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2. Systemic cytokines related to memory function 6–9 months and 12–15 months after SARS-CoV-2 infection.

Author

Nuber-Champier, A., Breville, G., Voruz, P., Jacot de Alcântara, I., Cionca, A., Allali, G., Lalive, P. H., Benzakour, L., Lövblad, K.-O., Braillard, O., Nehme, M., Coen, M., Serratrice, J., Reny, J.-L., Pugin, J., Guessous, I., Landis, B. N., Assal, F., and Péron, Julie Anne

Abstract

Cognitive symptoms persisting beyond the acute phase of COVID-19 infection are commonly described for up to 2 years after infection. The relationship between cognitive performance, in particular episodic memory processes observed chronically after infection, and cytokine levels in the acute phase of COVID-19 has not yet been identified in humans. To determine whether the levels of cytokines IL1β, IL-6 and TNFα secreted in the acute phase of SARS-CoV-2 infection are associated and predict verbal and visuospatial episodic memory performance in humans 6 to 9 months and 12 to 15 months post-infection. The associations and predictive value of the concentration of cytokines measured in acute phase (IL-1β, IL-6, TNFα) from plasma samples of N = 33 hospitalized COVID-19 patients (mean age 61 years, 39–78, 65% in intensive care) in relation to their verbal and visuospatial episodic memory performance measured at 6–9 months and 12–15 months post-infection were analyzed. To do this, we used Spearman correlations and generalised linear mixed models. IL-1β levels were associated with verbal episodic memory total recall scores 6–9 months post-infection. At 12–15 months post-infection IL-6 predicted verbal episodic memory score. This study demonstrated that the severity of inflammatory reaction at acute phase of SARS-CoV-2 infection predicts verbal episodic memory performance in the long-term post-infection. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Corrigendum to “Acute TNFα levels predict cognitive impairment 6–9 months after COVID-19 infection” [Psychoneuroendocrinology 153 (2023) 106104]

Author

Nuber-Champier, A., primary, Cionca, A., additional, Breville, G., additional, Voruz, P., additional, Jacot de Alcântara, I., additional, Allali, G., additional, Lalive, P.H., additional, Benzakour, L., additional, Lövblad, K.-O., additional, Braillard, O., additional, Nehme, M., additional, Coen, M., additional, Serratrice, J., additional, Reny, J.-L., additional, Pugin, J., additional, Guessous, I., additional, Landis, B.N., additional, Griffa, A., additional, Van De Ville, D., additional, Assal, F., additional, and Péron, J.A., additional

Published
2023
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4. Determining prognosis in acute exacerbation of COPD

Author

Flattet Y, Garin N, Serratrice J, Perrier A, Stirnemann J, and Carballo S

Subjects
Chronic onstructive pulmonary disease, exacerbation, prognosis, Diseases of the respiratory system, RC705-779
Abstract

Yves Flattet,1 Nicolas Garin,1,2 Jacques Serratrice,1 Arnaud Perrier,1 Jérome Stirnemann,1 Sebastian Carballo1 1Department of Internal Medicine, Service of General Internal Medicine, Geneva University Hospitals, Geneva, 2Service of Internal Medicine, Riviera Chablais Hospital, Monthey, Switzerland Background: Acute exacerbations are the leading causes of hospitalization and mortality in patients with COPD. Prognostic tools for patients with chronic COPD exist, but there are scarce data regarding acute exacerbations. We aimed to identify the prognostic factors of death and readmission after exacerbation of COPD.Methods: This was a retrospective study conducted in the Department of Internal Medicine of Geneva University Hospitals. All patients admitted to the hospital with a diagnosis of exacerbation of COPD between 2008 and 2011 were included. The studied variables included comorbidities, Global Initiative for Chronic Obstructive Lung Disease (GOLD) severity classification, and biological and clinical parameters. The main outcome was death or readmission during a 5-year follow-up. The secondary outcome was death. Survival analysis was performed (log-rank and Cox).Results: We identified a total of 359 patients (195 men and 164 women, average age 72 years). During 5-year follow-up, 242 patients died or were hospitalized for the exacerbation of COPD. In multivariate analysis, age (hazard ratio [HR] 1.03, 95% CI 1.02–1.05; P

Published
2017

5. Frequency of Abnormally Low Neuropsychological Scores in Post-COVID-19 Syndrome: the Geneva COVID-COG Cohort

Author

Voruz, P, primary, Jacot de Alcântara, I, additional, Nuber-Champier, A, additional, Cionca, A, additional, Allali, G, additional, Benzakour, L, additional, Lalive, P H, additional, Lövblad, K-O, additional, Braillard, O, additional, Nehme, M, additional, Coen, M, additional, Serratrice, J, additional, Reny, J-L, additional, Pugin, J, additional, Guessous, I, additional, Ptak, R, additional, Landis, B N, additional, Assal, F, additional, and Péron, J A, additional

