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Three novel bile acid-based molecular dimers, 3α,3'α-bis(n-acetoxyphenylcarboxy)-5β-cholan-24-oic acid ethane-1,2-diol diesters (n = 2–4), 1–3, were synthesized from lithocholic acid (3α-hydroxy-5β-cholan-24-oic acid) ethane-1,2-diol diester and isomeric n-acetoxybenzoyl chlorides (n = 2–4). Their cleft type conformational preferences were suggested theoretically by PM3 molecular orbital calculations. Molecular weights determined by the matrix-assisted laser desorption/ionization time-of-flight technique and ¹³C NMR chemical shifts of the 1–3 are also presented. Copyright © 2000 John Wiley & Sons, Ltd.

AbstractThe large number of lakes covering 10% of Finland's surface area provide an opportunity for both full-time and part-time professional fishing. However, the development of the fishing industry is hindered by unpredictable fluctuations in fish stocks, by the elaborate hierarchy of the fisheries system, as well as by certain features of Finnish professional fishing, such as the small size of fishing enterprises, the scattered pattern of production, and long transportation distances to the core demand areas. According to Finnish catch statistics, the stock of vendace Coregonus albula has clearly diminished since the mid 1980s. Our results show that full-time professional fishermen differ from part-time professional fishermen in their adaptation to diminished fish stocks: they increase their fishing efforts, they try to extend their fishing grounds, and they switch to or supplement with a new species. Moreover, their desire to develop their fishing is stronger than that of part-time professional fishermen, and they can be regarded as active agents in the fishing industry. When a fishing enterprise has adequate access to fishing grounds and is allowed to use different kinds of gear effectively, it may develop and expand its operations (i.e., use its entrepreneurial capacity). An important policy implication of resource use would be to ensure the availability of fishing licenses to full-time professional fishermen, in the hope that the most active would also lead the continued development of inland professional fishing as a whole.

The characteristic, bloodhound-like appearance, which degenerates gradually, of patients with primary hereditary systemic amyloidosis, also called Meretoja's syndrome (MS), is attributable to amyloid degeneration of the craniofacial skin and peripheral facial nerves, but apparently also to amyloid deposits in the muscles; a finding not previously described. A material of five patients treated with plastic surgery is presented, and the peculiarities and differences of this rare disease in comparison with other peripheral neuropathies is discussed from a reconstructive viewpoint.

3α,3'α-Bis(arylcarboxy)-5β-cholan-24-oic acid ethane-1,2-diol diesters (1–3) were synthesized by the reaction of an aroyl chloride (aroyl=2,6-dichlorobenzoyl, 2-naphthoyl and 1-pyrenoyl) with lithocholic acid (3α-hydroxy-5β-cholan-24-oic acid) ethane-1,2-diol diester. The ¹³C NMR chemical shift assignments of the formed molecular clefts 1–3, pyrene-1-carboxylic acid methyl ester (4) (used as model compound) and 1-pyrenoyl chloride (5) are based on literature data and ¹³C DEPT-135, ¹H,¹³C HMQC and ¹H,¹³C HMBC experiments. The molecular weights of 1–3 were determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Copyright © 1999 John Wiley & Sons, Ltd.