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A 62–year–old woman, with a history of systemic hypertension, smoking habit and paroxysmal atrial fibrillation treated with Flecainide, was admitted to the ER of our Hospital for chest pain. She reported that the symptoms appeared after an emotional stress at work. Troponin I was of 895 pg/mL. The electrocardiogram showed: negative T waves in the inferior leads and an early repolarization pattern/ ST elevated in the antero–lateral leads. The patient underwent transthoracic echocardiography which showed: EF 45%, akinesia of the posterior and inferior segments of the septum. Invasive coronary angiography showed absence of lesions. CMR presented: EF 51% and mild hypokinesia of the mid septum and inferior segment; signs of oedema affecting the left ventricular myocardium in the apex, the mid inferior segment and in the lower apical wall, with subendocardial hypoperfusion layer in the mid inferior septum (microvascular dysfunction?). The patient was dismissed with the diagnosis of M.I.N.O.C.A. A month later, she was admitted again to our ER suffering from a new episode of acute chest pain; she also reported a short episode of atrial fibrillation (documented by an EKG) lasting about 10 minutes occurred the day before. The EKG showed: negative T waves in anterolateral leads. TnI was of 2052,5 pg/ml. The patient underwent a transthoracic echocardiogram which demonstrated: reduced global systolic function (EF 35%), akinesia of the apex, mid–anterior septum and mid– anterior wall. The day after the echo was repeated and it demonstrated a gaining of Vsx EF which was of approximately of 50%. Invasive coronary angiography showed absence of lesions. A methylergometrine test was negative for vasospasm on anterior descending artery. The CMR showed: EF 58%, signs of oedema in the basal and mid anterior wall, mid–anterior septum. LGE intra wall of the apical septum and of the basal part of the anterior wall (coronary spasm? Vasculitis?) Absence of edema. The final diagnosis was of Tako Tsubo. Discussion and conclusions This case offers the inspiration to reflect on differential diagnosis of chest pain with undamaged coronary arteries. In addition to this, it should be considered coronary emboli arisen through various mechanisms including left atrial appendage thrombi due to atrial fibrillation, so that also anticoagulation therapy is suggested as discharge treatment.

A 62–year–old man repeatedly subjected to PTCA + stent with severe left ventricular dysfunction and estimated FE 15%. After some hospitalizations for heart failure in 2015 he underwent an AICD implant Biventricular. Followed up in our clinics dedicated to heart failure, the patient did not present the characters of the CRT responder presenting a constant high end–systolic volume (224 ml) and none FE improvement of 15%. There was also an asthenia and tendency to inactivity and elevated NT Pro BNP levels despite optimal medical therapy even with entresto 24/26 mg x 2 / day. It has been decided to submit the patient enrolled in the cardiac transplant and / or VAD implantation lists to an implantation procedure of CCM system (cardiac contractility modulation). After two active fixation placement leads on the interventricular septum and connection to the CCM system housed in the subcutaneous pocket right contralateral to the biventricular AICD, the patient was monitored. We have noticed since the first days conditions of hemodynamic stability. Scheduled CCM therapy delivery for 10 hours a day. Following subsequently in the follow up at 3 – 6 – 12 – 18 months the patient showed an improvement of minneshota quality of life questionnaire in heart failure: MLWHFQ (44 at baseline, 17 at two months, 15 to six months, 10 to 12 months and 3 to 18 months), an increase in FE from 15 to 23 up to 26%, a reduction of the NTPROBNP from 13444 to 1178 then climbed back to 5549 and 3712 at 18 months for atrial fibrillation, without any requires re–hospitalization, an increased physical activity of the patient detected by the sensors of the two devices