Published
2022
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8. Long-Term Outcomes Among Participants in the WEGENT Trial of Remission-Maintenance Therapy for Granulomatosis With Polyangiitis (Wegenerʼs) or Microscopic Polyangiitis

Author

Puéchal, Xavier, Pagnoux, Christian, Perrodeau, Élodie, Hamidou, Mohamed, Boffa, Jean-Jacques, Kyndt, Xavier, Lifermann, François, Papo, Thomas, Merrien, Dominique, Smail, Amar, Delaval, Philippe, Hanrotel-Saliou, Catherine, Imbert, Bernard, Khouatra, Chahéra, Lambert, Marc, Leské, Charles, Ly, Kim H., Pertuiset, Edouard, Roblot, Pascal, Ruivard, Marc, Subra, Jean-François, Viallard, Jean-François, Terrier, Benjamin, Cohen, Pascal, Mouthon, Luc, Le Jeunne, Claire, Ravaud, Philippe, Guillevin, Loïc, Rispal, P., Baidi, N., Chrétien, O., Cevallos, R., Ducroix, J.-P., Darmaillacq, J.-G., Dubas, F., Maghakian, M.-N., Moreau, C., Dubos-Arvis, C., Frognier, R., Gobert, P., Pollini, J., Pingat, D., Janin-Manificat, L., Lafon, B., Kettaneh, A., Moiton, M., Ragnaud, J. M., Boudray, C., Raphanel, B., Renand, J.-P., Roux, M., Bonnaire, G., Guiso, A., André, J. M., Perrichot, R., Louvet, J., Artigues, N., Bienvenu, B., de Ligny, Hurault B., Le Hello, C., Letellier, P., Lobbedez, T., Ollivier, Y., Pujo, M., Ryckelynck, J.-P., Montseny, J.-J., Collet, P., Ayach, B., Dion, J.-J., Mouawad, H., Damade, R., Dupouët, L., Asgaraly, K., Depernet, B., Colin, T., Ioos, V., Rieu, V., Belmatoug, N., Foulon, L., Jebrak, G., du Coedic, L., Bachmeyer, C., Dumoulin, A., Godeau, B., Khellaf, M., Michel, M., Pastural, M., Schaeffer, A., Geffroy, M., Bielefeld, P., Fichet, D., Saraux, J.-L., Vinzio, S., Ehrlacher, P., Azria, A., Mariette, X., Tiab, M., Delansorne, D., Boullanger, N., Closs-Prophette, F., Goldstein, A., Bouscaud, L., Meunier, V., Hachulla, E., Hatron, P.-Y., Launay, D., Hottelart, C., Liozon, E., Longuet, O., Loustaud-Ratti, V., Soria, P., Vidal, E., Geffray, L., Henri, P., Landru, I., Guillemot, J.-M., Le Noach, J., Cordier, J.-F., Cottin, V., Gentil, B., Demolombe-Rague, S., Girard-Madoux, M.-H., Ninet, J., Pinède, L., Meynieux, J.-P., Serratrice, J., Xeridat, B., Bagnères, D., Roudier, J., Denis, B., Boillet, N., Geraads, A., Teyssandier, R., Degraeve, F., Le Quellec, A., Rivière, S., Rogé, C., Fauchay, J.-P., Wahl, D., Agard, C., Généreau, T., Meker, D., Bensakel, S., Vecina, F., Aubier, M., Foulon, G., Lelièvre, P., Lidove, O., Mignon, F., Meyer, O., Piperaud, M., Queffeulou, G., Vrtovsnik, F., Aouba, A., Arène, J.-P., Bérezné, A., Le Guern, V., Amoura, Z., Benveniste, O., Dimitri, D., Huong, Lê Thi D., Bergeron, A., Bourgarit, A., Farge, D., Mahr, A., Martinez, F., Séréni, D., Aslangul, E., Arnal, C., Cadranel, J., Daugas, E., Pelle, G., Rossert, J., Wislez, M., Gayraud, M., Bruet, A., Hillion, Y., Paccalin, M., Léone, J., Pennaforte, J.-L., Barbier, S., Legallicier, B., Dominique, S., Charasse, C., Coëtmeur, D., Duhamel, E., Goulias, J.-P., Bournerias, F., Gautherie, P., Schlienger, J.-L., Vidal, A., Diot, E., Diot, P., Vanhille, P., Bindi, P., and Cervantes, G.

Published
2016
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9. Frequency of Abnormally Low Neuropsychological Scores in Post-COVID-19 Syndrome: the Geneva COVID-COG Cohort.

