1. Preoperative NLR and PLR are predictive of clinically relevant postoperative pancreatic fistula
- Author
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Antoine El Asmar, Elie Ghabi, Bernard Akl, Christina Abou Malhab, Toufic Saber, Sarah Eid, Elissa Mahfouz, Hind Rahban, and Ziad El Rassi
- Subjects
Pancreatoduodenectomy ,Pancreatic neoplasms ,Pancreatic fistulas ,Chemical biomarkers ,Surgery ,RD1-811 - Abstract
Background: Clinically relevant postoperative pancreatic fistula (CR-POPF) is a dreaded complication following pancreatic surgery. Several scores attempt to predict CR-POPF occurrence to better manage outcomes in patients undergoing pancreaticoduodenectomy (PD). In our study, we investigate the prognostic role of several demographic and clinico-pathological variables. We focus on clinical biomarkers, the Neutrophil-to-Lymphocytes Ratio (NLR) and Platelet-to-Lymphocyte ratio (PLR), which can be easily used in predicting CR-POPF occurrence. Methods: Patients who underwent a PD with curative intent at our institution, between 2008 and 2018 were reviewed. Statistical analysis was conducted to determine the association between various demographic and clinico-pathological variables, with the occurrence of clinically significant POPF. Results: 117 patients underwent a PD at our institution. Statistically significant associations on multivariate analysis were observed for the absence of preoperative diabetes mellitus, a pathological stage ≥III, an elevated NLR (> 4) and an elevated PLR (> 158). Conclusion: The NLR and PLR are predictive of CR-POPF occurrence following PD. These readily available biomarkers can add value to risk stratification tools to assess CR-POPF occurrence and individualize patient care plans.
- Published
- 2022
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