptors, Endothelin, business.industry, Myocardium, Heart, Cell Biology, Receptor, Endothelin A, medicine.disease, Coronary Vessels, Capillaries, Rats, medicine.anatomical_structure, Endocrinology, Circulatory system, cardiovascular system, Calcium, Cardiology and Cardiovascular Medicine, Endothelin receptor, business, Oligopeptides, Perfusion
Abstract

The endothelin receptor antagonists BQ-610 and BQ-123 were used to clarify the role of endothelin in the pathogenesis of postischemic microvascular incompetence in the myocardium. Forty-five isolated rat hearts were perfused with Krebs-Henseleit buffer (KHB) for 15 min and then subjected to 0, 15, or 60 min of ischemia followed by 5 min of reperfusion with KHB, KHB + BQ-610, or KHB + BQ-123. They were fixed by perfusion with 2.5% glutaraldehyde and then perfused with nuclear track emulsion as an indicator of vascular flow. Transmural sections of resin-embedded myocardium were examined by scanning and transmission electron microscopy. Following 60 min of ischemia, the subendocardial third of the LV wall of hearts treated with BQ-123 showed nearly three times the proportion (P < 0.001) of competent capillaries in untreated hearts. Reperfusion after 15 min of ischemia of hearts treated with BQ-123 showed a 30% increase in the proportion of competent capillaries compared to controls (P < 0. 002). Treatment of corresponding groups with BQ-610 increased the proportion of competent capillaries but these differences were not statistically significant. In addition, both ET-I antagonists dramatically reduced the amount of ultrastructural change evident in myocardium reperfused after 60 min of ischemia. Thus endothelin plays a significant role in the pathogenesis of postischemic microvascular incompetence in the myocardium and, probably by its effects on Ca(2+) uptake, contributes also to the ultrastructural damage to the myocytes and endothelium which follows postischemic reperfusion of irreversibly injured myocardium.

Published
2000
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5. Selected bibliography of Susumu Ohno

Author

D. Meschede, W. Schempp, W. Traut, J. Klein, T.W. Glover, S.J. Palmer, J.T. Epplen, E.J.M. Santos, B.R. Migeon, R. Toder, J. Horst, M. Guttenbach, G. Bonnet, T. Matsunaga, C.V. Beechey, B. Choudhary, M. Cohn, D. Weichenhan, S. Ball, G. Bernardi, S. Lautsch, H. Winking, T. Vogel, E.Y. Cheng, K. Benirschke, N. Nassar, U. Wolf, J. Schmidtke, L.-S. Correa-Cerro, M. Sugimoto, W. Beçak, B. Kerem, T. Sharma, S.S. Wachtel, J. Zhang, A.T. Midro, K. Sperling, C. O’hUigin, V.V. Kapitonov, R. Lesniewicz, S.K. Mahadevaiah, W.R. Harrison, C. Geerkens, C. Dixkens, W. Just, H. Shibata, R.M. Cabrera, C.M. Disteche, M. Schartl, N. Zhdanova, J.A.M. Graves, U. Drews, S. Saccone, G.P. Holmquist, D.K. Lamatsch, M.F. Lyon, S. Zeitler, S.K. Davis, K. Bender, C. Klett, J. Bruch, G.G. Sharma, M.L. Houck, S. Henschel, N. Takagi, A.T. Kumamoto, R. Raman, H. Neitzel, P.S. Burgoyne, M. Erdel, O.L. Serov, A. Kollak, S. Jainta, S. Mizuno, Y. Hayashizaki, J. Jurka, F.A. Ponce de León, W. Rietschel, Y. Narain, B. Kunze, V. Kalscheuer, C. Ebenhoch, G. Beller, W. Rau, M. Held, A. Baumstark, J. Parzefall, T.J. Robinson, M. Digweed, S. Schmidt Drury, S.M. Gartler, M. Döbler, G. Wanner, Y.-F.C. Lau, H. Hameister, M.L. Beçak, H. Ogura, Y.-J. Chen, S. Takada, F.F.B. Elder, S. Ganesh, A. Ashworth, G. Scherer, K. Fredga, A. Sato, J. Perry, W. Vogel, I. Nanda, W. Mäueler, N. Mise, B.M. Cattanach, W. Feichtinger, H. Macgregor, R.P. Erickson, C. Federico, N.B. Atkin, S.-S. Tan, M. Schmid, I. Schlupp, K.M.S. Townsend, and C. Steinlein

Subjects
Evolutionary biology, Genetics, Bibliography, Animals, Humans, History, 20th Century, Biology, Molecular Biology, United States, Genetics (clinical), Genealogy
Published
1998
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6. Contents, Vol. 78, 1997

