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1. Electronic Health Record Data for Lyme Disease Surveillance, Massachusetts, USA, 2017-2018

Author

Nagavedu, Kshema, Eberhardt, Karen, Willis, Sarah, Morrison, Monica, Ochoa, Aileen, Soliva, Susan, Scotland, Sarah, Cocoros, Noelle M., Callahan, Myfanwy, Randall, Liisa M., Brown, Catherine M., and Klompas, Michael

Subjects
Massachusetts -- Health aspects, Medical research, Medicine, Experimental, Sentinel health events -- Methods -- Technology application, Medical records -- Usage, Electronic records -- Usage, Lyme disease -- Research, Algorithms -- Usage -- Health aspects, Health, Algorithm, Technology application, Usage, Research, Methods, Health aspects
Abstract

Lyme disease, caused by infection with the bacterium Borrelia burgdorferi, is the most common vectorborne illness in the United States and is steadily affecting an expanding area of the country [...]

Published
2024
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2. Outcomes up to age 36 months after congenital Zika virus infection—U.S. states

Author

Neelam, Varsha, Woodworth, Kate R., Chang, Daniel J., Roth, Nicole M., Reynolds, Megan R., Akosa, Amanda, Carr, Christopher P., Anderson, Kayla N., Mulkey, Sarah B., DeBiasi, Roberta L., Biddle, Cara, Lee, Ellen H., Elmore, Amanda L., Scotland, Sarah J., Sowunmi, Similoluwa, Longcore, Nicole D., Ahmed, Muhammad, Langlois, Peter H., Khuwaja, Salma, Browne, Shea Elizabeth, Lind, Leah, Shim, Kyoo, Gosciminski, Michael, Blumenfeld, Rachel, Khuntia, Shreya, Halai, Umme-Aiman, Locklear, Autumn, Chan, Mary, Willabus, Teri’, Tonzel, Julius, Marzec, Natalie S., Barreto, Nianest Alers, Sanchez, Connie, Fornoff, Jane, Hale, Shelby, Nance, Amy, Iguchi, Lisa, Adibhatla, Sowmya N., Potts, Emily, Schiffman, Elizabeth, Raman, Devin, McDonald, Morgan F., Stricklin, Brandi, Ludwig, Elizabeth, Denson, Lindsay, Contreras, Dianna, Romitti, Paul A., Ferrell, Emily, Marx, Meghan, Signs, Kimberly, Cook, Amie, Leedom, Vinita Oberoi, Beauregard, Suzann, Orantes, Lucia C., Cronquist, Laura, Roush, Lesley, Godfred-Cato, Shana, Gilboa, Suzanne M., Meaney-Delman, Dana, Honein, Margaret A., Moore, Cynthia A., and Tong, Van T.

Published
2024
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3. Evaluation of Placental and Fetal Tissue Specimens for Zika Virus Infection — 50 States and District of Columbia, January–December, 2016

Author

U.S. Zika Pregnancy Registry Collaboration, Zika Virus Response Epidemiology and Surveillance Task Force Pathology Team, Reagan-Steiner, Sarah, Simeone, Regina, Simon, Elizabeth, Bhatnagar, Julu, Oduyebo, Titilope, Free, Rebecca, Denison, Amy M., Rabeneck, Demi B., Ellington, Sascha, Petersen, Emily, Gary, Joy, Hale, Gillian, Keating, M. Kelly, Martines, Roosecelis B., Muehlenbachs, Atis, Ritter, Jana, Lee, Ellen, Davidson, Alexander, Conners, Erin, Scotland, Sarah, Sandhu, Kayleigh, Bingham, Andrea, Kassens, Elizabeth, Smith, Lou, St. George, Kirsten, Ahmad, Nina, Tanner, Mary, Beavers, Suzanne, Miers, Brooke, VanMaldeghem, Kelley, Khan, Sumaiya, Rabe, Ingrid, Gould, Carolyn, Meaney-Delman, Dana, Honein, Margaret A., Shieh, Wun-Ju, Jamieson, Denise J., Fischer, Marc, and Zaki, Sherif R.

