Search

Your search keyword '"Tejwani, Vickram"' showing total 172 results
Start Over Author "Tejwani, Vickram" Publication Year Range Last 50 years
172 results on '"Tejwani, Vickram"'

1. Impact of Bronchiectasis on COPD Severity and Alpha-1 Antitrypsin Deficiency as a Risk Factor in Individuals with a Heavy Smoking History.

Author

Izquierdo, Manuel, Marion, Chad, Genese, Frank, Newell, John, ONeal, Wanda, Li, Xingnan, Hawkins, Gregory, Barjaktarevic, Igor, Barr, R, Christenson, Stephanie, Cooper, Christopher, Couper, David, Curtis, Jeffrey, Han, Meilan, Hansel, Nadia, Kanner, Richard, Martinez, Fernando, Paine, Robert, Tejwani, Vickram, Woodruff, Prescott, Zein, Joe, Hoffman, Eric, Peters, Stephen, Meyers, Deborah, Bleecker, Eugene, and Ortega, Victor

Subjects
COPD, alpha-1 antitrypsin, bronchiectasis, lung function
Abstract

RATIONALE: Bronchiectasis is common among those with heavy smoking histories, but risk factors for bronchiectasis, including alpha-1 antitrypsin deficiency, and its implications for COPD severity are uncharacterized in such individuals. OBJECTIVES: To characterize the impact of bronchiectasis on COPD and explore alpha-1antitrypsin as a risk factor for bronchiectasis. METHODS: SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) participants (N=914; ages 40-80 years; ≥20-pack-year smoking) had high-resolution computed tomography (CT) scans interpreted visually for bronchiectasis, based on airway dilation without fibrosis or cicatrization. We performed regression-based models of bronchiectasis with clinical outcomes and quantitative CT measures. We deeply sequenced the gene encoding -alpha-1 antitrypsin, SERPINA1, in 835 participants to test for rare variants, focusing on the PiZ genotype (Glu366Lys, rs28929474). MEASUREMENTS AND MAIN RESULTS: We identified bronchiectasis in 365 (40%) participants, more frequently in women (45% versus 36%, p=0.0045), older participants (mean age=66[standard deviation (SD)=8.3] versus 64[SD=9.1] years, p=0.0083), and those with lower lung function (forced expiratory volume in 1 second [FEV1 ] percentage predicted=66%[SD=27] versus 77%[SD=25], p

Published
2023

2. Disparities in access to food and chronic obstructive pulmonary disease (COPD)-related outcomes: a cross-sectional analysis

Author

Moughames, Eric, Woo, Han, Galiatsatos, Panagis, Romero-Rivero, Karina, Raju, Sarath, Tejwani, Vickram, Hoffman, Eric A, Comellas, Alejandro P, Ortega, Victor E, Parekh, Trisha, Krishnan, Jerry A, Drummond, Michael B, Couper, David, Buhr, Russell G, Paine, Robert, Kaufman, Joel D, Paulin, Laura M, Putcha, Nirupama, and Hansel, Nadia N

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Lung, Chronic Obstructive Pulmonary Disease, Clinical Research, Respiratory, Good Health and Well Being, Aged, Cross-Sectional Studies, Female, Food, Humans, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive, Access, COPD, Disparities, Food desert, Cardiorespiratory Medicine and Haematology, Respiratory System, Cardiovascular medicine and haematology
Abstract

BackgroundMillions of Americans are living in food deserts in the United States, however the role of the local food environment on COPD has not been studied. The aim of this study is to determine the association between food deserts and COPD-related outcomes.MethodIn this cross-sectional analysis we linked data collected from SPIROMICS (SubPopulations and InteRmediate Outcome Measures in COPD Study) between 2010 and 2015 and food desert data, defined as an underserved area that lacks access to affordable healthy foods, from the Food Access Research Atlas. COPD outcomes include percentage of predicted forced expiratory volume in one second (FEV1%), St. George's Respiratory Questionnaire (SGRQ), COPD Assessment Test (CAT), 6-min walk distance test (6MWD), exacerbations, and air trapping. We used generalized linear mixed models to evaluate the association between living in food deserts and respiratory outcomes, adjusting for age, gender, race, education, income, marital status, BMI, smoking status, pack years, and urban status RESULTS: Among 2713 participants, 22% lived in food deserts. Participants living in food deserts were less likely to be white and more likely to have a lower income than those who did not live in food deserts. In the adjusted model controlling for demographics and individual income, living in food deserts was associated lower FEV1% (β = - 2.51, P = 0.046), higher air trapping (β = 2.47, P = 0.008), worse SGRQ (β = 3.48, P = 0.001) and CAT (β = 1.20, P = 0.003) scores, and 56% greater odds of severe exacerbations (P = 0.004). Results were consistent when looking at food access alone, regardless of whether participants lived in low income areas.ConclusionsFindings suggest an independent association between food desert and food access alone with COPD outcomes. Health program planning may benefit from addressing disparities in access to food.