Author

Jeffery M. Vance, C.H. Rhodes, H. Osada, B.L Barnoski, Thomas Meitinger, D.B. Zimonjic, N. Tiso, A.A. Bosma, M.J. Kemper, K. Sims, A. Girardet, J. Milbrandt, P. Thorner, V. Fagundes, F. Goossens, L. Rampoldi, E. Boye, H. Chen, J. Hozier, J. Zhou, J. Wienberg, Y. Narain, B. Andréo, M.C Gubler, R.J. Zahorchak, A. Masuda, M.L Budarf, G. Lefort, M. Douaire, J.P. Charlieu, T. Muto, S.J. Zullo, K. Schatteman, M. Herranz, S. Sasaki, J. Gellin, J.P. Park, S. Bortoluzzi, Y. Takei, M.J. Flores, C. Antignac, S.M. Galloway, A. Miyajima, D. Hendriks, F. Pellestor, W.R. Harrison, V. Fillon, S. Scharpé, M. Macville, T. Takahashi, L. Cohen-Solal, F.F.B. Elder, K. Uchida, G. Vanhoof, J. Piñero, N.A. de Haan, A. Yoshimura, Y. Omori, H.M. Henry, R. Cinti, C.R. Merril, I. Ceccherini, M.A. Ferguson-Smith, A. Kawai, L.F. Almeida-Toledo, Z.A. Jenkins, C. Zijlstra, I. Pérez de Castro, Shigenobu Takeda, K. Fredga, F. Cortés, K.G. Dodds, S. Müller, R. Zimbello, R.V. Rambau, B.S. Emanuel, T.J. Robinson, F. Flinter, Y. Yonenaga-Yassuda, G.W. Montgomery, M.A. Juliano, G. Romeo, S.H. Bigner, X. Zhang, K.M. Call, T. Ortiz, C.J. Bell, A. David, S.A. Toledo-Filho, L. Coignet, A. Mäkinen, P.C.M. O’Brien, F.M.C. Fernandes-Matioli, S.E. Antonarakis, L. Larget Piet, L Butler, L. Juliano, T. Fujiwara, N.C. Popescu, G. Valle, Y. Nakamura, M. Suzuki, A. Vignal, C. Wilkes, G. Lanfranchi, J. Inazawa, P. Langlois, T.K. Mohandas, C.H.M. Mellink, K. Yanagisawa, G.A. Danieli, A. Gorodinsky, M. Seri, J.M. Scalzi-Martin, T. Saito, A. Puliti, H. Kyushiki, A.H. Lin, J. Santos, B. Meléndez, E. Takahashi, J.. Fernández-Piqueras, and L. Heidet

Subjects
Botany, Genetics, Zoology, Biology, Molecular Biology, Genetics (clinical)
Published
1997
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7. X chromosome evolution in the suni and eland antelope: detection of homologous regions by fluorescence in situ hybridization and G-banding

Author

Terence J. Robinson, F.F.B. Elder, W.R. Harrison, and A. Ponce de León

Subjects
Male, medicine.medical_specialty, X Chromosome, G banding, Neotragus moschatus, Evolution, Molecular, Taurotragus, Species Specificity, Genetics, medicine, Animals, Molecular Biology, In Situ Hybridization, Fluorescence, Phylogeny, Genetics (clinical), X chromosome, Gene Rearrangement, biology, medicine.diagnostic_test, Cytogenetics, Karyotype, Gene rearrangement, biology.organism_classification, Chromosome Banding, Antelopes, Molecular Probes, Cattle, Female, Fluorescence in situ hybridization
Abstract

Comparative cytogenetics and fluorescence in situ hybridization (FISH) were used to track structural rearrangements in the X chromosomes of two African antelope species, the eland (Taurotragus oryx; tribe Tragelaphini) and the suni (Neotragus moschatus; tribe Neotragini). Using two microdissected cattle chromosome painting probes (one specific for Xp-containing sequences corresponding to Xp24→p12 of the cattle X, and one specific for Xq-containing sequences corresponding to Xq12→qter), we show that intrachromosomal rearrangements distinguish the X chromosomes of these species. Furthermore, there is clear evidence that, superimposed on this background of intrachromosomal evolutionary change, the sequences contained in the cattle Xp painting probe appear to have moved as a complete unit during the repatteming of the bovid X. Although we are unable to infer the order of the rearranged chromosomal segments, given the large regions of homology detected by the chromosome paints, we nonetheless believe that this approach (combining conventional and molecular cytogenetic studies on the X chromosome) will prove useful for inferring phylogenetic relationships in the family Bovidae, particularly as more probes become available.

