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38 results on '"Ton That B"'

1. Optical Coherence Tomography of Tumor Spheroids Identifies Candidates for Drug Repurposing in Ovarian Cancer

Author

Yan, Feng, primary, Ha, Ji-Hee, additional, Yan, Yuyang, additional, Ton, Sam B., additional, Wang, Chen, additional, Mutembei, Bornface, additional, Alhajeri, Zaid A., additional, McNiel, Aubrey F., additional, Keddissi, Andrew J., additional, Zhang, Qinghao, additional, Jayaraman, Muralidharan, additional, Dhanasekaran, Danny N., additional, and Tang, Qinggong, additional

Published
2023
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2. Optimal surgical management of stage 3 and 4 pelvic organ prolapse

Author

White, Amanda, Aguilar, Vivian, Rogers, Rebecca G., Huber, Sarah, Culligan, Patrick, Lucente, Vincent R., and Ton, Jessica B.

Subjects
Boston Scientific Corp. -- Management, Prolapse, Hysterectomy, Urinary incontinence, Women's health, Medical equipment industry, Sexual disorders, Company business management, Health
Abstract

What the evidence and the experts say about the various approaches for prolapse repair Effective surgical management of advanced pelvic organ prolapse (POP) depends on prolapse location and stage, presence [...]

Published
2018

12. INTEGRATING DNA: Transposases and Retroviral Integrases

Author

Haren, L., Ton-Hoang, B., and Chandler, M.

Subjects
Transposons -- Research, DNA -- Research, Insertion elements, DNA -- Research, Retroviruses -- Research, Translocations (Genetics) -- Research, Biological sciences
Abstract

Laboratorie de Microbiologie et Genetique Molecularie, CNRS (UPR 9007) and Universite Paul Sabatier, 31062 Toulouse, France; e-mail: mike@ibcg.biotoul.fr Key Words transposons, insertion sequences, structure, transposition mechanism * Abstract Transposable elements [...]

Published
1999

13. ISDra2 transposition in Deinococcus radiodurans is downregulated by TnpB

Author

Pasternak, C., Dulermo, R., Ton Hoang, B., Debuchy, R., Siguier, P., Coste, G., Chandler, M., Sommer, S., Institut de génétique et microbiologie [Orsay] (IGM), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de microbiologie et génétique moléculaires (LMGM), Centre de Biologie Intégrative (CBI), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre de Biologie Intégrative (CBI), and Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)

Subjects
DNA, Bacterial, Mutagenesis, Insertional, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Bacterial Proteins, DNA Transposable Elements, Escherichia coli, DNA, Single-Stranded, Down-Regulation, Transposases, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Deinococcus, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; Transposable elements belonging to the recently identified IS200/IS605 family radically differ from classical insertion sequences in their transposition mechanism by strictly requiring single-stranded DNA substrates. This IS family includes elements encoding only the transposase (TnpA), and others, like ISDra2 from Deinococcus radiodurans, which contain a second gene, tnpB, dispensable for transposition and of unknown function to date. Here, we show that TnpB has an inhibitory effect on the excision and insertion steps of ISDra2 transposition. This inhibitory action of TnpB was maintained when ISDra2 transposition was induced by γ-irradiation of the host cells and required the integrity of its putative zinc finger motif. We also demonstrate the negative role of TnpB when ISDra2 transposition was monitored in a heterologous Escherichia coli host, indicating that TnpB-mediated inhibition does not involve Deinococcus-specific factors. TnpB therefore appears to play a regulatory role in ISDra2 transposition.

Published
2013

14. The processing of repetitive extragenic palindromes: the structure of a repetitive extragenic palindrome bound to its associated nuclease

Author

Messing, S.A.J., Ton Hoang, B., Hickman, A.B., Mc Cubbin, A.J., Peasleee, G.F., Ghirlando, R., Chandler, M., Dyda, F., Laboratoire de microbiologie et génétique moléculaires (LMGM), Centre de Biologie Intégrative (CBI), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

15. Movement of Bacterial Transposons

Author

Ton Hoang, B., Chandler, M., Laboratoire de microbiologie et génétique moléculaires (LMGM), Centre de Biologie Intégrative (CBI), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Published
2011

16. Structuring the bacterial genome: Y1-transposases associated with REP-BIME sequences{dagger}

Author

Ton Hoang, B., Siguier, P., Quentin, Y., Onillon, S., Marty, B., Fichant, G., Chandler, M., Laboratoire de microbiologie et génétique moléculaires (LMGM), Centre de Biologie Intégrative (CBI), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2011

18. Control of IS911 target selection: how OrfA may ensure IS dispersion

Author

Rousseau, P., Loot, C., Guynet, Catherine, Ah-Seng, Y., Ton-Hoag, B., Chandler, M., Laboratoire de microbiologie et génétique moléculaires (LMGM), Centre de Biologie Intégrative (CBI), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Published
2007