Published
2021

3. Emphysema Progression and Lung Function Decline Among Angiotensin Converting Enzyme Inhibitors and Angiotensin-Receptor Blockade Users in the COPDGene Cohort

Author

Tejwani, Vickram, Fawzy, Ashraf, Putcha, Nirupama, Castaldi, Peter J, Cho, Michael H, Pratte, Katherine A, Bhatt, Surya P, Lynch, David A, Humphries, Stephen M, Kinney, Gregory L, D’Alessio, Franco R, Hansel, Nadia N, Crapo, James D, Silverman, Edwin K, Make, Barry J, Regan, Elizabeth A, Beaty, Terri, Begum, Ferdouse, Cho, Michael, DeMeo, Dawn L, Boueiz, Adel R, Foreman, Marilyn G, Halper-Stromberg, Eitan, Hayden, Lystra P, Hersh, Craig P, Hetmanski, Jacqueline, Hobbs, Brian D, Hokanson, John E, Laird, Nan, Lange, Christoph, Lutz, Sharon M, McDonald, Merry-Lynn, Parker, Margaret M, Prokopenko, Dmitry, Qiao, Dandi, Regan, Elizabeth, Sakornsakolpat, Phuwanat, Wan, Emily S, Won, Sungho, Centeno, Juan Pablo, Charbonnier, Jean-Paul, Coxson, Harvey O, Galban, Craig J, Han, MeiLan K, Hoffman, Eric A, Humphries, Stephen, Jacobson, Francine L, Judy, Philip F, Kazerooni, Ella A, Kluiber, Alex, Nardelli, Pietro, Newell, John D, Notary, Aleena, Oh, Andrea, Ross, James C, San Jose Estepar, Raul, Schroeder, Joyce, Sieren, Jered, Stoel, Berend C, Tschirren, Juerg, Van Beek, Edwin, Ginneken, Bramvan, van Rikxoort, Eva, Sanchez-Ferrero, Gonzalo Vegas, Veitel, Lucas, Washko, George R, Wilson, Carla G, Jensen, Robert, Everett, Douglas, Crooks, Jim, Pratte, Katherine, Strand, Matt, Kinney, Gregory, Young, Kendra A, Bon, Jessica, Diaz, Alejandro A, Make, Barry, Murray, Susan, Soler, Xavier, Bowler, Russell P, Kechris, Katerina, Banaei-Kashani, Farnoush, Curtis, Jeffrey L, Pernicano, Perry G, Hanania, Nicola, Atik, Mustafa, Boriek, Aladin, Guntupalli, Kalpatha, and Guy, Elizabeth

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Clinical Research, Emphysema, Lung, Tobacco, Chronic Obstructive Pulmonary Disease, Tobacco Smoke and Health, Cancer, Respiratory, Aged, Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors, Cohort Studies, Disease Progression, Female, Forced Expiratory Volume, Humans, Lung Volume Measurements, Male, Middle Aged, Prospective Studies, Protective Factors, Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema, Spirometry, Tomography, X-Ray Computed, Vital Capacity, Walk Test, angiotensin II, COPD, emphysema progression, COPDGene Investigators, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundAttenuation of transforming growth factor β by blocking angiotensin II has been shown to reduce emphysema in a murine model. General population studies have demonstrated that the use of angiotensin converting enzyme inhibitors (ACEis) and angiotensin-receptor blockers (ARBs) is associated with reduction of emphysema progression in former smokers and that the use of ACEis is associated with reduction of FEV1 progression in current smokers.Research questionIs use of ACEi and ARB associated with less progression of emphysema and FEV1 decline among individuals with COPD or baseline emphysema?MethodsFormer and current smokers from the Genetic Epidemiology of COPD Study who attended baseline and 5-year follow-up visits, did not change smoking status, and underwent chest CT imaging were included. Adjusted linear mixed models were used to evaluate progression of adjusted lung density (ALD), percent emphysema (%total lung volume

Published
2021

7. Association of Insulin Resistance With Radiographic Lung Abnormalities and Incident Lung Disease: The Framingham Offspring Study.

Author

Raju, Sarath, Sierra, Paula, Tejwani, Vickram, Staggers, Kristen A., McCormack, Meredith, Villareal, Dennis T., Rosas, Ivan O., Hanania, Nicola A., and Wu, Tianshi David

Subjects
DISEASE risk factors, LUNG diseases, INSULIN resistance, COMPUTED tomography, ODDS ratio
Abstract

OBJECTIVE: Insulin resistance (IR) may be a risk factor for lung disease, but objective evidence is limited. We sought to define the relationship of longitudinal IR with radiographic imaging outcomes and examiner-identified incident lung disease in the Framingham Offspring Study. RESEARCH DESIGN AND METHODS: Participants without baseline lung disease underwent repeated measurements of fasting insulin and glucose levels over an average period of 13.6 years, from which time-weighted average HOMA-IR was calculated. Each participant then underwent a cardiac gated whole-lung computed tomography scan, which was analyzed for the presence of emphysema, interstitial lung abnormalities (ILAs), and quantitative airway features. Incident lung disease was determined by a study examiner. The relationship of HOMA-IR to these outcomes was estimated in models adjusted for demographics, BMI, and lifetime smoking. RESULTS: A total of 875 participants with longitudinal IR data and outcomes were identified. Their mean age was 51.5 years, and BMI was 26.7 kg/m2. HOMA-IR was temporally unstable, with a within-person SD approximately two-thirds of the between-person SD. In adjusted models, a 1 SD increase in log(HOMA-IR) z score was associated with higher odds of qualitative emphysema (odds ratio [OR] 1.33; 95% CI 1.04–1.70), ILAs (OR 1.35; 95% CI 1.05–1.74), and modest increases in airway wall thickness and wall area percentage. These radiographic findings were corroborated by a positive association of HOMA-IR with incident lung disease. CONCLUSIONS: IR is associated with radiographic lung abnormalities and incident lung disease. Deeper phenotyping is necessary to define mechanisms of IR-associated lung injury. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

