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7. Association of Mu opioid receptor (A118G) and BDNF (G196A) polymorphisms with rehabilitation-induced cortical inhibition and analgesic response in chronic osteoarthritis pain

Author

Gonçalves, Fernanda de Toledo, Pacheco-Barrios, Kevin, Rebello-Sanchez, Ingrid, Castelo-Branco, Luis, de Melo, Paulo S., Parente, Joao, Cardenas-Rojas, Alejandra, Firigato, Isabela, Pessotto, Anne Victorio, Imamura, Marta, Simis, Marcel, Battistella, Linamara, and Fregni, Felipe

Published
2023
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9. Digitalized transcranial electrical stimulation: A consensus statement

Author

Brunoni, Andre R, Ekhtiari, Hamed, Antal, Andrea, Auvichayapat, Paradee, Baeken, Chris, Benseñor, Isabela M., Bikson, Marom, Boggio, Paulo, Borroni, Barbara, Brighina, Filippo, Brunelin, Jerome, Carvalho, Sandra, Caumo, Wolnei, Ciechanski, Patrick, Charvet, Leigh, Clark, Vincent P., Cohen Kadosh, Roi, Cotelli, Maria, Datta, Abhishek, Deng, Zhi-De, De Raedt, Rudi, De Ridder, Dirk, Fitzgerald, Paul B., Floel, Agnes, Frohlich, Flavio, George, Mark S., Ghobadi-Azbari, Peyman, Goerigk, Stephan, Hamilton, Roy H., Jaberzadeh, Shapour J., Hoy, Kate, Kidgell, Dawson J., Zonoozi, Arash Khojasteh, Kirton, Adam, Laureys, Steven, Lavidor, Michal, Lee, Kiwon, Leite, Jorge, Lisanby, Sarah H., Loo, Colleen, Martin, Donel M., Miniussi, Carlo, Mondino, Marine, Monte-Silva, Katia, Morales-Quezada, Leon, Nitsche, Michael A., Okano, Alexandre H., Oliveira, Claudia S., Onarheim, Balder, Pacheco-Barrios, Kevin, Padberg, Frank, Nakamura-Palacios, Ester M., Palm, Ulrich, Paulus, Walter, Plewnia, Christian, Priori, Alberto, Rajji, Tarek K., Razza, Lais B., Rehn, Erik M., Ruffini, Giulio, Schellhorn, Klaus, Zare-Bidoky, Mehran, Simis, Marcel, Skorupinski, Pawel, Suen, Paulo, Thibaut, Aurore, Valiengo, Leandro C.L., Vanderhasselt, Marie-Anne, Vanneste, Sven, Venkatasubramanian, Ganesan, Violante, Ines R., Wexler, Anna, Woods, Adam J., and Fregni, Felipe

Published
2022
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11. Neuroplasticity changes in knee osteoarthritis (KOA) indexed by event-related desynchronization/synchronization during a motor inhibition task.

Author

Marques, Lucas M., Castellani, Ana, Barbosa, Sara P., Imamura, Marta, Battistella, Linamara R., Simis, Marcel, and Fregni, Felipe

Subjects
KNEE osteoarthritis, NEURAL inhibition, MOTOR imagery (Cognition), PAIN perception, CROSS-sectional method
Abstract

Purpose: Event-related desynchronisation (ERD) and event-related synchronisation (ERS) reflect pain perception and integration of the nociceptive sensory inputs. This may contribute to the understanding of how neurophysiological markers of Knee Osteoarthritis (KOA) patients can differ from control individuals, which would improve aspects such as prediction and prognosis. We performed a cross-sectional analysis of our cohort study (DEFINE cohort), KOA arm, with 71 patients, compared with 65 control participants. The study aimed to examine possible differences between ERD and ERS in control participants compared to Knee Osteoarthritis (KOA) patients when adjusting for important covariates. Materials and methods: We performed independent multivariate regression models considering as dependent variables the power value related to ERD and ERS for four different sensorimotor tasks (Motor Execution, Motor Imagery, Active Observation and Passive Observation) and four sensorimotor oscillations (Alpha, Beta, Low Beta, and High Beta), each model, controlled by age and sex. Results: We demonstrate that the differences between KOA and healthy subjects are frequency specific, as most differences are in the beta bandwidth range. Also, we observed that subjects in the KOA group had significantly higher ERD and ERS. This may be correlated to the amount of lack of brain organisation and a subsequent attempt at compensation induced by KOA. Conclusions: Our findings strengthen the notion that subjects with KOA have a higher degree of brain plasticity changes that are also likely correlated to the degree of compensation and behavioural dysfunction. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Primary Motor Area Activity in Phantom Limb Imagery of Traumatic Unilateral Lower Limb Amputees With Phantom Limb Pain.