Published
1997
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8. Contents, Vol. 77, 1997

Author

A. Botta, K. Rojas, P. Zaragoza, X.-X. Zhang, M. Pritchard, B.P. Chowdhary, J.P. Park, J.L. Kissil, A. Rocchi, T.K. Watanabe, T. Siddque, N.P. Mertvetsov, W. Engel, A.A. Bosma, C. Rodellar, A. Arai, F. Shimizu, B. Hoebee, K.N. Sastry, R. Houlgatte, P.A. Voûte, N. Guo, U.W. Kenkare, J.-J. Cassiman, J. Guimera, W.R. Harrison, M.Z. Limongi, G. Mirza, A. Fratello, C.H. van Os, T. Ikeuchi, M. Chaffanet, T. Goldammer, M. Mannens, D. Grady, D. Wells, V. Romano, O. Miura, As. Ricco, M. Schwerin, M. Gersh, M.L. Filipenko, S.A. Wilcox, H. Levéziel, S.J. O’Brien, G.F.M. Merkx, C.C. Morton, G. Hardiman, R. Marzella, S. Hirosawa, T.J. Robinson, K.B.M. Reid, C. Elduque, A.S. Hewson, P.M.T. Deen, J.A. Squire, J.A.M. Graves, L. Vatteroni, E. Viegas-Péquignot, K. Yamamoto, M. Carter, L. Frönicke, N.V. Vorobieva, J. Overhauser, N. Ceratto, N.A. de Haan, M. Suzuki, T. Kozaki, M.S. Aly, B. Redeker, S. van Beersum, P.M. Borodin, F.F.B. Elder, A. Kimchi, A.S. Graphodatsky, B. Beatty, J.A. McMahon, M. de Meulemeester, J.B. Searle, I.V. Koroleva, W.Y. Hung, Y. Kuga, M. Jeanpierre, N. Sakuragawa, S. Feo, C. Auffray, M. Ogawa, M. Rocchi, M.P. Hande, C.K. Ullrich, J. Widmer, A. Ponce de León, F.O. Fackelmayer, S. Weremowicz, A. Pizzuti, K. Ohsugi, S. Okuno, R.J.M. Bindels, L.D. Matyakhina, A.P. McMahon, R. Leube, Y. Yang, A. Pandita, M. Lachtermacher, A. Tanzariello, B. Dallapiccola, M.A. Ferguson-Smith, A. Musio, A.F. Davies, D. Patterson, N. Lynch, Y. Nakamura, G. Rainaldi, M. Steenman, S.-T. Lee, H. Hayes, P.C.M. O’Brien, G.G. Karpova, C.H.M. Mellink, E. Jenkins, J.H. Xia, M. Schepens, A.T. Natarajan, B.-L. Lim, R. Meneveri, W.G. Nash, J. Kissing, M. Stacey, T. Fujiwara, M. Schmid, L.A. Witters, C. Zijlstra, L. Viggiano, F. Yang, M. Nagata, W. Bie, H. Scherthan, H. Murer, B. Ghebrehiwet, A. Westerveld, S. Kurata, H.N. Seuánez, M. Lovett, K.-H. Lee, R. Godbout, H.G. Brunner, J.M. Varley, P. Thygesen, R. Slater, S. Ishikawa, S.D. Pack, E. Takahashi, O.V. Cheryaukene, C. Bendixen, F. Ugolini, M. Matsumoto, R.M. Brunner, A. Risch, D. Birnbaum, Y. Takei, C.H. Fan, L.A. James, E.M. Ladenburger, P. Laurent, G. von Beust, T.K. Mohandas, H. Kobayashi, E. Burt, K. Wiesmeijer, M. Kai, A. Baldini, P. Eydoux, F.C. Canavez, F. Pelliccia, A. Geurts van Kessel, Déborah Bourc'his, S.-H. Park, S. Sebastian, C. Dobkin, R. Stanyon, R.A. Kastelein, L. Langbein, R. Toder, K. Okui, O.L. Serov, N. Matas, M.R. Koehler, R. Moyzis, J.F. Bazan, M.A. van Kuijck, A. Simons, P. Miniou, Y. Yokoyama, D. Molina Gomes, L. Xu, M.A.M. Moreira, H. Kim, E. Sim, J. Ragoussis, F. Saito-Ohara, M. Kool, N. Miyasaka, T. Katagiri, P. Bosco, X. Estivill, N. Archidiacono, G. Novelli, R. Knippers, P. Maccarone, J. Wienberg, M.-J. Pébusque, H.S. Tenenhouse, M. Nadal, W. Schwaeble, H. Hameister, H. van Bokhoven, T. Takahashi, E.I.B. Peerschke, V. Jurecic, X.-L. Yao, Y. Hey, P. Riegman, S.N. Malchenko, H.X. Deng, A.B. Spurdle, and N. Hoggard

