Search

Your search keyword '"Tertti, Kristiina"' showing total 40 results
Start Over Author "Tertti, Kristiina" Publication Year Range Last 50 years
40 results on '"Tertti, Kristiina"'

12. Potential pathobionts in vaginal microbiota are affected by fish oil and/or probiotics intervention in overweight and obese pregnant women

Author

Houttu, Noora, Mokkala, Kati, Saleem, Wisam Tariq, Virtanen, Seppo, Juhila, Juuso, Koivuniemi, Ella, Pellonperä, Outi, Tertti, Kristiina, Luokola, Paula, Sorsa, Timo, Salonen, Anne, Lahti, Leo, Laitinen, Kirsi, HUMI - Human Microbiome Research, Faculty of Medicine, HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, HUS Head and Neck Center, Department of Oral and Maxillofacial Diseases, University of Helsinki, Clinicum, and Research Programs Unit

Subjects
COMPLEX, Probiotics, LACTOBACILLI, Fish oil, Gestational diabetes mellitus, Active matrix metalloproteinase-8, COLONIZATION, Insulin-like growth factor-binding protein-1, Pregnancy, 317 Pharmacy, BACTERIAL VAGINOSIS, Vaginal microbiota, High sensitivity C-reactive protein, FATTY-ACIDS, HEALTH, 3111 Biomedicine
Abstract

New means to stabilize the microbial balance during pregnancy could benefit maternal health. Our objectives were to investigate in overweight/obese pregnant women 1) the impact of long-chain polyunsaturated fatty acids (fish oil) and/or probiotics on the vaginal microbiota, 2) its relation to gestational diabetes mellitus (GDM) and 3) its interaction with vaginal active matrix metalloproteinase-8 (aMMP-8) and serum high sensitivity C-reactive protein (hsCRP) and phosphorylated insulin-like growth factor-binding protein-1 (phIGFBP-1), IGFBP-1 and aMMP-8.& nbsp;The women were allocated to fish oil + placebo, probiotics + placebo, fish oil + probiotics and placebo + placebo-groups, from early pregnancy onwards (fish oil: 1.9 g docosahexaenoic acid and 0.22 g eicosapentaenoic acid; probiotics: Lacticaseibacillus rhamnosus HN001 (formerly Lactobacillus rhamnosus HN001) and Bifidobacterium animalis ssp. lactis 420, 10(10) colony-forming units each). Vaginal and serum samples (early pregnancy, n = 112; late pregnancy, n = 116), were analyzed for vaginal microbiota using 16S rRNA gene amplicon sequencing and vaginal aMMP-8 and serum hsCRP, aMMP-8, phIGFBP-1 and IGFBP-1 by immunoassays. GDM was diagnosed from a 2-h 75 g OGTT. ClinicalTrials.gov, NCT01922791.& nbsp;The intervention exerted effects on many low-abundant bacteria. Compared to the placebo-group, there was a lower abundance of potential pathobionts, namely Ureaplasma urealyticum in the fish oil-group, Ureaplasma, U. urealyticum and Prevotella disiens in the probiotics-group, Dialister invisus and Prevotella timonensis in the fish oil + probiotics-group. Moreover, probiotics decreased the abundance of a few potential pathobionts during pregnancy. Many bacteria were related to GDM. The vaginal aMMP-8 level correlated significantly with alpha-diversity and inversely with two Lactobacillus species.& nbsp;Dietary interventions, especially probiotics, may have beneficial effects on the vaginal microbiota during pregnancy.

Published
2022

13. Potential pathobionts in vaginal microbiota are affected by fish oil and/or probiotics intervention in overweight and obese pregnant women

Author

Houttu, Noora, primary, Mokkala, Kati, additional, Saleem, Wisam Tariq, additional, Virtanen, Seppo, additional, Juhila, Juuso, additional, Koivuniemi, Ella, additional, Pellonperä, Outi, additional, Tertti, Kristiina, additional, Luokola, Paula, additional, Sorsa, Timo, additional, Salonen, Anne, additional, Lahti, Leo, additional, and Laitinen, Kirsi, additional

Published
2022
Full Text
View/download PDF

21. Metformin versus insulin therapy for gestational diabetes: Effects on offspring anthropometrics and metabolism at the age of 9 years: A follow‐up study of two open‐label, randomized controlled trials