Author

Sugawara, André Tadeu, De Pretto, Lucas Ramos, Simis, Marcel, Fregni, Felipe, and Battistella, Linamara Rizzo

Subjects
TRAUMATIC amputation, PHANTOM limbs, PHYSICAL therapy, DATA analysis, RESEARCH funding, QUESTIONNAIRES, DESCRIPTIVE statistics, IMAGING phantoms, PAIN, ANALYSIS of variance, STATISTICS, COMPARATIVE studies, CONFIDENCE intervals, DATA analysis software
Abstract

Introduction: Estimates of the worldwide increase in amputees raises the awareness to solve long-standing problems. Understanding the functional brain modifications after a lower limb amputation (LLA) is one of the first steps towards proposing new rehabilitation approaches. Functional modifications in the central nervous system due the amputation could be involved in prosthesis use failures and Phantom Limb Pain (PLP), increasing costs and overwhelming the health services. Objective: This study analyses orphan primary motor area (M1-Orphan) hemodynamic and metabolic behaviour, which previously controlled the limb that was amputated, in comparison with the M1-Preserved, responsible for the intact limb (IL) during phantom limb imagery moving during Mirror Therapy (MT), compared to Isolated Intact Limb Movement Task (I-ILMT). Methodology: A case-control study with unilateral traumatic LLA with moderate PLP who measured [oxy-Hb] and [deoxy-Hb] in the M1 area by Functional Near InfraredSpectroscopy (fNIRS) during the real (I-ILMT) and MT task. Results: Sixty-five patients, with 67.69% of men, young (40.32 ± 12.91), 65.63% amputated due motorcycle accidents, 4.71 ± 7.38 years ago, predominantly above the knee (57.14%). The M1 activation in the orphan cortex did not differ from the activation in the intact cortex during MT (P >.05). Conclusion: The perception of the Phantom limb moving or intact limb moving is metabolically equivalent in M1, even in the absence of a limb. In other words, the amputation does not alter the brain metabolism in control of phantom movement. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Decentralizing Rehabilitation: Using Blockchain to Store Exoskeletons’ Movement

Author

da Silva, Daniela America, Lelis, Claudio Augusto Silveira, Coura, Luiz Henrique, dos Santos, Samara Cardoso, Yanaguya, Leticia, Junior, Jose Crisostomo Ozorio, da Silva Tiburcio, Isaias, Goncalves, Gildarcio Sousa, da Fonseca, Breslei Max Reis, Nascimento, Alexandre, Marques, Johnny Cardoso, Dias, Luiz Alberto Vieira, da Cunha, Adilson Marques, Tasinaffo, Paulo Marcelo, Terranova, Thais Tavares, Simis, Marcel, de Castro, Pedro Claudio Gonsales, Battistella, Linamara Rizzo, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, and Latifi, Shahram, editor

Published
2019
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23. Neuroplasticity changes in knee osteoarthritis (KOA) indexed by event-related desynchronization/synchronization during a motor inhibition task

Author

Marques, Lucas M., Castellani, Ana, Barbosa, Sara P., Imamura, Marta, Battistella, Linamara R., Simis, Marcel, and Fregni, Felipe

Subjects
Physiology, Sensory Systems
Abstract

Event-related desynchronisation (ERD) and event-related synchronisation (ERS) reflect pain perception and integration of the nociceptive sensory inputs. This may contribute to the understanding of how neurophysiological markers of Knee Osteoarthritis (KOA) patients can differ from control individuals, which would improve aspects such as prediction and prognosis. We performed a cross-sectional analysis of our cohort study (DEFINE cohort), KOA arm, with 71 patients, compared with 65 control participants. The study aimed to examine possible differences between ERD and ERS in control participants compared to Knee Osteoarthritis (KOA) patients when adjusting for important covariates. We performed independent multivariate regression models considering as dependent variables the power value related to ERD and ERS for four different sensorimotor tasks (Motor Execution, Motor Imagery, Active Observation and Passive Observation) and four sensorimotor oscillations (Alpha, Beta, Low Beta, and High Beta), each model, controlled by age and sex. We demonstrate that the differences between KOA and healthy subjects are frequency specific, as most differences are in the beta bandwidth range. Also, we observed that subjects in the KOA group had significantly higher ERD and ERS. This may be correlated to the amount of lack of brain organisation and a subsequent attempt at compensation induced by KOA. Our findings strengthen the notion that subjects with KOA have a higher degree of brain plasticity changes that are also likely correlated to the degree of compensation and behavioural dysfunction.