Subjects
Botany, Genetics, Zoology, Biology, Molecular Biology, Genetics (clinical)
Published
1997
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9. Bibliography of Karl Fredga

Author

K. Klinga-Levan, J. Hausser, E. Capanna, M.J. Puertas, H. Neitzel, N. Ihara, D.A. Martí, U. Fiedorczuk, V.T. Volobouev, B.S. Milne, H. Kühl, L.E. Jensen, W.R. Harrison, S. Henschel, F. Ståhl, W. Vogel, R.M. Jones, A. Behboudi, B. Schreiner, C.W. Beattie, B.A. Reutter, T.V. Karamysheva, G.L. Bennett, B. Fu, P. Vise, W. Schempp, O.V. Andreenkova, T. Haaf, A.L. Barlow, Larisa S. Biltueva, C. Mais, G. Levan, M.D.B. Eldridge, I. Reisert, S. Röttger, C. Steinlein, F. Yang, M.D. Giménez, R.J. Baker, J. Catalan, Natalya A. Serdukova, M.N. Bochkaerev, A. Janke, Polina L. Perelman, U. Arnason, B. Sicard, E. Sjöstrand, S. Santos, W. Just, T. Raudsepp, R. Chaves, J.A. Marshall Graves, Pavel M. Borodin, Y. Sugimoto, W. Feichtinger, A. Bardhan, D.A. Parish, M. Rábová, J.B. Searle, C. Tease, Y.M. Borissov, E. Lecompte, H. Brünner, P. Nová, T. Sharma, Terence J. Robinson, D.W. Burt, T.L. Lear, J. Britton-Davidian, I. Nanda, H. Guedes-Pinto, N. Lugon-Moulin, V.M. Aniskin, K.M. Mendoza, H.A. Wichman, P. Gómez-Fabre, K. Sperling, N.O. Bianchi, K.A. Szałaj, P.G. Johnston, Patricia C. M. O’Brien, S.-I. Kawada, Å. Sjöling, S. Garagna, H. Hameister, R. Wimmer, V. Aniskin, K.M. Reed, A. Baumstark, A. Banaszek, P. Mariani, M. Lombard, C.A. Redi, S. Fedyk, R. Castiglia, A.P. Singh, J.J. Bull, J.S. Heslop-Harrison, N.B. Rubtsov, M. Morgan-Richards, R. Bellavia, K. Belkhir, L. Granjon, N.V. Vorobieva, V. Kalscheuer, G. Dobigny, A. Fernández Badillo, J.-F. Ducroz, R. Visbal García, C.J. Bidau, M. Corti, M. Zuccotti, M.A. Ferguson-Smith, M.A. Hultén, W. Chetnicki, M. Hakhverdyan, B.M.N. Wallace, N. Bogdanchikova, P.M. Mirol, M. Bahadur, T. Ashley, Z. Taib, V. Volobouev, C.J. Metcalfe, M. Schmid, F. Adega, B.P. Chowdhary, Alexander S. Graphodatsky, C.A. Everett, F.A. Ponce de León, and Jan Zima

Subjects
Genetics, Bibliography, Biology, Molecular Biology, Genetics (clinical), Classics
Published
2002
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10. Chromosome painting refines the history of genome evolution in hares and rabbits (order Lagomorpha)

Author

W.R. Harrison, Terence J. Robinson, and Fengtang Yang

Subjects
Genome evolution, Mitochondrial DNA, medicine.medical_specialty, Genome, Sensitivity and Specificity, Riverine rabbit, Chromosome Painting, Evolution, Molecular, Genetics, medicine, Image Processing, Computer-Assisted, Animals, Molecular Biology, Genetics (clinical), In Situ Hybridization, Fluorescence, biology, medicine.diagnostic_test, Cytogenetics, Chromosome, Chromosome Mapping, Karyotype, biology.organism_classification, Hares, Chromosome Banding, Karyotyping, Rabbits, Fluorescence in situ hybridization
Abstract

Fluorescence in situ hybridization (FISH) was used to define homologous segments among representatives of 7 of the 11 recognized leporid genera. Chromosome painting using 22 rabbit chromosome-specific paints derived from flow-sorted chromosomes revealed that at least 18 fusions and six fissions differentiate the extant karyotypes from the presumed ancestral state (2n = 48). The riverine rabbit, Bunolagus monticularis, has the most derived karyotype, differing from the ancestor by seven fusions and five fissions, followed by Pronolagus rupestris, with four fusions and one fission. These findings are consistent with the proposed Palaeolaginae/Leporinae dichotomy in the lagomorphs. The molecular cytogenetic data allow for a refinement of the structural changes that have shaped genome evolution in this group of mammals and underscore the rapid radiation of the Leporidae suggested by mitochondrial DNA sequence data.