Published
2017

4. Outcomes up to age 36 months after congenital Zika virus infection—U.S. states

Author

Neelam, Varsha, primary, Woodworth, Kate R., additional, Chang, Daniel J., additional, Roth, Nicole M., additional, Reynolds, Megan R., additional, Akosa, Amanda, additional, Carr, Christopher P., additional, Anderson, Kayla N., additional, Mulkey, Sarah B., additional, DeBiasi, Roberta L., additional, Biddle, Cara, additional, Lee, Ellen H., additional, Elmore, Amanda L., additional, Scotland, Sarah J., additional, Sowunmi, Similoluwa, additional, Longcore, Nicole D., additional, Ahmed, Muhammad, additional, Langlois, Peter H., additional, Khuwaja, Salma, additional, Browne, Shea Elizabeth, additional, Lind, Leah, additional, Shim, Kyoo, additional, Gosciminski, Michael, additional, Blumenfeld, Rachel, additional, Khuntia, Shreya, additional, Halai, Umme-Aiman, additional, Locklear, Autumn, additional, Chan, Mary, additional, Willabus, Teri’, additional, Tonzel, Julius, additional, Marzec, Natalie S., additional, Barreto, Nianest Alers, additional, Sanchez, Connie, additional, Fornoff, Jane, additional, Hale, Shelby, additional, Nance, Amy, additional, Iguchi, Lisa, additional, Adibhatla, Sowmya N., additional, Potts, Emily, additional, Schiffman, Elizabeth, additional, Raman, Devin, additional, McDonald, Morgan F., additional, Stricklin, Brandi, additional, Ludwig, Elizabeth, additional, Denson, Lindsay, additional, Contreras, Dianna, additional, Romitti, Paul A., additional, Ferrell, Emily, additional, Marx, Meghan, additional, Signs, Kimberly, additional, Cook, Amie, additional, Leedom, Vinita Oberoi, additional, Beauregard, Suzann, additional, Orantes, Lucia C., additional, Cronquist, Laura, additional, Roush, Lesley, additional, Godfred-Cato, Shana, additional, Gilboa, Suzanne M., additional, Meaney-Delman, Dana, additional, Honein, Margaret A., additional, Moore, Cynthia A., additional, and Tong, Van T., additional

Published
2023
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5. Male-to-Female Sexual Transmission of Zika Virus—United States, January–April 2016

Author

Russell, Kate, Hills, Susan L., Oster, Alexandra M., Porse, Charsey Cole, Danyluk, Gregory, Cone, Marshall, Brooks, Richard, Scotland, Sarah, Schiffman, Elizabeth, Fredette, Carolyn, White, Jennifer L., Ellingson, Katherine, Hubbard, Allison, Cohn, Amanda, Fischer, Marc, Mead, Paul, Powers, Ann M., and Brooks, John T.

Published
2017

6. Supplementary Table S7 from Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

Author

Farge, Thomas, primary, Saland, Estelle, primary, de Toni, Fabienne, primary, Aroua, Nesrine, primary, Hosseini, Mohsen, primary, Perry, Robin, primary, Bosc, Claudie, primary, Sugita, Mayumi, primary, Stuani, Lucille, primary, Fraisse, Marine, primary, Scotland, Sarah, primary, Larrue, Clément, primary, Boutzen, Héléna, primary, Féliu, Virginie, primary, Nicolau-Travers, Marie-Laure, primary, Cassant-Sourdy, Stéphanie, primary, Broin, Nicolas, primary, David, Marion, primary, Serhan, Nizar, primary, Sarry, Audrey, primary, Tavitian, Suzanne, primary, Kaoma, Tony, primary, Vallar, Laurent, primary, Iacovoni, Jason, primary, Linares, Laetitia K., primary, Montersino, Camille, primary, Castellano, Rémy, primary, Griessinger, Emmanuel, primary, Collette, Yves, primary, Duchamp, Olivier, primary, Barreira, Yara, primary, Hirsch, Pierre, primary, Palama, Tony, primary, Gales, Lara, primary, Delhommeau, François, primary, Garmy-Susini, Barbara H., primary, Portais, Jean-Charles, primary, Vergez, François, primary, Selak, Mary, primary, Danet-Desnoyers, Gwenn, primary, Carroll, Martin, primary, Récher, Christian, primary, and Sarry, Jean-Emmanuel, primary

