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18 results on '"Verwer, Bart J."'

1. Assessing the efficacy and safety of mycophenolate mofetil versus azathioprine in patients with autoimmune hepatitis (CAMARO trial): study protocol for a randomised controlled trial

Author

Snijders, Romée J. A. L. M., Stoelinga, Anna E. C., Gevers, Tom J. G., Pape, Simon, Biewenga, Maaike, Verdonk, Robert C., de Jonge, Hendrik J. M., Vrolijk, Jan Maarten, Bakker, Sjoerd F., Vanwolleghem, Thomas, de Boer, Ynto S., Pronk, Martine A. M. C. Baven, Beuers, Ulrich H. W., van der Meer, Adriaan J., van Gerven, Nicole M. F., Sijtsma, Marijn G. M., Verwer, Bart J., Gisbertz, Ingrid A. M., Bartelink, Maartje, van den Brand, Floris F., Sebib Korkmaz, Kerem, van den Berg, Aad P., Guichelaar, Maureen M. J., Soufidi, Khalida, Levens, Amar D., van Hoek, Bart, and Drenth, Joost P. H.

Published
2022
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3. Additional file 1 of Assessing the efficacy and safety of mycophenolate mofetil versus azathioprine in patients with autoimmune hepatitis (CAMARO trial): study protocol for a randomised controlled trial

Author

Snijders, Romée J. A. L. M., Stoelinga, Anna E. C., Gevers, Tom J. G., Pape, Simon, Biewenga, Maaike, Verdonk, Robert C., de Jonge, Hendrik J. M., Vrolijk, Jan Maarten, Bakker, Sjoerd F., Vanwolleghem, Thomas, de Boer, Ynto S., Pronk, Martine A. M. C. Baven, Beuers, Ulrich H. W., van der Meer, Adriaan J., van Gerven, Nicole M. F., Sijtsma, Marijn G. M., Verwer, Bart J., Gisbertz, Ingrid A. M., Bartelink, Maartje, van den Brand, Floris F., Sebib Korkmaz, Kerem, van den Berg, Aad P., Guichelaar, Maureen M. J., Soufidi, Khalida, Levens, Amar D., van Hoek, Bart, and Drenth, Joost P. H.

Abstract

Additional file 1. Spirit checklist.

Published
2023
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5. Assessing the efficacy and safety of mycophenolate mofetil versus azathioprine in patients with autoimmune hepatitis (CAMARO trial): study protocol for a randomised controlled trial

Author

Snijders*, Romée, primary, Stoelinga*, Anna EC, additional, Gevers, Tom JG, additional, Pape, Simon, additional, Biewenga, Maaike, additional, Verdonk, Robert C, additional, de Jonge, Hendrik JM, additional, Vrolijk, Jan Maarten, additional, Bakker, Sjoerd F, additional, Vanwolleghem, Thomas, additional, de Boer, Ynto S, additional, Pronk, Martine AMC Baven, additional, Beuers, Ulrich HW, additional, Meer, Adriaan J van der, additional, Gerven, Nicole MF van, additional, Sijtsma, Marijn GM, additional, Verwer, Bart J, additional, Gisbertz, Ingrid AM, additional, Bartelink, Maartje, additional, Brand, Floris F van den, additional, Korkmaz, Kerem Sebib, additional, Berg, Aad P van den, additional, Guichelaar, Maureen MJ, additional, Soufidi, Khalida, additional, Levens, Amar D, additional, Hoek*, Bart van, additional, and Drenth*, Joost PH, additional

Published
2022
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6. Assessing the efficacy and safety of mycophenolate mofetil versus azathioprine in patients with autoimmune hepatitis (CAMARO trial):study protocol for a randomised controlled trial

