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Different techniques developed for the encapsulation of biological drugs within polymeric nanoparticles.

It is critical to investigate the charge carrier gradient generation in semiconductor junctions with an asymmetric configuration, which can open a new platform for developing lateral photovoltaic and self-powered devices. This paper reports the generation of a charge carrier gradient in a 3C-SiC/Si heterojunction with an asymmetric electrode configuration. 3C-SiC/Si heterojunction devices with different electrode widths were illuminated by laser beams (wavelengths of 405, 521, and 637 nm) and a halogen bulb. The charge carrier distribution along the heterojunction was investigated by measuring the lateral photovoltage generated when the laser spot scans across the 3C-SiC surface between the two electrodes. The highest lateral photovoltage generated is 130.58 mV, measured in the device with an electrode width ratio of 5 and under 637 nm wavelength and 1000 μW illumination. Interestingly, the lateral photovoltage was generated even under uniform illumination at zero bias, which is unusual for the lateral photovoltage, as it can only be generated when unevenly distributed photogenerated charge carriers exist. In addition, the working mechanism and uncovered behavior of the lateral photovoltaic effect are explained based on the generation and separation of electron-hole pairs under light illumination and charge carrier diffusion theory. The finding further elaborates the underlying physics of the lateral photovoltaic effect in nano-heterojunctions and explores its potential in developing optoelectronic sensors.

Giant piezoresistive effect enables the development of ultrasensitive sensing devices to address the increasing demands from hi-tech applications such as space exploration and self-driving cars. The discovery of the giant piezoresistive effect by optoelectronic coupling leads to a new strategy for enhancing the sensitivity of mechanical sensors, particularly with light from light-emitting diodes (LEDs). This paper reports on the piezoresistive effect in a 3C-SiC/Si heterostructure with a bonded LED that can reach a gauge factor (GF) as high as 18 000. This value represents an approximately 1000 times improvement compared to the configuration without a bonded LED. This GF is one of the highest GFs reported to date for the piezoresistive effect in semiconductors. The generation of carrier concentration gradient in the top thin 3C-SiC film under illumination from the LED coupling with the tuning current contributes to the modulation of the piezoresistive effect in a 3C-SiC/Si heterojunction. In addition, the feasibility of using different types of LEDs as the tools for modulating the piezoresistive effect is investigated by evaluating lateral photovoltage and photocurrent under LED's illumination. The generated lateral photovoltage and photocurrent are as high as 14 mV and 47.2 μA, respectively. Recent technologies for direct bonding of micro-LEDs on a Si-based device and the discovery reported here may have a significant impact on mechanical sensors.

A highly versatile, low-cost, and robust tactile sensor capable of acquiring load measurements under static and dynamic modes employing a poly(vinylidene fluoride

Recently, wearable electronics for health monitoring have been demonstrated with considerable benefits for early-stage disease detection. This article reports a flexible, bending-insensitive, bio-compatible and lightweight respiration sensor. The sensor consists of highly oriented carbon nanotube (HO-CNT) films embedded between electro-spun polyacrylonitrile (PAN) layers. By aligning carbon nanotubes between the PAN layers, the sensor exhibits a high sensitivity towards airflow (340 mV/(m/s)) and excellent flexibility and robustness. In addition, the HO-CNT sensor is insensitive to mechanical bending, making it suitable for wearable applications. We successfully demonstrated the attachment of the sensor to the human philtrum for real-time monitoring of the respiration quality. These results indicate the potential of HO-CNT flow sensor for ubiquitous personal health care applications.

Utilizing harvesting energy to power sensors has been becoming more critical in the current age of the Internet of Things. In this paper, we propose a novel technology using a monolithic 3C-SiC/Si heterostructure to harvest photon energy to power itself and simultaneously sense the surrounding temperature. The 3C-SiC/Si heterostructure converts photon energy into electrical energy, which is manifested as a lateral photovoltage across the top material layer of the heterostructure. Simultaneously, the lateral photovoltage varies with the surrounding temperature, and this photovoltage variation with temperature is used to monitor the temperature. We characterized the thermoresistive properties of the 3C-SiC/Si heterostructure, evaluated its energy conversion, and investigated its performance as a light-harvesting self-powered temperature sensor. The resistance of the heterostructure gradually drops with increasing temperature with a temperature coefficient of resistance (TCR) ranging from more than -3500 to approximately -8200 ppm/K. The generated lateral photovoltage is as high as 58.8 mV under 12 700 lx light illumination at 25 °C. The sensitivity of the sensor in the self-power mode is as high as 360 μV·K

