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3. A consensus protocol for functional connectivity analysis in the rat brain

Author

Grandjean, Joanes, Desrosiers-Gregoire, Gabriel, Anckaerts, Cynthia, Angeles-Valdez, Diego, Ayad, Fadi, Barrière, David A., Blockx, Ines, Bortel, Aleksandra, Broadwater, Margaret, Cardoso, Beatriz M., Célestine, Marina, Chavez-Negrete, Jorge E., Choi, Sangcheon, Christiaen, Emma, Clavijo, Perrin, Colon-Perez, Luis, Cramer, Samuel, Daniele, Tolomeo, Dempsey, Elaine, Diao, Yujian, Doelemeyer, Arno, Dopfel, David, Dvořáková, Lenka, Falfán-Melgoza, Claudia, Fernandes, Francisca F., Fowler, Caitlin F., Fuentes-Ibañez, Antonio, Garin, Clément M., Gelderman, Eveline, Golden, Carla E. M., Guo, Chao C. G., Henckens, Marloes J. A. G., Hennessy, Lauren A., Herman, Peter, Hofwijks, Nita, Horien, Corey, Ionescu, Tudor M., Jones, Jolyon, Kaesser, Johannes, Kim, Eugene, Lambers, Henriette, Lazari, Alberto, Lee, Sung-Ho, Lillywhite, Amanda, Liu, Yikang, Liu, Yanyan Y., López -Castro, Alejandra, López-Gil, Xavier, Ma, Zilu, MacNicol, Eilidh, Madularu, Dan, Mandino, Francesca, Marciano, Sabina, McAuslan, Matthew J., McCunn, Patrick, McIntosh, Alison, Meng, Xianzong, Meyer-Baese, Lisa, Missault, Stephan, Moro, Federico, Naessens, Daphne M. P., Nava-Gomez, Laura J., Nonaka, Hiroi, Ortiz, Juan J., Paasonen, Jaakko, Peeters, Lore M., Pereira, Mickaël, Perez, Pablo D., Pompilus, Marjory, Prior, Malcolm, Rakhmatullin, Rustam, Reimann, Henning M., Reinwald, Jonathan, Del Rio, Rodrigo Triana, Rivera-Olvera, Alejandro, Ruiz-Pérez, Daniel, Russo, Gabriele, Rutten, Tobias J., Ryoke, Rie, Sack, Markus, Salvan, Piergiorgio, Sanganahalli, Basavaraju G., Schroeter, Aileen, Seewoo, Bhedita J., Selingue, Erwan, Seuwen, Aline, Shi, Bowen, Sirmpilatze, Nikoloz, Smith, Joanna A. B., Smith, Corrie, Sobczak, Filip, Stenroos, Petteri J., Straathof, Milou, Strobelt, Sandra, Sumiyoshi, Akira, Takahashi, Kengo, Torres-García, Maria E., Tudela, Raul, van den Berg, Monica, van der Marel, Kajo, van Hout, Aran T. B., Vertullo, Roberta, Vidal, Benjamin, Vrooman, Roël M., Wang, Victora X., Wank, Isabel, Watson, David J. G., Yin, Ting, Zhang, Yongzhi, Zurbruegg, Stefan, Achard, Sophie, Alcauter, Sarael, Auer, Dorothee P., Barbier, Emmanuel L., Baudewig, Jürgen, Beckmann, Christian F., Beckmann, Nicolau, Becq, Guillaume J. P. C., Blezer, Erwin L. A., Bolbos, Radu, Boretius, Susann, Bouvard, Sandrine, Budinger, Eike, Buxbaum, Joseph D., Cash, Diana, Chapman, Victoria, Chuang, Kai-Hsiang, Ciobanu, Luisa, Coolen, Bram F., Dalley, Jeffrey W., Dhenain, Marc, Dijkhuizen, Rick M., Esteban, Oscar, Faber, Cornelius, Febo, Marcelo, Feindel, Kirk W., Forloni, Gianluigi, Fouquet, Jérémie, Garza-Villarreal, Eduardo A., Gass, Natalia, Glennon, Jeffrey C., Gozzi, Alessandro, Gröhn, Olli, Harkin, Andrew, Heerschap, Arend, Helluy, Xavier, Herfert, Kristina, Heuser, Arnd, Homberg, Judith R., Houwing, Danielle J., Hyder, Fahmeed, Ielacqua, Giovanna Diletta, Jelescu, Ileana O., Johansen-Berg, Heidi, Kaneko, Gen, Kawashima, Ryuta, Keilholz, Shella D., Keliris, Georgios A., Kelly, Clare, Kerskens, Christian, Khokhar, Jibran Y., Kind, Peter C., Langlois, Jean-Baptiste, Lerch, Jason P., López-Hidalgo, Monica A., Manahan-Vaughan, Denise, Marchand, Fabien, Mars, Rogier B., Marsella, Gerardo, Micotti, Edoardo, Muñoz-Moreno, Emma, Near, Jamie, Niendorf, Thoralf, Otte, Willem M., Pais-Roldán, Patricia, Pan, Wen-Ju, Prado-Alcalá, Roberto A., Quirarte, Gina L., Rodger, Jennifer, Rosenow, Tim, Sampaio-Baptista, Cassandra, Sartorius, Alexander, Sawiak, Stephen J., Scheenen, Tom W. J., Shemesh, Noam, Shih, Yen-Yu Ian, Shmuel, Amir, Soria, Guadalupe, Stoop, Ron, Thompson, Garth J., Till, Sally M., Todd, Nick, Van Der Linden, Annemie, van der Toorn, Annette, van Tilborg, Geralda A. F., Vanhove, Christian, Veltien, Andor, Verhoye, Marleen, Wachsmuth, Lydia, Weber-Fahr, Wolfgang, Wenk, Patricia, Yu, Xin, Zerbi, Valerio, Zhang, Nanyin, Zhang, Baogui B., Zimmer, Luc, Devenyi, Gabriel A., Chakravarty, M. Mallar, and Hess, Andreas

Published
2023
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7. Utilizing MRI, [18F]FDG-PET and [89Zr]Zr-DFO-28H1 FAP-PET tracer to assess inflammation and fibrogenesis in a reproducible lung injury rat model: a multimodal imaging study.

