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5. Ecuadorian Spanish translation and validation of the VELO quality of life instrument

Author

Ridgell, Lucille, Roth, Christina T, Bow, Mikaela, Hares-Helou, Rayyan, Arias, Karina Mayorga, Pollard, Sarah Hatch, Hamdan, Usama, Tollefson, Travis T, and Skirko, Jonathan R

Subjects
Paediatrics, Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Pediatric, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Adolescent, Child, Child, Preschool, Cross-Sectional Studies, Ecuador, Female, Humans, Male, Prospective Studies, Psychometrics, Quality of Life, Reproducibility of Results, Surveys and Questionnaires, Velopharyngeal Insufficiency, VPI, Velopharyngeal insufficiency, Quality of life, International, Translation, Paediatrics and Reproductive Medicine, Clinical sciences
Abstract

ObjectivesAdapt the Spanish translation of VPI Effects on Life Outcome (VELO) instrument into Ecuadorian Spanish; test the resulting instrument for reliability and validity.MethodsA cross-sectional, prospective design, set at a humanitarian mission within a community hospital. Linguistic validation: native Ecuadorian-Spanish speakers modified the Spanish VELO to Ecuadorian Spanish. Cognitive interviews were conducted with children with cleft palate (CP) and their parents (n = 50), guiding instrument modifications. An expert panel reviewed changes, resulting in the VELO-Ecuadorian dialect (VELO-Ec).Instrument assessment88 participants with CP (88 parents, 46 children) and 33 non-cleft controls (33 adult, 11 children) completed the VELO-Ec, Spanish-Pediatric Voice Handicap Index (pVHI), and Spanish-Intelligibility in Context Scale (ICS). Internal consistency was assessed with Cronbach's alpha; test-retest reliability was assessed by calculating the intraclass correlation coefficient (ICC); standard error of measurement (SEM) was calculated. Concurrent validity was assessed with Pearson correlations of VELO-Ec with pVHI and ICS. Discriminant validity assessment used an established ICS cutoff. Construct validity was assessed by grouping patients by parent report of hypernasality and early vs. late cleft repair (>24 months) using the Wilcoxon Rank-Sum test.ResultsVELO-Ec showed excellent internal consistency (alpha 0.96) and test-retest reliability (ICC = 0.85, 95% CI 0.68-0.93, SEM 5.71). It had strong concurrent validity, correlating with ICS (r = 0.75, p

Published
2020

7. Spanish Linguistic Validation of the Velopharyngeal Insufficiency Effects on Life Outcomes: VELO-Spanish.

Author

Skirko, Jonathan R, Santillana, Rosario M, Roth, Christina T, Dunbar, Chance, and Tollefson, Travis T

Abstract

Background:Quality of life (QOL) assessments are useful tools that measure a patient's health status and monitor patient-reported outcome measures. This study highlights the process of linguistic validation of a QOL assessment to serve Spanish-speaking families and ultimately help decrease language barriers in the treatment of velopharyngeal insufficiency (VPI). Methods:The standardized linguistic validation process included forward and backward translation, reconciliation, and cognitive interviews with patients and families. Preliminary instrument test-retest measurement was assessed. Eligibility for cognitive interviews included families with familiarity of velopharyngeal insufficiency. Exclusion criteria included illiteracy and parent and child respondents who do not speak Spanish. Reliability was tested by intraclass correlation (ICC) on VPI Effects on Life Outcomes (VELO)-Spanish instruments completion on 2 measurements from the medical record. Results:The instrument was optimized through a standardized forward and backward translation process. Further problematic language was identified during cognitive interviews with families and their children. In the second interview, only minimal changes were needed. Twenty-one patients (8 males and 13 females) were included. Mean (SD) age was 8.0 (5.3) years (range, 3-21 years). The mean (SD) Velo-Spanish score was 65 (22.1); range 32.7-100. The VELO-Spanish instrument demonstrated excellent test-retest reliability [ICC = 0.91; n = 21 and internal consistency (α = 0.96)]. Conclusions:The Spanish VELO has been developed and refined for use in Spanish-speaking populations as a VPI-specific QOL instrument. The linguistic validation process including cognitive interviews and initial reliability testing. The instrument may improve the understanding of patient-reported outcomes and potential disparities from linguistic and cultural barriers in VPI treatment.

