The purpose of the qualitative research study was to identify factors and challenges that led to insecure housing among rural residents in Manitoba, Canada. Using a case study approach, five participants and two key informants were interviewed. When the participants were asked about personal factors and challenges affecting housing insecurity in rural Manitoba, their responses were focused on past and current health issues. Health, including acute and chronic conditions, became the critical intersection of housing insecurity and rurality. Systemic barriers such as invisibility, stigma, and lack of access to healthcare services in the rural setting created additional challenges for participants who required assistance and support to obtain and maintain stable housing. Integration of and collaboration among health, housing, and social service providers and informal supports in the rural community are required to address housing insecurity. Rural communities tend to be unique, therefore, strategies and interventions to diminish or prevent houselessness need to be flexible, targeted, and community-specific. [ABSTRACT FROM AUTHOR]