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Your search keyword '"Sahlman, Johanna"' showing total 27 results
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27 results on '"Sahlman, Johanna"'

2. Eosinophilia, asthma, NERD and the use of oral corticosteroids predict uncontrolled chronic rhinosinusitis with nasal polyps after surgery.

Author

Penttilä, Elina, Sillanpää, Saara, Vento, Seija I., Myller, Jyri, Koskinen, Anni, Hammarén-Malmi, Sari, Laulajainen-Hongisto, Anu, Hytönen, Maija, Lyly, Annina, Lilja, Markus, Kauppi, Paula, Numminen, Jura, Rautiainen, Markus, Sahlman, Johanna, Nuutinen, Mikko, Toppila-Salmi, Sanna, and Virkkula, Paula

Published
2024
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4. Deep learning enables accurate automatic sleep staging based on ambulatory forehead EEG

Author

Leino, Akseli, Korkalainen, Henri, Kalevo, Laura, Nikkonen, Sami, Kainulainen, Samu, Ryan, Alexander, Duce, Brett, Sipila, Kirsi, Ahlberg, Jari, Sahlman, Johanna, Miettinen, Tomi, Westeren-Punnonen, Susanna, Mervaala, Esa, Toyras, Juha, Myllymaa, Sami, Leppanen, Timo, Myllymaa, Katja, Clinicum, Department of Oral and Maxillofacial Diseases, HUS Head and Neck Center, Department of Oncology, and HUS Comprehensive Cancer Center

Subjects
automatic scoring, General Computer Science, General Engineering, deep learning, 217 Medical engineering, General Medicine, MODEL, ambulatory EEG, sleep staging, RELIABILITY, RECORDINGS, TO-NIGHT VARIABILITY, General Materials Science, CLINICAL POPULATION, HOME, 316 Nursing, Ambulatory EEG, electroencephalography
Abstract

We have previously developed an ambulatory electrode set (AES) for the measurement of electroencephalography (EEG), electrooculography (EOG), and electromyography (EMG). The AES has been proven to be suitable for manual sleep staging and self-application in in-home polysomnography (PSG). To further facilitate the diagnostics of various sleep disorders, this study aimed to utilize a deep learning-based automated sleep staging approach for EEG signals acquired with the AES. The present neural network architecture comprises a combination of convolutional and recurrent neural networks previously shown to achieve excellent sleep scoring accuracy with a single standard EEG channel (F4-M1). In this study, the model was re-trained and tested with 135 EEG signals recorded with AES. The recordings were conducted for subjects suspected of sleep apnea or sleep bruxism. The performance of the deep learning model was evaluated with 10-fold cross-validation using manual scoring of the AES signals as a reference. The accuracy of the neural network sleep staging was 79.7% (kappa = 0.729) for five sleep stages (W, N1, N2, N3, and R), 84.1% (kappa = 0.773) for four sleep stages (W, light sleep, deep sleep, R), and 89.1% (kappa = 0.801) for three sleep stages (W, NREM, R). The utilized neural network was able to accurately determine sleep stages based on EEG channels measured with the AES. The accuracy is comparable to the inter-scorer agreement of standard EEG scorings between international sleep centers. The automatic AES-based sleep staging could potentially improve the availability of PSG studies by facilitating the arrangement of self-administrated in-home PSGs.

Published
2022

5. Deep Learning Enables Accurate Automatic Sleep Staging Based on Ambulatory Forehead EEG

Author

Leino, Akseli, primary, Korkalainen, Henri, additional, Kalevo, Laura, additional, Nikkonen, Sami, additional, Kainulainen, Samu, additional, Ryan, Alexander, additional, Duce, Brett, additional, Sipila, Kirsi, additional, Ahlberg, Jari, additional, Sahlman, Johanna, additional, Miettinen, Tomi, additional, Westeren-Punnonen, Susanna, additional, Mervaala, Esa, additional, Toyras, Juha, additional, Myllymaa, Sami, additional, Leppanen, Timo, additional, and Myllymaa, Katja, additional

Published
2022
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12. Sustained improvement in mild obstructive sleep apnea after a diet- and physical activity--based lifestyle intervention: postinterventional follow-up