Author

Paavilainen, Elisa, primary, Tertti, Kristiina, additional, Nikkinen, Hilkka, additional, Veijola, Riitta, additional, Vääräsmäki, Marja, additional, Loo, Britt‐Marie, additional, Tossavainen, Päivi, additional, Rönnemaa, Tapani, additional, and Niinikoski, Harri, additional

Published
2021
Full Text
View/download PDF

26. Additional file 4 of Metformin and insulin treatment of gestational diabetes: effects on inflammatory markers and IGF-binding protein-1 – secondary analysis of a randomized controlled trial

Author

Huhtala, Mikael S., Tertti, Kristiina, Juhila, Juuso, Sorsa, Timo, and Rönnemaa, Tapani

Subjects
nutritional and metabolic diseases
Abstract

Additional file 4: Table S3. Associations of inflammatory markers and IGFBP-1 concentrations at baseline and 36 gestational weeks with clinical outcomes adjusted for pre-pregnancy BMI in metformin and insulin treated patients combined.

Published
2020
Full Text
View/download PDF

27. Metformin versus insulin therapy for gestational diabetes: Effects on offspring anthropometrics and metabolism at the age of 9 years: A follow‐up study of two open‐label, randomized controlled trials.

Author

Paavilainen, Elisa, Tertti, Kristiina, Nikkinen, Hilkka, Veijola, Riitta, Vääräsmäki, Marja, Loo, Britt‐Marie, Tossavainen, Päivi, Rönnemaa, Tapani, and Niinikoski, Harri

Subjects
*GESTATIONAL diabetes, *HIGH density lipoproteins, *INSULIN therapy, *INSULIN aspart, *METFORMIN, *LDL cholesterol, *GLUCOSE tolerance tests, *HDL cholesterol
Abstract

Aims: To compare anthropometrics, and lipid and glucose metabolism in the 9‐year‐old offspring of mothers treated with metformin or insulin for gestational diabetes mellitus (GDM). Materials and Methods: This was a Finnish two‐centre, 9‐year follow‐up study of two open‐label, randomized controlled trials comparing the effects observed in the offspring of mothers who received metformin and insulin treatment for GDM. Measurements included anthropometrics, blood pressure, lipoproteins, and oral glucose tolerance tests. This study was registered with ClinicalTrials.gov, number NCT02417090. Results: At the age of 9 years 172 children (55% of the original study cohort, 82 from the metformin and 90 from the insulin group) participated in the study. No differences were found between the 9‐year‐old offspring groups in anthropometric variables, including body mass index and waist‐to‐height ratio. The offspring in the metformin group had higher high‐density lipoprotein (HDL) cholesterol concentrations (1.72 vs. 1.54 mmol/L; P = 0.039) but lower low‐density lipoprotein cholesterol (2.39 vs. 2.58 mmol/L; P = 0.046) and apolipoprotein B concentrations (0.63 vs. 0.67 g/L; P = 0.043) than the offspring in the insulin group. The difference in HDL cholesterol concentration was found to be significant only in boys (P = 0.003). The 2‐hour glucose value in the oral glucose tolerance test was 0.6‐mmol/L lower in boys from the metformin group than in those from the insulin group (P = 0.015). Conclusions: Metformin treatment for GDM is associated with similar offspring growth and glucose metabolism but a more favourable lipid profile at the age of 9 years as compared to insulin treatment. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

30. Metagenomics analysis of gut microbiota in response to diet intervention and gestational diabetes in overweight and obese women: a randomised, double-blind, placebo-controlled clinical trial

Author

Mokkala, Kati, primary, Paulin, Niklas, additional, Houttu, Noora, additional, Koivuniemi, Ella, additional, Pellonperä, Outi, additional, Khan, Sofia, additional, Pietilä, Sami, additional, Tertti, Kristiina, additional, Elo, Laura L, additional, and Laitinen, Kirsi, additional

Published
2020
Full Text
View/download PDF

31. Metformin in Pregnancy Study (MiPS): protocol for a systematic review with individual patient data meta-analysis

Author

Mousa, Aya, primary, Løvvik, Tone, additional, Hilkka, Ijäs, additional, Carlsen, Sven M, additional, Morin-Papunen, Laure, additional, Tertti, Kristiina, additional, Rönnemaa, Tapani, additional, Syngelaki, Argyro, additional, Nicolaides, Kypros, additional, Shehata, Hassan, additional, Burden, Christy, additional, Norman, Jane E, additional, Rowan, Janet, additional, Dodd, Jodie M, additional, Hague, William, additional, Vanky, Eszter, additional, and Teede, Helena J, additional

Published
2020
Full Text
View/download PDF

32. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil.