Author

Snijders, Romée J.A.L.M., Stoelinga, Anna E.C., Gevers, Tom J.G., Pape, Simon, Biewenga, Maaike, Verdonk, Robert C., de Jonge, Hendrik J.M., Vrolijk, Jan Maarten, Bakker, Sjoerd F., Vanwolleghem, Thomas, de Boer, Ynto S., Pronk, Martine A.M.C.Baven, Beuers, Ulrich H.W., van der Meer, Adriaan J., van Gerven, Nicole M.F., Sijtsma, Marijn G.M., Verwer, Bart J., Gisbertz, Ingrid A.M., Bartelink, Maartje, van den Brand, Floris F., Sebib Korkmaz, Kerem, van den Berg, Aad P., Guichelaar, Maureen M.J., Soufidi, Khalida, Levens, Amar D., van Hoek, Bart, Drenth, Joost P.H., Snijders, Romée J.A.L.M., Stoelinga, Anna E.C., Gevers, Tom J.G., Pape, Simon, Biewenga, Maaike, Verdonk, Robert C., de Jonge, Hendrik J.M., Vrolijk, Jan Maarten, Bakker, Sjoerd F., Vanwolleghem, Thomas, de Boer, Ynto S., Pronk, Martine A.M.C.Baven, Beuers, Ulrich H.W., van der Meer, Adriaan J., van Gerven, Nicole M.F., Sijtsma, Marijn G.M., Verwer, Bart J., Gisbertz, Ingrid A.M., Bartelink, Maartje, van den Brand, Floris F., Sebib Korkmaz, Kerem, van den Berg, Aad P., Guichelaar, Maureen M.J., Soufidi, Khalida, Levens, Amar D., van Hoek, Bart, and Drenth, Joost P.H.

Abstract

Background: Currently, the standard therapy for autoimmune hepatitis (AIH) consists of a combination of prednisolone and azathioprine. However, 15% of patients are intolerant to azathioprine which necessitates cessation of azathioprine or changes in therapy. In addition, not all patients achieve complete biochemical response (CR). Uncontrolled data indicate that mycophenolate mofetil (MMF) can induce CR in a majority of patients. Better understanding of first-line treatment and robust evidence from randomised clinical trials are needed. The aim of this study was to explore the potential benefits of MMF as compared to azathioprine, both combined with prednisolone, as induction therapy in a randomised controlled trial in patients with treatment-naive AIH. Methods: CAMARO is a randomised (1:1), open-label, parallel-group, multicentre superiority trial. All patients with AIH are screened for eligibility. Seventy adult patients with AIH from fourteen centres in the Netherlands and Belgium will be randomised to receive MMF or azathioprine. Both treatment arms will start with prednisolone as induction therapy. The primary outcome is biochemical remission, defined as serum levels of alanine aminotransferase and immunoglobulin G below the upper limit of normal. Secondary outcomes include safety and tolerability of MMF and azathioprine, time to remission, changes in Model For End-Stage Liver Disease (MELD)-score, adverse events, and aspects of quality of life. The study period will last for 24 weeks. Discussion: The CAMARO trial investigates whether treatment with MMF and prednisolone increases the proportion of patients in remission compared with azathioprine and prednisolone as the current standard treatment strategy. In addition, we reflect on the challenges of conducting a randomized trial in rare diseases. Trial registration: EudraCT 2016-001038-91. Prospectively registered on 18 April 2016. Graphical Abstract: [Figure not available: see fulltext.].

Published
2022

9. Biochemical efficacy of tioguanine in autoimmune hepatitis: a retrospective review of practice in the Netherlands

Author

van den Brand, Floris F., primary, van Nieuwkerk, Carin M. J., additional, Verwer, Bart J., additional, de Boer, Ynto S., additional, de Boer, Nanne K. H., additional, Mulder, Chris J. J., additional, Bloemena, Elisabeth, additional, Bakker, Christine M., additional, Vrolijk, Jan M., additional, Drenth, Joost P. H., additional, Tan, Adriaan C. I. T. L., additional, ter Borg, Frank, additional, ter Borg, Martijn J., additional, van den Hazel, Sven J., additional, Inderson, Akin, additional, Tushuizen, Maarten E., additional, and Bouma, Gerd, additional

Published
2018
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10. Diagnose en behandeling van auto-immune hepatitis

Author

Verwer, Bart J., Bouma, Gerd, Bloemena, Elisabeth, Schreuder, Tim C.M.A., Mulder, Chris J.J., van Nieuwkerk, Karin M.J., Gastroenterology and hepatology, and Pathology