Author

Boswinkel, Milou, Raavé, René, Veltien, Andor, Scheenen, Tom WJ, Petterson, Nina Fransén, 't Zandt, René in, Olsson, Lars E., Wachenfeldt, Karin von, Heskamp, Sandra, and Persson, Irma Mahmutovic

Subjects
PREVENTION of weight loss, DATA analysis, T-test (Statistics), STATISTICAL hypothesis testing, RESEARCH funding, STATISTICAL sampling, COMPUTED tomography, MAGNETIC resonance imaging, LUNG injuries, POSITRON emission tomography, MANN Whitney U Test, BLEOMYCIN, TRACHEA intubation, FIBROBLASTS, RATS, ANIMAL experimentation, ONE-way analysis of variance, STATISTICS, INFLAMMATION, DATA analysis software, BIOMARKERS, DISEASE progression
Abstract

Objective: Accurate imaging biomarkers that indicate disease progression at an early stage are highly important to enable timely mitigation of symptoms in progressive lung disease. In this context, reproducible experimental models and readouts are key. Here, we aim to show reproducibility of a lung injury rat model by inducing disease and assessing disease progression by multi-modal non-invasive imaging techniques at two different research sites. Furthermore, we evaluated the potential of fibroblast activating protein (FAP) as an imaging biomarker in the early stage of lung fibrosis. Methods: An initial lung injury rat model was set up at one research site (Lund University, Lund, Sweden) and repeated at a second site (Radboudumc, Nijmegen, The Netherlands). To induce lung injury, Sprague-Dawley rats received intratracheal instillation of bleomycin as one single dose (1,000 iU in 200 µL) or saline as control. Thereafter, longitudinal images were acquired to track inflammation in the lungs, at 1 and 2 weeks after the bleomycin challenge by magnetic resonance imaging (MRI) and [18F]FDG-PET. After the final [18F] FDG-PET scan, rats received an intravenous tracer [89Zr]Zr-DFO-28H1 (anti-FAP antibody) and were imaged at day 15 to track fibrogenesis. Upon termination, bronchoalveolar lavage (BAL) was performed to assess cell and protein concentration. Subsequently, the biodistribution of [89Zr]Zr-DFO-28H1 was measured ex vivo and the spatial distribution in lung tissue was studied by autoradiography. Lung sections were stained and fibrosis assessed using the modified Ashcroft score. Results: Bleomycin-challenged rats showed body weight loss and increased numbers of immune cells and protein concentrations after BAL compared with control animals. The initiation and progression of the disease were reproduced at both research sites. Lung lesions in bleomycin-exposed rats were visualized by MRI and confirmed by histology. [18F]FDG uptake was higher in the lungs of bleomycin-challenged rats compared with the controls, similar to that observed in the Lund study. [89Zr]Zr-DFO-28H1 tracer uptake in the lung was increased in bleomycin-challenged rats compared with control rats (p = 0.03). Conclusion: Here, we demonstrate a reproducible lung injury model and monitored disease progression using conventional imaging biomarkers MRI and [18F]FDG-PET. Furthermore, we showed the first proof-of-concept of FAP imaging. This reproducible and robust animal model and imaging experimental set-up allows for future research on new therapeutics or biomarkers in lung disease. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Utilizing MRI, [18F]FDG-PET and [89Zr]Zr-DFO-28H1 FAP-PET tracer to assess inflammation and fibrogenesis in a reproducible lung injury rat model: a multimodal imaging study

Author

Boswinkel, Milou, primary, Raavé, René, additional, Veltien, Andor, additional, Scheenen, Tom WJ, additional, Fransén Petterson, Nina, additional, in ‘t Zandt, René, additional, Olsson, Lars E., additional, von Wachenfeldt, Karin, additional, Heskamp, Sandra, additional, and Mahmutovic Persson, Irma, additional

Published
2023
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12. Repeatability and reproducibility of longitudinal relaxation rate in 12 small-animal MRI systems

Author

Waterton, John C., Hines, Catherine D.G., Hockings, Paul D., Laitinen, Iina, Ziemian, Sabina, Campbell, Simon, Gottschalk, Michael, Green, Claudia, Haase, Michael, Hassemer, Katja, Juretschke, Hans-Paul, Koehler, Sascha, Lloyd, William, Luo, Yanping, Mahmutovic Persson, Irma, O'Connor, James P.B., Olsson, Lars E., Pindoria, Kashmira, Schneider, Jurgen E., Sourbron, Steven, Steinmann, Denise, Strobel, Klaus, Tadimalla, Sirisha, Teh, Irvin, Veltien, Andor, Zhang, Xiaomeng, and Schütz, Gunnar

Published
2019
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14. Perinatal exposure to the immune-suppressant di-n-octyltin dichloride affects brain development in rats.

Author

de Groot, Didima M. G., Linders, Louisa, Kayser, Reinier, Nederlof, Rianne, de Esch, Celine, Slieker, Roderick C., Kuper, C. Frieke, Wolterbeek, Andre, de Groot, V. Jeroen, Veltien, Andor, Heerschap, Arend, van Waarde, Aren, Dierckx, Rudi A. J. O, and de Vries, Erik F. J.

Subjects
NEURAL development, EMBRYOLOGY, POSITRON emission tomography, STARTLE reaction, SPECIFIC gravity
Abstract

Disruption of the immune system during embryonic brain development by environmental chemicals was proposed as a possible cause of neurodevelopmental disorders. We previously found adverse effects of di-n-octyltin dichloride (DOTC) on maternal and developing immune systems of rats in an extended one-generation reproductive toxicity study according to the OECD 443 test guideline. We hypothesize that the DOTC-induced changes in the immune system can affect neurodevelopment. Therefore, we used in-vivo MRI and PET imaging and genomics, in addition to behavioral testing and neuropathology as proposed in OECD test guideline 443, to investigate the effect of DOTC on structural and functional brain development. Male rats were exposed to DOTC (0, 3, 10, or 30 mg/kg of diet) from 2 weeks prior to mating of the F0-generation until sacrifice of F1-animals. The brains of rats, exposed to DOTC showed a transiently enlarged volume of specific brain regions (MRI), altered specific gravity, and transient hyper-metabolism ([18F]FDG PET). The alterations in brain development concurred with hyper-responsiveness in auditory startle response and slight hyperactivity in young adult animals. Genomics identified altered transcription of key regulators involved in neurodevelopment and neural function (e.g. Nrgrn, Shank3, Igf1r, Cck, Apba2, Foxp2); and regulators involved in cell size, cell proliferation, and organ development, especially immune system development and functioning (e.g. LOC679869, Itga11, Arhgap5, Cd47, Dlg1, Gas6, Cml5, Mef2c). The results suggest the involvement of immunotoxicity in the impairment of the nervous system by DOTC and support the hypothesis of a close connection between the immune and nervous systems in brain development. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Perinatal exposure to the immune-suppressant di-n-octyltin dichloride affects brain development in rats

Author

de Groot, Didima M. G., primary, Linders, Louisa, additional, Kayser, Reinier, additional, Nederlof, Rianne, additional, de Esch, Celine, additional, Slieker, Roderick C., additional, Kuper, C. Frieke, additional, Wolterbeek, Andre, additional, de Groot, V. Jeroen, additional, Veltien, Andor, additional, Heerschap, Arend, additional, van Waarde, Aren, additional, Dierckx, Rudi A. J. O, additional, and de Vries, Erik F. J., additional

Published
2023
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20. Utilizing MRI, [18F]FDG-PET and [ 89Zr]Zr-DFO-28H1 FAP-PET tracer to assess inflammation and fibrogenesis in a reproducible lung injury rat model: a multimodal imaging study.

