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3,200 results on '"Tanaka, Nobuyuki"'

2. Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration

Author

Lawrence, Jessica A, Aguilar-Calvo, Patricia, Ojeda-Juárez, Daniel, Khuu, Helen, Soldau, Katrin, Pizzo, Donald P, Wang, Jin, Malik, Adela, Shay, Timothy F, Sullivan, Erin E, Aulston, Brent, Song, Seung Min, Callender, Julia A, Sanchez, Henry, Geschwind, Michael D, Roy, Subhojit, Rissman, Robert A, Trejo, JoAnn, Tanaka, Nobuyuki, Wu, Chengbiao, Chen, Xu, Patrick, Gentry N, and Sigurdson, Christina J

Subjects
Biomedical and Clinical Sciences, Neurosciences, Acquired Cognitive Impairment, Dementia, Emerging Infectious Diseases, Neurodegenerative, Rare Diseases, Transmissible Spongiform Encephalopathy (TSE), Infectious Diseases, Aging, Brain Disorders, 2.1 Biological and endogenous factors, Neurological, Male, Female, Mice, Humans, Animals, Prions, Prion Proteins, Receptors, AMPA, Neurons, Prion Diseases, Neurodegenerative Diseases, Endosomal Sorting Complexes Required for Transport, amyloid, ESCRT, neurodegeneration, proteostasis, synapse, ubiquitin, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

Endolysosomal defects in neurons are central to the pathogenesis of prion and other neurodegenerative disorders. In prion disease, prion oligomers traffic through the multivesicular body (MVB) and are routed for degradation in lysosomes or for release in exosomes, yet how prions impact proteostatic pathways is unclear. We found that prion-affected human and mouse brain showed a marked reduction in Hrs and STAM1 (ESCRT-0), which route ubiquitinated membrane proteins from early endosomes into MVBs. To determine how the reduction in ESCRT-0 impacts prion conversion and cellular toxicity in vivo, we prion-challenged conditional knockout mice (male and female) having Hrs deleted from neurons, astrocytes, or microglia. The neuronal, but not astrocytic or microglial, Hrs-depleted mice showed a shortened survival and an acceleration in synaptic derangements, including an accumulation of ubiquitinated proteins, deregulation of phosphorylated AMPA and metabotropic glutamate receptors, and profoundly altered synaptic structure, all of which occurred later in the prion-infected control mice. Finally, we found that neuronal Hrs (nHrs) depletion increased surface levels of the cellular prion protein, PrPC, which may contribute to the rapidly advancing disease through neurotoxic signaling. Taken together, the reduced Hrs in the prion-affected brain hampers ubiquitinated protein clearance at the synapse, exacerbates postsynaptic glutamate receptor deregulation, and accelerates neurodegeneration.SIGNIFICANCE STATEMENT Prion diseases are rapidly progressive neurodegenerative disorders characterized by prion aggregate spread through the central nervous system. Early disease features include ubiquitinated protein accumulation and synapse loss. Here, we investigate how prion aggregates alter ubiquitinated protein clearance pathways (ESCRT) in mouse and human prion-infected brain, discovering a marked reduction in Hrs. Using a prion-infection mouse model with neuronal Hrs (nHrs) depleted, we show that low neuronal Hrs is detrimental and markedly shortens survival time while accelerating synaptic derangements, including ubiquitinated protein accumulation, indicating that Hrs loss exacerbates prion disease progression. Additionally, Hrs depletion increases the surface distribution of prion protein (PrPC), linked to aggregate-induced neurotoxic signaling, suggesting that Hrs loss in prion disease accelerates disease through enhancing PrPC-mediated neurotoxic signaling.

Published
2023

4. What's Next? Lessons on Education Recovery: Findings from a Survey of Ministries of Education amid the COVID-19 Pandemic