Author

Tuomilehto, Henri, Gylling, Helena, Peltonen, Markku, Martikainen, Tarja, Sahlman, Johanna, Kokkarinen, Jouko, Randell, Jukka, Tukiainen, Hannu, Vanninen, Esko, Partinen, Markku, Tuomilehto, Jaakko, and Uusitupa, Matti

Subjects
Exercise -- Physiological aspects, Diet therapy -- Health aspects, Sleep apnea syndromes -- Risk factors, Sleep apnea syndromes -- Research, Sleep apnea syndromes -- Care and treatment, Food/cooking/nutrition, Health
Abstract

Background: Obesity is the most important risk factor for obstructive sleep apnea (OSA). Weight-reduction programs have been observed to represent effective treatment of overweight patients with OSA. However, it is not known whether beneficial changes remain after the end of the intervention. Objective: The aim of the study was to assess the long-term efficacy of a lifestyle intervention based on a healthy diet and physical activity in a randomized, controlled, 2-y postintervention follow-up in OSA patients. Design: Eighty-one consecutive overweight [body mass index (in kg/[m.sup.2]): 28-40] adult patients with mild OSA were recruited. The intervention group completed a 1-y lifestyle modification regimen that included an early 12-wk weight-reduction program with a very-low-calorie diet. The control group received routine lifestyle counseling. During the second year, no dietary counseling was offered. Change in the apnea-hypopnea index (AHI) was the main objective outcome variable, and changes in symptoms were used as a subjective measurement. Results: A total of 71 patients completed the 2-y follow-up. The mean ([+ or -] SD) changes in diet and lifestyle with simultaneous weight reduction (-7.3 [+ or -] 6.5 kg) in the intervention group reflected sustained improvements in findings and symptoms of OSA. After 2 y, the reduction in the AHI was significantly greater in the intervention group (P = 0.049). The intervention lowered the risk of OSA at follow-up; the adjusted odds ratio for OSA was 0.35 (95% CI: 0.12-0.97; P = 0.045). Conclusion: Favorable changes achieved by a 1-y lifestyle intervention aimed at weight reduction with a healthy diet and physical activity were sustained in overweight patients with mild OSA after the termination of supervised lifestyle counseling. This trial was registered at clinicaltrials.gov as NCT00486746. Am J Clin Nutr 2010;92:688-96. doi: 10.3945/ajcn.2010.29485.

Published
2010

14. Asthma is Underdiagnosed and Often Uncontrolled in Preoperative Patients With Chronic Rhinosinusitis With Nasal Polyps.

Author

Genberg, Emma, Kauppi, Paula, Sahlman, Johanna, Laulajainen‐Hongisto, Anu, Lilja, Markus, Hammarén‐Malmi, Sari, Hafrén, Lena, Mäkitie, Antti, Vento, Seija, Toppila‐Salmi, Sanna, and Virkkula, Paula

Subjects
*NASAL polyps, *ENDOSCOPIC surgery, *ASTHMA, *SINUSITIS, *FORCED expiratory volume
Abstract

A study published in Clinical & Experimental Allergy reveals that asthma is often overlooked and poorly managed in preoperative patients with chronic rhinosinusitis with nasal polyps (CRSwNP). The study, conducted at a tertiary center, aimed to determine the prevalence of asthma and assess its control in this group. The findings indicate a high prevalence of asthma in these patients, with approximately half potentially having undiagnosed or uncontrolled asthma prior to undergoing endoscopic sinus surgery. The study also identifies factors associated with asthma in this population. However, the document acknowledges the study's limitations, such as its small sample size, and suggests the need for further research to validate the results. [Extracted from the article]

Published
2024
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15. Mild obstructive sleep apnea does not modulate baroreflex sensitivity in adult patients

Author

Blomster,Henry, Laitinen,Tomi P, Hartikainen,Juha EK, Laitinen,Tiina M, Vanninen,Esko, Gylling,Helena, Sahlman,Johanna, Kokkarinen,Jouko, Randell,Jukka, Seppä,Juha, Tuomilehto,Henri, Blomster,Henry, Laitinen,Tomi P, Hartikainen,Juha EK, Laitinen,Tiina M, Vanninen,Esko, Gylling,Helena, Sahlman,Johanna, Kokkarinen,Jouko, Randell,Jukka, Seppä,Juha, and Tuomilehto,Henri