A 72–year–old woman with hypertension for thirty years, resuscitated from cardiac arrest during prosthetic surgery of the right knee in January 2020, with external heart massage and orotracheal intubation. On examination Holter performed in February 2021, presence of couples and R / T phenomenon with Lown 1B–3–4A–5 class. The patient is subjected to coronary angiography which showed only mild atheroma without stenosis hemodynamically significant of the arterial districts explored. On the Echocardiogram, FE estimated at 60%. Based on the anamnestic data and the feedback from the fifth class of Lown at the Holter, it was decided to implant a dual chamber defibrillator for secondary prevention. The vulnerable point of refractory ventricular notoriously falls below 300 msec and in the clinical case in question there is a comparison to the holter of fifth class of lown with phenomenon R on T and coupling interval of 276 msec. The precocity of the ventricular ectopias is already in itself a risk factor for MI, reinforced in the case of clincio in question from a history of resuscitated cardiac arrest in a hospital setting. Not indicated to ours opinion of the electrophysiological inducibility study, given the positive clinical history and dynamic ECG according to Holter who examines the arrhythmic phenomenon in its spontaneous and natural way of presenting itself in circadian rhythm. The reproducibility in the laboratory with the SEI, of the electrical vulnerability was in fact in the recent years downsized, due to high specificity but low sensitivity, as there is in the clinical reality of patient neurovegetative and biohumoral fluxuonary factors, which favor the induction of malignant arrhythmias and that escape the predictive laboratory analysis. Making the patient safe with the implant of the bicameral AICD resulted from a clinical – diagnostic – instrumental analysis and after extensive discussion by the heart team in our Operating Unit.

Despite it is generally recognized the beneficial role of physical activity, large portion of the population is physically inactive. Very alarmingly, the well-known gender gap in physical activity is constantly increasing. Several barriers obstacle women to perform physical activity although exercising would be of paramount importance for their health in particular during pregnancy and menopause. In addition to physical health benefits, physical activity may influence well-being and resilience, greatly impacting on quality of life. Here we explore the relationship between physical activity resilience and well-being in a group of 1107 female residents in the Metropolitan area of Naples.

The merger rate of primordial black holes depends on their initial clustering. In the absence of primordial non-Gaussianity correlating short and large-scales, primordial black holes are distributed \`a la Poisson at the time of their formation. However, primordial non-Gaussianity of the local-type may correlate primordial black holes on large-scales. We show that future experiments looking for CMB $\mu$-distortion would test the hypothesis of initial primordial black hole clustering induced by local non-Gaussianity, while existing limits already show that significant non-Gaussianity is necessary to induce primordial black hole clustering., Comment: 6 pages, 2 figures. v2: matching published version

We show that black holes with a Schwarzschild radius of the order of the electroweak scale may act as seeds for the baryon number violation within the Standard model via sphaleron transitions. The corresponding rate is faster than the one in the pure vacuum and baryon number violation around black holes can take place during the evolution of the universe after the electroweak phase transition. We show however that this does not pose any threat for a pre-existing baryon asymmetry in the universe., Comment: 6 pages, 2 figures. v2: matching published version

We perform a hierarchical Bayesian analysis of the GWTC-2 catalog to investigate the mixed scenario in which the merger events are explained by black holes of both astrophysical and primordial origin. For the astrophysical scenario we adopt the phenomenological model used by the LIGO/Virgo collaboration and we include the correlation between different parameters inferred from data, the role of the spins in both the primordial and astrophysical scenarios, and the impact of accretion in the primordial scenario. Our best-fit mixed model has a strong statistical evidence relative to the single-population astrophysical model, thus supporting the coexistence of populations of black-hole mergers of two different origins. In particular, our results indicate that the astrophysical mergers account for roughly four times the number of primordial black hole events and predict that third-generation detectors, such as the Einstein Telescope and Cosmic Explorer, should detect up to hundreds of mergers from primordial black hole binaries at redshift $z\gtrsim30$., Comment: 20 pages, 8 figures. v2: matching published version

Mainly motivated by the recent GW190521 mass gap event which we take as a benchmark point, we critically assess if binaries made of a primordial black hole and a black hole of astrophysical origin may form, merge in stellar clusters and reproduce the LIGO/Virgo detection rate. While two previously studied mechanisms -- the direct capture and the three body induced -- seem to be inefficient, we propose a new "catalysis" channel based on the idea that a subsequent chain of single-binary and binary-binary exchanges may lead to the formation of a high mass binary pairs and show that it may explain the recent GW190521 event if the local overdensity of primordial black holes in the globular cluster is larger than a few., 24 pages, 4 figures. v2: matching published version