A valveless microfluidic pump using a lead zirconate titanate (PZT) diaphragm actuated synthetic jet is developed and fabricated. For this present design, a valveless pump structure is developed in which the pump chamber is sealed on one side and connected to an emitting nozzle at another side. The design is simulated using the multiphysics approach and then successfully investigated with a prototype produced by a low-cost additive fabrication technique. The device's parameters, including the liquid pumping characteristics and the size of the PZT membrane, are optimized based on its desired performance. The developed device can be applied over a wide range of applications from micromixing to fluidic controlling.

Calcium phosphate (CaP) coating on melt electrowritten (MEW) substrates is a potential candidate for bone regeneration influencing the interaction of osteoblasts with implanted scaffolds. Pretreatment to improve hydrophilicity of the hydrophobic polymer fibres affects subsequent coating with bioactive compounds like CaP. Therefore, this study evaluated the subsequent stability and structural properties of CaP coated MEW Poly-ε-caprolactone (PCL) scaffolds following pre-treatment with either argon-oxygen plasma or sodium hydroxide (NaOH). Scanning electron microscopy and μ-CT showed uniform CaP coating after one hour immersion in simulated body fluid following plasma pretreatment. Moreover, fourier transform infrared spectroscopy, energy dispersive spectrometry and X-ray diffraction analysis confirmed the presence of hydroxyapatite, tetracalcium phosphate and halite structures on the coated scaffolds. Contact angle measurement showed that the plasma pretreatment and CaP coating improved the hydrophilicity of the scaffold. However, the mechanical properties of the scaffolds were degraded after both plasma and NaOH treatments. The tensile stability was significantly improved following mineralization in plasma-treated scaffolds due to the smaller crystal size formed on the surface resulting in a dense CaP layer. The results obtained by thermogravimetric analysis also confirmed higher deposition of CaP particles on coated scaffolds following plasma modification. The results of this study show that plasma pre-treated mineralized MEW PCL scaffolds are sufficiently stable to be useful for further development in bone regeneration applications. Keywords: Calcium phosphate coating, Polycaprolactone, Melt electrowriting, Apatite mineralization, Plasma treatment, Bone regeneration

In forests and membranes, Carbon nano tubes (CNT) are not individual, instead they tend to be agglomerated into bundles because of the strong van der Waals interaction. CNTs usually form into bundles containing up to hundreds or thousands of parallel CNTs named as fibres which create networks within a CNT membrane. Recently, CNT based macrostructures (yarn and membrane) have increasingly been used in various applications in electronics, medical and bioengineering. Meanwhile the volume density of CNTs impacts on mechanical and physical properties of macrostructures, the controlling of the density of membranes is very complex. Thus, in this paper, an electric processing to dilate CNT membrane is sufficiently studied and investigated by both the experiment and particle based numerical simulation. Several initially potential applications of the method are also represented not only to control the density of CNTs but also to improve the CNTs’ alignment in macro-structures.

The piezoresistive effect has been a dominant mechanical sensing principle that has been widely employed in a range of sensing applications. This transducing concept still receives great attention because of the huge demand for developing small, low-cost, and high-performance sensing devices. Many researchers have extensively explored new methods to enhance the piezoresistive effect and to make sensors more and more sensitive. Many interesting phenomena and mechanisms to enhance the sensitivity have been discovered. Numerous review papers on the piezoresistive effect have been published; however, there is no comprehensive review article that thoroughly analyses methods and approaches to enhance the piezoresistive effect. This paper comprehensively reviews and presents all the advanced enhancement methods ranging from the quantum physical effect and new materials to nanoscopic and macroscopic structures, and from conventional rigid to flexible, stretchable and wearable applications. In addition, the paper summarises results recently achieved on applying the above-mentioned innovative sensing enhancement techniques in making extremely sensitive piezoresistive transducers.