Published
2023

24. Functional and Neural Correlates Associated with Conditioned Pain Modulation in Patients with Chronic Knee Osteoarthritis Pain: A Cross-Sectional Study

Author

Simis, Marcel, primary, Pacheco-Barrios, Kevin, additional, Vasquez-Avila, Karen, additional, Rebello-Sanchez, Ingrid, additional, Parente, Joao, additional, Castelo-Branco, Luis, additional, Marduy, Anna, additional, de Melo, Paulo S., additional, Imamura, Marta, additional, Battistella, Linamara, additional, and Fregni, Felipe, additional

Published
2023
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25. Popular stroke knowledge in Brazil: A multicenter survey during “World Stroke Day”

Author

Gomes, Ana Beatriz Ayroza Galvão Ribeiro, Henrique, Mauro, Jr, Schoeps, Vinicius Andreoli, Santos, Mariana Monteiro Saldanha Altenfelder, Pellegrinelli, Ada, de Matos, Bárbara Pessoa, Kubota, Gabriel Taricani, Araújo, Haniel Alves, da Silva, Letícia Sant' Ana Cardoso, de Paula Leite Battisti, Fabrício, Kubota, Bruno Yukio, Ferreira, Areta Cavalcanti, Pellegrino, Mateus Paquesse, de Andrade Prado, Renata, Abrahm, Ronaldo, Gagliardi, Vivian Dias Baptista, Simis, Marcel, and Gagliardi, Rubens José

Published
2017
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26. Factors associated with pain pressure threshold in both local and remote sites in knee osteoarthritis.

Author

Imamura, Marta, Rebello‐Sanchez, Ingrid, Parente, Joao, Marduy, Anna, Vasquez‐Avila, Karen, Pacheco‐Barrios, Kevin, Castelo‐Branco, Luis, Simis, Marcel, Battistella, Linamara, and Fregni, Felipe

Subjects
PAIN threshold, KNEE osteoarthritis, KNEE pain, MENTAL depression, CHRONIC pain, CROSS-sectional method
Abstract

Background: Knee osteoarthritis (KOA) is a prevalent condition, and its most frequent symptom is pain that often leads to disability. Pain sensitization is a core feature of KOA, and it can be measured through quantitative sensory testing protocols such as pain pressure threshold (PPT). However, there is a lack of understanding about the factors that may influence changes in PPTs in the KOA population. Objective: To explore the clinical and functional factors associated with PPTs in a sample of people with chronic KOA pain and to compare models of local (knees) and remote (thenar regions) sites. Design: Cross‐sectional analysis of a prospective cohort. Setting: Primary care in public institution. Participants: 113 adults with KOA. Intervention: N/A. Main Outcome Measures: Multivariable regression analyses evaluating demographic, clinical, and functional variables that could be associated with local and remote PPTs (main outcomes) were performed. Results: Both thenar region (adjusted‐R2: 0.29) and knee (adjusted‐R2: 0.45) models had the same significant negative association with being a female, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain levels (thenar: β: −0.15, p =.002; knee: β: −0.2, p <.001), and the 10‐Meter Walking Test (thenar: β: −0.05, p =.038; knee: β: −0.08, p =.004). A small significant positive association with depressive symptoms was identified in both models, which acted as a confounder for WOMAC pain and was likely affected by unmeasured confounders. Conclusions: PPTs in KOA pain are associated with functional outcomes such as the 10‐Meter Walking Test and activity‐related pain intensity; thus more disability is associated with smaller pain thresholds. Similarity between models may suggest central sensitization. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Decentralizing Rehabilitation: Using Blockchain to Store Exoskeletons’ Movement