The NANOGrav Collaboration has recently published strong evidence for a stochastic common-spectrum process that may be interpreted as a stochastic gravitational wave background. We show that such a signal can be explained by second-order gravitational waves produced during the formation of primordial black holes from the collapse of sizeable scalar perturbations generated during inflation. This possibility has two predictions: (i) the primordial black holes may comprise the totality of the dark matter with the dominant contribution to their mass function falling in the range (10^{-15}÷10^{-11})M_{⊙} and (ii) the gravitational wave stochastic background will be seen as well by the Laser Interferometer Space Antenna experiment.

[EN] Araujia sericifera Brot. is a weed that was introduced in Europe from South America as an ornamental species. It has had a successfully adaptation to citrus orchards management in the Mediterranean area, especially on poorly weed managed or abandoned ones. The objective of this study was to determine the efficacy of the authorized herbicides in Spain for citrus against A. sericifera and a Natural product under development. The study was conducted in a controlled environmental chamber where the weed was cultivated in pots. The whole study consisted in 2 experiments applying 11 pre-emergent herbicides and mixtures and 3 experiments applying 14 post-emergent herbicides and mixtures in two different phenological stages. In conclusion, post-emergent control was better than pre-emergent treatments, especially with contact herbicides (pelargonic acid, diquat, Natural and pyraflufen ethyl). However, the penoxsulam + florasulam combination applied to the soil was very effective. The Natural herbicide was just effective when it was applied on post-emergence of the weed., [ES] La mala hierba Araujia sericifera Brot. fue introducida en Europa como especie ornamental procedente de Sudamérica. Se ha adaptado al manejo de los huertos de cítricos del área Mediterránea, sobre todo a los que descuidan el control de las malas hierbas y a los abandonados. El objetivo de este estudio fue comprobar la eficacia de los herbicidas autorizados en España en citricultura y de un producto natural en desarrollo frente a esta mala hierba. El trabajo se llevó a cabo en una cámara de crecimiento controlado donde se cultivó la mala hierba en macetas. Se realizaron 2 ensayos en preemergencia de la mala hierba aplicando 11 materias activas y mezclas y otros 3 ensayos en postemergencia, aplicando 14 materias activas y mezclas en dos estados fenológicos diferentes. Se concluyó que la mezcla de penoxsulam + florasulam aplicada al suelo en preemergencia de la mala hierba resultó muy efectiva, sin embargo, el control en postemergencia fue más efectivo que en preemergencia, sobre todo con los herbicidas de contacto (ácido pelargónico, diquat, Natural y piraflufen etil). El herbicida Natural se mostró efectivo solo en postemergencia.

The black holes detected by current and future interferometers can have diverse origins. Their expected mass and spin distributions depend on the specifics of the formation mechanisms. When a physically motivated prior distribution is used in a Bayesian inference, the parameters estimated from the gravitational-wave data can change significantly, potentially affecting the physical interpretation of certain gravitational-wave events and their implications on theoretical models. As a case study we analyze primordial black holes, which might be formed in the early universe and could comprise at least a fraction of the dark matter. If accretion is not efficient during their cosmic history, primordial black holes are expected to be almost non-spinning. If accretion is efficient, massive binaries tend to be symmetrical and highly spinning. We show that incorporating these priors can significantly change the inferred mass ratio and effective spin of some binary black hole events, especially those identified as high-mass, asymmetrical, or spinning by a standard analysis using agnostic priors. For several events, the Bayes factors are only mildly affected by the new priors, implying that it is hard to distinguish whether merger events detected so far are of primordial or astrophysical origin. In particular, if binaries identified by LIGO/Virgo as strongly asymmetrical (including GW190412) are of primordial origin, their mass ratio inferred from the data can be closer to unity. For GW190412, the latter property is strongly affected by the inclusion of higher harmonics in the waveform model., 30 pages, 10 figures; v3: This version updates the previous analysis by including the effects of higher harmonics in the waveform model for GW190412. Version accepted in JCAP"