Abstract

Autoimmune hepatitis (AIH) is a progressive, chronic form of hepatitis of unknown cause that occurs in people of all ages. The diagnosis is based on characteristic clinical and biochemical abnormalities, absence of other causes of hepatitis and histopathological characteristics. The variety of symptoms that AIH patients may have and the importance of considering the disease is illustrated in three case studies. The first was a 22-year-old woman with fulminant hepatitis and jaundice. Corticosteroid and azathioprine treatment resulted in prolonged remission. The second patient, a 48-year-old woman, had hepatocellular carcinoma in a cirrhotic liver, based on AIH. Radiofrequency ablation was planned, after which the patient would be put on the waiting list for transplantation. The third patient was an 81-year-old man with impaired liver function and cirrhosis. His treatment was the same as in the first patient and resulted in remission as well. No curative therapy for AIH is yet available, but appropriate management of the disease can prolong survival, improve the quality of life, and avoid the need for liver transplantation.

Published
2009

11. Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1

Author

de Boer, Ynto S., primary, van Gerven, Nicole M.F., additional, Zwiers, Antonie, additional, Verwer, Bart J., additional, van Hoek, Bart, additional, van Erpecum, Karel J., additional, Beuers, Ulrich, additional, van Buuren, Henk R., additional, Drenth, Joost P.H., additional, den Ouden, Jannie W., additional, Verdonk, Robert C., additional, Koek, Ger H., additional, Brouwer, Johannes T., additional, Guichelaar, Maureen M.J., additional, Vrolijk, Jan M., additional, Kraal, Georg, additional, Mulder, Chris J.J., additional, van Nieuwkerk, Carin M.J., additional, Fischer, Janett, additional, Berg, Thomas, additional, Stickel, Felix, additional, Sarrazin, Christoph, additional, Schramm, Christoph, additional, Lohse, Ansgar W., additional, Weiler-Normann, Christina, additional, Lerch, Markus M., additional, Nauck, Matthias, additional, Völzke, Henry, additional, Homuth, Georg, additional, Bloemena, Elisabeth, additional, Verspaget, Hein W., additional, Kumar, Vinod, additional, Zhernakova, Alexandra, additional, Wijmenga, Cisca, additional, Franke, Lude, additional, and Bouma, Gerd, additional

Published
2014
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12. Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission

Author

van Gerven, Nicole M.F., primary, Verwer, Bart J., additional, Witte, Birgit I., additional, van Hoek, Bart, additional, Coenraad, Minneke J., additional, van Erpecum, Karel J., additional, Beuers, Ulrich, additional, van Buuren, Henk R., additional, de Man, Rob A., additional, Drenth, Joost P.H., additional, den Ouden, Jannie W., additional, Verdonk, Robert C., additional, Koek, Ger H., additional, Brouwer, Johannes T., additional, Guichelaar, Maureen M.J., additional, Mulder, Chris J.J., additional, van Nieuwkerk, Karin M.J., additional, and Bouma, Gerd, additional

Published
2013
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13. Maintenance Treatment is Necessary Even When Auto Immune Hepatitis is in Remission

Author

van Gerven, Nicole M., primary, Verwer, Bart J., additional, Mulder, Chris J., additional, Guichelaar, Maureen, additional, van Hoek, Bart, additional, Pronk, Martine, additional, Coenraad, Minneke J., additional, van Buuren, Henk R., additional, De Man, Robert A., additional, Van Erpecum, Karel J., additional, Drenth, Joost P., additional, Beuers, Ulrich, additional, den Ouden, Jannie, additional, Koek, Ger H., additional, Brouwer, Johannes T., additional, van Nieuwkerk, Karin, additional, and Bouma, Gerd, additional

Published
2011
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14. Epidemiology of Autoimmune Hepatitis in the Netherlands: A Nationwide Study

Author

van Gerven, Nicole M., primary, Verwer, Bart J., additional, van Hoek, Bart, additional, Brouwer, Johannes T., additional, Visscher, Arjan P., additional, Pronk, Martine, additional, Coenraad, Minneke J., additional, van Buuren, Henk R., additional, De Man, Robert A., additional, Van Erpecum, Karel J., additional, Drenth, Joost P., additional, Beuers, Ulrich, additional, de Zwart, Brenda, additional, den Ouden, Jannie, additional, Koek, Ger H., additional, van Nieuwkerk, Karin, additional, and Bouma, Gerd, additional

Published
2011
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16. Epidemiology and clinical characteristics of autoimmune hepatitis in the Netherlands.

