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Your search keyword '"Rong, Wanjing"' showing total 8 results
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8 results on '"Rong, Wanjing"'

4. Vitexin loaded mixed polymeric micelles: preparation, optimization, evaluation and anti-osteoporotic effect

Author

Zhang, Jian, primary, Li, Xiaoxiao, additional, Xia, Xiaoli, additional, Adu-Frimpong, Michael, additional, Shen, Xinyi, additional, He, Qing, additional, Rong, Wanjing, additional, Shi, Feng, additional, Cao, Xia, additional, Ji, Hao, additional, Toreniyazov, Elmurat, additional, Wang, Qilong, additional, Yu, Jiangnan, additional, and Xu, Xi-ming, additional

Published
2023
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5. Preparation, in vitro and in vivo evaluation of pinocembrin-loaded TPGS modified liposomes with enhanced bioavailability and antihyperglycemic activity

Author

Shen, Xinyi, primary, Rong, Wanjing, additional, Adu-Frimpong, Michael, additional, He, Qing, additional, Li, Xiaoxiao, additional, Shi, Feng, additional, Ji, Hao, additional, Toreniyazov, Elmurat, additional, Xia, Xiaoli, additional, Zhang, Jian, additional, Wang, Qilong, additional, Yu, Jiangnan, additional, and Xu, Ximing, additional

Published
2022
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6. Hyperoside-loaded TPGs/mPEG-PDLLA self-assembled polymeric micelles: preparation, characterization and in vitro/in vivo evaluation

Author

Xia, Xiaoli, primary, Zhang, Jian, additional, Adu‑Frimpong, Michael, additional, Li, Xiaoxiao, additional, Shen, Xinyi, additional, He, Qing, additional, Rong, Wanjing, additional, Ji, Hao, additional, Toreniyazov, Elmurat, additional, Xu, Ximing, additional, Yu, Jiangnan, additional, and Wang, Qilong, additional

Published
2022
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7. Pinocembrin polymeric micellar drug delivery system: preparation, characterisation and anti-hyperuricemic activity evaluation

Author

Rong, Wanjing, primary, Shen, Xinyi, additional, Adu-Frimpong, Michael, additional, He, Qing, additional, Zhang, Jian, additional, Li, Xiaoxiao, additional, Xia, Xiaoli, additional, Shi, Feng, additional, Cao, Xia, additional, Ji, Hao, additional, Toreniyazov, Elmurat, additional, Wang, Qilong, additional, Yu, Jiangnan, additional, and Xu, Ximing, additional

Published
2022
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8. Hyperoside-loaded TPGs/mPEG-PDLLA self-assembled polymeric micelles: preparation, characterization and in vitro / in vivo evaluation.

Author

Xia X, Zhang J, Adu-Frimpong M, Li X, Shen X, He Q, Rong W, Ji H, Toreniyazov E, Xu X, Yu J, and Wang Q

Subjects
Drug Carriers chemistry, Particle Size, Polymers chemistry, Quercetin analogs & derivatives, Solubility, Micelles, Polyethylene Glycols chemistry
Abstract

Hyperoside (Hyp) self-assembled polymeric micelles (Hyp-PMs) were purposely developed to enhance aqueous solubility, in vivo availability and anti-oxidative effect of Hyp. In preparing Hyp-PMs, we employed the thin film dispersion method with the micelles consisting of TPGs and mPEG2000-PDLLA3000. The particle size, polydispersity index and zeta potential of Hyp-PMs were 67.42 ± 1.44 nm, 0.229 ± 0.015 and -18.67 ± 0.576 mV, respectively, coupled with high encapsulation efficiency （EE）of 90.63 ± 1.45% and drug loading (DL) of 6.97 ± 1.56%. Furthermore, the value of critical micelle concentration (CMC) was quite low, which indicated good stability and improved self-assembly ability of Hyp-PMs. Also, trend of in vitro Hyp release from Hyp-PMs demonstrated enhanced solubility of Hyp. Similarly, in comparison with free Hyp, oral bioavailability of Hyp-PMs was improved (about 8 folds) whilst half-life of Hyp-PMs was extended (about 3 folds). In vitro anti-oxidative effect showed obvious strong scavenging DPPH capability of Hyp-PMs, which may be attributed to its smaller size and better solubility. Altogether, Hyp-PMs may serve as a possible strategy to potentially enhance aqueous solubility, bioavailability and anti-oxidative effect of Hyp, which may play a key role in Hyp application in the pharmaceutical industries.

Published
2022
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