Published
2002

11. Contents Vol. 96, 2002

Author

V. Volobouev, W. Schempp, M. Corti, C.J. Metcalfe, M. Schmid, Z. Taib, M.D.B. Eldridge, M. Hakhverdyan, B.M.N. Wallace, N.V. Vorobieva, V. Kalscheuer, A. Bardhan, D.A. Parish, M. Rábová, S.-I. Kawada, T.V. Karamysheva, A. Janke, H. Neitzel, J.B. Searle, V. Aniskin, P. Mariani, U. Fiedorczuk, N. Lugon-Moulin, J. Hausser, C. Tease, S. Henschel, P. Vise, V.T. Volobouev, B.S. Milne, M. Zuccotti, L.E. Jensen, V.M. Aniskin, Terence J. Robinson, B.A. Reutter, N. Bogdanchikova, A. Behboudi, U. Arnason, K.A. Szałaj, F. Adega, B.P. Chowdhary, K.M. Reed, G. Levan, C. Mais, B. Schreiner, M.J. Puertas, G. Dobigny, Alexander S. Graphodatsky, F. Yang, M.D. Giménez, C.A. Everett, S. Fedyk, H. Guedes-Pinto, M.A. Ferguson-Smith, Natalya A. Serdukova, S. Garagna, C.W. Beattie, F.A. Ponce de León, Y.M. Borissov, Patricia C. M. O’Brien, Å. Sjöling, J.A. Marshall Graves, I. Nanda, J.S. Heslop-Harrison, M. Lombard, N. Ihara, H. Brünner, S. Röttger, P.G. Johnston, R. Visbal García, E. Lecompte, J.J. Bull, R. Chaves, T. Sharma, M. Morgan-Richards, B. Sicard, E. Sjöstrand, C.A. Redi, H.A. Wichman, K.M. Mendoza, K. Klinga-Levan, E. Capanna, H. Kühl, S. Santos, G.L. Bennett, L. Granjon, D.W. Burt, T.L. Lear, I. Reisert, R. Bellavia, C.J. Bidau, R. Wimmer, A. Banaszek, O.V. Andreenkova, J. Catalan, W.R. Harrison, T. Haaf, A.L. Barlow, W. Vogel, R.M. Jones, Larisa S. Biltueva, K. Sperling, N.O. Bianchi, R.J. Baker, P. Nová, Polina L. Perelman, W. Just, T. Raudsepp, W. Feichtinger, M.A. Hultén, K. Belkhir, W. Chetnicki, A. Fernández Badillo, N.B. Rubtsov, J. Britton-Davidian, P. Gómez-Fabre, Jan Zima, D.A. Martí, B. Fu, A.P. Singh, C. Steinlein, F. Ståhl, M.N. Bochkaerev, Pavel M. Borodin, Y. Sugimoto, A. Baumstark, R. Castiglia, H. Hameister, P.M. Mirol, M. Bahadur, T. Ashley, and J.-F. Ducroz

Subjects
Botany, Genetics, Biology, Molecular Biology, Genetics (clinical)
Published
2002
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12. Subject Index Vol. 96, 2002

Author

Å. Sjöling, P.G. Johnston, M. Lombard, J.J. Bull, C. Tease, N. Lugon-Moulin, V.M. Aniskin, V. Volobouev, C.J. Metcalfe, M. Schmid, M. Morgan-Richards, K.A. Szałaj, F. Adega, B.P. Chowdhary, Alexander S. Graphodatsky, C.A. Everett, F.A. Ponce de León, U. Fiedorczuk, P. Vise, S.-I. Kawada, V. Aniskin, H. Guedes-Pinto, V.T. Volobouev, B.S. Milne, K. Klinga-Levan, L. Granjon, Z. Taib, U. Arnason, E. Lecompte, P. Mariani, E. Capanna, B. Fu, P.M. Mirol, M. Bahadur, T. Ashley, S. Röttger, G.L. Bennett, C.A. Redi, I. Reisert, K.M. Mendoza, Y.M. Borissov, A. Behboudi, D.W. Burt, T.L. Lear, J.B. Searle, A. Bardhan, C. Steinlein, B. Schreiner, D.A. Parish, M. Rábová, K. Sperling, H. Neitzel, N.O. Bianchi, M. Hakhverdyan, A.P. Singh, J. Catalan, K.M. Reed, S. Henschel, M.N. Bochkaerev, C.W. Beattie, B.M.N. Wallace, B.A. Reutter, C.J. Bidau, W. Schempp, R.J. Baker, H. Hameister, M.D.B. Eldridge, M.A. Hultén, Pavel M. Borodin, Y. Sugimoto, Polina L. Perelman, J.-F. Ducroz, O.V. Andreenkova, R. Chaves, G. Dobigny, T. Haaf, S. Garagna, F. Ståhl, W. Just, T. Raudsepp, A.L. Barlow, R. Visbal García, Larisa S. Biltueva, S. Fedyk, W. Feichtinger, W. Chetnicki, P. Nová, M.A. Ferguson-Smith, N. Ihara, J.S. Heslop-Harrison, J. Hausser, I. Nanda, T.V. Karamysheva, M. Corti, H.A. Wichman, H. Brünner, H. Kühl, R. Wimmer, A. Janke, A. Banaszek, R. Bellavia, N.V. Vorobieva, V. Kalscheuer, A. Baumstark, M. Zuccotti, M.J. Puertas, W. Vogel, R.M. Jones, S. Santos, R. Castiglia, J. Britton-Davidian, K. Belkhir, A. Fernández Badillo, P. Gómez-Fabre, Jan Zima, D.A. Martí, B. Sicard, E. Sjöstrand, N.B. Rubtsov, Patricia C. M. O’Brien, W.R. Harrison, Terence J. Robinson, T. Sharma, L.E. Jensen, G. Levan, F. Yang, M.D. Giménez, N. Bogdanchikova, C. Mais, Natalya A. Serdukova, and J.A. Marshall Graves