5-Aminolevulinate (ALA) patches with red light (630-nm light source and a total light dose of 37 J/cm2 ) is an effective treatment indicated by food and drug administration (FDA) and european medicines agency (EMA) only for grade I to II actinic keratosis located on the scalp and face. Currently, there are no efficacy data on their use in the treatment of other types of epithelial neoplasms. We analyzed the efficacy of ALA patches in seven superficial basal cell carcinomas (sBCCs) that occurred in four patients. All lesions were treated with topical ALA patches. A complete response of all sBCCs was achieved at week 24 after treatment. Our study suggests that ALA patches for sBCCs have good efficacy rates and excellent safety profile.

We elaborate on the mass function of primordial black holes in the case in which the power spectrum of the curvature perturbation is broad. For the case of a broad and flat spectrum, we argue that such a mass function is peaked at the smallest primordial black mass which can be formed and possesses a tail decaying like $M^{-3/2}$, where $M$ is the mass of the primordial black hole., 14 pages, 3 figures

The LIGO and Virgo Interferometers have so far provided 11 gravitational-wave (GW) observations of black-hole binaries. Similar detections are bound to become very frequent in the near future. With the current and upcoming wealth of data, it is possible to confront specific formation models with observations. We investigate here whether current data are compatible with the hypothesis that LIGO/Virgo black holes are of primordial origin. We compute in detail the mass and spin distributions of primordial black holes (PBHs), their merger rates, the stochastic background of unresolved coalescences, and confront them with current data from the first two observational runs, also including the recently discovered GW190412. We compute the best-fit values for the parameters of the PBH mass distribution at formation that are compatible with current GW data. In all cases, the maximum fraction of PBHs in dark matter is constrained by these observations to be $f_{\text{PBH}}\approx {\rm few}\times 10^{-3}$. We discuss the predictions of the PBH scenario that can be directly tested as new data become available. In the most likely formation scenarios where PBHs are born with negligible spin, the fact that at least one of the components of GW190412 is moderately spinning is incompatible with a primordial origin for this event, unless accretion or hierarchical mergers are significant. In the absence of accretion, current non-GW constraints already exclude that LIGO/Virgo events are all of primordial origin, whereas in the presence of accretion the GW bounds on the PBH abundance are the most stringent ones in the relevant mass range. A strong phase of accretion during the cosmic history would favour mass ratios close to unity, and a redshift-dependent correlation between high masses, high spins and nearly-equal mass binaries, with the secondary component spinning faster than the primary., 38 pages, 17 figures. v2: references added; corrected typo in the value of $\sigma_M$ reported in Ref. [73] mildly affecting the suppression factor. Figs. 10 and 13 updated. Results and conclusions unchanged

Lentigo maligna (LM) is an in situ subtype of melanoma, clinically presenting as a pigmented, asymmetric macule that originates mostly on the head and neck and spreads slowly. The diagnosis may be challenging both for clinicians and pathologists. Dermatoscopy and reflectance confocal microscopy represent a useful tool in the differentiation of LM from other pigmented lesions, such as pigmented actinic keratosis, solar lentigines, seborrheic keratosis and lichen planus-like keratosis. Moreover, those non-invasive diagnostic technique may be crucial in the selection of optimal biopsy sites in equivocal lesions, in pre-surgical mapping and in evaluating and monitoring response to non-surgical treatments. Histologic examination remains the gold standard for the diagnosis of LM, showing a lentiginous proliferation of basal atypical melanocytes on a severe sun-damaged skin. The management of LM is constantly evolving. Treatments include surgery (the first choice, when available), radiotherapy and imiquimod cream (in patients not candidates to surgery). Many other possible treatments for LM have been tested, but they are not yet supported by strong evidences. We collected current guidelines and PubMed available reviews, studies and case-reports in order to make an overview on diagnosis and treatment of LM.