Published
2023
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7. Data from Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

Author

Farge, Thomas, primary, Saland, Estelle, primary, de Toni, Fabienne, primary, Aroua, Nesrine, primary, Hosseini, Mohsen, primary, Perry, Robin, primary, Bosc, Claudie, primary, Sugita, Mayumi, primary, Stuani, Lucille, primary, Fraisse, Marine, primary, Scotland, Sarah, primary, Larrue, Clément, primary, Boutzen, Héléna, primary, Féliu, Virginie, primary, Nicolau-Travers, Marie-Laure, primary, Cassant-Sourdy, Stéphanie, primary, Broin, Nicolas, primary, David, Marion, primary, Serhan, Nizar, primary, Sarry, Audrey, primary, Tavitian, Suzanne, primary, Kaoma, Tony, primary, Vallar, Laurent, primary, Iacovoni, Jason, primary, Linares, Laetitia K., primary, Montersino, Camille, primary, Castellano, Rémy, primary, Griessinger, Emmanuel, primary, Collette, Yves, primary, Duchamp, Olivier, primary, Barreira, Yara, primary, Hirsch, Pierre, primary, Palama, Tony, primary, Gales, Lara, primary, Delhommeau, François, primary, Garmy-Susini, Barbara H., primary, Portais, Jean-Charles, primary, Vergez, François, primary, Selak, Mary, primary, Danet-Desnoyers, Gwenn, primary, Carroll, Martin, primary, Récher, Christian, primary, and Sarry, Jean-Emmanuel, primary

Published
2023
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8. Supplementary Methods and Supplementary Figures 1 through 18 from Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

Author

Farge, Thomas, primary, Saland, Estelle, primary, de Toni, Fabienne, primary, Aroua, Nesrine, primary, Hosseini, Mohsen, primary, Perry, Robin, primary, Bosc, Claudie, primary, Sugita, Mayumi, primary, Stuani, Lucille, primary, Fraisse, Marine, primary, Scotland, Sarah, primary, Larrue, Clément, primary, Boutzen, Héléna, primary, Féliu, Virginie, primary, Nicolau-Travers, Marie-Laure, primary, Cassant-Sourdy, Stéphanie, primary, Broin, Nicolas, primary, David, Marion, primary, Serhan, Nizar, primary, Sarry, Audrey, primary, Tavitian, Suzanne, primary, Kaoma, Tony, primary, Vallar, Laurent, primary, Iacovoni, Jason, primary, Linares, Laetitia K., primary, Montersino, Camille, primary, Castellano, Rémy, primary, Griessinger, Emmanuel, primary, Collette, Yves, primary, Duchamp, Olivier, primary, Barreira, Yara, primary, Hirsch, Pierre, primary, Palama, Tony, primary, Gales, Lara, primary, Delhommeau, François, primary, Garmy-Susini, Barbara H., primary, Portais, Jean-Charles, primary, Vergez, François, primary, Selak, Mary, primary, Danet-Desnoyers, Gwenn, primary, Carroll, Martin, primary, Récher, Christian, primary, and Sarry, Jean-Emmanuel, primary

Published
2023
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9. Contact Tracing and Exposure Investigation in Response to the First Case of Monkeypox Virus Infection in the United States During the 2022 Global Monkeypox Outbreak

