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Your search keyword '"Rybicka,Anna"' showing total 11 results
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11 results on '"Rybicka,Anna"'

5. Mitochondrial functioning abnormalities observed in blood platelets of chronic smoke-exposed guinea pigs – a pilot study

Author

Białas,Adam J, Siewiera,Karolina, Watala,Cezary, Rybicka,Anna, Grobelski,Bartlomiej, Kośmider,Leon, Kurek,Jolanta, Miłkowska-Dymanowska,Joanna, Piotrowski,Wojciech J, Górski,Paweł, Białas,Adam J, Siewiera,Karolina, Watala,Cezary, Rybicka,Anna, Grobelski,Bartlomiej, Kośmider,Leon, Kurek,Jolanta, Miłkowska-Dymanowska,Joanna, Piotrowski,Wojciech J, and Górski,Paweł

Abstract

Adam J BiaÅ‚as,1 Karolina Siewiera,2 Cezary WataÅ‚a,2 Anna Rybicka,3 BartÅ‚omiej Grobelski,3 Leon KoÅ›mider,4,5 Jolanta Kurek,6 Joanna MiÅ‚kowska-Dymanowska,1 Wojciech J Piotrowski,1 PaweÅ‚ Górski1 1Department of Pneumology and Allergy, Medical University of Lodz, Lodz, Poland; 2Department of Hemostasis and Hemostatic Disorders, Medical University of Lodz, Lodz, Poland; 3The animal house, Pharmaceutical Faculty, Medical University of Lodz, Lodz, Poland; 4Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, USA; 5Center for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, VA, USA; 6Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland Background: COPD represents a major global health issue, which is often accompanied by cardiovascular diseases. A considerable body of evidence suggests that cardiovascular risk is elevated by the activation of blood platelets, which in turn is exacerbated by inflammation. As reactive oxygen species are believed to be an important factor in platelet metabolism and functioning, the aim of our study was to perform a complex assessment of mitochondrial function in platelets in chronic smoke exposed animals with COPD-like lung lesions. Materials and methods: Eight-week-old, male Dunkin Hartley guinea pigs (the study group) were exposed to the cigarette smoke from commercial unfiltered cigarettes (0.9 mg/cig of nicotine content) or to the air without cigarette smoke (control group), using the Candela Constructions® exposure system. The animals were exposed for 4 hours daily, 5 days a week, with 2×70 mL puff/minute, until signs of dyspnea were observed. The animals were bled, and isolated platelets were used to monitor blood platelet respiration. The mitochondrial respiratory parameters of the platelets were monitored in vitro based on continuous recording of oxygen consumption by high-resolution respirometry. Results: A

Published
2018

11. [Prediction of adverse cardiac events in patients with acute anterior wall myocardial infarction treated with PCI].

Author

Wita K, Filipecki A, Szczogiel J, Drzewiecka-Gerber A, Rybicka A, Krauze J, Wróbel W, Szydło K, Urbańczyk D, Turski M, Tabor Z, Kwaśniewski W, Mróz I, and Trusz-Gluza M

Subjects
Aged, Coronary Angiography, Disease-Free Survival, Electrocardiography, Female, Follow-Up Studies, Heart Rate, Humans, Male, Middle Aged, Myocardial Infarction physiopathology, Myocardial Reperfusion, Predictive Value of Tests, Prognosis, Prospective Studies, Severity of Illness Index, Ventricular Dysfunction, Left physiopathology, Angioplasty, Balloon, Coronary, Myocardial Infarction diagnosis, Myocardial Infarction therapy, Ventricular Dysfunction, Left diagnosis
Abstract

Unlabelled: Despite common use of reperfusion therapy, particularly primary PCI during acute myocardial infarction, steadily increasing number of patients with low left ventricular ejection fraction, with heart failure (HF), requiring frequent rehospitalisation justifies the study establishing the best indices of prediction of major adverse cardiac events (MACE) occurrence. The aim of the study was to define the frequency of MACE (death, re MI, sVT, rehospitalisation for HF) in patients with acute anterior wall myocardial infarction in 6 month follow up and the factors determinatig its occurence. The 115 consecutive patients (86 males of age 57.7 +/- 11 yrs) with first anterior MI were studied. After successful PCI (TIMI 3) the angiographic assessment was performed (MBG 0-1 - no perfusion, MBG 2-3 - perfusion preserved). During first 48 hours 12-lead ECG was monitored in order to analyse the time to reduction of ST elevation in the lead with the highest elevation (deltatST 50%). On 2nd day LV function (LVEF and WMSI) and dyssfunctional segment perfusion (RPSI) were assessed. On 5th day Holter monitoring with arrhythmia and time domain parameters (SDNN, rMSSD) of heart rate variability were performed, on 30 day TWA test was done., Results: During 180 follow-up 18 MACE occurred (3 death, 2 MI, 11 rehospitalisations for HF). In univariate analysis cigarette smoking, higher maximum troponin I value, LVEDV, LVESV, ST elevation sum, longer time to reduction of ST elevation, lower LVEF and RPSI, lack of microvessel integrity and positive TWA test had significant relationship with occurrence of MACE. The multivariate analysis of Cox proportional risk regression demonstrated that only lower value of RPSI and LVEF, longer time of ST elevation reduction in the lead with the highest ST elevation and positive TWA test were independent indices of MACE prediction., Conclusions: Cumulative evaluation of LVEF, indices of preserved perfusion and results of TWA test turned out to be the best predictors of MACE occurrence in 6 month follow up in patients after anterior MI treated with PCI.

Published
2006

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