We consider the constraints on the fraction of dark matter in the universe in the form of primordial black holes taking into account the crucial role of accretion which may change both their mass and mass function. We show that accretion may drastically weaken the constraints at the present epoch for primordial black holes with masses larger than a few solar masses., 6 pages, 4 figures. v2 : matching published version

Chronic obstructive pulmonary (COPD) disease is a progressive illness that will intensify over time. Exacerbation are frequent and likely caused by bacterial and viral respiratory infections. The management of COPD includes home assistance by noninvasive ventilation (NIV), but no remote monitoring system is generally applied. In this work a telemedicine device based on Smart Breath Analyzer (SBA) devoted to the remote-monitoring of parameters in the exhaled air of COPD patients during NIV was developed. System architecture and preliminary pre-clinical test results were here presented.

Background Photodynamic therapy (PDT) is recommended for both lesion and field therapy of actinic keratoses (AKs). The 5-aminolaevulinic acid (5-ALA) patch PDT is indicated for the treatment of isolated mild AKs (≤1.8 cm) on the face and bald scalp. It was demonstrated to be effective and safe in clinical trials with a good tolerability profile. Methods In this retrospective multicenter real-life study, 33 patients with a total of 99 AKs of the scalp, face, ears, and/or hands and 2 actinic cheilitis were treated with one treatment session of 5-ALA patch PDT with a red light source (total dose of 37 J/cm2). Results Overall, 12 weeks after treatment, 68/99 (69%) lesions were completely cleared. Complete response was obtained in 82% of AKs on the ears, 78% on the face, 57% on the hands, and 56% on the scalp and in the two actinic cheilitis. The treatment was very effective on grade I AKs, cleared in 87% of the cases and less efficient on grade II-III lesions, cleared in 47% of the cases. 5-ALA patch PDT was well tolerated with a good to excellent cosmetic outcome in 97% of the patients and with 94% of the patients being satisfied or very satisfied with the treatment. Conclusions Our results confirm that 5-ALA patch PDT is a good option for AK treatment in clinical practice, it is easy to use, effective and well tolerated even in difficult-to-treat-areas. Moreover, it has an excellent cosmetic outcome.

An observable stochastic background of gravitational waves is generated whenever primordial black holes are created in the early universe thanks to a small-scale enhancement of the curvature perturbation. We calculate the anisotropies and non-Gaussianity of such stochastic gravitational waves background which receive two contributions, the first at formation time and the second due to propagation effects. The former contribution can be generated if the distribution of the curvature perturbation is characterized by a local and scale-invariant shape of non-Gaussianity. Under such an assumption, we conclude that a sizeable magnitude of anisotropy and non-Gaussianity in the gravitational waves would suggest that primordial black holes may not comply the totality of the dark matter., 20 pages, 5 figures, version accepted by JCAP

This work presents a representation of the heat and mass processes dependent on wavelength spectrum which acts in a radiative cavity filled with a fluid mixture and interfaced with a porous medium. The formulation mainly aims to account for the wavelength dependent response of the transparent solid material and all involving constituents in order to improve the simulation of their radiation interaction. The model is based on a set of governing equations of mass, momentums and energy balance approximated by a finite-difference scheme and some empirical relations. The model is validated against data measured in a field experimentation of a greenhouse. The reasonable agreement between numerical and experimental results, in term of temperature and water mass content of fluid and porous medium, demonstrate the effectiveness of the proposed numerical model.

Pityriasis rubra pilaris (PRP) is a rare chronic inflammatory papulosquamous skin disease. Its clinical presentation and evolution is very variable. The most frequent clinical features are follicular papules, progressing to yellow-orange erythroderma with round small areas of normal skin and the well-demarcated palmoplantar keratoderma. Actually, six different types of PRP have been described based on clinical characteristics, age of onset, and prognosis. The pathogenesis is still unknown, and treatment can be challenging. Available treatments are mainly based on case reports or case series of clinical experience because no controlled randomized trials have never been performed because of the rarity of the condition. Traditional systemic treatment consists in retinoids, which are actually considered as first-line therapy, but refractory cases that do not respond or relapse after drug interruption do exist. In recent years, numerous reports have demonstrated the efficacy of new agents such as biological drugs. This article is an overview on available therapeutic options, in particular for refractory forms of PRP.