Author

van Gerven, Nicole M.F., Verwer, Bart J., Witte, Birgit I., van Erpecum, Karel J., van Buuren, Henk R., Maijers, Ingrid, Visscher, Arjan P., Verschuren, Edwin C., van Hoek, Bart, Coenraad, Minneke J., Beuers, Ulrich H.W., de Man, Robert A., Drenth, Joost P.H., den Ouden, Jannie W., Verdonk, Robert C., Koek, Ger H., Brouwer, Johannes T., Guichelaar, Maureen M.J., Vrolijk, Jan Maarten, and Mulder, Chris J.J.

Subjects
*EPIDEMIOLOGY, *CHRONIC active hepatitis, *AUTOIMMUNE diseases, *CIRRHOSIS of the liver, *DISEASE prevalence, *TRANSPLANTATION of organs, tissues, etc.
Abstract

Background and aims. Epidemiological data on autoimmune hepatitis (AIH) are scarce. In this study, we determined the clinical and epidemiological characteristics of AIH patients in the Netherlands (16.7 million inhabitants). Methods. Clinical characteristics were collected from 1313 AIH patients (78% females) from 31 centers, including all eight academic centers in the Netherlands. Additional data on ethnicity, family history and symptoms were obtained by the use of a questionnaire. Results. The prevalence of AIH was 18.3 (95% confidential interval [CI]: 17.3-19.4) per 100,000 with an annual incidence of 1.1 (95% CI: 0.5-2) in adults. An incidence peak was found in middle-aged women. At diagnosis, 56% of patients had fibrosis and 12% cirrhosis in liver biopsy. Overall, 1% of patients developed HCC and 3% of patients underwent liver transplantation. Overlap with primary biliary cirrhosis and primary sclerosing cholangitis was found in 9% and 6%, respectively. The clinical course did not differ between Caucasian and non-Caucasian patients. Other autoimmune diseases were found in 26% of patients. Half of the patients reported persistent AIH-related symptoms despite treatment with a median treatment period of 8 years (range 1-44 years). Familial occurrence was reported in three cases. Conclusion. This is the largest epidemiological study of AIH in a geographically defined region and demonstrates that the prevalence of AIH in the Netherlands is uncommon. Although familial occurrence of AIH is extremely rare, our twin data may point towards a genetic predisposition. The high percentage of patients with cirrhosis or fibrosis at diagnosis urges the need of more awareness for AIH. [ABSTRACT FROM AUTHOR]

Published
2014
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18. [Diagnosis and treatment of autoimmune hepatitis].

Author

Verwer BJ, Bouma G, Bloemena E, Schreuder TC, Mulder CJ, and van Nieuwkerk KM

Subjects
Aged, 80 and over, Diagnosis, Differential, Female, Hepatitis, Autoimmune therapy, Humans, Liver Transplantation, Male, Middle Aged, Quality of Life, Treatment Outcome, Young Adult, Adrenal Cortex Hormones therapeutic use, Azathioprine therapeutic use, Hepatitis, Autoimmune diagnosis, Hepatitis, Autoimmune drug therapy, Immunosuppressive Agents therapeutic use
Abstract

Autoimmune hepatitis (AIH) is a progressive, chronic form of hepatitis of unknown cause that occurs in people of all ages. The diagnosis is based on characteristic clinical and biochemical abnormalities, absence of other causes of hepatitis and histopathological characteristics. The variety of symptoms that AIH patients may have and the importance of considering the disease is illustrated in three case studies. The first was a 22-year-old woman with fulminant hepatitis and jaundice. Corticosteroid and azathioprine treatment resulted in prolonged remission. The second patient, a 48-year-old woman, had hepatocellular carcinoma in a cirrhotic liver, based on AIH. Radiofrequency ablation was planned, after which the patient would be put on the waiting list for transplantation. The third patient was an 81-year-old man with impaired liver function and cirrhosis. His treatment was the same as in the first patient and resulted in remission as well. No curative therapy for AIH is yet available, but appropriate management of the disease can prolong survival, improve the quality of life, and avoid the need for liver transplantation.

Published
2009

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