The study presents the design and fabrication process of a novel microfluidic active droplet generator and development of a controller to actuate the integrated micropumps. The proposed active droplet generator consists of a droplet generation geometry and two microfluidic pumps to control the flow rate of the continuous phase fluid and the dispersed phase fluid to generate a microflow towards the droplet generation geometry. The droplet generator is developed based on flow-focusing geometry. Proposed micropumps have a pump chamber and a reservoir. A layer by layer method is adapted in fabricating the active droplet generator in which Polymethyl Methacrylate (PMMA) is used as the material. A heat treating based bonding method is discussed in combining fabricated PMMA layers together. Piezoelectric transducer, which is used as the actuator, is made of Lead Zirconate Titanate (PZT) and integrated into the micropump geometry to produce the microflow. The developed controller is capable of providing a range of shapes, frequencies, and amplitudes for the input signal leading to successful operations of the active droplet generator.

We present a multi-physics simulation associated with experimental investigation for an electrohydrodynamic gyroscope based on ion wind corona discharge. The present device consisting of multiple point-ring electrodes generates a synthetic jet flow of ions for inertial sensing applications. Meanwhile the residual charge of jet is neutralized by an external ring electrode to guarantee the ion wind stable while circulating inside the device's channels. The working principle including the generation and then circulation of jet flow within the present device is firstly demonstrated by a numerical simulation and the feasibility and stability of the device are then successfully investigated by experimental work. Results show owing to the ion wind corona discharge based approach associated with new configuration, the present device is robust and consumes low energy.

The development of a multimodal sensing platform with multiple layers for electronic skin (e-skin) sensing of temperature and pressure has attracted considerable interest to practical applications in soft robotics, human-machine interfaces, and wearable health monitoring. In this work, we demonstrated a new platform technology with multiple sandwiched layers of highly oriented carbon nanotube membrane and polyacrylonitrile for the integration of pressure and temperature sensory functionalities into a single platform that is thin, ultra-lightweight, flexible, and wearable. The key technology of in situ deposition of sensor platform on objects or in robot interface makes this a unique method for the development of e-skins for robotic applications, offering a new approach to wearable electronics and portable health care.

A novel gyroscope using circulatory electro-hydrodynamics flow in a confined space is presented for the first time. The configuration of the new gyroscope includes three point-ring corona discharge actuators that generate ion flows in three separated sub-channels. The three ion flows then merge together when going through a nozzle of the main chamber entrance and create a jet flow. In the new configuration, the residual charge of ion wind flow is removed by a master-ring electrode located at one end of the main chamber. Under the effect of the angular speed of gyroscope, the jet flow is deflected and this deflection is sensed using hotwires. The results, which are consistently acquired by both the numerical simulation and experiment on our prototypes, demonstrate the repeatability and stability of the new approach. Since the ion wind can be generated by a minimum power, the present configuration-based device does not require any vibrating component. Thus, the device is robust, cost, and energy-effective.

Electrohydrodynamic atomization has been emerging as a powerful approach for respiratory treatment, including the generation and delivery of micro/nanoparticles as carriers for drugs and antigens. In this work, we present a new conceptual design in which two nozzles facilitate dual electrospray coexisting with ionic wind at chamfered tips by a direct current power source. Experimental results by a prototype have demonstrated the capability of simultaneously generating-and-delivering a stream of charged reduced particles. The concept can be beneficial to pulmonary nano-medicine delivery since the mist of nanoparticles is migrated without any restriction of either the collector or the assistance of external flow, but is pretty simple in designing and manufacturing devices.

A new conceptual design of electrospray has been developed to generate neutralized micro-droplet using on-chip electro-hydrodynamic. A prototype of a bipolar electrostatic atomization with chambered nozzle tips has been carried out to demonstrate the capability of spaying viable, safe, neutral and alternative droplets which can be applied in micro/nano-encapsulation, bio-scaffold production and also the polymeric micro/nanoparticle fabrication over conventional fabrication techniques as well as the direct current electro-spraying/electrospinning. Several initially experimental results as presented through this work have shown the potential application of the present device in drug delivery.