Author

United Nations Educational, Scientific, and Cultural Organization (UNESCO), Institute for Statistics (UIS) (Canada), UNICEF Office of Research – Innocenti (Italy), United Nations Children's Fund (UNICEF), World Bank, Organisation for Economic Cooperation and Development (OECD) (France), Chang, Gwang-Chol, Eck, Matthias, McOmish, Elspeth, Sass, Justine, Vargas Tamez, Carlos, Wallet, Peter, Imhof, Adolfo Gustavo, Montoya, Silvia, Li, Yifan, Antoninis, Manos, Murakami, Yuki, Zekrya, Lema, Dewan, Pragya, Mishra, Sakshi, Mizunoya, Suguru, Onam, Oscar, Reuge, Nicolas, Yao, Haogen, Yameogo, Jean Luc, Brossard, Matt, Dreesen, Thomas, Dsouza, Andrea, Jeon, Youngkwang, Kamei, Akito, Nagesh, Radhika, Nugroho, Anindita, Pontuschka, Rafael, Akmal, Maryam, Azevedo, João Pedro, Azzi-Huck, Kaliope, Cobo, Cristobal, Gilberto, Alison, Holla, Alaka, Shmis, Tigran, Tanaka, Nobuyuki, Wong, Yi Ning, Carvalho, António, Charbonnier, Eric, Doumet, Marie-Hélène, and Heckmann, Corinne

Abstract

United Nations Educational, Scientific and Cultural Organization (UNESCO), the United Nations Children's Fund (UNICEF), the World Bank and the Organisation for Economic Co-operation and Development (OECD) have collaborated in the third round of the Survey on National Education Responses to COVID-19 School Closures, administered by the UNESCO Institute for Statistics (UIS) and OECD to Ministry of Education officials. The questions covered four levels of education: preprimary, primary, lower secondary and upper secondary. While the first two rounds of the survey were implemented during the periods May-June and July-October 2020, respectively, the third round was implemented during the period February-June 2021. In total, 143 countries responded to the questionnaire. Thirty-one countries submitted responses to the OECD ("OECD survey") and 112 countries responded to the UIS ("UIS survey"). Seven countries responded to both surveys. In these instances, the more complete set responses were used in analysis.

Published
2021

5. Integrating a Manual Pipette into a Collaborative Robot Manipulator for Flexible Liquid Dispensing

Author

Zhang, Junbo, Wan, Weiwei, Tanaka, Nobuyuki, Fujita, Miki, and Harada, Kensuke

Subjects
Computer Science - Robotics
Abstract

This paper presents a system integration approach for a 6-DoF (Degree of Freedom) collaborative robot to operate a pipette for liquid dispensing. Its technical development is threefold. First, we designed an end-effector for holding and triggering manual pipettes. Second, we took advantage of a collaborative robot to recognize labware poses and planned robotic motion based on the recognized poses. Third, we developed vision-based classifiers to predict and correct positioning errors and thus precisely attached pipettes to disposable tips. Through experiments and analysis, we confirmed that the developed system, especially the planning and visual recognition methods, could help secure high-precision and flexible liquid dispensing. The developed system is suitable for low-frequency, high-repetition biochemical liquid dispensing tasks. We expect it to promote the deployment of collaborative robots for laboratory automation and thus improve the experimental efficiency without significantly customizing a laboratory environment.

Published
2022

19. Call for emergency action to restore dietary diversity and protect global food systems in times of COVID-19 and beyond: Results from a cross-sectional study in 38 countries

