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Your search keyword '"Tolentino, Neil J."' showing total 9 results
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9 results on '"Tolentino, Neil J."'

1. The Ability of Functional Magnetic Resonance Imaging to Predict Heavy Drinking and Alcohol Problems 5 Years Later.

Author

Schuckit, Marc A, Smith, Tom L, Paulus, Martin P, Tapert, Susan F, Simmons, Alan N, Tolentino, Neil J, and Shafir, Alexandra

Subjects
Brain, Cerebral Cortex, Prefrontal Cortex, Humans, Alcoholism, Magnetic Resonance Imaging, Logistic Models, Risk Assessment, Follow-Up Studies, Predictive Value of Tests, Alcohol Drinking, Image Processing, Computer-Assisted, Adult, Female, Male, Young Adult, Functional Neuroimaging, Binge Drinking, Alcohol, Alcohol Outcomes, Alcohol Sensitivity, Functional Magnetic Resonance Imaging, Prediction, Prospective, Clinical Research, Substance Misuse, Neurosciences, Alcoholism, Alcohol Use and Health, Mental health, Good Health and Well Being, Clinical Sciences, Psychology, Substance Abuse
Abstract

BackgroundLow levels of alcohol responses (low LRs) are genetically influenced phenotypes that are identified before alcohol dependence and predict future heavy drinking and alcohol problems. A recent paper described 13 LR-related blood oxygen level-dependent (BOLD) response contrast patterns observed during an emotional face recognition task that might reflect cognitive processes contributing to LR and that might themselves predict adverse alcohol outcomes (Paulus et al., Biol Psychiatry 2012; 72: 848). This paper evaluates the predictive implications of those functional magnetic resonance imaging (fMRI) patterns.MethodsOf 120 subjects from Paulus and colleagues (2012), 114 (57 low and high LRs; ~50% females) were interviewed 5 years later at age 25. Correlations between baseline fMRI patterns and alcohol-related outcomes were evaluated, and regression analyses were used to determine if BOLD response contrasts incremented over LR in predicting outcomes.ResultsBaseline fMRI patterns in 5 of 13 baseline regions of interest correlated with adverse outcomes. Such patterns in insular regions, particularly the left anterior insula, and the right frontal gyrus, added to LR in predicting alcohol problems. The relationships remained robust when exact binomial procedures were used, but, reflecting the small sample size, it was not possible to adequately consider Bonferroni corrections.ConclusionsThe data suggest that fMRI BOLD response contrasts predicted heavier drinking and alcohol problems 5 years later, even after considering baseline low LRs. Future work will focus on whether fMRI results can predict outcomes in larger samples and among young nondrinkers, as well as how the imaging results increase understanding of the processes through which LR operates.

Published
2016

6. The Ability of fMRI Imaging to Predict Heavy Drinking and Alcohol Problems 5 Years Later

Author

Schuckit, Marc A., Smith, Tom L., Paulus, Martin P., Tapert, Susan F., Simmons, Alan N., Tolentino, Neil J., and Shafir, Alexandra

Subjects
Adult, Cerebral Cortex, Male, Alcohol Drinking, Functional Neuroimaging, Brain, Prefrontal Cortex, Magnetic Resonance Imaging, Risk Assessment, Article, Binge Drinking, Alcoholism, Young Adult, Logistic Models, Predictive Value of Tests, Image Processing, Computer-Assisted, Humans, Female, Follow-Up Studies
Abstract

Low levels of alcohol responses (low LRs) are genetically influenced phenotypes that are identified before alcohol dependence and predict future heavy drinking and alcohol problems. A recent paper described 13 LR-related blood oxygen level-dependent (BOLD) response contrast patterns observed during an emotional face recognition task that might reflect cognitive processes contributing to LR and that might themselves predict adverse alcohol outcomes (Paulus et al., Biol Psychiatry 2012; 72: 848). This paper evaluates the predictive implications of those functional magnetic resonance imaging (fMRI) patterns.Of 120 subjects from Paulus and colleagues (2012), 114 (57 low and high LRs; ~50% females) were interviewed 5 years later at age 25. Correlations between baseline fMRI patterns and alcohol-related outcomes were evaluated, and regression analyses were used to determine if BOLD response contrasts incremented over LR in predicting outcomes.Baseline fMRI patterns in 5 of 13 baseline regions of interest correlated with adverse outcomes. Such patterns in insular regions, particularly the left anterior insula, and the right frontal gyrus, added to LR in predicting alcohol problems. The relationships remained robust when exact binomial procedures were used, but, reflecting the small sample size, it was not possible to adequately consider Bonferroni corrections.The data suggest that fMRI BOLD response contrasts predicted heavier drinking and alcohol problems 5 years later, even after considering baseline low LRs. Future work will focus on whether fMRI results can predict outcomes in larger samples and among young nondrinkers, as well as how the imaging results increase understanding of the processes through which LR operates.

Published
2016

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