Regina Fölster-Holst, Judith Fischer, Kathrin A. Giehl, Dirk Breitkreutz, Illiana Tantcheva-Poór, Marie-Luise Preil, Kirstin Kiekbusch, Ingrid Hausser, Geske Wehr, Steffen Emmert, Barbara Kleinow, Irina Zaraeva, Ana Maria Perusquia-Ortiz, Heiko Traupe, Stefan Weidinger, Vinzenz Oji, Hagen Ott, Karola Stieler, Anja Diem, Karin Aufenvenne, Peter Höger, Henning Hamm, and Hans Christian Hennies
Ichthyoses are a group of rare genetic skin disorders that pose numerous clinical\ud challenges, in particular with respect to the correct diagnosis and appropriate management.\ud The present update of the German ichthyosis guidelines addresses recent\ud diagnostic advances that have resulted in the Sorèze consensus classification. In this\ud context, we provide an updated diagnostic algorithm, taking into account clinical features\ud as well as the molecular genetic basis of these disorders. Moreover, we highlight\ud current therapeutic approaches such as psychosocial support, balneotherapy, mechanical\ud scale removal, topical therapy, and systemic retinoid therapy. General aspects\ud such as the indication for physical therapy, ergotherapy, or genetic counseling are\ud also discussed. The present update was consented by an interdisciplinary consensus\ud conference that included dermatologists, pediatricians, human geneticists, and natural\ud scientists as well as representatives of the German patient support organization\ud Selbsthilfe Ichthyose e. V.