Published
2018

11. Massive migration from the steppe is a source for Indo-European languages in Europe

Author

Haak, Wolfgang, Lazaridis, Iosif, Patterson, Nick, Rohland, Nadin, Mallick, Swapan, Llamas, Bastien, Brandt, Guido, Nordenfelt, Susanne, Harney, Eadaoin, Stewardson, Kristin, Fu, Qiaomei, Mittnik, Alissa, Bánffy, Eszter, Economou, Christos, Francken, Michael, Friederich, Susanne, Pena, Rafael Garrido, Hallgren, Fredrik, Khartanovich, Valery, Khokhlov, Aleksandr, Kunst, Michael, Kuznetsov, Pavel, Meller, Harald, Mochalov, Oleg, Moiseyev, Vayacheslav, Nicklisch, Nicole, Pichler, Sandra L., Risch, Roberto, Guerra, Manuel A. Rojo, Roth, Christina, Szécsényi-Nagy, Anna, Wahl, Joachim, Meyer, Matthias, Krause, Johannes, Brown, Dorcas, Anthony, David, Cooper, Alan, Alt, Kurt Werner, and Reich, David

Subjects
Quantitative Biology - Populations and Evolution
Abstract

We generated genome-wide data from 69 Europeans who lived between 8,000-3,000 years ago by enriching ancient DNA libraries for a target set of almost four hundred thousand polymorphisms. Enrichment of these positions decreases the sequencing required for genome-wide ancient DNA analysis by a median of around 250-fold, allowing us to study an order of magnitude more individuals than previous studies and to obtain new insights about the past. We show that the populations of western and far eastern Europe followed opposite trajectories between 8,000-5,000 years ago. At the beginning of the Neolithic period in Europe, ~8,000-7,000 years ago, closely related groups of early farmers appeared in Germany, Hungary, and Spain, different from indigenous hunter-gatherers, whereas Russia was inhabited by a distinctive population of hunter-gatherers with high affinity to a ~24,000 year old Siberian6 . By ~6,000-5,000 years ago, a resurgence of hunter-gatherer ancestry had occurred throughout much of Europe, but in Russia, the Yamnaya steppe herders of this time were descended not only from the preceding eastern European hunter-gatherers, but from a population of Near Eastern ancestry. Western and Eastern Europe came into contact ~4,500 years ago, as the Late Neolithic Corded Ware people from Germany traced ~3/4 of their ancestry to the Yamnaya, documenting a massive migration into the heartland of Europe from its eastern periphery. This steppe ancestry persisted in all sampled central Europeans until at least ~3,000 years ago, and is ubiquitous in present-day Europeans. These results provide support for the theory of a steppe origin of at least some of the Indo-European languages of Europe.

Published
2015
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24. Recycling of perfluorosulfonic acid-based membranes and their Re-application in PEM fuel cells

Author

Kutter, Maximilian, primary, Greve, Christopher, additional, Maier, Maximilian, additional, Schilling, Monja, additional, Mauel, Anika, additional, Hilgert, Annika, additional, Hoffmann, Hendrik, additional, Hagemeier, Wiebke, additional, Rosin, Andreas, additional, Muggli, Mark, additional, Zeis, Roswitha, additional, Senker, Jürgen, additional, Böhm, Thomas, additional, Herzig, Eva M., additional, Gerdes, Thorsten, additional, and Roth, Christina, additional

Published
2023
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35. Dynamics of bulk and surface oxide evolution in copper foams for electrochemical CO2 reduction.

Author

Yang, Fan, Jiang, Shan, Liu, Si, Beyer, Paul, Mebs, Stefan, Haumann, Michael, Roth, Christina, and Dau, Holger

Subjects
ELECTROLYTIC reduction, SERS spectroscopy, COPPER oxide, SURFACE dynamics, CARBON dioxide reduction, RAMAN spectroscopy
Abstract