Subjects
Index (economics), Statistics, Genetics, Subject (documents), Biology, Molecular Biology, Genetics (clinical)
Published
2002
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13. Mutations in a new photoreceptor-pineal gene on 17p cause Leber congenital amaurosis. Nat Gen 2000;24:79–83

Author

Lori S. Sullivan, W.R Harrison, Constance L. Cepko, S.J Browne, F.F.B Elder, Stephen P. Daiger, S Khaliq, Shomi S. Bhattacharya, M.M Sohoki, John R. Heckenlively, A.M Payne, S. Q. Mehdi, Seth Blackshaw, and David G. Birch

Subjects
Genetics, Ophthalmology, genetic structures, Nat, business.industry, Optometry, Medicine, sense organs, Leber congenital amaurosis, business, Gene, eye diseases, Article
Abstract

Leber congenital amaurosis (LCA, MIM 204000) accounts for at least 5% of all inherited retinal disease1 and is the most severe inherited retinopathy with the earliest age of onset2. Individuals affected with LCA are diagnosed at birth or in the first few months of life with severely impaired vision or blindness, nystagmus and an abnormal or flat electroretinogram (ERG). Mutations in GUCY2D (ref. 3), RPE65 (ref. 4) and CRX (ref. 5) are known to cause LCA, but one study identified disease-causing GUCY2D mutations in only 8 of 15 families whose LCA locus maps to 17p13.1 (ref. 3), suggesting another LCA locus might be located on 17p13.1. Confirming this prediction, the LCA in one Pakistani family mapped to 17p13.1, between D17S849 and D17S960—a region that excludes GUCY2D. The LCA in this family has been designated LCA4 (ref. 6). We describe here a new photoreceptor/pineal-expressed gene, AIPL1 (encoding arylhydrocarbon interacting protein-like 1), that maps within the LCA4 candidate region and whose protein contains three tetratricopeptide (TPR) motifs, consistent with nuclear transport or chaperone activity. A homozygous nonsense mutation at codon 278 is present in all affected members of the original LCA4 family. AIPL1 mutations may cause approximately 20% of recessive LCA, as disease-causing mutations were identified in 3 of 14 LCA families not tested previously for linkage.

Published
2000
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14. Subject Index, Vol. 78, 1997