8. Longitudinal Association Between Muscle Loss and Mortality in Ever Smokers

Author

Crapo, James D., Silverman, Edwin K., Cummings, Sara, Madden, Kelley, Make, Barry J., Nabbosa, Juliet, Port, Emily, Rashdi, Serine, Regan, Elizabeth A., Stepp, Lori, Watts, Shandi, Weaver, Michael, Beaty, Terri, Bowler, Russell P., Curtis, Jeffrey L., Han, MeiLan K., Hokanson, John E., Lynch, David A., Strand, Matthew J., Anderson, Gary, Bleecker, Eugene R., Coxson, Harvey O., Crystal, Ronald G., Hogg, James C., Province, Michael A., Rennard, Stephen I., Croxton, Thomas, Gan, Weiniu, Postow, Lisa A., Viviano, Lisa M., Costa-Davis, Corinne, Malanga, Elisha, Prieto, Delia, Tal-Singer, Ruth, Farzadegan, Homayoon, Hadji, Akila, Sathe, Leena, Baraghoshi, David, Chen, Grace, Crooks, James, Knowles, Ruthie, Pratte, Katherine, Wilson, Carla, Zelarney, Pearlanne T., Kechris, Katerina J., Leach, Sonia, Austin, Erin E., Czizik, Annika, Kinney, Gregory, Li, Yisha, Lutz, Sharon M., Ragland, Margaret F., Richmond, Nicole, Young, Kendra A., Cho, Michael, Castaldi, Peter J., Glass, Kimberly, Hersh, Craig, Kim, Wonji, Liu, Yang-Yu, Hersh, Craig P., Bidinger, Jacqueline, Cho, Michael H., Conrad, Douglas, DeMeo, Dawn L., El-Boueiz, Adel R., Foreman, Marilyn G., Ghosh, Auyon, Hahn, Georg, Hansel, Nadia N., Hayden, Lystra P., Hobbs, Brian, Kim, Woori, Lange, Christoph, McDonald, Merry- Lynn, McGeachie, Michael, Moll, Matthew, Morris, Melody, Patsopoulos, Nikolaos A., Qiao, Dandi, Ruczinski, Ingo, Wan, Emily S., Dy, Jennifer G., Fain, Sean B., Ginsburg, Shoshana, Hoffman, Eric A., Humphries, Stephen, Judy, Philip F., Stefanie Mason, Alex Kluiber, Oh, Andrea, Poynton, Clare, Reinhardt, Joseph M., Ross, James, San Jose Estepar, Raul, Schroeder, Joyce D., Sitek, Arkadiusz, Steiner, Robert M., van Beek, Edwin, Ginneken, Bram van, van Rikxoort, Eva, Washko, George R., Jensen, Robert, John E. Hokanson, Co-Chair, Bhatt, Surya P., Casaburi, Richard, Kim, Victor, Putcha, Nirupama, Han, MeiLan, Bon, Jessica, Diaz, Alejandro A., Regan, Elizabeth, Anzueto, Antonio, Bailey, William C., Criner, Gerard J., Dransfield, Mark T., Kinney, Greg, Sprenger, Kim, Benos, Takis, Hanania, Nicola A., Hoth, Karin F., Lambert, Allison, Lowe, Katherine, Oates, Gabriela, Parekh, Trisha, Westney, Gloria, Young, Kendra, Balasubramanian, Aparna, Boriek, Aladin, Fawzy, Ashraf, Jacobson, Francine, LaFon, David C., MacIntyre, Neil, Maselli-Caceres, Diego, McCormack, Meredith C., McDonald, Merry-Lynn, Sciurba, Frank, Soler, Xavier, Tejwani, Vickram, van Beek, Edwin JR., Wade, Raymond C., Wells, Mike, Wendt, Chris H., Yun, Jeong H., Zhang, Jingzhou, Gillenwater, Lucas, Lowe, Katherine E., Pratte, Katherine A., Ragland, Margaret, Attaway, Amy, Mason, Stefanie, Rossiter, Harry B., Saha, Punam Kumar, Wilson, Ava, Amaza, Hannatu, Baldomero, Adrienne, Mamary, A. James, O’Brien, James, Wise, Robert A., Eakin, Michelle, Fiedorowicz, Jess G., Henkle, Ben, Holm, Kristen, Iyer, Anand, Kunisaki, Ken M., McEvoy, Charlene, Mkorombindo, Takudzwa, Shinozaki, Gen, Yohannes, Abebaw, Hobbs, Brian D., Miller, Bruce E., Retson, Tara, McCloskey, Lisa, Pernicano, Perry G., Atik, Mustafa, Bertrand, Laura, Monaco, Thomas, Narendra, Dharani, Lenge de Rosen, Veronica V., Badu-Danso, Kwame, Jacobson, Francine L., Kaufman, Laura, Maguire, Cherie, Struble, Sophie, Wilson, Seth, Barr, R. Graham, Almonte, Casandra, Austin, John H.M., Gomez Blum, Maria Lorena, D’Souza, Belinda M., Florez, Emilay, Martinez, Rodney, MacIntyre, Neil, Jr., Curry, Wendy, McAdams, H. Page, Reikofski, Charlotte V., Washington, Lacey, Brown, Robert, Clare, Cheryl, Daniel, Marie, Horton, Karen, Ting “Tony” Lin, Cheng, Mirza, Tahira, Scott, Meagan, Shade, Becky, Budoff, Matt, Calmelat, Robert, Cavanaugh, Deborah, Dailing, Chris, Diaz, Leticia, Fischer, Hans, Indelicato, Renee Love, Porszasz, Janos, Soriano, April, Stringer, William, Urrutia, Miriam, Baldomero, Arianne, Bell, Brian, Deconcini, Miranda, Loes, Linda, Phelan, Jonathan, Robichaux, Camille, Sasse, Cheryl, Tashjian, Joseph H., Flenaugh, Eric L., Abson, Kema, Gebrekristos, Hirut, Johnson, Priscilla, Jordan, Jessica, Ponce, Mario, Terpenning, Silanath, Wilson, Derrick, Broadhurst, Grace, Dyer, Debra, Engel, Elena, Finigan, Jay, Hill, Andrew, Jones, Alex, Jones, Ryan, Owen, Jordan, Rosiello, Richard, Andries, Nicole, Charpentier, Mary, Kirk, Diane, Pace, David, Ciccolella, David, Cordova, Francis, Dass, Chandra, D’Alonzo, Gilbert, Davis, Valena, Desai, Parag, Fehrle, Dee, Grabianowski, Carla, Jacobs, Michael, Jameson, Laurie, Jones, Gayle M., Kelsen, Steven, Marchetti, Nathaniel, McGonagle, Francine, Satti, Aditi, Shenoy, Kartik, Sheridan, Regina, Vega-Sanchez, Maria, Wallace, Samantha, Akinseye-kolapo, Samuel, Baker, Matthew, Goggins, Arnissa, McClain, Anny, Nath, Hrudaya, Singh, Satinder P., Sonavane, Sushil K., Westfall, Elizabeth, Gil, Marissa, El Hajjaoui, Tarek, Hsiao, Albert, Martineau, Amber, Mielke, Jenna, Perez, Karl, Querido, Gabriel, Reston, Tara, Yen, Andrew, Comellas, Alejandro, Fortis, Spyridon, Galizia, Mauricio, Garcia, Eric, Keating, Janet, Laroia, Archana, Lee, Changhyun, Meyer, Amber, Mullan, Brian, Nagpal, Prashant, Ofori, Oloigbe, Suiter, Sierra, Mason, Stefanie E., Moreta-Martinez, Rafael, Labaki, Wassim W., San Jose Estepar, Ruben, Make, Barry, and Stringer, Kathleen

