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Background: Adenolipoma of the thyroid gland is a rare benign tumor composed of thyroid tissue admixed with mature adipose elements. The objective of this case is to highlight this extraordinary fatty tumor since such fatty tissue is not a usual finding within the thyroid gland. Case presentation: We describe a case of a Caucasian female patient who suffered from multinodular goiter due to a thyroid Adenolipoma. The mass had progressed for four years and subsequently complicated by dyspnea and dysphagia. Histopathological examination revealed a fibrous capsule encompassing varicolored nodules of thyroid follicles and mature adipocytes. Based on the serologic, radiologic and microscopic findings, the patient was diagnosed with adenolipoma (Thyrolipoma) associated with multinodular goiter. A total thyroidectomy was performed and followed by Levothyroxine replacement therapy. Postoperative evaluation of the neck and the respiratory functions showed a positive response to the surgery with no signs or evidence of recurrence. Conclusion: The comprehensive etiopathology of the fatty infiltrates within the thyroid tissue is still unclear. This case provides a range of clinical findings of thyrolipoma, but more studies are required to determine the underlying mechanisms, diagnostic criteria, and possible therapies.

Thyrolipomas are rare benign neoplasms composed of mature adipose tissue and glandular elements. The most common clinical manifestation is a slowly enlarging neck mass. If thyroid fine-needle aspiration biopsy discloses a mixed population of adipocytes and follicular cells, the possibility of an adenolipoma should be considered in the differential diagnosis. Complete surgical excision is curative and the prognosis is favorable. We report a case of a 59 year-old female, with a recent diagnosis of multinodular goitre. The diagnosis of thyrolipoma was only possible after surgery, performed because of a suspicious fine-needle aspiration biopsy. We also briefly discuss the clinic and diagnosis of this entity.

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Background: We have reported three cases of incidental findings of solid cell nests, ectopic thymus with parathyroid tissue and thyrolipoma in thyroidectomy specimens. These patients presented clinically as nodular thyromegaly and were directed for FNAC. Ultrasound findings were suggestive of nodular goiter and on histopathology revealed features compatible with nodular goiter along with incidental findings of solid cell nests, ectopic thymus with parathyroid tissue and thyrolipoma. Differential diagnosis of thyroid nodules should include these rare diagnostic findings which create confusion in thyroid pathology as they mimic malignancies both clinically and histologically and also because neoplasms may arise in the background of these rare findings. Objectives: To analyze clinicopathological findings in thyroid specimens, to correlate with Ultrasonography (USG), Fine needle aspiration cytology (FNAC), hormonal assay and immunohistochemistry. Materials and methods: All the specimens were analyzed and routinely processed for histopathology and stained with haematoxylin and eosin. Results: Incidental associated findings were noted in three cases composed of solid cell nests, ectopic thymus with parathyroid tissue and thyrolipoma. Conclusion: Three incidental and relatively unusual findings of solid cell nests, ectopic thymus with parathyroid tissue and thyrolipoma were diagnosed on histopathology. These lesions of thyroid gland must be differentiated from close mimickers including both non-neoplastic and neoplastic lesions clinically, radiologically and microscopically. Though benign and rare, these incidental findings should be thought of in all the thyroid specimens to avoid confusion with neoplastic thyroid pathology and also because they carry a potential risk for developing into neoplastic lesions. [ABSTRACT FROM AUTHOR]

The presence of adipose tissue in the thyroid gland is a rare finding. Thyrolipoma or adenolipoma of the thyroid is a benign, encapsulated lesion of the thyroid composed of variable amounts of fat and glandular elements. This report presents a case of thyrolipoma in a 69-yr-old female presenting with neck swelling and respiratory distress. Differential diagnosis of the fat-containing thyroid lesion is also presented. Differentiation of the condition from similar lesions is necessary for accurate diagnosis of thyrolipoma. [ABSTRACT FROM AUTHOR]

