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During autopsies of 34 individuals, 110 specimens were taken from femoral arteries and examined by microscopy and lipid chemical analyses. Five types of lesions were differentiated: 1. normal intima, 2. diffuse intimal hyperplasia, 3. fatty streaks, 4. fibrous plaques, 5. atheromatous lesions. Since studies on femoral arteries have not been performed so far, our results were compared with known results from aortas and coronary arteries. However, no essential differences were found by comparing morphologic results and lipid compositions. Esterified and free cholesterol increased approximately 30-fold, phospholipids approximately 6.5-fold, with progressing atherosclerosis. The intima of a 40-year-old alcoholic was found to have an extremely low level of cholesterol esters, while the other findings were not changed.