Published
2022
Full Text
View/download PDF

9. Black carbon content in airway macrophages is associated with increased severe exacerbations and worse COPD morbidity in SPIROMICS

Author

Tejwani, Vickram, Woo, Han, Liu, Chen, Tillery, Anna K., Gassett, Amanda J., Kanner, Richard E., Hoffman, Eric A., Martinez, Fernando J., Woodruff, Prescott G., Barr, R. Graham, Fawzy, Ashraf, Koehler, Kirsten, Curtis, Jeffrey L., Freeman, Christine M., Cooper, Christopher B., Comellas, Alejandro P., Pirozzi, Cheryl, Paine, Robert, Tashkin, Donald, Krishnan, Jerry A., Sack, Coralynn, Putcha, Nirupama, Paulin, Laura M., Zusman, Marina, Kaufman, Joel D., Alexis, Neil E., and Hansel, Nadia N.

Published
2022
Full Text
View/download PDF

10. Emphysema Progression and Lung Function Decline Among Angiotensin Converting Enzyme Inhibitors and Angiotensin-Receptor Blockade Users in the COPDGene Cohort

Author

Crapo, James D., Silverman, Edwin K., Make, Barry J., Regan, Elizabeth A., Beaty, Terri, Begum, Ferdouse, Castaldi, Peter J., Cho, Michael, DeMeo, Dawn L., Boueiz, Adel R., Foreman, Marilyn G., Halper-Stromberg, Eitan, Hayden, Lystra P., Hersh, Craig P., Hetmanski, Jacqueline, Hobbs, Brian D., Hokanson, John E., Laird, Nan, Lange, Christoph, Lutz, Sharon M., McDonald, Merry-Lynn, Parker, Margaret M., Prokopenko, Dmitry, Qiao, Dandi, Sakornsakolpat, Phuwanat, Wan, Emily S., Won, Sungho, Centeno, Juan Pablo, Charbonnier, Jean-Paul, Coxson, Harvey O., Galban, Craig J., Han, MeiLan K., Hoffman, Eric A., Humphries, Stephen, Jacobson, Francine L., Judy, Philip F., Kazerooni, Ella A., Kluiber, Alex, Lynch, David A., Nardelli, Pietro, Newell, John D., Jr., Notary, Aleena, Oh, Andrea, Ross, James C., San Jose Estepar, Raul, Schroeder, Joyce, Sieren, Jered, Stoel, Berend C., Tschirren, Juerg, Van Beek, Edwin, Ginneken, Bramvan, van Rikxoort, Eva, Sanchez-Ferrero, Gonzalo Vegas, Veitel, Lucas, Washko, George R., Wilson, Carla G., Jensen, Robert, Everett, Douglas, Crooks, Jim, Pratte, Katherine, Strand, Matt, Kinney, Gregory, Young, Kendra A., Bhatt, Surya P., Bon, Jessica, Diaz, Alejandro A., Make, Barry, Murray, Susan, Regan, Elizabeth, Soler, Xavier, Bowler, Russell P., Kechris, Katerina, Banaei-Kashani, Farnoush, Curtis, Jeffrey L., Pernicano, Perry G., Hanania, Nicola, Atik, Mustafa, Boriek, Aladin, Guntupalli, Kalpatha, Guy, Elizabeth, Parulekar, Amit, Hersh, Craig, Washko, George, Barr, R. Graham, Austin, John, D’Souza, Belinda, Thomashow, Byron, MacIntyre, Neil, Jr., McAdams, H. Page, Washington, Lacey, Flenaugh, Eric, Terpenning, Silanth, McEvoy, Charlene, Tashjian, Joseph, Wise, Robert, Brown, Robert, Hansel, Nadia N., Horton, Karen, Lambert, Allison, Putcha, Nirupama, Casaburi, Richard, Adami, Alessandra, Budoff, Matthew, Fischer, Hans, Porszasz, Janos, Rossiter, Harry, Stringer, William, Sharafkhaneh, Amir, Lan, Charlie, Wendt, Christine, Bell, Brian, Kunisaki, KenM., Bowler, Russell, Rosiello, Richard, Pace, David, Criner, Gerard, Ciccolella, David, Cordova, Francis, Dass, Chandra, D’Alonzo, Gilbert, Desai, Parag, Jacobs, Michael, Kelsen, Steven, Kim, Victor, Mamary, A. James, Marchetti, Nathaniel, Satti, Aditi, Shenoy, Kartik, Steiner, Robert M., Swift, Alex, Swift, Irene, Vega-Sanchez, Maria Elena, Dransfield, Mark, Bailey, William, Iyer, Anand, Nath, Hrudaya, Wells, J. Michael, Conrad, Douglas, Yen, Andrew, Comellas, Alejandro P., Hoth, Karin F., Newell, John, Jr., Thompson, Brad, Kazerooni, Ella, Labaki, Wassim, Galban, Craig, Vummidi, Dharshan, Billings, Joanne, Begnaud, Abbie, Allen, Tadashi, Sciurba, Frank, Chandra, Divay, Fuhrman, Carl, Weissfeld, Joel, Tejwani, Vickram, Fawzy, Ashraf, Cho, Michael H., Pratte, Katherine A., Humphries, Stephen M., Kinney, Gregory L., and D’Alessio, Franco R.

