1. Perinatal and 2-year neurodevelopmental outcome in late preterm fetal compromise: the TRUFFLE 2 randomised trial protocol
- Author
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Neil Marlow, Luigi Raio, Roland Devlieger, Aris Papageorghiou, Rebecca Cannings-John, Christoph C Lees, Andrew Breeze, Andrew Sharp, Wessel Ganzevoort, Jim G Thornton, Julia Townson, Tanja Groten, Irene Cetin, Peter Lindgren, Federico Prefumo, Edward Mullins, Astrid Berger, Sofia Amylidi-Mohr, Cathrine Ebbing, Ladislav Krofta, Bianca Masturzo, Amarnath Bhide, Hans Wolf, Tiziana Frusca, Kurt Hecher, Tullio Ghi, Silvia Salvi, Wilfried Gyselaers, Raffaele Napolitano, MARK KILBY, Erich Cosmi, Claire Potter, Enrico Ferrazzi, Basky Thilaganathan, Dietmar Schlembach, Christine Morfeld, Bronacha Mylrea-Foley, Christina Ammari, Birgit Arabin, Eva Bergman, Caterina Bilardo, Julia Binder, Jana Brodszki, Pavel Calda, Andrej Černý, Elena Cesari, Andrea Dall'Asta, Anke Diemert, Torbjørn Eggebø, Ilaria Fantasia, Jenny Goodier, Patrick Greimel, Wassim Hassan, Constantin Von Kaisenberg, Alexey Kholin, Philipp Klaritsch, Silvia Lobmaier, Karel Marsal, Giuseppe M Maruotti, Federico Mecacci, Kirsti Myklestad, Eva Ostermayer, Jute Richter, Ragnar Kvie Sande, Ekkehard Schleußner, Tamara Stampalija, Herbert Valensise, Gerard HA Visser, Ling Wee, Andy Simm, Angela Ramoni, Barry Lloyd, Christopher Lloyd, Claudia Seidig, Danielle Thornton, Elena Mantovani, Emanuela Taricco, Emma Bertucci, Ferenc Macsali, Francesca Ferrari, Francesco D'Antonio, Giuseppe Cali, Giuseppe Rizzo, Ilaria Giuditta Ramezzana, Ioannis Kyvernitakis, Karen Melchiorre, Kristiina Rull, Laura Sarno, Liina Rajasalu, Louisa Jones, Makrina Savvidou, Maria Stefopoulou, Nicola Fratelli, Nishigandh Deole, Petra Pateisky, Pilar Palmrich, Ralf Schild, Sabina Ondrová, Sarah Gumpert, Serena Simeone, Silvia Visentin, Stefan Verlohren, Tatjana Radaelli, Tinne Mesens, Tiziana Fanelli, Yvonne Heiman, Zulfiya Khodzhaeva, Christoph Brezinka, Sanne Gordijn, Abin Thomas, and Ligita Jokubkiene
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Medicine - Abstract
Introduction Following the detection of fetal growth restriction, there is no consensus about the criteria that should trigger delivery in the late preterm period. The consequences of inappropriate early or late delivery are potentially important yet practice varies widely around the world, with abnormal findings from fetal heart rate monitoring invariably leading to delivery. Indices derived from fetal cerebral Doppler examination may guide such decisions although there are few studies in this area. We propose a randomised, controlled trial to establish the optimum method of timing delivery between 32 weeks and 36 weeks 6 days of gestation. We hypothesise that delivery on evidence of cerebral blood flow redistribution reduces a composite of perinatal poor outcome, death and short-term hypoxia-related morbidity, with no worsening of neurodevelopmental outcome at 2 years.Methods and analysis Women with non-anomalous singleton pregnancies 32+0 to 36+6 weeks of gestation in whom the estimated fetal weight or abdominal circumference is
- Published
- 2022
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