Author

Boswinkel, Milou, Raavé, René, Veltien, Andor, Scheenen, Tom W.J., Petterson, Nina Fransén, in ‘t Zandt, René, Olsson, Lars E., von Wachenfeldt, Karin, Heskamp, Sandra, and Persson, Irma Mahmutovic

Subjects
LUNG injuries, DIAGNOSTIC imaging, ANIMAL disease models, MAGNETIC resonance imaging, INTERSTITIAL lung diseases, LUNG diseases, PULMONARY fibrosis
Abstract

Objective: Accurate imaging biomarkers that indicate disease progression at an early stage are highly important to enable timely mitigation of symptoms in progressive lung disease. In this context, reproducible experimental models and readouts are key. Here, we aim to show reproducibility of a lung injury rat model, by inducing disease and assessing disease progression by multi-modal non-invasive imaging techniques at two different research sites. Furthermore, we evaluated the potential of fibroblast activating protein (FAP) as an imaging biomarker in the early stage of lung fibrosis. Methods: An initial lung injury rat model was set up at one research site (Lund University, Lund, Sweden) and repeated at a second site (Radboudumc, Nijmegen, The Netherlands). To induce lung injury, Sprague-Dawley rats received intratracheal instillation of bleomycin as one single dose (1,000 iU in 200 µL) or saline as control. Thereafter, longitudinal images were acquired to track inflammation in the lungs, at 1 and 2 weeks after the bleomycin challenge by magnetic resonance imaging (MRI) and [18F]FDG-PET. After the final [18F]FDG-PET scan, rats received an intravenous tracer [89Zr]Zr-DFO-28H1 (anti-FAP antibody) and were imaged at day 15, to track fibrogenesis. Upon termination, bronchoalveolar lavage (BAL) was performed to assess cell and protein concentration. Subsequently, the biodistribution of [89Zr]Zr-DFO-28H1 was measured ex vivo and the spatial distribution in lung tissue was studied by autoradiography. Lung sections were stained, and fibrosis assessed using the modified Ashcroft score. Results: Bleomycin-challenged rats showed body weight loss and increased numbers of immune cells and protein concentrations after BAL compared with control animals. The initiation and progression of the disease were reproduced at both research sites. Lung lesions in bleomycin-exposed rats were visualized by MRI and confirmed by histology. [18F]FDG uptake was higher in the lungs of bleomycin-challenged rats compared with the controls, similar to that observed in the Lund study. [89Zr]Zr-DFO-28H1 tracer uptake in the lung was increased in bleomycin-challenged rats compared with control rats (p = 0.03). Conclusion: Here, we demonstrate a reproducible lung injury model and monitored disease progression using conventional imaging biomarkers MRI and [18F]FDG-PET. Furthermore, we showed the first proof-of-concept of FAP imaging. This reproducible and robust animal model and imaging experimental set-up allows for future research on new therapeutics or biomarkers in lung disease. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Author Correction: A consensus protocol for functional connectivity analysis in the rat brain

Author

Grandjean, Joanes, primary, Desrosiers-Gregoire, Gabriel, additional, Anckaerts, Cynthia, additional, Angeles-Valdez, Diego, additional, Ayad, Fadi, additional, Barrière, David A., additional, Blockx, Ines, additional, Bortel, Aleksandra, additional, Broadwater, Margaret, additional, Cardoso, Beatriz M., additional, Célestine, Marina, additional, Chavez-Negrete, Jorge E., additional, Choi, Sangcheon, additional, Christiaen, Emma, additional, Clavijo, Perrin, additional, Colon-Perez, Luis, additional, Cramer, Samuel, additional, Daniele, Tolomeo, additional, Dempsey, Elaine, additional, Diao, Yujian, additional, Doelemeyer, Arno, additional, Dopfel, David, additional, Dvořáková, Lenka, additional, Falfán-Melgoza, Claudia, additional, Fernandes, Francisca F., additional, Fowler, Caitlin F., additional, Fuentes-Ibañez, Antonio, additional, Garin, Clément M., additional, Gelderman, Eveline, additional, Golden, Carla E. M., additional, Guo, Chao C. G., additional, Henckens, Marloes J. A. G., additional, Hennessy, Lauren A., additional, Herman, Peter, additional, Hofwijks, Nita, additional, Horien, Corey, additional, Ionescu, Tudor M., additional, Jones, Jolyon, additional, Kaesser, Johannes, additional, Kim, Eugene, additional, Lambers, Henriette, additional, Lazari, Alberto, additional, Lee, Sung-Ho, additional, Lillywhite, Amanda, additional, Liu, Yikang, additional, Liu, Yanyan Y., additional, López -Castro, Alejandra, additional, López-Gil, Xavier, additional, Ma, Zilu, additional, MacNicol, Eilidh, additional, Madularu, Dan, additional, Mandino, Francesca, additional, Marciano, Sabina, additional, McAuslan, Matthew J., additional, McCunn, Patrick, additional, McIntosh, Alison, additional, Meng, Xianzong, additional, Meyer-Baese, Lisa, additional, Missault, Stephan, additional, Moro, Federico, additional, Naessens, Daphne M. P., additional, Nava-Gomez, Laura J., additional, Nonaka, Hiroi, additional, Ortiz, Juan J., additional, Paasonen, Jaakko, additional, Peeters, Lore M., additional, Pereira, Mickaël, additional, Perez, Pablo D., additional, Pompilus, Marjory, additional, Prior, Malcolm, additional, Rakhmatullin, Rustam, additional, Reimann, Henning M., additional, Reinwald, Jonathan, additional, Del Rio, Rodrigo Triana, additional, Rivera-Olvera, Alejandro, additional, Ruiz-Pérez, Daniel, additional, Russo, Gabriele, additional, Rutten, Tobias J., additional, Ryoke, Rie, additional, Sack, Markus, additional, Salvan, Piergiorgio, additional, Sanganahalli, Basavaraju G., additional, Schroeter, Aileen, additional, Seewoo, Bhedita J., additional, Selingue, Erwan, additional, Seuwen, Aline, additional, Shi, Bowen, additional, Sirmpilatze, Nikoloz, additional, Smith, Joanna A. B., additional, Smith, Corrie, additional, Sobczak, Filip, additional, Stenroos, Petteri J., additional, Straathof, Milou, additional, Strobelt, Sandra, additional, Sumiyoshi, Akira, additional, Takahashi, Kengo, additional, Torres-García, Maria E., additional, Tudela, Raul, additional, van den Berg, Monica, additional, van der Marel, Kajo, additional, van Hout, Aran T. B., additional, Vertullo, Roberta, additional, Vidal, Benjamin, additional, Vrooman, Roël M., additional, Wang, Victora X., additional, Wank, Isabel, additional, Watson, David J. G., additional, Yin, Ting, additional, Zhang, Yongzhi, additional, Zurbruegg, Stefan, additional, Achard, Sophie, additional, Alcauter, Sarael, additional, Auer, Dorothee P., additional, Barbier, Emmanuel L., additional, Baudewig, Jürgen, additional, Beckmann, Christian F., additional, Beckmann, Nicolau, additional, Becq, Guillaume J. P. C., additional, Blezer, Erwin L. A., additional, Bolbos, Radu, additional, Boretius, Susann, additional, Bouvard, Sandrine, additional, Budinger, Eike, additional, Buxbaum, Joseph D., additional, Cash, Diana, additional, Chapman, Victoria, additional, Chuang, Kai-Hsiang, additional, Ciobanu, Luisa, additional, Coolen, Bram F., additional, Dalley, Jeffrey W., additional, Dhenain, Marc, additional, Dijkhuizen, Rick M., additional, Esteban, Oscar, additional, Faber, Cornelius, additional, Febo, Marcelo, additional, Feindel, Kirk W., additional, Forloni, Gianluigi, additional, Fouquet, Jérémie, additional, Garza-Villarreal, Eduardo A., additional, Gass, Natalia, additional, Glennon, Jeffrey C., additional, Gozzi, Alessandro, additional, Gröhn, Olli, additional, Harkin, Andrew, additional, Heerschap, Arend, additional, Helluy, Xavier, additional, Herfert, Kristina, additional, Heuser, Arnd, additional, Homberg, Judith R., additional, Houwing, Danielle J., additional, Hyder, Fahmeed, additional, Ielacqua, Giovanna Diletta, additional, Jelescu, Ileana O., additional, Johansen-Berg, Heidi, additional, Kaneko, Gen, additional, Kawashima, Ryuta, additional, Keilholz, Shella D., additional, Keliris, Georgios A., additional, Kelly, Clare, additional, Kerskens, Christian, additional, Khokhar, Jibran Y., additional, Kind, Peter C., additional, Langlois, Jean-Baptiste, additional, Lerch, Jason P., additional, López-Hidalgo, Monica A., additional, Manahan-Vaughan, Denise, additional, Marchand, Fabien, additional, Mars, Rogier B., additional, Marsella, Gerardo, additional, Micotti, Edoardo, additional, Muñoz-Moreno, Emma, additional, Near, Jamie, additional, Niendorf, Thoralf, additional, Otte, Willem M., additional, Pais-Roldán, Patricia, additional, Pan, Wen-Ju, additional, Prado-Alcalá, Roberto A., additional, Quirarte, Gina L., additional, Rodger, Jennifer, additional, Rosenow, Tim, additional, Sampaio-Baptista, Cassandra, additional, Sartorius, Alexander, additional, Sawiak, Stephen J., additional, Scheenen, Tom W. J., additional, Shemesh, Noam, additional, Shih, Yen-Yu Ian, additional, Shmuel, Amir, additional, Soria, Guadalupe, additional, Stoop, Ron, additional, Thompson, Garth J., additional, Till, Sally M., additional, Todd, Nick, additional, Van Der Linden, Annemie, additional, van der Toorn, Annette, additional, van Tilborg, Geralda A. F., additional, Vanhove, Christian, additional, Veltien, Andor, additional, Verhoye, Marleen, additional, Wachsmuth, Lydia, additional, Weber-Fahr, Wolfgang, additional, Wenk, Patricia, additional, Yu, Xin, additional, Zerbi, Valerio, additional, Zhang, Nanyin, additional, Zhang, Baogui B., additional, Zimmer, Luc, additional, Devenyi, Gabriel A., additional, Chakravarty, M. Mallar, additional, and Hess, Andreas, additional