Author

da Silva, Daniela America, primary, Lelis, Claudio Augusto Silveira, additional, Coura, Luiz Henrique, additional, dos Santos, Samara Cardoso, additional, Yanaguya, Leticia, additional, Junior, Jose Crisostomo Ozorio, additional, da Silva Tiburcio, Isaias, additional, Goncalves, Gildarcio Sousa, additional, da Fonseca, Breslei Max Reis, additional, Nascimento, Alexandre, additional, Marques, Johnny Cardoso, additional, Dias, Luiz Alberto Vieira, additional, da Cunha, Adilson Marques, additional, Tasinaffo, Paulo Marcelo, additional, Terranova, Thais Tavares, additional, Simis, Marcel, additional, de Castro, Pedro Claudio Gonsales, additional, and Battistella, Linamara Rizzo, additional

Published
2019
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29. List of Contributors of Volume 3

Author

Abell, Thomas, primary, Abraham, William T., additional, Alabbad, Ali, additional, Al-Kaisy, Adnan, additional, Andréll, Paulin, additional, Andrew McKinley, Richard, additional, Angeli, Claudia A., additional, Ardell, Jeffrey L., additional, Arnold, Anthony, additional, Audu, Musa, additional, Baker, Kenneth B., additional, Barolat, Giancarlo, additional, Baskin, Jonathan Z., additional, Benderro, Girriso F., additional, Bennett, Maria E., additional, Bikson, Marom, additional, Bouton, Chad E., additional, Buckley, Una, additional, Carvalho, Sandra, additional, Cavuoto, James, additional, Chae, John, additional, Chen, Jiande D.Z., additional, Chen, Shuo, additional, Cohn, Joshua A., additional, Creasey, Graham H., additional, Czura, Christopher J., additional, Damato, Elizabeth G., additional, de Groat, William C., additional, Decker, Michael J., additional, DiMarco, Anthony F., additional, Dipietro, Laura, additional, Dmochowski, Roger R., additional, Dorman, Michael F., additional, Duarte, Rui V., additional, Durand, Dominique M., additional, Elizabeth Germany, Robin, additional, Emala, Charles, additional, Errico, J.P., additional, Faltys, Michael, additional, Franke, Manfred, additional, Fregni, Felipe, additional, French, Melanie, additional, Fritz, Jason R., additional, Gassler, John P., additional, Gonzalez Calle, Alejandra, additional, Harkema, Susan J., additional, Hassouna, Magdy, additional, Horsch, Svante, additional, Humayun, Mark S., additional, Huston, Jared M., additional, Jin, Haifeng, additional, Kapural, Leonardo, additional, Kaufman, Melissa R., additional, Kilgore, Kevin L., additional, Knutson, Jayme S., additional, Kobetic, Rudi, additional, Kowalski, Krzysztof E., additional, Kowalik, Casey G., additional, Krames, Elliot S., additional, Leite, Jorge, additional, Levine, Yaakov A., additional, Li, Yanmei, additional, Loudin, James, additional, Lu, Peter L., additional, Machado, Andre G., additional, Makowski, Nathaniel S., additional, Malde, Sachin, additional, Michael Ackermann, D., additional, Milam, Douglas F., additional, Mogilner, Alon Y., additional, Mousa, Hayat M., additional, Moynahan, Megan, additional, Murray, Drew, additional, Olofsson, Peder S., additional, Onders, Raymond P., additional, Peckham, P. Hunter, additional, Perryman, Laura, additional, Piedimonte, Fabian, additional, Prager, Joshua P., additional, Rejc, Enrico, additional, Reynolds, William S., additional, Sahai, Arun, additional, Salavatian, Siamak, additional, Schiefer, Matthew A., additional, Schneider, Marabel, additional, Schulte, Stefan, additional, Selkirk, Stephen, additional, Simis, Marcel, additional, Simon, Bruce, additional, Simon, Jesse, additional, Snyder, Jon, additional, Staats, Peter, additional, Strohl, Kingman P., additional, Thibaut, Aurore, additional, Thomson, Simon J., additional, Triolo, Ronald J., additional, Tyler, Dustin J., additional, Unal, Gozde, additional, Vasquez, Alejandra, additional, Wagner, Timothy, additional, Wathen, Connor A., additional, Weiland, James D., additional, Wilson, Blake S., additional, Wilson, Richard D., additional, Yao, Shukun, additional, Yin, Jieyun, additional, Yoruk, Ayhan, additional, and Zitnik, Ralph, additional

Published
2018
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31. The Institute of Physical Medicine and Rehabilitation, Hospital das Clínicas University of São Paulo School of Medicine comprehensive rehabilitation program for elderly people with knee osteoarthritis