Author

F. Cortés, T.K. Mohandas, A. Gorodinsky, L. Juliano, F.F.B. Elder, W.R. Harrison, M. Seri, K. Schatteman, J. Gellin, S. Bortoluzzi, T. Muto, J. Hozier, H. Osada, Thomas Meitinger, D.B. Zimonjic, A. Girardet, M.C Gubler, M. Douaire, R.J. Zahorchak, A. Kawai, A. David, J. Milbrandt, I. Pérez de Castro, J.P. Charlieu, Shigenobu Takeda, S. Müller, J. Piñero, P. Thorner, V. Fagundes, F. Goossens, J. Wienberg, G. Romeo, R.V. Rambau, P. Langlois, Y. Yonenaga-Yassuda, P.C.M. O’Brien, K. Yanagisawa, B. Andréo, G. Valle, M. Suzuki, A. Vignal, C. Wilkes, S. Sasaki, Y. Narain, A.A. Bosma, K.G. Dodds, M. Macville, Jeffery M. Vance, R. Cinti, I. Ceccherini, G.W. Montgomery, M.J. Kemper, B.S. Emanuel, A. Puliti, H. Kyushiki, N.C. Popescu, K. Fredga, M. Herranz, C.H. Rhodes, B.L Barnoski, A. Yoshimura, K. Uchida, L.F. Almeida-Toledo, M.A. Juliano, Y. Omori, K. Sims, S.A. Toledo-Filho, L. Coignet, F. Flinter, J.M. Scalzi-Martin, Z.A. Jenkins, L Butler, A. Miyajima, F.M.C. Fernandes-Matioli, T. Saito, G.A. Danieli, T. Ortiz, S.H. Bigner, A. Masuda, X. Zhang, H. Chen, A.H. Lin, C. Zijlstra, J. Santos, G. Vanhoof, S. Scharpé, K.M. Call, A. Mäkinen, M.A. Ferguson-Smith, N.A. de Haan, N. Tiso, T.J. Robinson, C.J. Bell, B. Meléndez, E. Takahashi, S.J. Zullo, M.L Budarf, F. Pellestor, J. Inazawa, C. Antignac, T. Takahashi, J.P. Park, J.. Fernández-Piqueras, L. Rampoldi, L. Heidet, C.H.M. Mellink, Y. Nakamura, G. Lefort, G. Lanfranchi, R. Zimbello, D. Hendriks, V. Fillon, L. Larget Piet, C.R. Merril, M.J. Flores, H.M. Henry, Y. Takei, S.E. Antonarakis, T. Fujiwara, E. Boye, J. Zhou, S.M. Galloway, and L. Cohen-Solal

Subjects
Index (economics), Statistics, Genetics, Subject (documents), Biology, Molecular Biology, Genetics (clinical)
Published
1997
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15. Subject Index, Vol. 77, 1997

Author

A.S. Graphodatsky, G. Hardiman, J.A. Squire, L. Frönicke, P. Bosco, N. Ceratto, S. van Beersum, J.A.M. Graves, H.N. Seuánez, X. Estivill, N. Archidiacono, G. Novelli, G.G. Karpova, C.H.M. Mellink, E. Jenkins, M. Stacey, T. Fujiwara, M. Lovett, R. Knippers, R. Moyzis, M. Jeanpierre, P. Maccarone, J. Wienberg, M. Rocchi, C. Bendixen, S. Weremowicz, B.P. Chowdhary, Y. Yang, A. Pandita, M. Lachtermacher, N. Matas, K.-H. Lee, N. Miyasaka, T. Katagiri, F. Pelliccia, M.-J. Pébusque, R. Godbout, M. Gersh, R. Leube, F. Ugolini, M. Kai, S.-T. Lee, O. Miura, H.G. Brunner, O.V. Cheryaukene, K. Ohsugi, A. Tanzariello, M.A. Ferguson-Smith, A. Geurts van Kessel, P.C.M. O’Brien, W.G. Nash, A. Baldini, T.J. Robinson, M. Matsumoto, A. Pizzuti, Y. Nakamura, M. Mannens, V. Romano, A. Musio, J. Widmer, Déborah Bourc'his, A. Botta, K. Rojas, M.Z. Limongi, L.A. James, A.F. Davies, M. de Meulemeester, R.M. Brunner, C.H. van Os, J.H. Xia, T.K. Watanabe, E.M. Ladenburger, S.-H. Park, C. Rodellar, M. Pritchard, J.L. Kissil, A.S. Hewson, A. Arai, K.N. Sastry, P.M.T. Deen, P. Eydoux, J.A. McMahon, F.C. Canavez, L. Langbein, R. Toder, G. von Beust, M. Schmid, R. Houlgatte, T. Takahashi, P.A. Voûte, N.V. Vorobieva, J. Overhauser, R. Stanyon, E.I.B. Peerschke, K. Yamamoto, J.P. Park, T.K. Mohandas, S. Feo, C. Zijlstra, N.P. Mertvetsov, M. Steenman, U.W. Kenkare, S.A. Wilcox, J. Guimera, P. Zaragoza, N.A. de Haan, W.Y. Hung, J. Ragoussis, D. Birnbaum, M. Ogawa, H. Kobayashi, W. Engel, F. Shimizu, B. Hoebee, B. Ghebrehiwet, T. Ikeuchi, M. Chaffanet, W.R. Harrison, T. Goldammer, S. Ishikawa, E. Burt, K. Wiesmeijer, V. Jurecic, S.D. Pack, M.R. Koehler, B. Beatty, M. Nagata, E. Takahashi, J.F. Bazan, N. Lynch, M. Schwerin, Y. Yokoyama, G. Mirza, A. Fratello, D. Grady, D. Molina Gomes, F. Saito-Ohara, N. Hoggard, C. Dobkin, H. Scherthan, H. van Bokhoven, L.D. Matyakhina, R. Meneveri, A.P. McMahon, H. Murer, R. Marzella, K. Okui, J. Kissing, A. Risch, J.M. Varley, X.-L. Yao, M. Carter, X.-X. Zhang, H.S. Tenenhouse, S. Kurata, O.L. Serov, P.M. Borodin, M. Nadal, M.L. Filipenko, A. Rocchi, M. Kool, W. Schwaeble, H. Hayes, Y. Takei, H. Levéziel, S.J. O’Brien, P. Thygesen, C.H. Fan, H.X. Deng, M. Suzuki, H. Hameister, G.F.M. Merkx, R. Slater, P. Laurent, S. Sebastian, B. Redeker, R.A. Kastelein, E. Viegas-Péquignot, M.A. van Kuijck, L. Xu, M.A.M. Moreira, T. Kozaki, C.C. Morton, M.S. Aly, I.V. Koroleva, H. Kim, E. Sim, A. Ponce de León, A.B. Spurdle, A. Kimchi, A. Simons, G. Rainaldi, Y. Hey, P. Miniou, D. Wells, F.F.B. Elder, P. Riegman, D. Patterson, M. Schepens, S.N. Malchenko, L.A. Witters, L. Viggiano, S. Hirosawa, F. Yang, K.B.M. Reid, C. Elduque, C. Auffray, A.A. Bosma, N. Guo, J.-J. Cassiman, F.O. Fackelmayer, R.J.M. Bindels, A.T. Natarajan, B.-L. Lim, J.B. Searle, As. Ricco, N. Sakuragawa, L. Vatteroni, M.P. Hande, C.K. Ullrich, S. Okuno, T. Siddque, W. Bie, A. Westerveld, Y. Kuga, and B. Dallapiccola