Author

Shenoy, Erica S., primary, Wright, Sharon B., additional, Barbeau, Deborah N., additional, Foster, Lisa A., additional, King, Aleah D., additional, Gordon, Patrick S., additional, Mehrotra, Preeti, additional, Pepe, Dana E., additional, Caroff, Daniel A., additional, Kim, Lindsey R., additional, McGrath, Shannon E., additional, Courtney, Amy, additional, Fahy, Meredith, additional, Hooper, David C., additional, Macdonald, Kaitlin, additional, Searle, Eileen F., additional, Shearer, Jennifer A., additional, Zachary, Kimon C., additional, Bouton, Lindsay, additional, Cumming, Melissa, additional, Hopkins, Brandi, additional, Jacoboski, Juliana, additional, Mann, Erin, additional, Osborne, Matthew, additional, Perez, Carley, additional, Schultz, Jordan, additional, Scotland, Sarah, additional, Traphagen, Elizabeth, additional, Madoff, Lawrence C., additional, and Brown, Catherine M., additional

Published
2022
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11. Zika virus evolution and spread in the Americas

Author

Metsky, Hayden C., Matranga, Christian B., Wohl, Shirlee, Schaffner, Stephen F., Freije, Catherine A., Winnicki, Sarah M., West, Kendra, Qu, James, Baniecki, Mary Lynn, Gladden-Young, Adrianne, Lin, Aaron E., Tomkins-Tinch, Christopher H., Ye, Simon H., Park, Daniel J., Luo, Cynthia Y., Barnes, Kayla G., Shah, Rickey R., Chak, Bridget, Barbosa-Lima, Giselle, Delatorre, Edson, Vieira, Yasmine R., Paul, Lauren M., Tan, Amanda L., Barcellona, Carolyn M., Porcelli, Mario C., Vasquez, Chalmers, Cannons, Andrew C., Cone, Marshall R., Hogan, Kelly N., Kopp, Edgar W., Anzinger, Joshua J., Garcia, Kimberly F., Parham, Leda A., Ramrez, Rosa M. Glvez, Montoya, Maria C. Miranda, Rojas, Diana P., Brown, Catherine M., Hennigan, Scott, Sabina, Brandon, Scotland, Sarah, Gangavarapu, Karthik, Grubaugh, Nathan D., Oliveira, Glenn, Robles-Sikisaka, Refugio, Rambaut, Andrew, Gehrke, Lee, Smole, Sandra, Halloran, M. Elizabeth, Villar, Luis, Mattar, Salim, Lorenzana, Ivette, Cerbino-Neto, Jose, Valim, Clarissa, Degrave, Wim, Bozza, Patricia T., Gnirke, Andreas, Andersen, Kristian G., Isern, Sharon, Michael, Scott F., Bozza, Fernando A., Souza, Thiago M. L., Bosch, Irene, Yozwiak, Nathan L., MacInnis, Bronwyn L., and Sabeti, Pardis C.

Subjects
America -- Health aspects, Zika virus -- Natural history, Zika virus infection -- Distribution, Company distribution practices, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Hayden C. Metsky [1, 2]; Christian B. Matranga [1]; Shirlee Wohl [1, 3]; Stephen F. Schaffner [1, 3, 4]; Catherine A. Freije [1, 3]; Sarah M. Winnicki [1]; Kendra [...]

Published
2017
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12. Ribavirin as a potential therapeutic for atypical teratoid/rhabdoid tumors

Author

Casaos, Joshua, primary, Huq, Sakibul, additional, Lott, Tarik, additional, Felder, Raphael, additional, Choi, John, additional, Gorelick, Noah, additional, Peters, Michael, additional, Xia, Yuanxuan, additional, Maxwell, Russell, additional, Zhao, Tianna, additional, Ji, Chenchen, additional, Simon, Thomas, additional, Sesen, Julie, additional, Scotland, Sarah J., additional, Kast, Richard E., additional, Rubens, Jeffrey, additional, Raabe, Eric, additional, Eberhart, Charles G., additional, Jackson, Eric M., additional, Brem, Henry, additional, Tyler, Betty, additional, and Skuli, Nicolas, additional

Published
2018
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13. Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