Author

Imamura, Marta, primary, Shinzato, Gilson T., additional, Sugawara, André T., additional, Uchiyama, Sabrina Saemy Tome, additional, Matheus, Denise, additional, Simis, Marcel, additional, Ayres, Denise Vianna Machado, additional, dos Santos, Artur C. A., additional, Assone, Tatiane, additional, Ramos, Vinícius Delgado, additional, Fregni, Felipe, additional, and Battistella, Linamara R., additional

Published
2022
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35. Digitizing Non-Invasive Neuromodulation Trials: Scoping Review, Process Mapping, and Recommendations from a Delphi Panel

Author

Brunoni, Andre R, primary, Ekhtiari, Hamed, additional, Antal, Andrea, additional, Auvichayapat, Paradee, additional, Baeken, Chris, additional, Benseñor, Isabela M., additional, Bikson, Marom, additional, Boggio, Paulo, additional, Borroni, Barbara, additional, Brighina, Filippo, additional, Brunelin, Jerome, additional, Carvalho, Sandra, additional, Caumo, Wolnei, additional, Ciechanski, Patrick, additional, Charvet, Leigh, additional, Clark, Vincent P., additional, Kadosh, Roi Cohen, additional, Cotelli, Maria, additional, Datta, Abhishek, additional, Deng, Zhi-De, additional, De Raedt, Rudi, additional, De Ridder, Dirk, additional, Fitzgerald, Paul B., additional, Floel, Agnes, additional, Frohlich, Flavio, additional, George, Mark S., additional, Ghobadi-Azbari, Peyman, additional, Goerigk, Stephan, additional, Hamilton, Roy H., additional, Jaberzadeh, Shapour J., additional, Hoy, Kate, additional, Kidgell, Dawson J., additional, Zonoozi, Arash Khojasteh, additional, Kirton, Adam, additional, Laureys, Steven, additional, Lavidor, Michal, additional, Lee, Kiwon, additional, Leite, Jorge, additional, Lisanby, Sarah H., additional, Loo, Colleen, additional, Martin, Donel M., additional, Miniussi, Carlo, additional, Mondino, Marine, additional, Monte-Silva, Katia, additional, Morales-Quezada, Leon, additional, Nitsche, Michael A., additional, Okano, Alexandre H., additional, Oliveira, Claudia S., additional, Onarheim, Balder, additional, Pacheco-Barrios, Kevin, additional, Padberg, Frank, additional, Nakamura-Palacios, Ester M, additional, Palm, Ulrich, additional, Paulus, Walter, additional, Plewnia, Christian, additional, Priori, Alberto, additional, Rajji, Tarek K., additional, Razza, Lais B., additional, Rehn, Erik M., additional, Ruffini, Giulio, additional, Schellhorn, Klaus, additional, Zare-Bidoky, Mehran, additional, Simis, Marcel, additional, Skorupinski, Pawel, additional, Suen, Paulo, additional, Thibaut, Aurore, additional, Valiengo, Leandro C. L., additional, Vanderhasselt, Marie-Anne, additional, Vanneste, Sven, additional, Venkatasubramanian, Ganesan, additional, Violante, Ines R., additional, Wexler, Anna, additional, Woods, Adam J., additional, and Fregni, Felipe, additional

Published
2022
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38. Digitizing Non-Invasive Neuromodulation Trials: Scoping Review, Process Mapping, and Recommendations from a Delphi Panel