Published
2023
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22. Small Suspicious Lymph Nodes Detected on Ultrahigh-field Magnetic Resonance Imaging (MRI) in Patients with Prostate Cancer with High Risk of Nodal Metastases: The First In-patient Study on Ultrasmall Superparamagnetic Iron Oxide–enhanced 7T MRI

Author

Fortuin, Ansje, primary, van Asten, Jack, additional, Veltien, Andor, additional, Philips, Bart, additional, Hambrock, Thomas, additional, Johst, Sören, additional, Orzada, Stephan, additional, Hadaschik, Boris, additional, Quick, Harald, additional, Barentsz, Jelle, additional, Maas, Marnix, additional, and Scheenen, Tom, additional

Published
2023
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23. Glucose versus fructose metabolism in the liver measured with deuterium metabolic imaging

Author

Highfield Research Group, Cancer, Circulatory Health, Hendriks, Arjan D., Veltien, Andor, Voogt, Ingmar J., Heerschap, Arend, Scheenen, Tom W.J., Prompers, Jeanine J., Highfield Research Group, Cancer, Circulatory Health, Hendriks, Arjan D., Veltien, Andor, Voogt, Ingmar J., Heerschap, Arend, Scheenen, Tom W.J., and Prompers, Jeanine J.

Published
2023

24. Author Correction: A consensus protocol for functional connectivity analysis in the rat brain (Nature Neuroscience, (2023), 26, 4, (673-681), 10.1038/s41593-023-01286-8)