19. Promoter-specific involvement of the FixJ receiver domain in transcriptional activation

Author

Ton-Hoang, B., Salhi, M., Schumacher, J., Da Re, S., Kahn, D., Bioinformatique, phylogénie et génomique évolutive (BPGE), Département PEGASE [LBBE] (PEGASE), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biologie Moléculaire des Relations Plantes-Microorganismes UMR 215, and Centre National de la Recherche Scientifique (CNRS)

Subjects
Transcriptional Activation, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], Alanine, Base Sequence, Nitrogen, Molecular Sequence Data, DNA Footprinting, DNA-Directed RNA Polymerases, Gene Expression Regulation, Bacterial, Protein Structure, Tertiary, DNA-Binding Proteins, Bacterial Proteins, Genes, Bacterial, Mutation, Phosphorylation, Pliability, Promoter Regions, Genetic, Dimerization, Sinorhizobium meliloti
Abstract

The "two-component" FixLJ system activates nitrogen fixation genes via nifA and fixK in Sinorhizobium meliloti. Like other response regulators, the FixJ protein can be decomposed into an N-terminal phosphorylatable "receiver" domain FixJN and a C-terminal transcriptional activator domain FixJC. The FixJN receiver domain was known to regulate activity of FixJC negatively at the nifA promoter. Here we show a different situation at the fixK promoter where FixJN also contributes positively to transcriptional activation. This promoter-specific effect was mapped by alanine-scanning mutagenesis to the beta2 strand of the receiver domain. This interaction with FixJN is required for the recruitment of RNA polymerase at the fixK promoter by phosphorylated FixJ. Altogether the FixJ receiver domain appears to carry at least four functions, some of which can be separated by mutation: (1) autophosphorylation; (2) inhibition of FixJC; (3) dimerization; (4) transcriptional activation at pfixK. This example illustrates the formidable functional plasticity of receiver domains.

Published
2001

20. Structural organization of the Streptococcus pneumoniae chromosome and relatedness of penicillin-sensitive and -resistant strains in type 9V

Author

Gasc, A. -M, Giammarinaro, P., Ton-Hoang, B., Geslin, P., Mark van der Giezen, and Sicard, M.

Subjects
EXPRESSION, EXCISION, MOLECULAR-CLONING, SIZE, ESCHERICHIA-COLI, NUCLEOTIDE-SEQUENCE, BINDING PROTEINS, MISMATCH-REPAIR GENE, PHYSICAL MAP, TRANSFORMATION
Abstract

Fragmentation of Streptococcus pneumoniae genomic DNA with low-frequency-cleavage restriction endonucleases and separation of the fragments by field-inversion gel electrophoresis (FIGE) provides a DNA-fingerprint of a strain. This method enables us to construct a physical and genetic map of the R6 laboratory strain what will be presented. The origin of replication containing several Dna boxes was located in the dnaA region. It was of interest to compare the profiles of subclones. Two clones of strain R36A (R6 and C13) were cultivated separately for more than 15,000 generations in two laboratories. FIGE profiles differed by only one band. Another R36A descendant, isolated in 1958 by Ravin, strain Rx was of interest since it was deficient in Dpn restriction enzymes and methylases and in the hex B function. Its origin was questionable; its profile is identical to others R6 descendants, demonstrating that Rx is derived from R36A. FIGE analysis was carried out on several penicillin-resistant strains of type 9V because penicillin-resistance in this type increased recently. The profiles of a collection of a number of these resistant isolates were very similar, showing that they result from a clone. The profiles of penicllin sensitive isolates of the same type are very similar to the resistant isolates. This suggests that the 9V type has spread recently from a clone, and the resistance genes have mutated and were selected when penicillin was extensively used.

Published
1997

31. Isolated congenital stapes ankylosis: surgical results in 32 ears and a review of the literature

Author

W. R. J. Cremers, Ton P. B. M. Pouwels, Bert Teunissen, and Patrick L. M. Huygen

Subjects
medicine.medical_specialty, Hearing loss, medicine.medical_treatment, Ankylosis, Audiology, Stapes Surgery, Bone conduction, Audiometry, otorhinolaryngologic diseases, medicine, Humans, Child, Hearing Disorders, Stapes, Absolute threshold of hearing, medicine.diagnostic_test, business.industry, Oval window, Stapedectomy, medicine.disease, Surgery, medicine.anatomical_structure, Otorhinolaryngology, medicine.symptom, business, Bone Conduction
Abstract

Isolated congenital stapes ankylosis is described in 32 operated ears from 28 patients. In 27 ears, a regular stapedectomy was performed. In the remaining 5 ears, 2 had stapes gushers, 2 had bony stapedial tendons, and 1 had an aberrant facial nerve crossing the oval window. The average individual hearing gain was 20 dB. The mean hearing gain for the 24 successful stapedectomies was 29 dB. In 24 of 32 ears (75%), an essential hearing gain of at least 15 dB Fletcher's index hearing threshold could be achieved. A Fletcher's index not exceeding 30 dB could be achieved in 19 of 32 ears (60%), in spite of several cases with a sensorineural component in the hearing loss. A review of the literature and overview of longer series with isolated congenital stapes ankylosis is presented.

