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556 results on '"Strecker G"'

1. Fine-tuning foundational models to code diagnoses from veterinary health records

Author

Boguslav, Mayla R., Kiehl, Adam, Kott, David, Strecker, G. Joseph, Webb, Tracy, Saklou, Nadia, Ward, Terri, and Kirby, Michael

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence, I.2.7
Abstract

Veterinary medical records represent a large data resource for application to veterinary and One Health clinical research efforts. Use of the data is limited by interoperability challenges including inconsistent data formats and data siloing. Clinical coding using standardized medical terminologies enhances the quality of medical records and facilitates their interoperability with veterinary and human health records from other sites. Previous studies, such as DeepTag and VetTag, evaluated the application of Natural Language Processing (NLP) to automate veterinary diagnosis coding, employing long short-term memory (LSTM) and transformer models to infer a subset of Systemized Nomenclature of Medicine - Clinical Terms (SNOMED-CT) diagnosis codes from free-text clinical notes. This study expands on these efforts by incorporating all 7,739 distinct SNOMED-CT diagnosis codes recognized by the Colorado State University (CSU) Veterinary Teaching Hospital (VTH) and by leveraging the increasing availability of pre-trained large language models (LLMs). Ten freely-available pre-trained LLMs were fine-tuned on the free-text notes from 246,473 manually-coded veterinary patient visits included in the CSU VTH's electronic health records (EHRs), which resulted in superior performance relative to previous efforts. The most accurate results were obtained when expansive labeled data were used to fine-tune relatively large clinical LLMs, but the study also showed that comparable results can be obtained using more limited resources and non-clinical LLMs. The results of this study contribute to the improvement of the quality of veterinary EHRs by investigating accessible methods for automated coding and support both animal and human health research by paving the way for more integrated and comprehensive health databases that span species and institutions., Comment: 26 pages, 5 figures

Published
2024

11. A category of Galois connections

Author

McDill, J. M., Melton, A. C., Strecker, G. E., Goos, G., editor, Hartmanis, J., editor, Barstow, D., editor, Brauer, W., editor, Brinch Hansen, P., editor, Gries, D., editor, Luckham, D., editor, Moler, C., editor, Pnueli, A., editor, Seegmüller, G., editor, Stoer, J., editor, Wirth, N., editor, Pitt, David H., editor, Poigné, Axel, editor, and Rydeheard, David E., editor

Published
1987
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12. Galois connections and computer science applications

Author

Melton, A., Schmidt, D. A., Strecker, G. E., Goos, G., editor, Hartmanis, J., editor, Barstow, D., editor, Brauer, W., editor, Brinch Hansen, P., editor, Gries, D., editor, Luckham, D., editor, Moler, C., editor, Pnueli, A., editor, Seegmüller, G., editor, Stoer, J., editor, Wirth, N., editor, Pitt, David, editor, Abramsky, Samson, editor, Poigné, Axel, editor, and Rydeheard, David, editor

Published
1986
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13. On residuated approximations

Author

Andréka, H., Greechie, R. J., Strecker, G. E., Goos, G., editor, Hartmanis, J., editor, Barstow, D., editor, Brauer, W., editor, Brinch Hansen, P., editor, Gries, D., editor, Luckham, D., editor, Moler, C., editor, Pnueli, A., editor, Seegmüller, G., editor, Stoer, J., editor, Wirth, N., editor, Ehrig, H., editor, Herrlich, H., editor, Kreowski, H. -J., editor, and Preuß, G., editor

Published
1989
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14. Concrete categories and injectivity

Author

Bargenda, H., Herrlich, H., Strecker, G. E., Goos, G., editor, Hartmanis, J., editor, Barstow, D., editor, Brauer, W., editor, Brinch Hansen, P., editor, Gries, D., editor, Luckham, D., editor, Moler, C., editor, Pnueli, A., editor, Seegmüller, G., editor, Stoer, J., editor, Wirth, N., editor, and Melton, Austin, editor

Published
1986
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30. Identification of the blood group Lewis(a) determinant in the oviducal mucins of Xenopus tropicalis

Author

Guerardel, Y., Petit, Daniel, MADIGOU, T., Guillet, B., Maes, E., Maftah, A., Boujard, D., Strecker, G., KOL, O., ProdInra, Archive Ouverte, Unité de Génétique Moléculaire Animale (UMR GMA), Institut National de la Recherche Agronomique (INRA)-Université de Limoges (UNILIM), Unité de Génétique Moléculaire Animale (UGMA), and Université de Limoges (UNILIM)-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

absent

Published
2003

31. Carbohydrate binding, quaternary structure and a novel hydrophobic binding site in two legume lectin oligomers from Dolichos biflorus

Author

Hamelryck, T.W., Loris, R., Bouckaert, J., Dao Thi, M.H., Strecker, G., Imberty, A., Fernandez, E., Wyns, L., Etzler, M.E., Centre de Recherches sur les Macromolécules Végétales (CERMAV), and Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1999

32. Lectin activities of cytokines and growth factors: function and implications for pathology

Author

Zanetta, J.P., Scior, T., Wantyghem, J., Wermuth, C., Aubery, M., Strecker, G., and Michalski, J.C.

Subjects
6 - Ciencias aplicadas::61 - Medicina::615 - Farmacología. Terapéutica. Toxicología. Radiología [CDU], Cytokine, Clustering
Abstract

The discovery that certain cytokines have carbohydrate-binding (lectin) properties opens new concepts in the understanding of their mechanism of action. The carbohydrate-recognition domain, which is localized opposite to the receptor-binding domain, makes these molecules bi-functional. The expression of the biological activity of the cytokine relies on its carbohydrate-binding activity which allows the association of the cytokine receptor with molecular complexes comprising the specific kinase involved in receptor phosphorylation and in specific signal transduction. It is expected that blood accumulation of free or membrane-bound glycan ligands of cytokines may dramatically perturb their endogenous function inducing specific immunodeficiencies.

Published
1996

35. Membrane Properties and Neural Circuits of the Suprachiasmatic Nucleus.

Author

COLORADO STATE UNIV FORT COLLINS DEPT OF ANATOMY AND NEUROBIOLOGY, Dudek, Edward F., Rash, John E., Yasumura, Thomas, Strecker, G. J., Smith, Bret N., COLORADO STATE UNIV FORT COLLINS DEPT OF ANATOMY AND NEUROBIOLOGY, Dudek, Edward F., Rash, John E., Yasumura, Thomas, Strecker, G. J., and Smith, Bret N.

Abstract

The goal of these studies was to examine local synaptic circuits in the suprachiasmatic nucleus and the effect of GABA on suprachiasmatic nucleus neurons. Electrophysiological evidence was provided to support the hypothesis that suprachiasmatic nucleus neurons are interconnected through a system of GABA- mediated local circuits. Previous studies had suggested that GABA was excitatory during subjective day, but our lab and two others corroborated and extended previous findings indicating that GABA is inhibitory during both subjective day and night. Other experiments showed that zinc and benzodiazepines modulate GABA-mediated inhibition of suprachiasmatic nucleus neurons. In particular, benzodiazepines augment the effect of GABA on these inhibitory circuits. These experiments have provided fundamental information on GABA-mediated local circuits in the suprachiasmatic nucleus, which would be expected to be a fundamental part of the circadian timing system in mammals.

Published
1999

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