Author

In Vivo NMR ISI, Trialbureau Beeld, Brain, Circulatory Health, Stroke, Hubrecht Institute with UMC, Projectafdeling KIND, Grandjean, Joanes, Desrosiers-Gregoire, Gabriel, Anckaerts, Cynthia, Angeles-Valdez, Diego, Ayad, Fadi, Barrière, David A., Blockx, Ines, Bortel, Aleksandra, Broadwater, Margaret, Cardoso, Beatriz M., Célestine, Marina, Chavez-Negrete, Jorge E., Choi, Sangcheon, Christiaen, Emma, Clavijo, Perrin, Colon-Perez, Luis, Cramer, Samuel, Daniele, Tolomeo, Dempsey, Elaine, Diao, Yujian, Doelemeyer, Arno, Dopfel, David, Dvořáková, Lenka, Falfán-Melgoza, Claudia, Fernandes, Francisca F., Fowler, Caitlin F., Fuentes-Ibañez, Antonio, Garin, Clément M., Gelderman, Eveline, Golden, Carla E.M., Guo, Chao C.G., Henckens, Marloes J.A.G., Hennessy, Lauren A., Herman, Peter, Hofwijks, Nita, Horien, Corey, Ionescu, Tudor M., Jones, Jolyon, Kaesser, Johannes, Kim, Eugene, Lambers, Henriette, Lazari, Alberto, Lee, Sung Ho, Lillywhite, Amanda, Liu, Yikang, Liu, Yanyan Y., López -Castro, Alejandra, López-Gil, Xavier, Ma, Zilu, MacNicol, Eilidh, Madularu, Dan, Mandino, Francesca, Marciano, Sabina, McAuslan, Matthew J., McCunn, Patrick, McIntosh, Alison, Meng, Xianzong, Meyer-Baese, Lisa, Missault, Stephan, Moro, Federico, Naessens, Daphne M.P., Nava-Gomez, Laura J., Nonaka, Hiroi, Ortiz, Juan J., Paasonen, Jaakko, Peeters, Lore M., Pereira, Mickaël, Perez, Pablo D., Pompilus, Marjory, Prior, Malcolm, Rakhmatullin, Rustam, Reimann, Henning M., Reinwald, Jonathan, Del Rio, Rodrigo Triana, Rivera-Olvera, Alejandro, Ruiz-Pérez, Daniel, Russo, Gabriele, Rutten, Tobias J., Ryoke, Rie, Sack, Markus, Salvan, Piergiorgio, Sanganahalli, Basavaraju G., Schroeter, Aileen, Seewoo, Bhedita J., Selingue, Erwan, Seuwen, Aline, Shi, Bowen, Sirmpilatze, Nikoloz, Smith, Joanna A.B., Smith, Corrie, Sobczak, Filip, Stenroos, Petteri J., Straathof, Milou, Strobelt, Sandra, Sumiyoshi, Akira, Takahashi, Kengo, Torres-García, Maria E., Tudela, Raul, van den Berg, Monica, van der Marel, Kajo, van Hout, Aran T.B., Vertullo, Roberta, Vidal, Benjamin, Vrooman, Roël M., Wang, Victora X., Wank, Isabel, Watson, David J.G., Yin, Ting, Zhang, Yongzhi, Zurbruegg, Stefan, Achard, Sophie, Alcauter, Sarael, Auer, Dorothee P., Barbier, Emmanuel L., Baudewig, Jürgen, Beckmann, Christian F., Beckmann, Nicolau, Becq, Guillaume J.P.C., Blezer, Erwin L.A., Bolbos, Radu, Boretius, Susann, Bouvard, Sandrine, Budinger, Eike, Buxbaum, Joseph D., Cash, Diana, Chapman, Victoria, Chuang, Kai Hsiang, Ciobanu, Luisa, Coolen, Bram F., Dalley, Jeffrey W., Dhenain, Marc, Dijkhuizen, Rick M., Esteban, Oscar, Faber, Cornelius, Febo, Marcelo, Feindel, Kirk W., Forloni, Gianluigi, Fouquet, Jérémie, Garza-Villarreal, Eduardo A., Gass, Natalia, Glennon, Jeffrey C., Gozzi, Alessandro, Gröhn, Olli, Harkin, Andrew, Heerschap, Arend, Helluy, Xavier, Herfert, Kristina, Heuser, Arnd, Homberg, Judith R., Houwing, Danielle J., Hyder, Fahmeed, Ielacqua, Giovanna Diletta, Jelescu, Ileana O., Johansen-Berg, Heidi, Kaneko, Gen, Kawashima, Ryuta, Keilholz, Shella D., Keliris, Georgios A., Kelly, Clare, Kerskens, Christian, Khokhar, Jibran Y., Kind, Peter C., Langlois, Jean Baptiste, Lerch, Jason P., López-Hidalgo, Monica A., Manahan-Vaughan, Denise, Marchand, Fabien, Mars, Rogier B., Marsella, Gerardo, Micotti, Edoardo, Muñoz-Moreno, Emma, Near, Jamie, Niendorf, Thoralf, Otte, Willem M., Pais-Roldán, Patricia, Pan, Wen Ju, Prado-Alcalá, Roberto A., Quirarte, Gina L., Rodger, Jennifer, Rosenow, Tim, Sampaio-Baptista, Cassandra, Sartorius, Alexander, Sawiak, Stephen J., Scheenen, Tom W.J., Shemesh, Noam, Shih, Yen Yu Ian, Shmuel, Amir, Soria, Guadalupe, Stoop, Ron, Thompson, Garth J., Till, Sally M., Todd, Nick, Van Der Linden, Annemie, van der Toorn, Annette, van Tilborg, Geralda A.F., Vanhove, Christian, Veltien, Andor, Verhoye, Marleen, Wachsmuth, Lydia, Weber-Fahr, Wolfgang, Wenk, Patricia, Yu, Xin, Zerbi, Valerio, Zhang, Nanyin, Zhang, Baogui B., Zimmer, Luc, Devenyi, Gabriel A., Chakravarty, M. Mallar, Hess, Andreas, In Vivo NMR ISI, Trialbureau Beeld, Brain, Circulatory Health, Stroke, Hubrecht Institute with UMC, Projectafdeling KIND, Grandjean, Joanes, Desrosiers-Gregoire, Gabriel, Anckaerts, Cynthia, Angeles-Valdez, Diego, Ayad, Fadi, Barrière, David A., Blockx, Ines, Bortel, Aleksandra, Broadwater, Margaret, Cardoso, Beatriz M., Célestine, Marina, Chavez-Negrete, Jorge E., Choi, Sangcheon, Christiaen, Emma, Clavijo, Perrin, Colon-Perez, Luis, Cramer, Samuel, Daniele, Tolomeo, Dempsey, Elaine, Diao, Yujian, Doelemeyer, Arno, Dopfel, David, Dvořáková, Lenka, Falfán-Melgoza, Claudia, Fernandes, Francisca F., Fowler, Caitlin F., Fuentes-Ibañez, Antonio, Garin, Clément M., Gelderman, Eveline, Golden, Carla E.M., Guo, Chao C.G., Henckens, Marloes J.A.G., Hennessy, Lauren A., Herman, Peter, Hofwijks, Nita, Horien, Corey, Ionescu, Tudor M., Jones, Jolyon, Kaesser, Johannes, Kim, Eugene, Lambers, Henriette, Lazari, Alberto, Lee, Sung Ho, Lillywhite, Amanda, Liu, Yikang, Liu, Yanyan Y., López -Castro, Alejandra, López-Gil, Xavier, Ma, Zilu, MacNicol, Eilidh, Madularu, Dan, Mandino, Francesca, Marciano, Sabina, McAuslan, Matthew J., McCunn, Patrick, McIntosh, Alison, Meng, Xianzong, Meyer-Baese, Lisa, Missault, Stephan, Moro, Federico, Naessens, Daphne M.P., Nava-Gomez, Laura J., Nonaka, Hiroi, Ortiz, Juan J., Paasonen, Jaakko, Peeters, Lore M., Pereira, Mickaël, Perez, Pablo D., Pompilus, Marjory, Prior, Malcolm, Rakhmatullin, Rustam, Reimann, Henning M., Reinwald, Jonathan, Del Rio, Rodrigo Triana, Rivera-Olvera, Alejandro, Ruiz-Pérez, Daniel, Russo, Gabriele, Rutten, Tobias J., Ryoke, Rie, Sack, Markus, Salvan, Piergiorgio, Sanganahalli, Basavaraju G., Schroeter, Aileen, Seewoo, Bhedita J., Selingue, Erwan, Seuwen, Aline, Shi, Bowen, Sirmpilatze, Nikoloz, Smith, Joanna A.B., Smith, Corrie, Sobczak, Filip, Stenroos, Petteri J., Straathof, Milou, Strobelt, Sandra, Sumiyoshi, Akira, Takahashi, Kengo, Torres-García, Maria E., Tudela, Raul, van den Berg, Monica, van der Marel, Kajo, van Hout, Aran T.B., Vertullo, Roberta, Vidal, Benjamin, Vrooman, Roël M., Wang, Victora X., Wank, Isabel, Watson, David J.G., Yin, Ting, Zhang, Yongzhi, Zurbruegg, Stefan, Achard, Sophie, Alcauter, Sarael, Auer, Dorothee P., Barbier, Emmanuel L., Baudewig, Jürgen, Beckmann, Christian F., Beckmann, Nicolau, Becq, Guillaume J.P.C., Blezer, Erwin L.A., Bolbos, Radu, Boretius, Susann, Bouvard, Sandrine, Budinger, Eike, Buxbaum, Joseph D., Cash, Diana, Chapman, Victoria, Chuang, Kai Hsiang, Ciobanu, Luisa, Coolen, Bram F., Dalley, Jeffrey W., Dhenain, Marc, Dijkhuizen, Rick M., Esteban, Oscar, Faber, Cornelius, Febo, Marcelo, Feindel, Kirk W., Forloni, Gianluigi, Fouquet, Jérémie, Garza-Villarreal, Eduardo A., Gass, Natalia, Glennon, Jeffrey C., Gozzi, Alessandro, Gröhn, Olli, Harkin, Andrew, Heerschap, Arend, Helluy, Xavier, Herfert, Kristina, Heuser, Arnd, Homberg, Judith R., Houwing, Danielle J., Hyder, Fahmeed, Ielacqua, Giovanna Diletta, Jelescu, Ileana O., Johansen-Berg, Heidi, Kaneko, Gen, Kawashima, Ryuta, Keilholz, Shella D., Keliris, Georgios A., Kelly, Clare, Kerskens, Christian, Khokhar, Jibran Y., Kind, Peter C., Langlois, Jean Baptiste, Lerch, Jason P., López-Hidalgo, Monica A., Manahan-Vaughan, Denise, Marchand, Fabien, Mars, Rogier B., Marsella, Gerardo, Micotti, Edoardo, Muñoz-Moreno, Emma, Near, Jamie, Niendorf, Thoralf, Otte, Willem M., Pais-Roldán, Patricia, Pan, Wen Ju, Prado-Alcalá, Roberto A., Quirarte, Gina L., Rodger, Jennifer, Rosenow, Tim, Sampaio-Baptista, Cassandra, Sartorius, Alexander, Sawiak, Stephen J., Scheenen, Tom W.J., Shemesh, Noam, Shih, Yen Yu Ian, Shmuel, Amir, Soria, Guadalupe, Stoop, Ron, Thompson, Garth J., Till, Sally M., Todd, Nick, Van Der Linden, Annemie, van der Toorn, Annette, van Tilborg, Geralda A.F., Vanhove, Christian, Veltien, Andor, Verhoye, Marleen, Wachsmuth, Lydia, Weber-Fahr, Wolfgang, Wenk, Patricia, Yu, Xin, Zerbi, Valerio, Zhang, Nanyin, Zhang, Baogui B., Zimmer, Luc, Devenyi, Gabriel A., Chakravarty, M. Mallar, and Hess, Andreas