Author

Bergheim, Ina, Staltner, Raphaela, Devine, Amanda, Sambell, Ros, Wallace, Ruth, Allehdan, Sabika Salem, Alalwan, Tariq Abdulkarim, Al-Mannai, Mariam Ahamad, Ouvrein, Gaëlle, Poels, Karolien, Vandebosch, Heidi, Maldoy, Katrien, Matthys, Christophe, Smits, Tim, Vrinten, Jules, DeSmet, Ann, Teughels, Nelleke, Geuens, Maggie, Vermeir, Iris, Proesmans, Viktor, Hudders, Liselot, De Barcellos, Marcia Dutra, Ostermann, Cristina, Brock, Ana Luiza, Favieiro, Cynthia, Trizotto, Rafaela, Stangherlin, Isadora, Mafra, Anthonieta Looman, Correa Varella, Marco Antônio, Valentova, Jaroslava Varella, Fisher, Maryanne L., MacEacheron, Melanie, White, Katherine, Habib, Rishad, Dobson, David S., Schnettler, Berta, Orellana, Ligia, Miranda-Zapata, Edgardo, Wen-Yu Chang, Angela, Jiao, Wen, Liu, Matthew Tingchi, Grunert, Klaus G., Christensen, Rikke Nyland, Reisch, Lucia, Janssen, Meike, Abril-Ulloa, Victoria, Encalada, Lorena, Kamel, Iman, Vainio, Annukka, Niva, Mari, Salmivaara, Laura, Mäkelä, Johanna, Torkkeli, Kaisa, Mai, Robert, Risch, Pamela Kerschke, Altsitsiadis, Efthymios, Stamos, Angelos, Antronikidis, Andreas, Henchion, Maeve, McCarthy, Sinead, McCarthy, Mary, Micalizzi, Alessandra, Schulz, Peter J., Farinosi, Manuela, Komatsu, Hidenori, Tanaka, Nobuyuki, Kubota, Hiromi, Tayyem, Reema, Al-Awwad, Narmeen J., Al-Bayyari, Nahla, Ibrahim, Mohammed O., Hammouh, Fadwa, Dashti, Somaia, Dashti, Basma, Alkharaif, Dhuha, Alshatti, Amani, Al Mazedi, Maryam, Mansour, Rania, Naim, Elissa, Mortada, Hussein, Gutierrez Gomez, Yareni Yunuen, Geyskens, Kelly, Goukens, Caroline, Roy, Rajshri, Egli, Victoria, Morenga, Lisa Te, Waly, Mostafa, Qasrawi, Radwan, Hamdan, Motasem, Sier, Rania Abu, Al Halawa, Diala Abu, Agha, Hazem, Liria Domínguez, María Reyna, Palomares, Lita, Wasowicz, Grazyna, Bawadi, Hiba, Othman, Manal, Pakari, Jaafar, Farha, Allam Abu, Abu-El-Ruz, Rasha, Petrescu, Dacinia Crina, Petrescu Mag, Ruxandra Malina, Arion, Felix, Vesa, Stefan Cristian, Alkhalaf, Majid M., Bookari, Khlood, Arrish, Jamila, Rahim, Zackaria, Kheng, Roy, Ngqangashe, Yandisa, June-Rose Mchiza, Zandile, Gonzalez-Gross, Marcela, Pantoja-Arévalo, Lisset, Gesteiro, Eva, Ríos, Yolanda, Yiga, Peter, Ogwok, Patrick, Ocen, Denis, Bamuwamye, Michael, Al Sabbah, Haleama, Taha, Zainab, Ismail, Leila Cheikh, Aldhaheri, Ayesha, Pineda, Elisa, Miraldo, Marisa, Holford, Dawn Liu, Van den Bulck, Hilde, Hoteit, Maha, Hoteit, Reem, Aljawaldeh, Ayoub, Van Royen, Kathleen, Pabian, Sara, Decorte, Paulien, Cuykx, Isabelle, Teunissen, Lauranna, and De Backer, Charlotte

Published
2023
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31. IMAGENE trial: multicenter, proof-of-concept, phase II study evaluating the efficacy and safety of combination therapy of niraparib with PD-1 inhibitor in solid cancer patients with homologous recombination repair genes mutation

Author

Kato, Taigo, Matsubara, Nobuaki, Shiota, Masaki, Eto, Masatoshi, Osawa, Takahiro, Abe, Takashige, Shinohara, Nobuo, Yasumizu, Yota, Tanaka, Nobuyuki, Oya, Mototsugu, Nishimoto, Koshiro, Hayashi, Takuji, Nakayama, Masashi, Kojima, Takahiro, Namikawa, Kenjiro, Fujisawa, Takao, Okano, Susumu, Hida, Eisuke, Nakamura, Yoshiaki, Bando, Hideaki, Yoshino, Takayuki, and Nonomura, Norio

Published
2022
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33. Prediction of undetectable circulating tumor DNA by comprehensive genomic profiling assay in metastatic prostate cancer: the SCRUM-Japan MONSTAR SCREEN project.