Author

Farge, Thomas, primary, Saland, Estelle, additional, de Toni, Fabienne, additional, Aroua, Nesrine, additional, Hosseini, Mohsen, additional, Perry, Robin, additional, Bosc, Claudie, additional, Sugita, Mayumi, additional, Stuani, Lucille, additional, Fraisse, Marine, additional, Scotland, Sarah, additional, Larrue, Clément, additional, Boutzen, Héléna, additional, Féliu, Virginie, additional, Nicolau-Travers, Marie-Laure, additional, Cassant-Sourdy, Stéphanie, additional, Broin, Nicolas, additional, David, Marion, additional, Serhan, Nizar, additional, Sarry, Audrey, additional, Tavitian, Suzanne, additional, Kaoma, Tony, additional, Vallar, Laurent, additional, Iacovoni, Jason, additional, Linares, Laetitia K., additional, Montersino, Camille, additional, Castellano, Rémy, additional, Griessinger, Emmanuel, additional, Collette, Yves, additional, Duchamp, Olivier, additional, Barreira, Yara, additional, Hirsch, Pierre, additional, Palama, Tony, additional, Gales, Lara, additional, Delhommeau, François, additional, Garmy-Susini, Barbara H., additional, Portais, Jean-Charles, additional, Vergez, François, additional, Selak, Mary, additional, Danet-Desnoyers, Gwenn, additional, Carroll, Martin, additional, Récher, Christian, additional, and Sarry, Jean-Emmanuel, additional

Published
2017
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14. Zika virus evolution and spread in the Americas

Author

Institute for Medical Engineering and Science, Broad Institute of MIT and Harvard, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Metsky, Hayden C., Schaffner, Stephen F, Quigley, James Edwin, Ye, Simon Huang, Park, Daniel, Barnes, Kayla, Gehrke, Lee, Valim, Clarissa, Gnirke, Andreas, Andersen, Kristian, Bosch, Irene, Matranga, Christian B., Wohl, Shirlee, Freije, Catherine A., Winnicki, Sarah M., West, Kendra, Baniecki, Mary Lynn, Gladden-Young, Adrianne, Lin, Aaron E., Tomkins-Tinch, Christopher H., Luo, Cynthia Y., Shah, Rickey R., Chak, Bridget, Barbosa-Lima, Giselle, Delatorre, Edson, Vieira, Yasmine R., Paul, Lauren M., Tan, Amanda L., Barcellona, Carolyn M., Porcelli, Mario C., Vasquez, Chalmers, Cannons, Andrew C., Cone, Marshall R., Hogan, Kelly N., Kopp, Edgar W., Anzinger, Joshua J., Garcia, Kimberly F., Parham, Leda A., Ramírez, Rosa M. Gélvez, Montoya, Maria C. Miranda, Rojas, Diana P., Brown, Catherine M., Hennigan, Scott, Sabina, Brandon, Scotland, Sarah, Gangavarapu, Karthik, Grubaugh, Nathan D., Oliveira, Glenn, Robles-Sikisaka, Refugio, Rambaut, Andrew, Smole, Sandra, Halloran, M. Elizabeth, Villar, Luis, Mattar, Salim, Lorenzana, Ivette, Cerbino-Neto, Jose, Degrave, Wim, Bozza, Patricia T., Isern, Sharon, Michael, Scott F., Bozza, Fernando A., Souza, Thiago M. L., Yozwiak, Nathan L., MacInnis, Bronwyn L., Sabeti, Pardis C., Institute for Medical Engineering and Science, Broad Institute of MIT and Harvard, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Metsky, Hayden C., Schaffner, Stephen F, Quigley, James Edwin, Ye, Simon Huang, Park, Daniel, Barnes, Kayla, Gehrke, Lee, Valim, Clarissa, Gnirke, Andreas, Andersen, Kristian, Bosch, Irene, Matranga, Christian B., Wohl, Shirlee, Freije, Catherine A., Winnicki, Sarah M., West, Kendra, Baniecki, Mary Lynn, Gladden-Young, Adrianne, Lin, Aaron E., Tomkins-Tinch, Christopher H., Luo, Cynthia Y., Shah, Rickey R., Chak, Bridget, Barbosa-Lima, Giselle, Delatorre, Edson, Vieira, Yasmine R., Paul, Lauren M., Tan, Amanda L., Barcellona, Carolyn M., Porcelli, Mario C., Vasquez, Chalmers, Cannons, Andrew C., Cone, Marshall R., Hogan, Kelly N., Kopp, Edgar W., Anzinger, Joshua J., Garcia, Kimberly F., Parham, Leda A., Ramírez, Rosa M. Gélvez, Montoya, Maria C. Miranda, Rojas, Diana P., Brown, Catherine M., Hennigan, Scott, Sabina, Brandon, Scotland, Sarah, Gangavarapu, Karthik, Grubaugh, Nathan D., Oliveira, Glenn, Robles-Sikisaka, Refugio, Rambaut, Andrew, Smole, Sandra, Halloran, M. Elizabeth, Villar, Luis, Mattar, Salim, Lorenzana, Ivette, Cerbino-Neto, Jose, Degrave, Wim, Bozza, Patricia T., Isern, Sharon, Michael, Scott F., Bozza, Fernando A., Souza, Thiago M. L., Yozwiak, Nathan L., MacInnis, Bronwyn L., and Sabeti, Pardis C.