Oxide-derived copper (OD-Cu) materials exhibit extraordinary catalytic activities in the electrochemical carbon dioxide reduction reaction (CO2RR), which likely relates to non-metallic material constituents formed in transitions between the oxidized and the reduced material. In time-resolved operando experiment, we track the structural dynamics of copper oxide reduction and its re-formation separately in the bulk of the catalyst material and at its surface using X-ray absorption spectroscopy and surface-enhanced Raman spectroscopy. Surface-species transformations progress within seconds whereas the subsurface (bulk) processes unfold within minutes. Evidence is presented that electroreduction of OD-Cu foams results in kinetic trapping of subsurface (bulk) oxide species, especially for cycling between strongly oxidizing and reducing potentials. Specific reduction-oxidation protocols may optimize formation of bulk-oxide species and thereby catalytic properties. Together with the Raman-detected surface-adsorbed *OH and C-containing species, the oxide species could collectively facilitate *CO adsorption, resulting an enhanced selectivity towards valuable C2+ products during CO2RR. Oxide-derived copper materials display high catalytic activities for the electrochemical reduction of carbon dioxide, but the mechanisms surrounding this high performance are not fully understood. Here, the authors use time-resolved operando spectroscopy to probe the structural dynamics of copper oxide reduction and reformation, both in the bulk and on the surface of copper foam catalysts. [ABSTRACT FROM AUTHOR]

Published
2024
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42. An assessment of the Arctic Ocean in a suite of interannual CORE-II simulations. Part III: Hydrography and fluxes

Author

Ilıcak, Mehmet, Drange, Helge, Wang, Qiang, Gerdes, Rüdiger, Aksenov, Yevgeny, Bailey, David, Bentsen, Mats, Biastoch, Arne, Bozec, Alexandra, Böning, Claus, Cassou, Christophe, Chassignet, Eric, Coward, Andrew C., Curry, Beth, Danabasoglu, Gokhan, Danilov, Sergey, Fernandez, Elodie, Fogli, Pier Giuseppe, Fujii, Yosuke, Griffies, Stephen M., Iovino, Doroteaciro, Jahn, Alexandra, Jung, Thomas, Large, William G., Lee, Craig, Lique, Camille, Lu, Jianhua, Masina, Simona, George Nurser, A.J., Roth, Christina, Salas y Mélia, David, Samuels, Bonita L., Spence, Paul, Tsujino, Hiroyuki, Valcke, Sophie, Voldoire, Aurore, Wang, Xuezhu, and Yeager, Steve G.

Published
2016
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43. An assessment of the Arctic Ocean in a suite of interannual CORE-II simulations. Part II: Liquid freshwater

Author

Wang, Qiang, Ilicak, Mehmet, Gerdes, Rüdiger, Drange, Helge, Aksenov, Yevgeny, Bailey, David A, Bentsen, Mats, Biastoch, Arne, Bozec, Alexandra, Böning, Claus, Cassou, Christophe, Chassignet, Eric, Coward, Andrew C., Curry, Beth, Danabasoglu, Gokhan, Danilov, Sergey, Fernandez, Elodie, Fogli, Pier Giuseppe, Fujii, Yosuke, Griffies, Stephen M., Iovino, Doroteaciro, Jahn, Alexandra, Jung, Thomas, Large, William G., Lee, Craig, Lique, Camille, Lu, Jianhua, Masina, Simona, Nurser, A.J. George, Rabe, Benjamin, Roth, Christina, Salas y Mélia, David, Samuels, Bonita L., Spence, Paul, Tsujino, Hiroyuki, Valcke, Sophie, Voldoire, Aurore, Wang, Xuezhu, and Yeager, Steve G.

Published
2016
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44. An assessment of the Arctic Ocean in a suite of interannual CORE-II simulations. Part I: Sea ice and solid freshwater

Author

Wang, Qiang, Ilicak, Mehmet, Gerdes, Rüdiger, Drange, Helge, Aksenov, Yevgeny, Bailey, David A., Bentsen, Mats, Biastoch, Arne, Bozec, Alexandra, Böning, Claus, Cassou, Christophe, Chassignet, Eric, Coward, Andrew C., Curry, Beth, Danabasoglu, Gokhan, Danilov, Sergey, Fernandez, Elodie, Fogli, Pier Giuseppe, Fujii, Yosuke, Griffies, Stephen M., Iovino, Doroteaciro, Jahn, Alexandra, Jung, Thomas, Large, William G., Lee, Craig, Lique, Camille, Lu, Jianhua, Masina, Simona, Nurser, A.J. George, Rabe, Benjamin, Roth, Christina, Salas y Mélia, David, Samuels, Bonita L., Spence, Paul, Tsujino, Hiroyuki, Valcke, Sophie, Voldoire, Aurore, Wang, Xuezhu, and Yeager, Steve G.

Published
2016
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