Published
2023

29. Abstract P1047: Imatinib Attenuates Reperfusion Injury In A Rat Model Of Acute Myocardial Infarction

Author

Konijnenberg, Lara S, primary, Uthman, Laween, additional, Veltien, Andor, additional, Kuster, Carolien T, additional, Luiken, Tom T, additional, De Waard, Guus A, additional, Lemmens-Hermans, Kitty, additional, de Haas-Cremers, Karin, additional, Kea-te Lindert, Mariska, additional, Daviran, Deniz, additional, Thijssen, Dick H, additional, Akiva, Anat, additional, Nijveldt, Robin, additional, and van Royen, Niels, additional

Published
2022
Full Text
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31. 19F MRI Imaging Strategies to Reduce Isoflurane Artifacts in In Vivo Images

Author

Staal, Alexander H.J., Veltien, Andor, Srinivas, Mangala, Scheenen, Tom W.J., Staal, Alexander H.J., Veltien, Andor, Srinivas, Mangala, and Scheenen, Tom W.J.

Abstract

Purpose: Isoflurane (ISO) is the most commonly used preclinical inhalation anesthetic. This is a problem in 19F MRI of fluorine contrast agents, as ISO signals cause artifacts that interfere with unambiguous image interpretation and quantification; the two most attractive properties of heteronuclear MRI. We aimed to avoid these artifacts using MRI strategies that can be applied by any pre-clinical researcher. Procedures: Three strategies to avoid ISO chemical shift displacement artifacts (CSDA) in 19F MRI are described and demonstrated with measurements of 19F-containing agents in phantoms and in vivo (n = 3 for all strategies). The success of these strategies is compared to a standard Rapid Acquisition with Relaxation Enhancement (RARE) sequence, with phantom and in vivo validation. ISO artifacts can successfully be avoided by (1) shifting them outside the region of interest using a narrow signal acquisition bandwidth, (2) suppression of ISO by planning a frequency-selective suppression pulse before signal acquisition or by (3) preventing ISO excitation with a 3D sequence with a narrow excitation bandwidth. Results: All three strategies result in complete ISO signal avoidance (p < 0.0001 for all methods). Using a narrow acquisition bandwidth can result in loss of signal to noise ratio and distortion of the image, and a frequency-selective suppression pulse can be incomplete when B1-inhomogeneities are present. Preventing ISO excitation with a narrow excitation pulse in a 3D sequence yields the most robust results (relative SNR 151 ± 28% compared to 2D multislice methods, p = 0.006). Conclusion: We optimized three easily implementable methods to avoid ISO signal artifacts and validated their performance in phantoms and in vivo. We make recommendation on the parameters that pre-clinical studies should report in their method section to make the used approach insightful.

Published
2022

32. Validation of In Vivo Nodal Assessment of Solid Malignancies with USPIO-Enhanced MRI: A Workflow Protocol

Author

Pathologie Pathologen staf, Cancer, Driessen, Daphne A.J.J., de Gouw, Didi J.J.M., Stijns, Rutger C.H., Litjens, Geke, Israël, Bas, Philips, Bart W.J., Hermans, John J., Dijkema, Tim, Klarenbeek, Bastiaan R., van der Post, Rachel S., Nagtegaal, Iris D., van Engen-Van Grunsven, Adriana C.H., Brosens, Lodewijk A.A., Veltien, Andor, Zámecnik, Patrik, Scheenen, Tom W.J., Pathologie Pathologen staf, Cancer, Driessen, Daphne A.J.J., de Gouw, Didi J.J.M., Stijns, Rutger C.H., Litjens, Geke, Israël, Bas, Philips, Bart W.J., Hermans, John J., Dijkema, Tim, Klarenbeek, Bastiaan R., van der Post, Rachel S., Nagtegaal, Iris D., van Engen-Van Grunsven, Adriana C.H., Brosens, Lodewijk A.A., Veltien, Andor, Zámecnik, Patrik, and Scheenen, Tom W.J.