Published
1990

36. A target specificity switch in IS911 transposition: the role of the OrfA protein.

Author

Loot, C., Turlan, C., Rousseau, P., Ton-Hoang, B., and Chandler, M.

Subjects
PROTEINS, DNA, GENES, MOLECULES, PROBABILITY theory, BIOMOLECULES
Abstract

The rote played by insertion sequence IS911 proteins, OrfA and OrfAB, in the choice of a target for insertion was studied. IS911 transposition occurs in several steps: synapsis of the two transposon ends (IRR and IRL); formation of a figure-of-eight intermediate where both ends are joined by a single-strand bridge; resolution into a circular form carrying an IRR-IRL junction; and insertion into a DNA target. In vivo, with OrfAB alone, an IS911-based transposon integrated with high probability next to an IS911 end located on the target plasmid. OrfA greatly reduced the proportion of these events. This was confirmed in vitro using a transposon with a preformed IRR-IRL junction to examine the final insertion step. Addition of OrfA resulted in a large increase in insertion frequency and greatly increased the proportion of non-targeted insertions. The intermolecular reaction leading to targeted insertion may resemble the intra-molecular reaction involving figure-of-eight molecules, which leads to the formation of circles. OrfA could, therefore, be considered as a molecular switch modulating the site-specific recombination activity of OrfAB and facilitating dispersion of the insertion sequence (IS) to 'non-homologous' target sites. [ABSTRACT FROM AUTHOR]

Published
2002
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37. Isolated congenital stapes ankylosis: Surgical results in 32 ears and a review of the literature.

Author

Teunissen, Bert, Cremers, W. R. J., Huygen, Patrick L. M., and Pouwels, Ton P. B. M.

Abstract

Isolated congenital stapes ankylosis is described in 32 operated ears from 28 patients. In 27 ears, a regular sta-pedectomy was performed. In the remaining 5 ears, 2 had stapes gushers, 2 had bony stapedial tendons, and 1 had an aberrant facial nerve crossing the oval window. The average individual hearing gain was 20 dB. The mean hearing gain for the 24 successful stapedectomies was 29 dB. In 24 of 32 ears (75%), an essential hearing gain of at least 15 dB Fletcher's index hearing threshold could be achieved. A Fletcher's index not exceeding 30 dB could be achieved in 19 of 32 ears (60%), in spite of several cases with a sensori-neural component in the hearing loss. A review of the literature and overview of longer series with isolated congenital stapes ankylosis is presented. [ABSTRACT FROM AUTHOR]

Published
1990
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38. [Acute intestinal tuberculosis].

Author

Nguyen Duc C, Pha Hai B, Pham Van T, Ton That B, and Huguier M

Subjects
Adolescent, Adult, Aged, Antitubercular Agents therapeutic use, Cachexia mortality, Constriction, Pathologic epidemiology, Enterostomy, Female, Follow-Up Studies, Gastrointestinal Hemorrhage epidemiology, Humans, Intestinal Obstruction epidemiology, Male, Middle Aged, Mycobacterium tuberculosis isolation & purification, Postoperative Complications, Retrospective Studies, Rural Health statistics & numerical data, Tuberculosis, Gastrointestinal mortality, Tuberculosis, Pulmonary epidemiology, Urban Health statistics & numerical data, Vietnam epidemiology, Tuberculosis, Gastrointestinal epidemiology
Abstract

Aim of Study: To report cases from Vietnam of intestinal tuberculosis disease, which is uncommon but did not disappear in occidental countries., Materials and Methods: Seventy-six patients were included in this retrospective study. Mean age was 40 years and sex ratio M/F was 6. Diagnosis was established on pathological examination of resected specimen or on presence of Mycobacterium tuberculosis or by polymerase chain reaction., Results: Intestinal obstruction or subobstruction was the most usual symptom (68%), and thereafter peritoneal symptoms with pain and tenderness (17%). Five patients had intractable digestive haemorrhage. Thirty-six patients had no past history or active pulmonary tuberculosis (47%). Lesions of stenosis on barium enema and thickness of intestinal wall on CT-scan were not specific. Sixty-two patients were operated on (82%) and 14 were not. Surgical techniques differed according symptoms, site and type of lesions. Intestinal resections were performed in half of the patients, others undergoing stomies or enterolysis. There were eight postoperative deaths (13% of patients operated on), seven out of these deaths were attributable to cachexy. In the postoperative period, all the patients were medically treated and follow-up in the antituberculosis centre of Hanoi., Conclusion: Symptomatology and operative findings of intestinal tuberculosis are similar to those observed in Crohn's disease, and sometimes in amoeboma or lymphoma. In face of stenosis and intestinal wall thickness, probability of intestinal tuberculosis is high in endemic area, but diagnosis must be suspected in occidental countries, mainly in patients immigrated coming from these areas, patients with immuno-deficiency even if they did not have past or present pulmonary tuberculosis.

Published
2006
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