Published
2021
Full Text
View/download PDF

13. The Neutrophil-to-Lymphocyte Ratio as a Predictor of Acute Exacerbations Among Patients With COPD in Uganda

Author

Alupo, Patricia, primary, Katagira, Winceslaus, additional, Mukunya, David, additional, Okimat, Paul, additional, Tejwani, Vickram, additional, Kayongo, Alex, additional, Nalunjogi, Joanitah, additional, Robertson, Nicole M., additional, Jones, Rupert, additional, Hurst, John R., additional, Kirenga, Bruce, additional, and Siddharthan, Trishul, additional

Published
2024
Full Text
View/download PDF

16. Functional imaging for assessing regional lung ventilation in preclinical and clinical research

Author

Karmali, Dipan, primary, Sowho, Mudiaga, additional, Bose, Sonali, additional, Pearce, Jackson, additional, Tejwani, Vickram, additional, Diamant, Zuzana, additional, Yarlagadda, Keerthi, additional, Ponce, Erick, additional, Eikelis, Nina, additional, Otvos, Tamas, additional, Khan, Akram, additional, Lester, Michael, additional, Fouras, Andreas, additional, Kirkness, Jason, additional, and Siddharthan, Trishul, additional

Published
2023
Full Text
View/download PDF

18. Imaging-derived biomarkers in Asthma: Current status and future perspectives

Author

Onderzoek Beeld, Cancer, Researchgr. Systems Radiology, MS Radiologie, Pompe, Esther, Kwee, Anastasia Kal, Tejwani, Vickram, Siddharthan, Trishul, Mohamed Hoesein, Firdaus Aa, Onderzoek Beeld, Cancer, Researchgr. Systems Radiology, MS Radiologie, Pompe, Esther, Kwee, Anastasia Kal, Tejwani, Vickram, Siddharthan, Trishul, and Mohamed Hoesein, Firdaus Aa

