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Introduction: Pediatric orbital tumors encompass a wide spectrum of neoplasms, many of which are malignant small round cell tumors with overlapping histology. Sarcomas with BCOR genetic alterations are undifferentiated round cell sarcomas (URCS) characterized by BCOR rearrangements or internal tandem duplications, having distinct clinical features. Being previously unrecognized in the orbit, they have potential for misdiagnosis. Patients: We describe two cases of orbital sarcomas with BCOR genetic alterations. Results: Both girls, 8 and 16 months of age, respectively, presented with progressive proptosis. Both tumors showed sheets of round to ovoid cells with monomorphic nuclei and frequent mitoses. Delicate branching capillaries and myxoid stroma were absent. Diffuse BCOR, cyclin D1, and SATB2 immunopositivity was present. Conclusion: Orbital sarcomas with BCOR genetic alterations are extremely rare. Pathologists should have high index of suspicion for novel genetically defined entities in the differential diagnosis of pediatric orbital URCS and perform appropriate ancillary tests for accurate diagnosis. [ABSTRACT FROM AUTHOR]

This research presents a comprehensive dynamic finite element analysis (FEA) of a cryogenic fuel tank made from an innovative aluminium/lithium–graphene nano-composite material, assessing its suitability for aerospace launch vehicles carrying cryogenic hydrogen and oxygen. The study focuses on the effects of lightweighting, utilizing 0.5 wt.% reinforced graphene in the Al 2195 matrix, a material poised to revolutionize the aerospace industry. Objectives include developing a digital twin of the fuel tank, CAD modeling to aerospace standards, and conducting ANSYS simulations under launch conditions to evaluate stress, strain, and deformation. Numerical results reveal a significant weight reduction of approximately 19,420 kg and a notable maximum stress reduction of 1.3% compared to traditional Al 2195 alloy tanks. The novelty of this research lies in its pioneering analysis of aluminium/lithium–graphene composites for lightweighting in cryogenic fuel tanks under space launch conditions. Conclusions affirm the composite's viability, advocating for the development of lighter yet robust aerospace structures and fostering innovation in spacecraft design and materials science. [ABSTRACT FROM AUTHOR]