Objective: The aim of this retrospective study was to investigate the lesions containing mature adipose tissues in surgical materials of the patients who underwent thyroidectomy operation owing to the diagnosis of nodular goiter. Methods: A total of 2800 pathologic specimens of thyroidectomies stained with hematoxylin-eosin were collected between January 2010 and November 2013 in Recep Tayyip Erdogan University School of Medicine. Pathologic sections were selected from pathology archive and re-examined. Upon examination, we determined 10 lesions with mature adipose tissue within thyroid parenchyma. Results: Thyroid lesions containing mature adipose tissue were observed in 10 (0.004 %) of 2800 thyroidectomy materials. Eight of the patients were female and two of them were male. Minimum, maximum and median age of the patients were found to be 31, 74 and 52 years respectively. All of the cases had underwent a bilateral total thyroidectomy operation. In macroscopic examination of the only one cases, a homogenous yellow-gray color was observed. In other cases a large number of colloid-rich nodules of various sizes were observed. On microscopic examination, five adipose tissues in the nodules (adenolipoma-thyrolipoma), four scattered foci of mature adipose tissues (heterotopic adiposis) and one diffuse infiltrating mature adipose tissue on entire thyroid gland (diffuse thyrolipomatosis) were determined among mature adipose tissue containing lesions. A follicular variant of papillary microcarcinoma was found in two of thyrolipoma cases. Conclusion: Nodular thyroid lesions containing mature adipose tissue, as a result of particularly on the outer surface of the gland and parathyroid glands containining mature adipose tissue may mimic parathyroid gland lesion. Therefore, to prevent from inappropriate treatments, pathologists should be aware of these kinds of lesions, especially when they are investigating the lesions of parathyroid glands during an intraoperative consultation. [ABSTRACT FROM AUTHOR]

Abstract: Because thyrolipoma (adenolipoma of thyroid) and thyrolipomatosis (diffuse lipomatosis of thyroid) are distinctively rare conditions with only few cases reported in the literature, we are reporting 5 additional cases. All the 5 patients were adult females, with ages from 38 to 79 years, who presented with thyroid masses. Four of the patients had normal thyroid function tests and one had mild hypothyroidism. All patients received partial or total thyroidectomy. The thyroid specimens showed either circumscribed yellow-tan masses (cases 1, 2, and 3) or diffuse yellow-brown discoloration (cases 4 and 5). Histologic examination revealed abundant mature fat infiltrating the affected thyroid tissue in 3 distinct patterns: (1) fat infiltration limited to follicular adenomas (thyrolipoma); (2) fat diffusely infiltrating throughout the thyroid gland (thyrolipomatosis); or (3) fat infiltration involving both follicular adenoma and their surrounding thyroid tissue. Because of the rarity of thyroid fat-containing lesions, confusion in differential diagnosis may occasionally occur. It is important to be aware during frozen section that these lesions may present as extrathyroidal nodules, which can be radioactive on intraoperative scan for parathyroid glands. In addition, a papillary thyroid carcinoma was also identified in one case of thyrolipomatosis. All patients recovered well after surgery and there has been no recurrence of the lesions after 1 to 24 years of clinical follow-up. In summary, we are reporting 5 rare cases of thyrolipoma and thyrolipomatosis with distinct histologic patterns. Previously reported cases of thyrolipomatosis were reviewed and analyzed with the current cases. [Copyright &y& Elsevier]

Thyrolipoma or adenolipoma of the thyroid gland is defined as a thyroid adenoma containing mature fat tissue. It is a rare encapsulated lesion. A case of a 35-year-old female presenting with swelling in the neck that was diagnosed as adenolipoma is described because of its extreme rarity.