Published
2022

34. StandardRat: A multi-center consensus protocol to enhance functional connectivity specificity in the rat brain

Author

Grandjean, Joanes, primary, Desrosiers-Gregoire, Gabriel, additional, Anckaerts, Cynthia, additional, Angeles-Valdez, Diego, additional, Ayad, Fadi, additional, Barrière, David A, additional, Blockx, Ines, additional, Bortel, Aleksandra B, additional, Broadwater, Margaret, additional, Cardoso, Beatriz M, additional, Célestine, Marina, additional, Chavez-Negrete, Jorge E, additional, Choi, Sangcheon, additional, Christiaen, Emma, additional, Clavijo, Perrin, additional, Colon-Perez, Luis, additional, Cramer, Samuel, additional, Daniele, Tolomeo, additional, Dempsey, Elaine, additional, Diao, Yujian, additional, Doelemeyer, Arno, additional, Dopfel, David, additional, Dvořáková, Lenka, additional, Falfán-Melgoza, Claudia, additional, Fernandes, Francisca F, additional, Fowler, Caitlin F, additional, Fuentes-Ibañez, Antonio, additional, Garin, Clément, additional, Gelderman, Eveline, additional, Golden, Carla EM, additional, Guo, Chao CG, additional, Henckens, Marloes JAG, additional, Hennessy, Lauren A, additional, Herman, Peter, additional, Hofwijks, Nita, additional, Horien, Corey, additional, Ionescu, Tudor M, additional, Jones, Jolyon, additional, Kaesser, Johannes, additional, Kim, Eugene, additional, Lambers, Henriette, additional, Lazari, Alberto, additional, Lee, Sung-Ho, additional, Lillywhite, Amanda, additional, Liu, Yikang, additional, Liu, Yanyan Y, additional, López-Castro, Alejandra, additional, López-Gil, Xavier, additional, Ma, Zilu, additional, MacNicol, Eilidh, additional, Madularu, Dan, additional, Mandino, Francesca, additional, Marciano, Sabina, additional, McAuslan, Matthew J, additional, McCunn, Patrick, additional, McIntosh, Alison, additional, Meng, Xianzong, additional, Meyer-Baese, Lisa, additional, Missault, Stephan, additional, Moro, Federico, additional, Naessens, Daphne, additional, Nava-Gomez, Laura J, additional, Nonaka, Hiroi, additional, Ortiz, Juan J, additional, Paasonen, Jaakko, additional, Peeters, Lore M, additional, Pereira, Mickaël, additional, Perez, Pablo D, additional, Pompilus, Marjory, additional, Prior, Malcolm, additional, Rakhmatullin, Rustam, additional, Reimann, Henning M, additional, Reinwald, Jonathan, additional, de Rio, Rodrigo Triana, additional, Rivera-Olvera, Alejandro, additional, Ruiz-Pérez, Daniel, additional, Russo, Gabriele, additional, Rutten, Tobias J, additional, Ryoke, Rie, additional, Sack, Markus, additional, Salvan, Piergiorgio, additional, Sanganahalli, Basavaraju G, additional, Schroeter, Aileen, additional, Seewoo, Bhedita J, additional, Selingue, Erwan, additional, Seuwen, Aline, additional, Shi, Bowen, additional, Sirmpilatze, Nikoloz, additional, Smith, Joanna AB, additional, Smith, Corrie, additional, Sobczak, Filip, additional, Stenroos, Petteri J, additional, Straathof, Milou, additional, Strobelt, Sandra, additional, Sumiyoshi, Akira, additional, Takahashi, Kengo, additional, Torres-García, Maria E, additional, Tudela, Raul, additional, van den Berg, Monica, additional, van der Marel, Kajo, additional, van Hout, Aran TB, additional, Vertullo, Roberta, additional, Vidal, Benjamin, additional, Vrooman, Roel M, additional, Wang, Victora X, additional, Wank, Isabel, additional, Watson, David JG, additional, Yin, Ting, additional, Zhang, Yongzhi, additional, Zurbruegg, Stefan, additional, Achard, Sophie, additional, Alcauter, Sarael, additional, Auer, Dorothee P, additional, Barbier, Emmanuel L, additional, Baudewig, Jürgen, additional, Beckmann, Christian F, additional, Beckmann, Nicolau, additional, Becq, Guillaume JPC, additional, Blezer, Erwin LA, additional, Bolbos, Radu, additional, Boretius, Susann, additional, Bouvard, Sandrine, additional, Budinger, Eike, additional, Buxbaum, Joseph D, additional, Cash, Diana, additional, Chapman, Victoria, additional, Chuang, Kai-Hsiang, additional, Ciobanu, Luisa, additional, Coolen, Bram, additional, Dalley, Jeffrey W, additional, Dhenain, Marc, additional, Dijkhuizen, Rick M, additional, Esteban, Oscar, additional, Faber, Cornelius, additional, Febo, Marcelo, additional, Feindel, Kirk W, additional, Forloni, Gianluigi, additional, Fouquet, Jérémie, additional, Garza-Villarreal, Eduardo A, additional, Gass, Natalia, additional, Glennon, Jeffrey C, additional, Gozzi, Alessandro, additional, Gröhn, Olli, additional, Harkin, Andrew, additional, Heerschap, Arend, additional, Helluy, Xavier, additional, Herfert, Kristina, additional, Heuser, Arnd, additional, Homberg, Judith R, additional, Houwing, Danielle J, additional, Hyder, Fahmeed, additional, Ielacqua, Giovanna Diletta, additional, Jelescu, Ileana O, additional, Johansen-Berg, Heidi, additional, Kaneko, Gen, additional, Kawashima, Ryuta, additional, Keilholz, Shella D, additional, Keliris, Georgios A, additional, Kelly, Clare, additional, Kerskens, Christian, additional, Khokhar, Jibran Y, additional, Kind, Peter C, additional, Langlois, Jean-Baptiste, additional, Lerch, Jason P, additional, López-Hidalgo, Monica A, additional, Manahan-Vaughan, Denise, additional, Marchand, Fabien, additional, Mars, Rogier B, additional, Marsella, Gerardo, additional, Micotti, Edoardo, additional, Muñoz-Moreno, Emma, additional, Near, Jamie, additional, Niendorf, Thoralf, additional, Otte, Willem M, additional, Pais, Patricia, additional, Pan, Wen-Ju, additional, Prado-Alcalá, Roberto A, additional, Quirarte, Gina L, additional, Rodger, Jennifer, additional, Rosenow, Tim, additional, Baptista, Cassandra Sampaio, additional, Sartorius, Alexander, additional, Sawiak, Stephen J, additional, Scheenen, Tom WJ, additional, Shemesh, Noam, additional, Shih, Yen-Yu Ian, additional, Shmuel, Amir, additional, Soria, Guadalupe, additional, Stoop, Ron, additional, Thompson, Garth J, additional, Till, Sally M, additional, Todd, Nick, additional, Van Der Linden, Annemie, additional, van der Toorn, Annette, additional, van Tilborg, Geralda AF, additional, Vanhove, Christian, additional, Veltien, Andor, additional, Verhoye, Marleen, additional, Wachsmuth, Lydia, additional, Weber-Fahr, Wolfgang, additional, Wenk, Patricia, additional, Yu, Xin, additional, Zerbi, Valerio, additional, Zhang, Nanyin, additional, Zhang, Baogui B, additional, Zimmer, Luc, additional, Devenyi, Gabriel A, additional, Chakravarty, M Mallar, additional, and Hess, Andreas, additional

Published
2022
Full Text
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35. Validation of In Vivo Nodal Assessment of Solid Malignancies with USPIO-Enhanced MRI: A Workflow Protocol

Author

Driessen, Daphne A. J. J., primary, de Gouw, Didi J. J. M., additional, Stijns, Rutger C. H., additional, Litjens, Geke, additional, Israël, Bas, additional, Philips, Bart W. J., additional, Hermans, John J., additional, Dijkema, Tim, additional, Klarenbeek, Bastiaan R., additional, van der Post, Rachel S., additional, Nagtegaal, Iris D., additional, van Engen-van Grunsven, Adriana C. H., additional, Brosens, Lodewijk A. A., additional, Veltien, Andor, additional, Zámecnik, Patrik, additional, and Scheenen, Tom W. J., additional

Published
2022
Full Text
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37. In Vivo PET Imaging of Monocytes Labeled with [89Zr]Zr-PLGA-NH2 Nanoparticles in Tumor and Staphylococcus aureus Infection Models