Published
2023

26. Longitudinal Association Between Muscle Loss and Mortality in Ever Smokers

Author

Mason, Stefanie E., primary, Moreta-Martinez, Rafael, additional, Labaki, Wassim W., additional, Strand, Matthew J., additional, Regan, Elizabeth A., additional, Bon, Jessica, additional, San Jose Estepar, Ruben, additional, Casaburi, Richard, additional, McDonald, Merry-Lynn, additional, Rossiter, Harry B., additional, Make, Barry, additional, Dransfield, Mark T., additional, Han, MeiLan K., additional, Young, Kendra, additional, Curtis, Jeffrey L., additional, Stringer, Kathleen, additional, Kinney, Greg, additional, Hokanson, John E., additional, San Jose Estepar, Raul, additional, Washko, George R., additional, Crapo, James D., additional, Silverman, Edwin K., additional, Cummings, Sara, additional, Madden, Kelley, additional, Make, Barry J., additional, Nabbosa, Juliet, additional, Port, Emily, additional, Rashdi, Serine, additional, Stepp, Lori, additional, Watts, Shandi, additional, Weaver, Michael, additional, Beaty, Terri, additional, Bowler, Russell P., additional, Lynch, David A., additional, Anderson, Gary, additional, Bleecker, Eugene R., additional, Coxson, Harvey O., additional, Crystal, Ronald G., additional, Hogg, James C., additional, Province, Michael A., additional, Rennard, Stephen I., additional, Croxton, Thomas, additional, Gan, Weiniu, additional, Postow, Lisa A., additional, Viviano, Lisa M., additional, Costa-Davis, Corinne, additional, Malanga, Elisha, additional, Prieto, Delia, additional, Tal-Singer, Ruth, additional, Farzadegan, Homayoon, additional, Hadji, Akila, additional, Sathe, Leena, additional, Baraghoshi, David, additional, Chen, Grace, additional, Crooks, James, additional, Knowles, Ruthie, additional, Pratte, Katherine, additional, Wilson, Carla, additional, Zelarney, Pearlanne T., additional, Kechris, Katerina J., additional, Leach, Sonia, additional, Austin, Erin E., additional, Czizik, Annika, additional, Kinney, Gregory, additional, Li, Yisha, additional, Lutz, Sharon M., additional, Ragland, Margaret F., additional, Richmond, Nicole, additional, Young, Kendra A., additional, Cho, Michael, additional, Castaldi, Peter J., additional, Glass, Kimberly, additional, Hersh, Craig, additional, Kim, Wonji, additional, Liu, Yang-Yu, additional, Hersh, Craig P., additional, Bidinger, Jacqueline, additional, Cho, Michael H., additional, Conrad, Douglas, additional, DeMeo, Dawn L., additional, El-Boueiz, Adel R., additional, Foreman, Marilyn G., additional, Ghosh, Auyon, additional, Hahn, Georg, additional, Hansel, Nadia N., additional, Hayden, Lystra P., additional, Hobbs, Brian, additional, Kim, Woori, additional, Lange, Christoph, additional, McDonald, Merry- Lynn, additional, McGeachie, Michael, additional, Moll, Matthew, additional, Morris, Melody, additional, Patsopoulos, Nikolaos A., additional, Qiao, Dandi, additional, Ruczinski, Ingo, additional, Wan, Emily S., additional, Dy, Jennifer G., additional, Fain, Sean B., additional, Ginsburg, Shoshana, additional, Hoffman, Eric A., additional, Humphries, Stephen, additional, Judy, Philip F., additional, Stefanie Mason, Alex Kluiber, additional, Oh, Andrea, additional, Poynton, Clare, additional, Reinhardt, Joseph M., additional, Ross, James, additional, Schroeder, Joyce D., additional, Sitek, Arkadiusz, additional, Steiner, Robert M., additional, van Beek, Edwin, additional, Ginneken, Bram van, additional, van Rikxoort, Eva, additional, Jensen, Robert, additional, John E. Hokanson, Co-Chair:, additional, Bhatt, Surya P., additional, Kim, Victor, additional, Putcha, Nirupama, additional, Han, MeiLan, additional, Diaz, Alejandro A., additional, Regan, Elizabeth, additional, Anzueto, Antonio, additional, Bailey, William C., additional, Criner, Gerard J., additional, Sprenger, Kim, additional, Benos, Takis, additional, Hanania, Nicola A., additional, Hoth, Karin F., additional, Lambert, Allison, additional, Lowe, Katherine, additional, Oates, Gabriela, additional, Parekh, Trisha, additional, Westney, Gloria, additional, Balasubramanian, Aparna, additional, Boriek, Aladin, additional, Fawzy, Ashraf, additional, Jacobson, Francine, additional, LaFon, David C., additional, MacIntyre, Neil, additional, Maselli-Caceres, Diego, additional, McCormack, Meredith C., additional, Sciurba, Frank, additional, Soler, Xavier, additional, Tejwani, Vickram, additional, van Beek, Edwin JR., additional, Wade, Raymond C., additional, Wells, Mike, additional, Wendt, Chris H., additional, Yun, Jeong H., additional, Zhang, Jingzhou, additional, Gillenwater, Lucas, additional, Lowe, Katherine E., additional, Pratte, Katherine A., additional, Ragland, Margaret, additional, Attaway, Amy, additional, Mason, Stefanie, additional, Saha, Punam Kumar, additional, Wilson, Ava, additional, Amaza, Hannatu, additional, Baldomero, Adrienne, additional, Mamary, A. James, additional, O’Brien, James, additional, Wise, Robert A., additional, Eakin, Michelle, additional, Fiedorowicz, Jess G., additional, Henkle, Ben, additional, Holm, Kristen, additional, Iyer, Anand, additional, Kunisaki, Ken M., additional, McEvoy, Charlene, additional, Mkorombindo, Takudzwa, additional, Shinozaki, Gen, additional, Yohannes, Abebaw, additional, Hobbs, Brian D., additional, Miller, Bruce E., additional, Retson, Tara, additional, McCloskey, Lisa, additional, Pernicano, Perry G., additional, Atik, Mustafa, additional, Bertrand, Laura, additional, Monaco, Thomas, additional, Narendra, Dharani, additional, Lenge de Rosen, Veronica V., additional, Badu-Danso, Kwame, additional, Jacobson, Francine L., additional, Kaufman, Laura, additional, Maguire, Cherie, additional, Struble, Sophie, additional, Wilson, Seth, additional, Barr, R. Graham, additional, Almonte, Casandra, additional, Austin, John H.M., additional, Gomez Blum, Maria Lorena, additional, D’Souza, Belinda M., additional, Florez, Emilay, additional, Martinez, Rodney, additional, Curry, Wendy, additional, McAdams, H. Page, additional, Reikofski, Charlotte V., additional, Washington, Lacey, additional, Brown, Robert, additional, Clare, Cheryl, additional, Daniel, Marie, additional, Horton, Karen, additional, Ting “Tony” Lin, Cheng, additional, Mirza, Tahira, additional, Scott, Meagan, additional, Shade, Becky, additional, Budoff, Matt, additional, Calmelat, Robert, additional, Cavanaugh, Deborah, additional, Dailing, Chris, additional, Diaz, Leticia, additional, Fischer, Hans, additional, Indelicato, Renee Love, additional, Porszasz, Janos, additional, Soriano, April, additional, Stringer, William, additional, Urrutia, Miriam, additional, Baldomero, Arianne, additional, Bell, Brian, additional, Deconcini, Miranda, additional, Loes, Linda, additional, Phelan, Jonathan, additional, Robichaux, Camille, additional, Sasse, Cheryl, additional, Tashjian, Joseph H., additional, Flenaugh, Eric L., additional, Abson, Kema, additional, Gebrekristos, Hirut, additional, Johnson, Priscilla, additional, Jordan, Jessica, additional, Ponce, Mario, additional, Terpenning, Silanath, additional, Wilson, Derrick, additional, Broadhurst, Grace, additional, Dyer, Debra, additional, Engel, Elena, additional, Finigan, Jay, additional, Hill, Andrew, additional, Jones, Alex, additional, Jones, Ryan, additional, Owen, Jordan, additional, Rosiello, Richard, additional, Andries, Nicole, additional, Charpentier, Mary, additional, Kirk, Diane, additional, Pace, David, additional, Ciccolella, David, additional, Cordova, Francis, additional, Dass, Chandra, additional, D’Alonzo, Gilbert, additional, Davis, Valena, additional, Desai, Parag, additional, Fehrle, Dee, additional, Grabianowski, Carla, additional, Jacobs, Michael, additional, Jameson, Laurie, additional, Jones, Gayle M., additional, Kelsen, Steven, additional, Marchetti, Nathaniel, additional, McGonagle, Francine, additional, Satti, Aditi, additional, Shenoy, Kartik, additional, Sheridan, Regina, additional, Vega-Sanchez, Maria, additional, Wallace, Samantha, additional, Akinseye-kolapo, Samuel, additional, Baker, Matthew, additional, Goggins, Arnissa, additional, McClain, Anny, additional, Nath, Hrudaya, additional, Singh, Satinder P., additional, Sonavane, Sushil K., additional, Westfall, Elizabeth, additional, Gil, Marissa, additional, El Hajjaoui, Tarek, additional, Hsiao, Albert, additional, Martineau, Amber, additional, Mielke, Jenna, additional, Perez, Karl, additional, Querido, Gabriel, additional, Reston, Tara, additional, Yen, Andrew, additional, Comellas, Alejandro, additional, Fortis, Spyridon, additional, Galizia, Mauricio, additional, Garcia, Eric, additional, Keating, Janet, additional, Laroia, Archana, additional, Lee, Changhyun, additional, Meyer, Amber, additional, Mullan, Brian, additional, Nagpal, Prashant, additional, Ofori, Oloigbe, additional, and Suiter, Sierra, additional