Abstract

Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention1,2, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States. We find that ZIKV circulated undetected in multiple regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections. We identify mutations with possible functional implications for ZIKV biology and pathogenesis, as well as those that might be relevant to the effectiveness of diagnostic tests., National Institutes of Health (U.S.) (Grant NIAID U19AI110818)

Published
2017

15. Male-to-Female Sexual Transmission of Zika Virus—United States, January–April 2016

Author

Russell, Kate, primary, Hills, Susan L., additional, Oster, Alexandra M., additional, Porse, Charsey Cole, additional, Danyluk, Gregory, additional, Cone, Marshall, additional, Brooks, Richard, additional, Scotland, Sarah, additional, Schiffman, Elizabeth, additional, Fredette, Carolyn, additional, White, Jennifer L., additional, Ellingson, Katherine, additional, Hubbard, Allison, additional, Cohn, Amanda, additional, Fischer, Marc, additional, Mead, Paul, additional, Powers, Ann M., additional, and Brooks, John T., additional

Published
2016
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16. Metformin Inhibits Growth of Human Glioblastoma Cells and Enhances Therapeutic Response

Author

Sesen, Julie, primary, Dahan, Perrine, additional, Scotland, Sarah J., additional, Saland, Estelle, additional, Dang, Van-Thi, additional, Lemarié, Anthony, additional, Tyler, Betty M., additional, Brem, Henry, additional, Toulas, Christine, additional, Cohen-Jonathan Moyal, Elizabeth, additional, Sarry, Jean-Emmanuel, additional, and Skuli, Nicolas, additional

Published
2015
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17. Evaluation of Placental and Fetal Tissue Specimens for Zika Virus Infection - 50 States and District of Columbia, January-December, 2016.

Author

Reagan-Steiner, Sarah, Simeone, Regina, Simon, Elizabeth, Bhatnagar, Julu, Oduyebo, Titilope, Free, Rebecca, Denison, Amy M., Rabeneck, Demi B., Ellington, Sascha, Petersen, Emily, Gary, Joy, Hale, Gillian, Keating, M. Kelly, Martines, Roosecelis B., Muehlenbachs, Atis, Ritter, Jana, Lee, Ellen, Davidson, Alexander, Conners, Erin, and Scotland, Sarah

Subjects
ZIKA virus infections, FETAL tissues, PLACENTA, MICROCEPHALY, BRAIN abnormalities, PREGNANCY, COMMUNICABLE disease diagnosis, PREGNANCY complications, POLYMERASE chain reaction, DIAGNOSIS
Abstract