Cette contribution historiographique se concentre sur les apports de l’économie politique de la fécondité pour éclairer les motivations et les mécanismes des transitions de la fécondité. Elle se focalise sur les travaux entrepris en Europe et aux États Unis couvrant la période 1850 1980 en s’intéressant plus particulièrement aux études qualitatives. Dans une première partie nous retraçons la genèse de cette approche. Comprendre ses liens de filiation permet de saisir non seulement le chemin parcouru à travers les paradigmes dont elle s’est nourrie et continue de se nourrir mais aussi de percevoir ce dont elle doit se libérer pour proposer des analyses toujours renouvelées. Dans une deuxième partie nous appuyant sur des travaux qui ont éclairé les contextes dans lesquels se situent les prises de décisions des hommes et des femmes nous montrons qu’ils permettent de cerner les ressorts des motivations individuelles à maitriser les naissances et leur calendrier. En conclusion nous invitons à prolonger cette approche et suggérons quelques pistes de recherches.

The idea that primordial black holes (PBHs) can comprise most of the dark matter of the Universe has recently reacquired a lot of momentum. Observational constraints, however, rule out this possibility for most of the PBH masses, with a notable exception around ${10}^{\ensuremath{-}12}\text{ }\text{ }{M}_{\ensuremath{\bigodot}}$. These light PBHs may be originated when a sizable comoving curvature perturbation generated during inflation reenters the horizon during the radiation phase. During such a stage, it is unavoidable that gravitational waves (GWs) are generated. Since their source is quadratic in the curvature perturbations, these GWs are generated fully non-Gaussian. Their frequency today is about a millihertz, which is exactly the range where the LISA mission has the maximum of its sensitivity. This is certainly an impressive coincidence. We show that this scenario of PBHs as dark matter can be tested by LISA by measuring the GW two-point correlator. On the other hand, we show that the short observation time (as compared to the age of the Universe) and propagation effects of the GWs across the perturbed Universe from the production point to the LISA detector suppress the bispectrum to an unobservable level. This suppression is completely general and not specific to our model.

Background The lifetime risk of suicide in patients with substance use disorder is five to ten times the risk in the general population. Critically, up to 19% of patients continue to think about and attempt suicide even after accessing treatment. Therefore, suicidality represents a significant clinical concern in patients struggling with substance use that warrants careful investigation of the factors involved. While most previous research has relied on limited cross-sectional designs, a growing number of prospective studies are improving our understanding of the factors involved. However, a systematic study of these factors has not yet been conducted. Methods The primary objective of this review and possible meta-analysis will be to identify key risk and protective factors for suicide ideation, attempt, and death in patients accessing substance use treatment, guided by current models of suicide. Secondary and tertiary objectives will be to obtain pooled effect sizes for the factors identified and to disaggregate factors for suicidality before and after treatment, and for suicidal thought versus action. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we will conduct an electronic search of the literature using the databases Embase, Medline, PsycINFO, and Web of Science. Two authors will independently screen studies based on pre-specified inclusion and exclusion criteria, extract relevant data, and assess study quality. Observational and randomized-controlled studies will be included, whereas case-studies and reviews will be excluded. We will extract data on risk and protective factors associated with suicide ideation, attempt (odds or risk ratios), and death (hazard ratio). Given sufficient data (> 5 studies), we will calculate pooled effects using comprehensive meta-analysis. Discussion This systematic review will contribute to our knowledge of risk and protective factors for suicidality in patients before and after treatment. Understanding these factors will help define areas of research for further investigation to ultimately inform risk assessment and prevention strategies. Systematic review registration PROSPERO (reference number: CRD42018076260). Electronic supplementary material The online version of this article (10.1186/s13643-019-1028-2) contains supplementary material, which is available to authorized users.