Published
2022
Full Text
View/download PDF

33. Black Carbon Content in Airway Macrophages is Associated with Reduced CD80 Expression and Increased Exacerbations in Former Smokers With COPD

Author

Tejwani, Vickram, primary, Moughames, Eric, additional, Suresh, Karthik, additional, Tang, Shih-En, additional, Mair, Laura G., additional, Romero, Karina, additional, Putcha, Nirupama, additional, Alexis, Neil E., additional, Woo, Han, additional, D’Alessio, Franco R., additional, and Hansel, Nadia N., additional

Published
2021
Full Text
View/download PDF

37. Dexamethasone-Induced FKBP51 Expression in CD4+ T-Lymphocytes Is Uniquely Associated With Worse Asthma Control in Obese Children With Asthma.

Author

Tejwani, Vickram, McCormack, Amanda, Suresh, Karthik, Woo, Han, Xu, Ningchun, Davis, Meghan F., Brigham, Emily, Hansel, Nadia N., McCormack, Meredith C., and D'Alessio, Franco R.

Subjects
OVERWEIGHT children, MONONUCLEAR leukocytes, ASTHMA in children, T cells, LYMPHOCYTE subsets, WHEEZE
Abstract

Introduction: There is evidence that obesity, a risk factor for asthma severity and morbidity, has a unique asthma phenotype which is less atopic and less responsive to inhaled corticosteroids (ICS). Peripheral blood mononuclear cells (PBMC) are important to the immunologic pathways of obese asthma and steroid resistance. However, the cellular source associated with steroid resistance has remained elusive. We compared the lymphocyte landscape among obese children with asthma to matched normal weight children with asthma and assessed relationship to asthma control. Methods: High-dimensional flow cytometry of PBMC at baseline and after dexamethasone stimulation was performed to characterize lymphocyte subpopulations, T-lymphocyte polarization, proliferation (Ki-67+), and expression of the steroid-responsive protein FK506-binding protein 51 (FKBP51). T-lymphocyte populations were compared between obese and normal-weight participants, and an unbiased, unsupervised clustering analysis was performed. Differentially expressed clusters were compared with asthma control, adjusted for ICS and exhaled nitric oxide. Results: In the obese population, there was an increased cluster of CD4+ T-lymphocytes expressing Ki-67 and FKBP51 at baseline and CD4+ T-lymphocytes expressing FKBP51 after dexamethasone stimulation. CD4+ Ki-67 and FKBP51 expression at baseline showed no association with asthma control. Dexamethasone-induced CD4+ FKBP51 expression was associated with worse asthma control in obese participants with asthma. FKBP51 expression in CD8+ T cells and CD19+ B cells did not differ among groups, nor did polarization profiles for Th1, Th2, Th9, or Th17 percentage. Discussion: Dexamethasone-induced CD4+ FKBP51 expression is uniquely associated with worse asthma control in obese children with asthma and may underlie the corticosteroid resistance observed in this population. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

38. The Transcriptional Signature in Alveolar Macrophages Dictates Acute Respiratory Distress Outcomes

Author

Tejwani, Vickram and D’Alessio, Franco R.