Author

Brunoni, André Russowsky, primary, Ekhtiari, Hamed, additional, Antal, Andrea, additional, Auvichayapat, Paradee, additional, Baeken, Chris, additional, Benseñor, Isabela M., additional, Bikson, Marom, additional, Boggio, Paulo, additional, Borroni, Barbara, additional, Brighina, Filippo, additional, Brunelin, Jerome, additional, Carvalho, Sandra, additional, Caumo, Wolnei, additional, Ciechanski, Patrick, additional, Charvet, Leigh, additional, Clark, Vincent P., additional, Cohen Kadosh, Roi, additional, Cotelli, Maria, additional, Datta, Abhishek, additional, Deng, Zhi-De, additional, De Raedt, Rudi, additional, De Ridder, Dirk, additional, Fitzgerald, Paul B., additional, Floel, Agnes, additional, Frohlich, Flavio, additional, George, Mark S., additional, Ghobadi-Azbari, Peyman, additional, Goerigk, Stephan, additional, Hamilton, Roy H., additional, Jaberzadeh, Shapour, additional, Hoy, Kate, additional, Kidgell, Dawson, additional, Khojasteh Zonoozi, Arash, additional, Kirton, Adam, additional, Laureys, Steven, additional, Lavidor, Michal, additional, Lee, Kiwon, additional, Leite, Jorge, additional, Lisanby, Sarah H., additional, Loo, Colleen, additional, Martin, Donel M., additional, Miniussi, Carlo, additional, Mondino, Marine, additional, Monte-Silva, Kátia, additional, Morales-Quezada, Leon, additional, Nitsche, Michael, additional, Hideki Okano, Alexandre, additional, S. Oliveira, Claudia, additional, Onarheim, Balder, additional, Pacheco-Barrios, Kevin, additional, Padberg, Frank, additional, Nakamura-Palacios, Ester M., additional, Palm, Ulrich, additional, Paulus, Walter, additional, Plewnia, Christian, additional, Priori, Alberto, additional, Rajji, Tarek K., additional, Razza, Lais B., additional, Rehn, Erik M., additional, Ruffini, Giulio, additional, Schellhorn, Klaus, additional, Zare-Bidoky, Mehran, additional, Simis, Marcel, additional, Skorupinski, Pawel, additional, Suen, Paulo, additional, Thibaut, Aurore, additional, Valiengo, Leandro C. L., additional, Vanderhasselt, Marie-Anne, additional, Vanneste, Sven, additional, Venkatasubramanian, Ganesan, additional, Violante, Ines R., additional, Wexler, Anna, additional, Woods, Adam J., additional, and Fregni, Felipe, additional

Published
2022
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42. Appraising the effectiveness of electrical and magnetic brain stimulation techniques in acute major depressive episodes: an umbrella review of meta-analyses of randomized controlled trials

Author

Razza, Laís B., primary, Afonso dos Santos, Leonardo, additional, Borrione, Lucas, additional, Bellini, Helena, additional, Branco, Luis C., additional, Cretaz, Eric, additional, Duarte, Dante, additional, Ferrão, Ygor, additional, Galhardoni, Ricardo, additional, Quevedo, João, additional, Simis, Marcel, additional, Fregni, Felipe, additional, Correll, Christoph U., additional, Padberg, Frank, additional, Trevizol, Alisson, additional, Daskalakis, Zafiris J., additional, Carvalho, Andre F., additional, Solmi, Marco, additional, and Brunoni, André R., additional

Published
2021
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47. Effects of Combined and Alone Transcranial Motor Cortex Stimulation and Mirror Therapy in Phantom Limb Pain: A Randomized Factorial Trial

Author

Gunduz, Muhammed Enes, primary, Pacheco-Barrios, Kevin, additional, Bonin Pinto, Camila, additional, Duarte, Dante, additional, Vélez, Faddi Ghassan Saleh, additional, Gianlorenco, Anna Carolyna Lepesteur, additional, Teixeira, Paulo Eduardo Portes, additional, Giannoni-Luza, Stefano, additional, Crandell, David, additional, Battistella, Linamara Rizzo, additional, Simis, Marcel, additional, and Fregni, Felipe, additional

Published
2021
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48. sj-docx-3-nnr-10.1177_15459683211017509 – Supplemental material for Effects of Combined and Alone Transcranial Motor Cortex Stimulation and Mirror Therapy in Phantom Limb Pain: A Randomized Factorial Trial

Author

Gunduz, Muhammed Enes, Pacheco-Barrios, Kevin, Bonin Pinto, Camila, Duarte, Dante, Vélez, Faddi Ghassan Saleh, Gianlorenco, Anna Carolyna Lepesteur, Teixeira, Paulo Eduardo Portes, Giannoni-Luza, Stefano, Crandell, David, Battistella, Linamara Rizzo, Simis, Marcel, and Fregni, Felipe

Subjects
FOS: Clinical medicine, 110308 Geriatrics and Gerontology, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-docx-3-nnr-10.1177_15459683211017509 for Effects of Combined and Alone Transcranial Motor Cortex Stimulation and Mirror Therapy in Phantom Limb Pain: A Randomized Factorial Trial by Muhammed Enes Gunduz, Kevin Pacheco-Barrios, Camila Bonin Pinto, Dante Duarte, Faddi Ghassan Saleh Vélez, Anna Carolyna Lepesteur Gianlorenco, Paulo Eduardo Portes Teixeira, Stefano Giannoni-Luza, David Crandell, Linamara Rizzo Battistella, Marcel Simis and Felipe Fregni in Neurorehabilitation and Neural Repair

