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The dynamic mechanical properties and crack evolution characteristics of coal and rock during split Hopkinson pressure bar (SHPB) impact failure are important contents for analysis. In previous studies, the coal and rock specimens used have usually been independent and not closely correlated. In addition, quantitative characterization and analysis methods for coal and rock cracks are immature, and more information has not been fully revealed. The aims of this paper are to comprehensively explore both the dynamic mechanical properties and crack evolution characteristics of coal and rock during impact failure. First, experimental specimens are prepared from coal seam, direct roof rock strata and direct floor rock strata in the same area to highlight the correlations between test pieces. Second, a dynamic strain gauge and high-speed (HS) camera are adopted to reflect the stress wave signal and crack evolution. Then, based on digital image correlation (DIC) technology and the mass screening method, the evolution laws of surface cracks during crushing and the distribution characteristics of sample fragments after crushing are studied from the perspective of fractal, and finally compared with those of the simulation analysis. The results are as follows. (1) The coal and rock samples from the same area have both consistency and differences. The dynamic mechanical properties of coal and rock are affected by the impact velocity and the physical properties of the specimen. Higher impact speeds and densities lead to the more obvious brittleness of the specimen when destroyed. Conversely, the sample shows more plasticity and ductile yield. (2) The self-similarity is significantly manifested in the evolution of surface cracks during impact and the distribution characteristics of fragments after impact. The box dimension and quality screening dimension are applicable to quantitatively characterize the evolution process and results of coal and rock fractures. (3) The simulation results based on the Holmquist–Johnson–Cook (HJC) and Riedel–Hiermaier–Thoma (RHT) constitutive models agree well with the experimental results, and the RHT constitutive model is more consistent. This study may contribute to a more comprehensive understanding of the dynamic characteristics and crack evolution laws of coal and rock under impact loading and provide references for further research and discussion.

Soil water characteristic curve (SWCC) has been an important role in hydraulic engineering, civil engineer and petroleum engineering, etc. Most of SWCC models neglected the film flow in the dry state, so that they cannot accurately describe the SWCC over entire range of water content. In this work, an alternative fractal model is proposed to predict the SWCC over entire range of water content by combining Campbell and Shiozawa model and Tao model. The proposed model can well predict twelve sets of experimental data, and its parameters, including the fractal dimension, the saturated volumetric water content, the matric suction at oven-dry condition, and the air-entry value, accord with theoretical value. The results show that there is a strong linear relationship between volumetric water content and matrix suction in log-log scale for different fractal pore-size distribution of soils. In addition, good agreement is obtained between the experimental data and the model predictions in all of the cases. Cited as : Jin, T., Cai, X., Chen, Y., Jiang, S., Wei, W. A fractal-based model for soil water characteristic curve over entire range of water content. Capillarity, 2019, 2(4): 66-75, doi: 10.26804/capi.2019.04.02

Arsenic is widely present in nature and is a common environmental poison that seriously damages human health. Chronic exposure to arsenic is a major environmental poisoning factor that promotes cell proliferation and leads to malignant transformation. However, its molecular mechanism remains unclear. In this study, we found that arsenite can promote the transformation of immortalized human keratinocyte cells (HaCaT) from the G0/G1 phase to S phase and demonstrated malignant phenotypes. This phenomenon is accompanied by obviously elevated levels of NRF2, NQO1, Cyclin E, and Cyclin-dependent kinase 2 (CDK2). Silencing the NRF2 expression with small interfering RNA (siRNA) in arsenite-transformed (T-HaCaT) cells was shown to reverse the malignant phenotype. Furthermore, the siRNA silencing of NQO1 significantly decreased the levels of the cyclin E-CDK2 complex, inhibiting the G0/G1 to S phase cell cycle progression and transformation to the T-HaCaT phenotypes. Thus, we hypothesized that the NRF2/NQO1 pathway played a key role in the arsenite-induced malignancy of HaCaT cells. By increasing the expression of Cyclin E-CDK2, the NRF2/NQO1 pathway can affect cell cycle progression and cell proliferation. A new common health effect mechanism of arsenic carcinogenesis has been identified; thus, it would contribute to the development of novel treatments to prevent and treat skin cancer caused by arsenic.

Highlights • SARS-CoV-2 virus was present in the air in the ICU. • Virus may be discharged in aerosol for days after patients test negative. • The finding may be one of the reasons for patients` re-detectable positive. • The clinical guidelines for recovered COVID-19 patients need to be improved., As coronavirus disease 2019 (COVID-19) is spreading worldwide, there have been arguments regarding the aerosol transmission of its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Moreover, some re-detectable positive (RP) patients have been reported. However, little attention has been given to the follow-up of recovered patients, and there is no environmental evidence to determine whether these patients continue to shed the virus after they test negative. Therefore, with an objective to test the hypothesis of airborne transmission of SARS-CoV-2, it is necessary to 1) determine whether SARS-CoV-2 particles are present in the indoor air and 2) determine whether recovered patients are still shedding virus, thus providing much-needed environmental evidence for the management of COVID-19 patients during the recovery period. In this study, surface and air samples were collected from an intensive care unit (ICU) containing one ready-for-discharge patient. All surface samples tested negative, but the air samples tested positive for SARS-CoV-2. This implies that SARS-CoV-2 particles may be shed in aerosol form for days after patients test negative. This finding may be one of the reasons for the observation of RP patients; therefore, there is a need for improved clinical and disease management guidelines for recovered COVID-19 patients.

Fluid flow in porous systems driven by capillary pressure is one of the most ubiquitous phenomena in nature and industry, including petroleum and hydraulic engineering as well as material and life sciences. The classical Lucas-Washburn (LW) equation and its modified forms were developed and have been applied extensively to elucidate the fundamental mechanisms underlying the basic statics and dynamics of the capillary-driven flow in porous systems. The LW equation assumes that fluids are incompressible Newton ones and that capillary channels all have the same radii. This kind of hypothesis is not true for many natural situations, however, where porous systems comprise complicated pore and capillary channel structures at microscales. The LW equation therefore often leads to inaccurate capillary imbibition predictions in such situations. Numerous studies have been conducted in recent years to develop and assess the modifications and extensions of the LW equation in various porous systems. Significant progresses in computational techniques have also been attained to further improve our understanding of imbibition dynamics. A state-of-the-art review is therefore needed to summarize the recent significant models and numerical simulation techniques as well as to discuss key ongoing research topics arising from various new engineering practices. The theoretical basis of the LW equation is first introduced in this review and recent progress in mathematical models is then summarized to demonstrate the modifications and extensions of this equation to various microchannels and porous media. These include capillary tubes with nonuniform and noncircular cross sections, discrete fractures, and capillary tubes that are not straight as well as heterogeneous porous media. Numerical studies on the LW equation are also reviewed, and comments on future works and research directions for LW-based capillary-driven flows in porous systems are listed.