Author

Voruz, P, Alcântara, I Jacot de, Nuber-Champier, A, Cionca, A, Allali, G, Benzakour, L, Lalive, P H, Lövblad, K-O, Braillard, O, Nehme, M, Coen, M, Serratrice, J, Reny, J-L, Pugin, J, Guessous, I, Ptak, R, Landis, B N, Assal, F, and Péron, J A

Subjects
SARS-CoV-2, EXECUTIVE function, CORONAVIRUS diseases, COVID-19 pandemic, POSTCONCUSSION syndrome
Abstract

Objective Several studies have reported poor long-term neuropsychological performances in patients following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but none has yet considered the effect of administering multiple intercorrelated neuropsychological tests and assessed the frequency of cognitive deficits in a normative population. Our aim was therefore to assess the presence of cumulative neuropsychological deficits in an actual post-coronavirus disease of 2019 (COVID-19) comparison group versus one simulated using Monte-Carlo methods. Method Validated neuropsychological Monte-Carlo simulation methods were applied to scores from a battery of neuropsychological tests (memory, executive, attentional, perceptual, logical reasoning, language, and ideomotor praxis) administered to 121 patients who had had mild, moderate, or severe COVID-19 (mean age: 56.70 years; 32% women), 222 ± 43 days post-infection. The cumulative percentages of the three severity subgroups were compared with the results of a false discovery rate-corrected probability analysis based on normative data. Results The cumulative percentages of deficits in memory and executive functions among the severe and moderate patients were significantly higher than those estimated for the normative population. Moderate patients also had significantly more deficits in perception and logical reasoning. In contrast, the mild group did not have significantly more cumulative deficits. Conclusions Moderate and severe forms of COVID-19 cause greater long-term neuropsychological deficits than those that would be found in a normative population, reinforcing the hypothesis of long-term effects of SARS-CoV-2 on cognitive function, independent of the severity of the initial infection. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Long COVID neuropsychological deficits after severe, moderate or mild infection

Author

Voruz, P., primary, Allali, G., additional, Benzakour, L., additional, Nuber-Champier, A., additional, Thomasson, M., additional, Jacot, I., additional, Pierce, J., additional, Lalive, P., additional, Lövblad, K-O., additional, Braillard, O., additional, Coen, M., additional, Serratrice, J., additional, Pugin, J., additional, Ptak, R., additional, Guessous, I., additional, Landis, B.N., additional, Assal, F., additional, and Péron, J.A., additional

Published
2021
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15. Cryptococcosis in sarcoidosis: cryptOsarc, a comparative study of 18 cases

Author

Bernard, C., Maucort-Boulch, D., Varron, L., Charlier, C., Sitbon, K., Freymond, N., Bouhour, D., Hot, A., Masquelet, A.C., Valeyre, D., Costedoat-Chalumeau, N., Etienne, M., Gueit, I., Jouneau, S., Delaval, P., Mouthon, L., Pouget, J., Serratrice, J., Brion, J.-P., Vaylet, F., Bremont, C., Chennebault, J.M., Jaffuel, S., Broussolle, C., Lortholary, O., and Sève, P.

Published
2013
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40. Maladie de lyme ou myopathie?

Author

Brah, S, Daou, M, Salissou, L, Andia, A, Balaka, A, Tchamdja, T, Sani, BS, Mahaman Sani, MA, Adehossi, E, Serratrice, J, and Weiller, PJ

Subjects
Lyme, amyotrophie, myosite, dystrophie scapulo-humérale, Lyme, amyotrophy, myositis, facial-scapular-humeral, Lyme, amyotrophie, myosite, dystrophie scapulo-humérale
Abstract

Pré-requis: Les atteintes musculaires atypiques dans la maladie de Lyme peuvent poser le problème de l’imputabilité directe de la maladie de Lyme ou comme facteur déclenchant de la maladie musculaire méconnue.But: Montrer la difficulté du diagnostic différentiel entre les atteintes musculaires de la maladie de Lyme et certaines myopathiesObservation: Nous rapportons le cas clinique d’une patiente de 65 ans chez qui le diagnostic de la maladie de Lyme a été posé avec une symptomatologie musculaire mimant une dystrophie facio-scapulo-humérale (FSH) ou une myosite inflammatoire.Conclusion: Cette observation soulève l’intérêt du traitement antibiotique précoce dés la phase de l’érythème migrans même avec une sérologie Lyme douteuse ou négative.Mots clés: Lyme, amyotrophie, myosite, dystrophie scapulo-huméraleEnglish Title: Lyme disease or myopathy?English AbstractBackground: Atypical myopathy in Lyme disease can pose the problem of the direct accountability of the disease or as a triggering factor of a unknown muscle disease.Aim: Show the difficulty of differential diagnosis between myopathy of Lyme disease and certain myopathies.Observation: We report the case of a 65 years old woman in whom the diagnosis of Lyme disease was made with muscular symptoms mimicking facial scapular-humeral dystrophy or myositis.Conclusion: This raises the need of early antibiotic treatment dice the erythema migrans phase even with insignificant or negative lyme serology.Keywords: Lyme, amyotrophy, myositis, facial-scapular-humeral