Author

Pellonperä, Outi, Vahlberg, Tero, Mokkala, Kati, Houttu, Noora, Koivuniemi, Ella, Tertti, Kristiina, Rönnemaa, Tapani, and Laitinen, Kirsi

Subjects
OBESITY complications, THERAPEUTIC use of probiotics, BODY composition, WEIGHT gain in pregnancy, PILOT projects, BIFIDOBACTERIUM, PLETHYSMOGRAPHY, CONFIDENCE intervals, DIETARY supplements, RANDOMIZED controlled trials, DESCRIPTIVE statistics, STATISTICAL sampling, GESTATIONAL diabetes, GLUCOSE tolerance tests, LACTOBACILLUS, FISH oils, ADIPOSE tissues, DISEASE complications
Abstract

We evaluated the effects of fish oil and/or probiotic supplementation in a randomised placebo-controlled intervention pilot trial on gestational weight gain (GWG) and body composition. Additionally, the influence of gestational diabetes (GDM) on GWG and body composition was assessed. We randomised 439 overweight women into intervention groups: fish oil + placebo, probiotics + placebo, fish oil + probiotics and placebo + placebo (fish oil: 1·9 g DHA and 0·22 g EPA and probiotics: Lactobacillus rhamnosus HN001 and Bifidobacterium animalis ssp. lactis 420, 1010 colony-forming units each). GDM was diagnosed with oral glucose tolerance test. Body composition was measured with air displacement plethysmography at randomisation (mean 13·9) and in late pregnancy (mean 35·2 gestational weeks). Intervention did not influence mean GWG or change in body fat mass/percentage (P > 0·17). Body composition in early pregnancy did not differ between the women who did or did not develop GDM (adjusted P > 0·23). Compared with the normoglycaemic women (n 278), women diagnosed with GDM (n 119) gained less weight (7·7 (sd 0·4) v. 9·3 (sd 0·4) kg, adjusted mean difference −1·66 (95 % CI −2·52, −0·80) and fat mass (0·4 (sd 0·4) v. 1·8 (sd 0·3) kg, adjusted mean difference −1·43 (95 % CI −2·19, −0·67) during the follow-up. In conclusion, adiposity of pregnant overweight women was not affected by supplementation with fish oil and/or probiotics, nor did it predict the development of GDM. However, adiposity was reduced in women with GDM compared with normoglycaemic women irrespective of the dietary intervention. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

34. Efficacy of Fish Oil and/or Probiotic Intervention on the Incidence of Gestational Diabetes Mellitus in an At-Risk Group of Overweight and Obese Women: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial

Author

Pellonperä, Outi, primary, Mokkala, Kati, additional, Houttu, Noora, additional, Vahlberg, Tero, additional, Koivuniemi, Ella, additional, Tertti, Kristiina, additional, Rönnemaa, Tapani, additional, and Laitinen, Kirsi, additional

Published
2019
Full Text
View/download PDF

35. Metagenomics analysis of gut microbiota in response to diet intervention and gestational diabetes in overweight and obese women: a randomised, double-blind, placebo-controlled clinical trial.

Author

Mokkala, Kati, Paulin, Niklas, Houttu, Noora, Koivuniemi, Ella, Pellonperä, Outi, Khan, Sofia, Pietilä, Sami, Tertti, Kristiina, Elo, Laura L., and Laitinen, Kirsi

Subjects
GUT microbiome, GESTATIONAL diabetes, OVERWEIGHT women, METAGENOMICS, CLINICAL trials
Published
2021
Full Text
View/download PDF

40. [Vasa previa].

Author

Tertti K and Palo P

Subjects
Adult, Cesarean Section, Female, Humans, Infant, Newborn, Pregnancy, Pregnancy Outcome, Placenta Previa diagnostic imaging, Ultrasonography, Prenatal methods
Published
2002

Catalog

Books, media, physical & digital resources
See catalog results