Abstract

Henry Blomster,1 Tomi P Laitinen,2 Juha EK Hartikainen,3,6 Tiina M Laitinen,2 Esko Vanninen,2 Helena Gylling,4,8 Johanna Sahlman,1 Jouko Kokkarinen,5 Jukka Randell,5 Juha Seppä,1 Henri Tuomilehto4,7 1Department of Otorhinolaryngology, Institute of Clinical Medicine, 2Department of Clinical Physiology and Nuclear Medicine, 3Department of Internal Medicine, 4Department of Clinical Nutrition, School of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 5Department of Respiratory Medicine, 6Heart Center, Kuopio University Hospital, 7Oivauni Sleep Clinic, Kuopio, 8Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland Background: Obstructive sleep apnea (OSA) is a chronic and progressive disease. OSA is associated with increased cardiovascular morbidity and mortality, the risk being more frequently encountered with severe degrees of OSA. Increased sympathetic activation and impaired cardiac autonomic control as reflected by depressed baroreceptor reflex sensitivity (BRS) are possible mechanisms involved in the cardiovascular complications of OSA. However, it is not known at what stage of OSA that changes in BRS appear. The aim of this study was to evaluate BRS in patients with mild OSA. Methods: The study population consisted of 81 overweight patients with mild OSA and 46 body weight-matched non-OSA subjects. BRS, apnea-hypopnea index, body mass index, and metabolic parameters were assessed. The phenylephrine test was used to measure BRS. Results: Patients in the OSA group were slightly but significantly older than the non-OSA population (50.3±9.3 years vs 45.7±11.1 years, P=0.02). Body mass index, percentage body fat, blood pressure, fasting glucose, insulin, and lipid levels did not differ between the OSA patients and non-OSA subjects. Absolute BRS values in patients with mild OSA and non-OSA subjects (9.97±6.70 ms/mmHg vs 10.51±7.16 ms/mmHg

Published
2015

19. Endothelial function is well preserved in obese patients with mild obstructive sleep apnea

Author

Blomster, Henry, primary, Laitinen, Tomi, additional, Lyyra-Laitinen, Tiina, additional, Vanninen, Esko, additional, Gylling, Helena, additional, Peltonen, Markku, additional, Martikainen, Tarja, additional, Sahlman, Johanna, additional, Kokkarinen, Jouko, additional, Randell, Jukka, additional, Smirnov, Grigori, additional, Seppä, Juha, additional, and Tuomilehto, Henri, additional

Published
2013
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27. Lung function and side effects of Aspirin desensitization: a real world study.

Author

Heikki T, Anu LH, Annina L, Jura N, Elina P, Sahlman J, Sanna TS, and Paula K

Abstract

Introduction : NSAID-exacerbated respiratory disease (N-ERD) is mainly treated with topical and oral corticosteroids, as well as acetylsalicylic acid (ASA) treatment after desensitization (ATAD). During desensitization and ATAD, it is common to experience an exacerbation of respiratory symptoms and other side effects, which may lead to cessation of treatment. Objectives : The aim of this retrospective follow-up study was to evaluate the effect of ATAD on lung functions and respiratory symptoms, and to clarify the occurrence of adverse events. Method s: We analysed the patient data of 67 patients treated with ASA desensitization between 2006 and 2016 in three hospitals, concerning adverse events, respiratory symptoms, lung function tests, and reasons for discontinuation. Results : 26 patients discontinued AD or ATAD. The most common reasons for discontinuation were lack of response (9%) and side effects (18%). ATAD did not affect lung function values in the follow-up of up to 5 years. Upper respiratory symptoms improved in 31 (52%) and lower respiratory symptoms (LRS) in 7 (10%) cases. Side effects occurred in 42 (63%) cases, the most common being dyspepsia and lower respiratory symptoms. Conclusion : Our study suggests that ATAD has little effect on lower airway functions. Side effects were common, and discontinuation rates high., Competing Interests: ALH has received research funding from Orion Research Foundation outside the submitted work. STS reports grant of GSK and consultancies for ERT, Novartis, Sanofi Pharma and Roche Products, outside the submitted work. All other authors declare no conflicts of interest. This work was supported by the Ahokas foundation under a small grant., (© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)

Published
2021
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