Author

Krekorian, Massis, primary, Cortenbach, Kimberley R. G., additional, Boswinkel, Milou, additional, Kip, Annemarie, additional, Franssen, Gerben M., additional, Veltien, Andor, additional, Scheenen, Tom W. J., additional, Raavé, René, additional, van Riessen, Nicolaas Koen, additional, Srinivas, Mangala, additional, de Vries, Ingrid Jolanda M., additional, Figdor, Carl G., additional, Aarntzen, Erik H. J. G., additional, and Heskamp, Sandra, additional

Published
2021
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43. Novel Fluorinated Poly (Lactic-Co-Glycolic acid) (PLGA) and Polyethylene Glycol (PEG) Nanoparticles for Monitoring and Imaging in Osteoarthritis

Author

Zerrillo, Luana, primary, Gupta, Karthick Babu Sai Sankar, additional, Lefeber, Fons A.W.M., additional, Da Silva, Candido G., additional, Galli, Federica, additional, Chan, Alan, additional, Veltien, Andor, additional, Dou, Weiqiang, additional, Censi, Roberta, additional, Di Martino, Piera, additional, Srinivas, Mangala, additional, and Cruz, Luis, additional

Published
2021
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44. Validation of in vivo nodal staging of solid malignancies with USPIO-enhanced MRI: a workflow protocol

Author

Driessen, Daphne A.J.J., primary, Gouw, Didi J.J.M. de, additional, Stijns, Rutger C.H., additional, Litjens, Geke, additional, Israël, Bas, additional, Philips, Bart W.J., additional, Hermans, John J., additional, Dijkema, Tim, additional, Klarenbeek, Bastiaan R., additional, Post, Rachel S. van der, additional, Nagtegaal, Iris D., additional, Grunsven, Adriana C.H. van Engen-van, additional, Brosens, Lodewijk A.A., additional, Veltien, Andor, additional, Zámecnik, Patrik, additional, and Scheenen, Tom W.J., additional

Published
2020
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45. Pyruvate‐lactate exchange and glucose uptake in human prostate cancer cell models. A study in xenografts and suspensions by hyperpolarized [1‐13C]pyruvate MRS and [18F]FDG‐PET

Author

Heijster, Frits H.A., primary, Heskamp, Sandra, additional, Breukels, Vincent, additional, Veltien, Andor, additional, Franssen, Gerben M., additional, Jansen, Kees (C).F.J., additional, Boerman, Otto C., additional, Schalken, Jack A., additional, Scheenen, Tom W.J., additional, and Heerschap, Arend, additional

Published
2020
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46. 19F MRI Imaging Strategies to Reduce Isoflurane Artifacts in In Vivo Images.

Author

Staal, Alexander H. J., Veltien, Andor, Srinivas, Mangala, and Scheenen, Tom W. J.

Subjects
*MAGNETIC resonance imaging, *IMAGE analysis, *ISOFLURANE, *SIGNAL-to-noise ratio, *INHALATION anesthetics, *INHALATION anesthesia, *IN vivo studies, *THREE-dimensional imaging, *ANIMAL experimentation, *DESCRIPTIVE statistics, *FLUORINE compounds, *MEDICAL artifacts, *IMAGING phantoms, *MICE
Abstract

Purpose : Isoflurane (ISO) is the most commonly used preclinical inhalation anesthetic. This is a problem in 19F MRI of fluorine contrast agents, as ISO signals cause artifacts that interfere with unambiguous image interpretation and quantification; the two most attractive properties of heteronuclear MRI. We aimed to avoid these artifacts using MRI strategies that can be applied by any pre-clinical researcher. Procedures: Three strategies to avoid ISO chemical shift displacement artifacts (CSDA) in 19F MRI are described and demonstrated with measurements of 19F-containing agents in phantoms and in vivo (n = 3 for all strategies). The success of these strategies is compared to a standard Rapid Acquisition with Relaxation Enhancement (RARE) sequence, with phantom and in vivo validation. ISO artifacts can successfully be avoided by (1) shifting them outside the region of interest using a narrow signal acquisition bandwidth, (2) suppression of ISO by planning a frequency-selective suppression pulse before signal acquisition or by (3) preventing ISO excitation with a 3D sequence with a narrow excitation bandwidth. Results: All three strategies result in complete ISO signal avoidance (p < 0.0001 for all methods). Using a narrow acquisition bandwidth can result in loss of signal to noise ratio and distortion of the image, and a frequency-selective suppression pulse can be incomplete when B1-inhomogeneities are present. Preventing ISO excitation with a narrow excitation pulse in a 3D sequence yields the most robust results (relative SNR 151 ± 28% compared to 2D multislice methods, p = 0.006). Conclusion: We optimized three easily implementable methods to avoid ISO signal artifacts and validated their performance in phantoms and in vivo. We make recommendation on the parameters that pre-clinical studies should report in their method section to make the used approach insightful. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

50. Pyruvate‐lactate exchange and glucose uptake in human prostate cancer cell models. A study in xenografts and suspensions by hyperpolarized [1‐13C]pyruvate MRS and [18F]FDG‐PET.

Author

Heijster, Frits H.A., Heskamp, Sandra, Breukels, Vincent, Veltien, Andor, Franssen, Gerben M., Jansen, Kees (C).F.J., Boerman, Otto C., Schalken, Jack A., Scheenen, Tom W.J., and Heerschap, Arend

Subjects
LACTATES, CANCER cells, POLARIZATION (Nuclear physics), CELL suspensions, GLUCOSE, ENERGY metabolism, PROSTATE cancer
Abstract

Reprogramming of energy metabolism in the development of prostate cancer can be exploited for a better diagnosis and treatment of the disease. The goal of this study was to determine whether differences in glucose and pyruvate metabolism of human prostate cancer cells with dissimilar aggressivenesses can be detected using hyperpolarized [1‐13C]pyruvate MRS and [18F]FDG‐PET imaging, and to evaluate whether these measures correlate. For this purpose, we compared murine xenografts of human prostate cancer LNCaP cells with those of more aggressive PC3 cells. [1‐13C]pyruvate was hyperpolarized by dissolution dynamic nuclear polarization (dDNP) and [1‐13C]pyruvate to lactate conversion was followed by 13C MRS. Subsequently [18F]FDG uptake was investigated by static and dynamic PET measurements. Standard uptake values (SUVs) for [18F]FDG were significantly higher for xenografts of PC3 compared with those of LNCaP. However, we did not observe a difference in the average apparent rate constant kpl of 13C label exchange from pyruvate to lactate between the tumor variants. A significant negative correlation was found between SUVs from [18F]FDG PET measurements and kpl values for the xenografts of both tumor types. The kpl rate constant may be influenced by various factors, and studies with a range of prostate cancer cells in suspension suggest that LDH inhibition by pyruvate may be one of these. Our results indicate that glucose and pyruvate metabolism in the prostate cancer cell models differs from that in other tumor models and that [18F]FDG‐PET can serve as a valuable complementary tool in dDNP studies of aggressive prostate cancer with [1‐13C]pyruvate. [ABSTRACT FROM AUTHOR]

Published
2020
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