Zika virus infection during pregnancy can cause congenital microcephaly and brain abnormalities (1), and detection of Zika virus RNA in clinical and tissue specimens can provide definitive laboratory evidence of recent Zika virus infection. Whereas duration of viremia is typically short, prolonged detection of Zika virus RNA in placental, fetal, and neonatal brain tissue has been reported and can provide key diagnostic information by confirming recent Zika virus infection (2). In accordance with recent guidance (3,4), CDC provides Zika virus testing of placental and fetal tissues in clinical situations where this information could add diagnostic value. This report describes the evaluation of formalin-fixed paraffin-embedded (FFPE) tissue specimens tested for Zika virus infection in 2016 and the contribution of this testing to the public health response. Among 546 live births with possible maternal Zika virus exposure, for which placental tissues were submitted by the 50 states and District of Columbia (DC), 60 (11%) were positive by Zika virus reverse transcription-polymerase chain reaction (RT-PCR). Among 81 pregnancy losses for which placental and/or fetal tissues were submitted, 18 (22%) were positive by Zika virus RT-PCR. Zika virus RT-PCR was positive on placental tissues from 38/363 (10%) live births with maternal serologic evidence of recent unspecified flavivirus infection and from 9/86 (10%) with negative maternal Zika virus immunoglobulin M (IgM) where possible maternal exposure occurred >12 weeks before serum collection. These results demonstrate that Zika virus RT-PCR testing of tissue specimens can provide a confirmed diagnosis of recent maternal Zika virus infection. [ABSTRACT FROM AUTHOR]

Published
2017
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18. Manipulation du métabolisme énergétique dans les leucémies aiguës myéloïdes : mitochondrie, apoptose et mécanisme d'action de la metformine

Author

Scotland, Sarah J. and Scotland, Sarah J.

Abstract

La metformine, utilisée pour le traitement du diabète de type 2, a été décrite comme pouvant réduire le risque de cancer. Cependant, les mécanismes responsables de cette activité n'ont pas encore été élucidés. Nous avons ici décidé d'étudier les effets de la metformine dans les cellules de leucémie aiguë myéloïde (LAM). La metformine bloque la progression dans le cycle cellulaire, inhibe la prolifération et la formation de colonies in vitro. In vivo, un traitement quotidien à la metformine induit l'apoptose et réduit la progression tumorale. Toutefois, cette induction d'apoptose est variable en fonction des cellules leucémiques. La metformine induit une inhibition de mTORC1 indépendante de l'AMPK, qui peut être responsable des effets anti-tumoraux observés. Par ailleurs, la metformine réduit fortement l'activité du complexe I de la chaîne respiratoire, la consommation d'oxygène et la production d'ATP par la mitochondrie alors qu'elle stimule la glycolyse pour la production d'ATP et de lactate (effet Pasteur). Les cellules leucémiques avec une forte glycolyse ou activation d'AKT montrent une réduction significative de l'induction de l'effet Pasteur et de l'apoptose en réponse à la metformine. Ainsi, la déprivation en glucose ou un inhibiteur de la glycolyse ou d'AKT sensibilisent ces cellules à la metformine. Nous proposons que le mécanisme d'apoptose est bloqué par la phosphorylation et la translocation au pore mitochondrial VDAC1 de l'hexokinase-II en aval d'AKT. En conclusion, ces travaux ont permis de mieux caractériser la signalisation et le métabolisme impliqués dans la réponse anti-tumorale induite par la metformine dans des lignées cellulaires de LAM., Normoglycemic agent, metformin, decreases the risk of cancer in type 2 diabetics and inhibits cell growth in various cancers. Metformin activates AMPK and inhibits electron transport chain complex I (ETCI), but its mechanism of action in cancer cells is unknown. Thus, we investigated metformin's activity in human acute myeloid leukemia (AML) cells. Metformin significantly blocks cell cycle progression and inhibits cell proliferation and colony formation. However, the apoptotic response to metformin varies among AML cell types. Furthermore, daily treatment with metformin induces apoptosis and reduces tumor growth in vivo. Metformin induces an AMPK-independent inhibition of mTORC1, which could be responsible for metformin's anti-tumoral activities. Additionally, metformin decreases ETCI activity, oxygen consumption and mitochondrial ATP synthesis, while stimulating glycolysis for ATP and lactate production (so-called Pasteur Effect). AML cells with high basal AKT phosphorylation or glycolysis exhibit a markedly reduced induction of the Pasteur effect in response to metformin and are resistant to metformin-induced apoptosis. Accordingly, glucose starvation or treatment with deoxyglucose or an AKT inhibitor induces sensitivity to metformin. Thus, we propose that activation of AKT, which can phosphorylate hexokinase-II to induce its translocation to the mitochondrial outer membrane pore, VDAC1, blocks cytochrome c release and mitochondrial-induced apoptosis. Overall, this work has allowed us to decipher the role of certain signaling and metabolic pathways in the anti-tumoral response to metformin in AML.