Author

Shiota, Masaki, Matsubara, Nobuaki, Kato, Taigo, Eto, Masatoshi, Osawa, Takahiro, Abe, Takashige, Shinohara, Nobuo, Nishimoto, Koshiro, Yasumizu, Yota, Tanaka, Nobuyuki, Oya, Mototsugu, Fujisawa, Takao, Horasawa, Satoshi, Nakamura, Yoshiaki, Yoshino, Takayuki, and Nonomura, Norio

Subjects
CIRCULATING tumor DNA, BONE metastasis, METASTASIS, PROSTATE cancer, ODDS ratio
Abstract

Background: Undetectable circulating tumor DNA (ctDNA) is an obstacle to performing comprehensive genomic profiling in daily practice to identify genomic alterations. We investigated the associations between clinicopathological factors and undetectable ctDNA using a commercially available comprehensive genomic profiling assay in metastatic prostate cancer. Patients and methods: Patients treated with systemic treatment for metastatic prostate cancer were included. ctDNA was analyzed by FoundationOne®Liquid CDx at enrollment. The associations between clinicopathological characteristics and ctDNA detection were analyzed. Results: The number of bone metastasis was associated with ctDNA detection (odds ratio [95% confidence interval], 13.6 [1.71–108], P = 0.014). An algorithm predicting ctDNA detection using clinicopathological parameters was created. If ≥ 4 bone metastases were observed, ctDNA detection was estimated to be 98.9%. Among the patients with < 4 bone metastases, if two or three features among ISUP grade group 5, PSA level ≥ 10 ng/ml, and castration resistance were present, the ctDNA detection rate was 96.7% while the ctDNA detection rate was 86.3% if no or only one feature was present. Conclusions: An algorithm created in this study is helpful in determining when to undertake comprehensive genomic profiling assay using blood. [ABSTRACT FROM AUTHOR]

Published
2024
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38. PD36-08 ARTIFICIAL INTELLIGENCE-BASED SURGICAL PHASE RECOGNITION IN ROBOT-ASSISTED RADICAL PROSTATECTOMY AND CROSS-SURGEON EXTERNAL VALIDITY VERIFICATION

Author

Konnai, Yuichiro, primary, Fukumoto, Keishiro, additional, Takeuchi, Masashi, additional, Tanigawa, Mio, additional, Takeuchi, Rei, additional, Yasumizu, Yota, additional, Tanaka, Nobuyuki, additional, Takeda, Toshikazu, additional, Matsumoto, Kazuhiro, additional, Morita, Shinya, additional, Kosaka, Takeo, additional, Mizuno, Ryuichi, additional, Asanuma, Hiroshi, additional, and Oya, Mototsugu, additional

Published
2024
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39. PD20-09 THREE-DIMENSIONAL IMAGING AND SPATIAL ANALYSIS OF INTACT TISSUE IMPROVE DIAGNOSTIC YIELD AND ACCURACY IN UPPER TRACT UROTHELIAL CARCINOMA DIAGNOSIS

Author

Fukumoto, Keishiro, primary, Yasumizu, Yota, additional, Tanaka, Nobuyuki, additional, Takeda, Toshikazu, additional, Matsumoto, Kazuhiro, additional, Morita, Shinya, additional, Kosaka, Takeo, additional, Mizuno, Ryuichi, additional, Asanuma, Hiroshi, additional, Uhlén, Per, additional, and Oya, Mototsugu, additional

Published
2024
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40. Genomic profiling and clinical utility of circulating tumor DNA in metastatic prostate cancer: SCRUM-Japan MONSTAR SCREEN project

Author

Shiota, Masaki, primary, Matsubara, Nobuaki, additional, Kato, Taigo, additional, Eto, Masatoshi, additional, Osawa, Takahiro, additional, Abe, Takashige, additional, Shinohara, Nobuo, additional, Nishimoto, Koshiro, additional, Yasumizu, Yota, additional, Tanaka, Nobuyuki, additional, Oya, Mototsugu, additional, Fujisawa, Takao, additional, Horasawa, Satoshi, additional, Nakamura, Yoshiaki, additional, Yoshino, Takayuki, additional, and Nonomura, Norio, additional

Published
2024
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41. Prediction of pathological up-staging after radical nephroureterectomy in patients with upper tract urothelial carcinoma

Author

Shojo, Kazunori, primary, Takeda, Toshikazu, additional, Akita, Hirotaka, additional, Suzuki, Tatsuya, additional, Mikami, Shuji, additional, Shigeta, Keisuke, additional, Yasumizu, Yota, additional, Tanaka, Nobuyuki, additional, Matsumoto, Kazuhiro, additional, Morita, Shinya, additional, Kosaka, Takeo, additional, Mizuno, Ryuichi, additional, Asanuma, Hiroshi, additional, Jinzaki, Masahiro, additional, and Oya, Mototsugu, additional

Published
2024
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