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603 results on '"Shafie, Asrul Akmal"'

19. Sustainable Dengue Prevention and Management: Integrating Dengue Vaccination Strategies with Population Perspectives.

Author

Shafie, Asrul Akmal, Moreira Jr., Edson Duarte, Vidal, Gabriela, Di Pasquale, Alberta, Green, Andrew, Tai, Rie, and Yoong, Joanne

Subjects
DENGUE, VACCINATION, VECTOR control, SUSTAINABLE design, POPULATION dynamics
Abstract

The GEMKAP study (2023) unveiled consistent knowledge, attitude, and practice (KAP) levels across Asia-Pacific (APAC) and Latin America (LATAM) countries regarding dengue, with variations in the willingness to vaccinate. Despite an overall KAP parity, the disparities within and between the countries indicated the need for both overarching and tailored strategies. Population-wide gaps in dengue awareness result in suboptimal vaccination priorities and preventive measures. This commentary delves into identifying the drivers and barriers for implementing a multi-pronged dengue prevention and management program, emphasizing the pivotal role of vaccination alongside education and vector control. Drawing on expert interviews in APAC and LATAM, informed by the Consolidated Framework for Implementation Research (CFIR), four key themes emerged: prioritizing and continuously advocating for dengue on national health agendas, fostering stakeholder collaboration, incorporating population perspectives for behavioral change, and designing sustainable dengue prevention and management programs. Successful implementation requires evidence-based decision making and a comprehensive understanding of population dynamics to design adaptive education tailored to diverse population views. This commentary provides actionable strategies for enhancing dengue prevention and management, with a pronounced emphasis on dengue vaccination, advocating for a holistic, population-centric approach for sustained effectiveness. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Economic evaluation of initial HAART regimen for HIV patients

Author

Shafie, Asrul Akmal

Subjects
616.97
Abstract

Although highly active antiretroviral regimen' (HAART) reduces HIV-related morbidity and mortality, it affects patients and induces HIV viral resistance which could lead to more complex therapeutic regimens. The present study evaluated and compared the cost-effectiveness of a protease inhibitor based highly active antiretroviral regimen' (PHAART) with a non nucleoside reverse transcriptase inhibitor based highly active antiretroviral regimen' (NHAART) in HIV-patients. The impact of initial HAART was investigated using retrospective cost analysis over a 10-year period and 6 months prospective HRQoL analysis of 150 patients (male 125, mean age 40 years) attending the Cardiff Royal Infirmary and the University Hospital of Wales. Data was collected on each patient's care resource utilization and their health-related quality of life (HRQoL) assessed using the Health Utility Index Mark III (HUI3) questionnaire. The effect of the HAART regimen, demographic attributes and clinical characteristics on costs and HRQoL were analyzed using a multilevel model of change. A Markov Monte Carlo model was then developed to simulate the impact, and evaluate the cost effectiveness, of both regimens beyond the study time horizon. The mean monthly outpatient cost for all patients was estimated to be 237.59. Patients receiving NHAART as the initial regimen cost significantly more (p 0.01, mean 262.19) than patients receiving PHAART (mean 234.98). Other factors associated with higher costs were being a non-British national, having a low CD4 count, a high viral load, and having AIDS. Patients receiving an initial NHAART regimen had a significantly better HRQoL (p 0.05). Factors associated with a higher HRQoL included being in employment and being in the asymptomatic stage of HIV. With respect to lifetime cost-effectiveness analysis, PHAART was found to be more cost-effective as an initial regimen since the incremental cost-effectiveness ratio of 8,871 per quality adjusted life years (QALY) gained, was below the UK threshold of 30,000 per QALY. The findings of this study indicate that patients receiving NHAART as their initial regimen had higher outpatient costs than those initiated on PHAART, but had a better HRQoL. In the long term, however, PHAART was estimated to be more cost- effective than NHAART as an initial regimen for HIV patients.