Published
2013

20. Metabolic Capability to Induce the Pasteur Effect Mediates Sensitivity of Human Leukemic Cells to Metformin

Author

Scotland, Sarah, primary, Saland, Estelle, additional, Peyriga, Lindsay, additional, Peyraud, Rémi, additional, Micklow, Elizabeth, additional, Danet-Desnoyers, Gwenn, additional, Manenti, Stéphane, additional, Récher, Christian, additional, Portais, Jean-Charles, additional, Selak, Mary, additional, Carroll, Martin, additional, and Sarry, Jean-Emmanuel, additional

Published
2011
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21. Anti-Leukemic Activity of PIK-75, a PI3-Kinase p110α Selective Inhibitor, In Acute Myeloid Leukemia

Author

Vergez, François, primary, Sarry, Jean-Emmanuel, additional, Gallay, Nathalie, additional, Fialin, Camille, additional, Scotland, Sarah, additional, Demur, Cécile, additional, Shepherd, Peter, additional, Danet-Desnoyer, Gwenn-ael, additional, Kruczynski, Anna, additional, Payrastre, Bernard, additional, Manenti, Stéphane, additional, and Recher, Christian, additional

Published
2010
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23. The Bad, the Good and eIF3e/INT6.

Author

Sesen J, Casaos J, Scotland SJ, Seva C, Eisinger-Mathason TS, and Skuli N

Subjects
Animals, Basic Helix-Loop-Helix Transcription Factors genetics, Basic Helix-Loop-Helix Transcription Factors metabolism, Epithelial-Mesenchymal Transition genetics, Epithelial-Mesenchymal Transition physiology, Eukaryotic Initiation Factor-3 chemistry, Eukaryotic Initiation Factor-3 genetics, Genes, Tumor Suppressor, Humans, Neoplasms blood supply, Neoplasms genetics, Neoplasms metabolism, Neovascularization, Pathologic, Neovascularization, Physiologic, Oncogenes, Protein Subunits, Eukaryotic Initiation Factor-3 metabolism
Abstract

Recent research on translation and protein synthesis in several pathologies, including cancer, peripheral artery disease, and wound healing, demonstrates the key role played by translational factors in tumorigenic and angiogenic processes. This review will focus on one specific translational factor, eIF3e also called INT6, the "e" subunit of the translation initiation factor eIF3. INT6/eIF3e has recently been described as a multifunction protein playing a role in translation, protein degradation, DNA repair, nonsense-mediated mRNA decay, cell cycle and control of cell response to low oxygen (hypoxia or ischemia) through modulation of the Hypoxia Inducible Factors (HIFs). Interestingly, INT6/eIF3e is a double-edged sword that has both oncogenic and tumor suppressive abilities. In addition to its role in tumorigenesis, its silencing has recently been suggested as a potential therapeutic strategy to improve cell survival and function after ischemic injuries. Although a deeper understanding of the molecular mechanisms involved in these pathophysiological functions is essential, particularly to transform the in vitro / in vivo findings into clinical applications, INT6/eIF3e modulation could provide therapeutic benefit for a variety of human diseases such as cancer or vascular diseases.

Published
2017
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