Published
2016

46. Forme pseudo-pathomimique de granulomatose avec polyangéite (anciennement maladie de Wegener)

Author

Ene, N., Bélénotti, P., Benyamine, A., Sovaila, S., Ben Sahla Talet, M.H., Kaminsky, P., Serratrice, J., Weiller, P.-J., Service de Médecine Interne (MARSEILLE - Med Int), Assistance Publique - Hôpitaux de Marseille (APHM), Service de Médecine Interne et Vasculaire [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Développement, Adaptation et Handicap. Régulations cardio-respiratoires et de la motricité (DevAH), and Université de Lorraine (UL)

Subjects
Anticorps anti-cytoplasme des polynucléaires, Wegener granulomatosis, Breast tumor, Maladie de Wegener, Granulomatosis with polyangiitis, Granulomatose avec polyangéite, Tumeur mammaire, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Anti-neutrophil cytoplasmic antibody
Abstract

International audience; IntroductionANCA vasculitis may involve the skin and develop slowly without specific histology, and without autoantibodies.Case reportWe report a 50-year-old woman who experienced bilateral mastectomy because of ulcero-necrotic, non-specific inflammatory cutaneous lesions of the breasts. First considered by others as a malinger patient, she developed oto-neurological lesions leading to the diagnosis of Wegener's granulomatosis. Five years later, specific antibodies of the disease were present.ConclusionCutaneous involvement by ANCA vasculitis can be isolated for a long time. Physicians must have a high degree of suspicion to avoid diagnostic delay of ANCA vasculitis.; IntroductionUne granulomatose avec polyangéite peut débuter par une atteinte cutanée isolée et torpide. L’analyse histologique peut alors être totalement aspécifique et les anticorps anti-cytoplasme des polynucléaires absents.ObservationNous rapportons l’observation d’une patiente de 50 ans qui avait subit une mastectomie bilatérale, devant des lésions ulcéro-nécrotiques sans diagnostic. Longtemps considérée par d’autres comme pathomimique, elle développait par la suite une atteinte otoneurologique spécifique de granulomatose avec polyangéite. Les auto-anticorps, quant à eux, ne se positivaient que cinq ans plus tard.ConclusionUne granulomatose avec polyangéite peut parfois avoir une évolution très torpide et le diagnostic peut en être largement retardé. Il ne faut pas conclure trop vite à une pathomimie devant une lésion cutanée qui ne cicatrise pas.

Published
2014

47. Où est le problème ?

Author

Serratrice, J., De Roux-Serratrice, C., Ene, N., Granel, B., Cantiniaux, S., Herzog-Landais, C., Swiader, L., Disdier, P., and Weiller, P.A.

Published
2004
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48. Un bon automobiliste!

Author

Serratrice, J., de Roux-Serratrice, C., Ene, N., Granel, B., Cantiniaux, S., HerzogLandais, C., Swiader, L., Disdier, P., Djiane, P., and Weiller, P.A.

Published
2004
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49. Chapitre 8 Processus physiques et outils pour le diagnostic et la conception des digues

Author

Veylon, G., Durand, E., Sharp, M., Simm, J., Gaines, R., Allsop, W., Briggs, M., Chassé, P., Criado, D., Habert, J., Morris, M., André Paquier, Pullen, T., Schwanz, N., Serratrice, J. F., Smith, J., Benahmed, N., Stéphane Bonelli, Degoutte, G., Mercklé, S., Philippe, P., Royet, P., Hemert, H., Igigabel, M., Pohl, R., Tourment, R., Wallis, M., Ouvrages hydrauliques et hydrologie (UR OHAX), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), CETE NORMANDIE CENTRE FRA, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), USACE USA, HR WALLINGFORD GBR, CETMEF FRA, DREAL PACA FRA, CETE, SAMUI DESIGN AND MANAGEMENT LTD GBR, Hydrologie-Hydraulique (UR HHLY), STOWA NLD, HR WALLINGFORD GRB, and Irstea Publications, Migration

Subjects
[SDE] Environmental Sciences, [SDE]Environmental Sciences
Abstract

International audience; Chapter 8 presents morphologic, hydraulic and geotechnical tools to assess performance of a levee section.

Published
2013

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