The presence of adipocytes within thyroid glands is a rare finding seen in thyrolipoma, diffuse lipomatosis, or thyroid teratoma. Although some cases present with multinodular goiter or autoimmune thyroiditis, the exact cause has not yet been elucidated. Among reported cases, thyrolipomas mainly occur in females and usually present as a solitary lesion. However, a few reported cases had coexisting papillary thyroid carcinomas. Herein, we present a 51-year-old female with synchronous thyrolipoma (2.0 × 1.5 × 1.3 cm) and papillary thyroid carcinoma (0.7 × 0.6 × 0.6 cm) within the same thyroid lobe. She had diabetes mellitus and hypertension and complained of anterior neck enlargement and discomfort for three months. Thyroid sonography showed multiple hypoechoic nodules, one of which was heterogeneous and ill-defined. Fine needle aspirate cytology for the ill-defined nodule was suspicious for papillary thyroid carcinoma. She subsequently received radical thyroidectomy and neck lymph node dissection. Histopathologically, one thyrolipoma and one papillary thyroid carcinoma were identified in the right lobe of the thyroid gland without metastases of lymph nodes, while other nodules were multinodular goiter. Notably, thyrolipoma may not be simply an incidental finding but might coexist with thyroid carcinomas. A brief review of the pertinent literature of prior reports is also provided. [ABSTRACT FROM AUTHOR]

Rare fat cell-containing adenomas (adenolipomas) found in the thyroid gland of two patients are presented. Previously documented cases are reviewed. An origin from embryonic rests for these tumours as for diffuse lipomatosis of the thyroid is discussed. [ABSTRACT FROM AUTHOR]

A thyroid adenoma consisting of lipid-rich follicle cells is presented which has not previously been described in this organ. The discussion focuses on the possibility of its metaplastic origin and on its histological analogy to lipid-rich carcinoma of the breast. [ABSTRACT FROM AUTHOR]

We report a rare case of thyrolipoma-thyrolipomatosis' association. A 48-year-old patient, with a past history of high blood pressure and chronic renal failure secondary to AA amyloidosis, presented with a midline neck swelling increasing in size since one year. Ultrasound showed a multinodular goiter, the worst nodule was left-lobar and categorized as EU-TIRADS 4. Grossly, cut section of the thyroïd specimen showed a yellow-tan left-lobar nodule measuring 2.5cm, the surrounding tissue had a diffuse yellow-brown appearance with scattered whitish areas. Histopathologic examination revealed that the nodule corresponded to a follicular adenoma.Thyroid fat infiltration was noticed both within the nodule and in the neighboring parenchyma. Thus, the diagnosis of an association thyrolipoma-thyrolipomatosis was rendered. The association of thyrolipoma-thyrolipomatosis is a very rare occurrence of unclear pathogenesis. To the best of our knowledge, this report describes the second case in the literature. The diagnosis is retained on the basis of certain histological features, revealing mature adipose tissue within thyroid gland as a combined nodular and diffuse pattern., (Copyright © 2020. Published by Elsevier Masson SAS.)

Thyrolipoma and thymolipoma are rare neoplasms of the thyroid gland and thymus, respectively. Their simultaneous occurrence is exceptional. Up to now, only 2 cases have been reported in literature in 1966 and in 1997. For the first time, we report the occurrence of both neoplasms associated with myasthenia gravis in a 64-year-old woman. The value of this case report lies not only in the fact that it allows us to speculate on the presence of a syndrome but also because a complete radiological work-up (computed tomography scanner, magnetic resonance imaging, Positron emission tomography (PET) with fluorodeoxyglucose (FDG)) is reported., (© The Author(s) 2020. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)

Thyrolipoma or thyroid adenolipoma is an extremely rare form of thyroid adenoma, which also contains mature adipose tissue and follicles covered with fibrous capsule. We present the case of the growing cervical lesion of a 52-year-old female with diabetes, which was removed during total thyreoidectomy. Autoimmune thyroiditis, bilateral papillary carcinoma and cervical thyrolipoma have been identified by the histopathological examination of the thyroid gland. Orv Hetil. 2018; 159(25): 1024-1032.