Subjects
Pulmonary and Respiratory Medicine, Respiratory Distress Syndrome, 0303 health sciences, business.industry, Editorials, MEDLINE, Original Articles, Acute respiratory distress, Critical Care and Intensive Care Medicine, Bioinformatics, 03 medical and health sciences, Dyspnea, 0302 clinical medicine, Text mining, 030228 respiratory system, Macrophages, Alveolar, Humans, Medicine, business, Bronchoalveolar Lavage Fluid, 030304 developmental biology
Abstract

Rationale: Serial measurements of alveolar macrophage (AM) transcriptional changes in patients with acute respiratory distress syndrome (ARDS) could identify cell-specific biological programs that are associated with clinical outcomes. Objectives: To determine whether AM transcriptional programs are associated with prolonged mechanical ventilation and 28-day mortality in individuals with ARDS. Methods: We performed genome-wide transcriptional profiling of AMs purified from BAL fluid collected from 35 subjects with ARDS. Cells were obtained at baseline (Day 1), Day 4, and Day 8 after ARDS onset (N = 68 total samples). We identified biological pathways that were enriched at each time point in subjects alive and extubated within 28 days after ARDS onset (alive/extubated(Day28)) versus those dead or persistently supported on mechanical ventilation at Day 28 (dead/intubated(Day28)). Measurements and Main Results: “M1-like” (classically activated) and proinflammatory gene sets such as IL-6/JAK/STAT5 (Janus kinase/signal transducer and activator of transcription 5) signaling were significantly enriched in AMs isolated on Day 1 in alive/extubated(Day28) versus dead/intubated(Day28) subjects. In contrast, by Day 8, many of these same proinflammatory gene sets were enriched in AMs collected from dead/intubated(Day28) compared with alive/extubated(Day28) subjects. Serially sampled alive/extubated(Day28) subjects were characterized by an AM temporal expression pattern of Day 1 enrichment of innate immune programs followed by prompt downregulation on Days 4 and 8. Dead/intubated(Day28) subjects exhibited an opposite pattern, characterized by progressive upregulation of proinflammatory programs over the course of ARDS. The relationship between AM expression profiles and 28-day clinical status was distinct in subjects with direct (pulmonary) versus indirect (extrapulmonary) ARDS. Conclusions: Clinical outcomes in ARDS are associated with highly distinct AM transcriptional programs.

Published
2019
Full Text
View/download PDF

41. The asthma evidence base: a call for core outcomes in interventional trials.

Author

Tejwani, Vickram, Chang, Hsing-Yuan, Tran, Annie P., Moloney, Rachael M., and Khatri, Sumita B.

Subjects
*ASTHMA, *ASTHMATICS, *BIOTHERAPY, *QUALITY of life, *DISEASE exacerbation
Abstract

Biologic therapies are emerging as an option to treat a subset of patients with severe asthma, however no direct comparison between these agents has been conducted. Furthermore, heterogeneity of outcomes in clinical trials makes it difficult to compare these agents and traditional therapies. The extent to which this heterogeneity exists has major implications for evidence-based decisions and is yet to be fully reported. We conducted a literature search to examine outcomes currently being used in clinical trials for asthma. The Cochrane Library and Clinicaltrials.gov were searched for clinical trials of asthma interventions. We limited our search to phase 2 through 4 clinical trials in adults, as early-phase trials tend to have pharmacodynamic and pharmacokinetic endpoints as primary outcomes. Interventions for acute exacerbations were excluded. We identified 117 studies and subsequently identified 111 outcomes. The most prevalent outcomes were asthma control and symptom severity, FEV1, and change in ACQ scale. Twenty patient-reported outcomes instruments were identified and de-facto standard asthma outcomes and PROs were under-reported in examined literature. Existing quality of life tools did not capture the day-to-day experience or the unique treatment burden from oral corticosteroids for patient with severe asthma. Compounding the absence of trials directly comparing therapies, the significant variation we identified in outcome definitions and measurement create hurdles to effectively compare traditional and biologic therapies. With the growing number of clinical trials evaluating advanced therapies such as biologics, a wide range of primary and secondary outcomes are evaluated. A core outcome set created by relevant stakeholders is needed to collectively evaluate pooled outcomes in order to allow more meaningful comparisons of asthma therapies and to incorporate the patient experience. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

48. Issues surrounding end-of-life decision-making

Author

Qian, Qi, Tejwani,Vickram, Bannon,Michael, Seggura,Luis, Serrano,Sabrina, and Wu,YiFan

Subjects
Patient Preference and Adherence
Abstract

Vickram Tejwani,1,* YiFan Wu,1,* Sabrina Serrano,2 Luis Segura,2 Michael Bannon,3 Qi Qian1 1Department of Medicine, Division of Nephrology and Hypertension, 2Mayo Graduate School, 3Department of Trauma, Critical Care, and General Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA *These authors contributed equally to this work Abstract: End-of-life decision-making is a complex process that can be extremely challenging. We describe a 42-year-old woman in an irreversible coma without an advance directive. The case serves to illustrate the complications that can occur in end-of-life decision-making and challenges in resolving difficult futility disputes. We review the role of advance directives in planning end-of-life care, the responsibility and historical performance of patient surrogates, the genesis of futility disputes, and approaches to resolving disputes. Keywords: end-of-life care, advance directive, surrogate, futility dispute, conflict resolution

Published
2013

49. Preserved Ratio Impaired Spirometry (PRISm) Prevalence, Risk Factors, and Outcomes: A Systematic Review and Meta-Analysis

Author

Robertson, Nicole M., Centner, Connor S., Tejwani, Vickram, Hossen, Shakir, Karmali, Dipan, Lu, Sibei, and Siddharthan, Trishul

Abstract

The prevalence of chronic respiratory diseases is increasing globally. There is evidence that those with spirometric impairment, and no evidence of obstruction, termed preserved ratio impaired spirometry (PRISm), have increased risk of morbidity and mortality, compared to those with normal lung function. There remain several gaps in characterizing PRISm.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results