Published
2021
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49. Evidence-based guidelines and secondary meta-analysis for the use of transcranial direct current stimulation in neurological and psychiatric disorders

Author

Fregni, Felipe, El-Hagrassy, Mirret M., Barrios, Kevin Pacheco, Carvalho, Sandra, Leite, Jorge, Simis, Marcel, Brunelin, Jerome, Palacios, Ester Miyuki Nakamura, Marangolo, Paola, Venkatasubramanian, Ganesan, San-Juan, Daniel, Caumo, Wolnei, Bikson, Marom, Brunoni, Andre Russowsky, Leffa, Douglas Teixeira, and Neuromodulation Center Working Group

Subjects
Estimulação transcraniana por corrente contínua, Evidence-based medicine, Prática clínica baseada em evidências, Medicina baseada em evidências, Clinical evidence, Doenças do sistema nervoso, Psychiatric disorders, Transtornos mentais, tDCS, Neurological disorders
Abstract

Background: Transcranial direct current stimulation has shown promising clinical results, leading to increased demand for an evidence-based review on its clinical effects. Objective: We convened a team of transcranial direct current stimulation experts to conduct a systematic review of clinical trials with more than 1 session of stimulation testing: pain, Parkinson’s disease motor function and cognition, stroke motor function and language, epilepsy, major depressive disorder, obsessive compulsive disorder, Tourette syndrome, schizophrenia, and drug addiction. Methods: Experts were asked to conduct this systematic review according to the search methodology from PRISMA guidelines. Recommendations on efficacy were categorized into Levels A (definitely effective), B (probably effective), C (possibly effective), or no recommendation. We assessed risk of bias for all included studies to confirm whether results were driven by potentially biased studies. Results: Although most of the clinical trials have been designed as proof-of-concept trials, some of the indications analyzed in this review can be considered as definitely effective (Level A), such as depression, and probably effective (Level B), such as neuropathic pain, fibromyalgia, migraine, post-operative patient-controlled analgesia and pain, Parkinson’s disease (motor and cognition), stroke (motor), epilepsy, schizophrenia, and alcohol addiction. Assessment of bias showed that most of the studies had low risk of biases, and sensitivity analysis for bias did not change these results. Effect sizes vary from 0.01 to 0.70 and were significant in about 8 conditions, with the largest effect size being in postoperative acute pain and smaller in stroke motor recovery (nonsignificant when combined with robotic therapy). Conclusion: All recommendations listed here are based on current published PubMed-indexed data. Despite high levels of evidence in some conditions, it must be underscored that effect sizes and duration of effects are often limited; thus, real clinical impact needs to be further determined with different study designs.

Published
2021

50. sj-docx-2-nnr-10.1177_15459683211017509 – Supplemental material for Effects of Combined and Alone Transcranial Motor Cortex Stimulation and Mirror Therapy in Phantom Limb Pain: A Randomized Factorial Trial

Author

Gunduz, Muhammed Enes, Pacheco-Barrios, Kevin, Bonin Pinto, Camila, Duarte, Dante, Vélez, Faddi Ghassan Saleh, Gianlorenco, Anna Carolyna Lepesteur, Teixeira, Paulo Eduardo Portes, Giannoni-Luza, Stefano, Crandell, David, Battistella, Linamara Rizzo, Simis, Marcel, and Fregni, Felipe

Subjects
FOS: Clinical medicine, 110308 Geriatrics and Gerontology, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-docx-2-nnr-10.1177_15459683211017509 for Effects of Combined and Alone Transcranial Motor Cortex Stimulation and Mirror Therapy in Phantom Limb Pain: A Randomized Factorial Trial by Muhammed Enes Gunduz, Kevin Pacheco-Barrios, Camila Bonin Pinto, Dante Duarte, Faddi Ghassan Saleh Vélez, Anna Carolyna Lepesteur Gianlorenco, Paulo Eduardo Portes Teixeira, Stefano Giannoni-Luza, David Crandell, Linamara Rizzo Battistella, Marcel Simis and Felipe Fregni in Neurorehabilitation and Neural Repair

Published
2021
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