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Your search keyword '"Turner, S.W. (Steve)"' showing total 2 results
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2 results on '"Turner, S.W. (Steve)"'

1. Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

Author

King, C. (Charlotte), McKenna, A. (Amanda), Farzan, N. (Niloufar), Vijverberg, S.J.H. (Susanne), Schee, M.P. (Marc P.) van der, Maitland-van der Zee, A-H. (Anke-Hilse), Arianto, L. (Lambang), Bisgaard, H. (Hans), BØnnelykke, K. (Klaus), Berce, V. (Vojko), Potočnik, U. (Uroš), Repnik, K. (Katja), Carleton, B.C. (Bruce), Daley, D. (Denise), Chew, F.T. (Fook Tim), Chiang, W.C. (Wen Chin), Sio, Y.Y. (Yang Yie), Cloutier, M.M. (Michelle M.), Dekker, H.T. (Herman) den, Duijts, L. (Liesbeth), Jongste, J.C. (Johan) de, Dijk, F.N. (F. Nicole), Koppelman, G.H. (Gerard), Flores, C. (Carlos), Hernandez-Pacheco, N. (Natalia), Pino-Yanes, M. (Maria), Mukhopadhyay, S. (Somnath), Basu, K. (Kaninika), Bignell, L. (Lauren), Tantisira, K.G. (Kelan G.), Turner, S.W. (Steve), Verhamme, K.M.C. (Katia), Francis, B. (Ben), Pirmohamed, M. (Munir), Sinha, I. (Ian), Hawcutt, D.B. (Daniel B.), King, C. (Charlotte), McKenna, A. (Amanda), Farzan, N. (Niloufar), Vijverberg, S.J.H. (Susanne), Schee, M.P. (Marc P.) van der, Maitland-van der Zee, A-H. (Anke-Hilse), Arianto, L. (Lambang), Bisgaard, H. (Hans), BØnnelykke, K. (Klaus), Berce, V. (Vojko), Potočnik, U. (Uroš), Repnik, K. (Katja), Carleton, B.C. (Bruce), Daley, D. (Denise), Chew, F.T. (Fook Tim), Chiang, W.C. (Wen Chin), Sio, Y.Y. (Yang Yie), Cloutier, M.M. (Michelle M.), Dekker, H.T. (Herman) den, Duijts, L. (Liesbeth), Jongste, J.C. (Johan) de, Dijk, F.N. (F. Nicole), Koppelman, G.H. (Gerard), Flores, C. (Carlos), Hernandez-Pacheco, N. (Natalia), Pino-Yanes, M. (Maria), Mukhopadhyay, S. (Somnath), Basu, K. (Kaninika), Bignell, L. (Lauren), Tantisira, K.G. (Kelan G.), Turner, S.W. (Steve), Verhamme, K.M.C. (Katia), Francis, B. (Ben), Pirmohamed, M. (Munir), Sinha, I. (Ian), and Hawcutt, D.B. (Daniel B.)

Abstract

A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhood Asthma (PiCA) consortia members was conducted. Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary or secondary outcome. Five studies met the inclusion criteria. The ADRs and polymorphisms identified were change in lung function tests (rs1042713), adrenal suppression (rs591118), and decreased bone mineral density (rs6461639) and accretion (rs9896933, rs2074439). Two of these polymorphisms were replicated within the paper, but none had external replication. Priorities from PiCA consortia members (representing 15 institution in eight countries) for future studies were tachycardia (SABA/LABA), adrenal suppression/crisis and growth suppression (corticosteroids), sleep/behaviour disturbances (leukotriene receptor antagonists), and nausea and vomiting (theophylline). Future pharmacogenomic studies in asthma should collect relevant ADR data as well as markers of efficacy.

Published
2020
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2. 17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use

Author

Farzan, Niloufar, Vijverberg, S.J.H. (Susanne), Hernandez-Pacheco, N., Bel, E.H., Berce, Vojko, Bønnelykke, K., Bisgaard, H. (Hans), Burchard, E.G. (Esteban), Canino, G., Celedón, Juan Carlos, Chew, Fook Tim, Chiang, W.C., Cloutier, M.M., Forno, Erick, Francis, Ben, Hawcutt, Daniel B., Herrera-Luis, E., Kabesch, M. (Michael), Karimi, L. (Leila), Melén, E., Mukhopadhyay, S., Merid, S.K. (Simon Kebede), Palmer, C.N.A. (Colin), Pino-Yanes, Maria, Pirmohamed, M. (Munir), Potočnik, Uros, Repnik, Katja, Schieck, Maximilian, Sevelsted, A. (Astrid), Sio, Y.Y., Smyth, Rosalind L., Soares, Patricia, Söderhäll, C. (Cilla), Tantisira, K.G., Tavendale, R. (Roger), Tse, Sze Man, Turner, S.W. (Steve), Verhamme, K.M.C. (Katia), Maitland-van der Zee, A-H. (Anke-Hilse), Farzan, Niloufar, Vijverberg, S.J.H. (Susanne), Hernandez-Pacheco, N., Bel, E.H., Berce, Vojko, Bønnelykke, K., Bisgaard, H. (Hans), Burchard, E.G. (Esteban), Canino, G., Celedón, Juan Carlos, Chew, Fook Tim, Chiang, W.C., Cloutier, M.M., Forno, Erick, Francis, Ben, Hawcutt, Daniel B., Herrera-Luis, E., Kabesch, M. (Michael), Karimi, L. (Leila), Melén, E., Mukhopadhyay, S., Merid, S.K. (Simon Kebede), Palmer, C.N.A. (Colin), Pino-Yanes, Maria, Pirmohamed, M. (Munir), Potočnik, Uros, Repnik, Katja, Schieck, Maximilian, Sevelsted, A. (Astrid), Sio, Y.Y., Smyth, Rosalind L., Soares, Patricia, Söderhäll, C. (Cilla), Tantisira, K.G., Tavendale, R. (Roger), Tse, Sze Man, Turner, S.W. (Steve), Verhamme, K.M.C. (Katia), and Maitland-van der Zee, A-H. (Anke-Hilse)

Abstract

_To the Editor,_ Approximately 25% of the asthmatic children suffer from uncontrolled asthma despite regular use of inhaled corticosteroids (ICS). Variation within the 17q21 locus is the strongest genetic determinant for childhood‐onset asthma. Recently, the influence of this locus on treatment outcomes has been shown in several studies. The Pharmacogenomics in Childhood Asthma (PiCA) consortium is a multiethnic consortium that brings together data from ≥14 000 asthmatic children/young adults from 12 different countries to study the pharmacogenomics of uncontrolled asthma despite treatment. In 14 PiCA populations (with over 4000 asthmatic patients), we studied the association between variation in the 17q21 locus, and asthma exacerbations despite ICS use. We specifically focused on rs7216389, a single nucleotide polymorphism (SNP) in the 17q21 locus strongly associated with childhood asthma and initially identified by Moffatt et al. [...]

Published
2018
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