Subjects
Index (economics), Statistics, Genetics, Subject (documents), Biology, Molecular Biology, Genetics (clinical)
Published
1997
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16. Addendum to the report of the fourth international workshop on human chromosome 12 mapping 1997

Author

A. Girardet, R.J. Zahorchak, Z.A. Jenkins, K.G. Dodds, J. Gellin, S. Bortoluzzi, D. Hendriks, V. Fillon, A. Puliti, H. Kyushiki, M. Herranz, J. Milbrandt, P. Thorner, V. Fagundes, F. Goossens, Y. Takei, M.A. Juliano, S.H. Bigner, X. Zhang, B. Meléndez, Jeffery M. Vance, S. Scharpé, S.A. Toledo-Filho, L. Coignet, E. Takahashi, C. Zijlstra, G.W. Montgomery, A. Miyajima, N.A. de Haan, T. Fujiwara, K. Uchida, J.. Fernández-Piqueras, K. Fredga, C.H. Rhodes, B.L Barnoski, L. Rampoldi, L.F. Almeida-Toledo, H. Osada, Thomas Meitinger, D.B. Zimonjic, K. Schatteman, L. Heidet, Y. Narain, F.M.C. Fernandes-Matioli, S.J. Zullo, T. Muto, T.K. Mohandas, Y. Omori, A. Gorodinsky, B. Andréo, P.C.M. O’Brien, A.A. Bosma, C. Antignac, C.J. Bell, N. Tiso, H. Chen, M. Seri, J. Wienberg, J. Hozier, N.C. Popescu, J. Inazawa, F. Cortés, J.P. Charlieu, M.C Gubler, J. Santos, C.H.M. Mellink, F.F.B. Elder, R. Cinti, M. Douaire, A. Yoshimura, I. Ceccherini, Y. Nakamura, F. Pellestor, G. Lanfranchi, S.E. Antonarakis, K. Sims, M. Macville, T. Takahashi, F. Flinter, T.J. Robinson, M.L Budarf, L. Juliano, S.M. Galloway, M.J. Flores, T. Ortiz, A. David, A. Masuda, L. Cohen-Solal, E. Boye, J. Zhou, H.M. Henry, I. Pérez de Castro, K.M. Call, J.M. Scalzi-Martin, A. Mäkinen, G. Valle, M. Suzuki, G. Romeo, A. Vignal, C. Wilkes, T. Saito, A.H. Lin, G. Lefort, L Butler, C.R. Merril, P. Langlois, R. Zimbello, S. Sasaki, L. Larget Piet, K. Yanagisawa, B.S. Emanuel, G.A. Danieli, W.R. Harrison, M.J. Kemper, A. Kawai, Shigenobu Takeda, S. Müller, R.V. Rambau, Y. Yonenaga-Yassuda, J. Piñero, G. Vanhoof, M.A. Ferguson-Smith, and J.P. Park

Subjects
Genetics, Addendum, Computational biology, Biology, Molecular Biology, Genetics (clinical), Chromosome 12
Published
1997
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