Published
2007

41. Receptiveness of and Implementation Considerations for COVID-19 Vaccination Certificates in Asia: A Survey Across 9 Countries

Author

Ananthakrishnan, Aparna, primary, Rachatan, Chayapat, additional, Faradiba, Dian, additional, KC, Sarin, additional, Sittimart, Manit, additional, Dabak, Saudamini Vishwanath, additional, Shafie, Asrul Akmal, additional, Suwantika, Auliya A., additional, Kang, Gagandeep, additional, Ahn, Jeonghoon, additional, Hsu, Li Yang, additional, Mayxay, Mayfong, additional, Howard, Natasha, additional, Wattanasri, Parinda, additional, Nakamura, Ryota, additional, George, Tarun K, additional, Isaranuwatchai, Wanrudee, additional, and Teerawattananon, Yot, additional

Published
2022
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42. Factors associated with the opposition to COVID-19 vaccination certificates: A multi-country observational study from Asia

Author

KC, Sarin, primary, Faradiba, Dian, additional, Sittimart, Manit, additional, Isaranuwatchai, Wanrudee, additional, Ananthakrishnan, Aparna, additional, Rachatan, Chayapat, additional, Dabak, Saudamini, additional, Shafie, Asrul Akmal, additional, Guerrero, Anna Melissa, additional, Suwantika, Auliya, additional, Kang, Gagandeep, additional, Ahn, Jeonghoon, additional, Hsu, Li Yang, additional, Mayxay, Mayfong, additional, Howard, Natasha, additional, Wattanasri, Parinda, additional, Nakamura, Ryota, additional, George, Tarun K., additional, and Teerawattananon, Yot, additional

Published
2022
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47. Do health preferences differ among Asian populations?:A comparison of EQ-5D-5L discrete choice experiments data from 11 Asian studies

Author

Yang, Zhihao, Purba, Fredrick Dermawan, Shafie, Asrul Akmal, Igarashi, Ataru, Wong, Eliza Lai Yi, Lam, Hilton, Van Minh, Hoang, Lin, Hsiang Wen, Ahn, Jeonghoon, Pattanaphesaj, Juntana, Jo, Min Woo, Mai, Vu Quynh, Busschbach, Jan, Luo, Nan, Jiang, Jie, Yang, Zhihao, Purba, Fredrick Dermawan, Shafie, Asrul Akmal, Igarashi, Ataru, Wong, Eliza Lai Yi, Lam, Hilton, Van Minh, Hoang, Lin, Hsiang Wen, Ahn, Jeonghoon, Pattanaphesaj, Juntana, Jo, Min Woo, Mai, Vu Quynh, Busschbach, Jan, Luo, Nan, and Jiang, Jie

Abstract

Introduction: Many countries have established their own EQ-5D value sets proceeding on the basis that health preferences differ among countries/populations. So far, published studies focused on comparing value set using TTO data. This study aims to compare the health preferences among 11 Asian populations using the DCE data collected in their EQ-5D-5L valuation studies. Methods: In the EQ-VT protocol, 196 pairs of EQ-5D-5L health states were valued by a general population sample using DCE method for all studies. DCE data were obtained from the study PI. To understand how the health preferences are different/similar with each other, the following analyses were done: (1) the statistical difference between the coefficients; (2) the relative importance of the five EQ-5D dimensions; (3) the relative importance of the response levels. Results: The number of statistically differed coefficients between two studies ranged from 2 to 16 (mean: 9.3), out of 20 main effects coefficients. For the relative importance, there is not a universal preference pattern that fits all studies, but with some common characteristics, e.g. mobility is considered the most important; the relative importance of levels are approximately 20% for level 2, 30% for level 3, 70% for level 4 for all studies. Discussion: Following a standardized study protocol, there are still considerable differences in the modeling and relative importance results in the EQ-5D-5L DCE data among 11 Asian studies. These findings advocate the use of local value set for calculating health state utility.

Published
2022

48. What Can We Learn From Others to Develop a Regional Centre for Infectious Diseases in ASEAN?; Comment on "Operationalising Regional Cooperation for Infectious Disease Control: A Scoping Review of Regional Disease Control Bodies and Networks"

Author

Teerawattananon, Yot, primary, Dabak, Saudamini Vishwanath, additional, Isaranuwatchai, Wanrudee, additional, Lertwilairatanapong, Thongchai, additional, Shafie, Asrul Akmal, additional, Suwantika, Auliya A., additional, Oh, Cecilia, additional, Srisasalux, Jaruayporn, additional, and Cheanklin, Nopporn, additional

Published
2022
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