218 results on '"Simon, Adam J."'
Search Results
2. A novel pathway for amyloid precursor protein processing
3. Sports Concussion And Mild Traumatic Brain Injury Assessment Is Enhanced With Portable, Non-invasive Biosensor Arrays: 112 May 27, 11: 00 AM - 11: 15 AM
4. Identification of Resting and Active State EEG Features of Alzheimer’s Disease using Discrete Wavelet Transform
5. Pharmacological applications of a novel neoepitope antibody to a modified amyloid precursor protein-derived beta-secretase product
6. Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI
7. Modeling Effect of a γ-Secretase Inhibitor on Amyloid-β Dynamics Reveals Significant Role of an Amyloid Clearance Mechanism
8. Enhanced in vivo transgene expression and immunogenicity from plasmid vectors following electrostimulation in rodents and primates
9. Decrease in age-adjusted cerebrospinal fluid β-secretase activity in Alzheimer's subjects
10. Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity
11. Plasma Biomarkers Associated With the Apolipoprotein E Genotype and Alzheimer Disease
12. Reference measurement procedures for Alzheimerʼs disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42
13. Biochemical and cell-based assays for characterization of BACE-1 inhibitors
14. Elevated Cerebrospinal Fluid BACE1 Activity in Incipient Alzheimer Disease
15. A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels
16. A cell-based β-lactamase reporter gene assay for the identification of inhibitors of hepatitis C virus replication
17. Effects of Exercise on EEG Activity and Standard Tools Used to Assess Concussion
18. Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency
19. SAR of tertiary carbinamine derived BACE1 inhibitors: Role of aspartate ligand amine p Ka in enzyme inhibition
20. P4-048: BIOMARKER STABILITY IN CSF: PRE-ANALYTICAL FACTORS IN A PROSPECTIVE COLLECTION
21. Stochastic Dynamic Modeling of the Human Brain EEG Signal
22. Evaluation of Plasma Proteomic Data for Alzheimer Disease State Classification and for the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease
23. Power based analysis of single-electrode human EEG recordings using continuous wavelet transform
24. Cisterna magna cannulated repeated CSF sampling rat model – effects of a gamma-secretase inhibitor on Aβ levels
25. P1‐112: A brain computer interface to detect Alzheimer's disease
26. Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex
27. Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid‐β oligomers
28. P1-187: Evidence for dose-dependent neurotoxicity of amyloid-β oligomers/Aβ-derived diffusible ligands generated from physiological processing of transgenic human APP in situ in mouse brain
29. Modeling Effect of a γ-Secretase Inhibitor on Amyloid-β Dynamics Reveals Significant Role of an Amyloid Clearance Mechanism
30. SAR of tertiary carbinamine derived BACE1 inhibitors: Role of aspartate ligand amine pKa in enzyme inhibition
31. Application of an End-to-End Biomarker Discovery Platform to Identify Target Engagement Markers in Cerebrospinal Fluid by High Resolution Differential Mass Spectrometry
32. Evolution of Tertiary Carbinamine BACE‐1 Inhibitors: Aβ Reduction in Rhesus CSF upon Oral Dosing
33. Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors
34. Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors
35. Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation
36. First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates
37. Discovery and X-ray Crystallographic Analysis of a Spiropiperidine Iminohydantoin Inhibitor of β-Secretase
38. P3-094: Three novel CSF assays expand a core panel of CSF biomarkers: BACE activity, oligomeric Aβ and homocysteine assessed in pathologically confirmed Alzheimer subjects within the Oxford project to investigate memory and aging (Optima) cohort
39. O1-04-02: Significant Aβ lowering in CSF and plasma after oral administration of a potent small molecule BACE1 inhibitor in non-human primates
40. O3‐02–06: Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer's disease
41. P3-263: The kinesin light chain 1 polymorphism rs8702 is associated with elevated CSF levels of secreted forms of amyloid precursor protein
42. P3-077: Cerebrospinal fluid levels of Alzheimer's disease biomarkers in term and pre-term newborn infants
43. In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1
44. Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1
45. Cover Picture: Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1 (ChemMedChem 7/2007)
46. Discovery of Isonicotinamide Derived β-Secretase Inhibitors: In Vivo Reduction of β-Amyloid
47. Discovery of Oxadiazoyl Tertiary Carbinamine Inhibitors of β-Secretase (BACE-1)
48. Macrocyclic Inhibitors of β-Secretase: Functional Activity in an Animal Model.
49. P2-165: A multi-analyte panel of six CSF biomarkers classifies AD and control in pathologically confirmed Alzheimer subjects within the OPTIMA cohort
50. P4–315: Pharmacodynamic changes in plasma Aβ40 following peripheral antibody treatment in transgenic mice
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