11 results on '"Rodríguez-Serrano D"'
Search Results
2. Multicenter study of ceftolozane/tazobactam for treatment of Pseudomonas aeruginosa infections in critically ill patients.
- Author
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Balandin B, Ballesteros D, Ruiz de Luna R, López-Vergara L, Pintado V, Sancho-González M, Soriano-Cuesta C, Pérez-Pedrero MJ, Asensio-Martín MJ, Fernández-Simón I, Rodríguez-Serrano D, Silva A, Chicot M, Iranzo R, Martínez-Sagasti F, and Royuela A
- Subjects
- Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents therapeutic use, Critical Illness, Cross Infection drug therapy, Cross Infection mortality, Dose-Response Relationship, Drug, Drug Resistance, Multiple, Bacterial, Female, Humans, Intensive Care Units, Male, Microbial Sensitivity Tests, Middle Aged, Pseudomonas aeruginosa isolation & purification, Retrospective Studies, Spain, Treatment Outcome, Cephalosporins therapeutic use, Pseudomonas Infections drug therapy, Pseudomonas Infections mortality, Pseudomonas aeruginosa drug effects, Tazobactam therapeutic use
- Abstract
Background: This study aimed to assess the efficacy of ceftolozane-tazobactam (C/T) for treating infections due to Pseudomonas aeruginosa (P. aeruginosa) in critically ill patients., Patients and Methods: A multicenter, retrospective and observational study was conducted in critically ill patients receiving different C/T dosages and antibiotic combinations for P. aeruginosa infections. Demographic data, localisation and severity of infection, clinical and microbiological outcome, and mortality were evaluated., Results: Ninety-five patients received C/T for P. aeruginosa serious infections. The main infections were nosocomial pneumonia (56.2%), intra-abdominal infection (10.5%), tracheobronchitis (8.4%), and urinary tract infection (6.3%). Most infections were complicated with sepsis (49.5%) or septic shock (45.3%), and bacteraemia (10.5%). Forty-six episodes were treated with high-dose C/T (3 g every 8 hours) and 38 episodes were treated with standard dosage (1.5 g every 8 hours). Almost half (44.2%) of the patients were treated with C/T monotherapy, and the remaining group received combination therapy with other antibiotics. Sixty-eight (71.6%) patients presented a favourable clinical response. Microbiological eradication was documented in 42.1% (40/95) of the episodes. The global ICU mortality was 36.5%. Univariate analysis showed that 30-day mortality was significantly associated (P < 0.05) with Charlson Index at ICU admission and the need of life-supporting therapies., Conclusions: C/T appeared to be an effective therapy for severe infections due to P. aeruginosa in critically ill patients. Mortality was mainly related to the severity of the infection. No benefit was observed with high-dose C/T or combination therapy with other antibiotics., (Copyright © 2021. Published by Elsevier Ltd.)
- Published
- 2021
- Full Text
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3. Development of a Knockout Competition in Basketball: A Study of the Spanish Copa del Rey.
- Author
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Ibáñez SJ, García-Rubio J, Rodríguez-Serrano D, and Feu S
- Abstract
Performance in basketball has been widely studied with regard to the results of the game using competition statistics. Few studies have analyzed the play process from a dynamic viewpoint regarding tactical actions and styles of play. The general objective of this research was to analyze the development in the styles of play of the teams participating in the Spanish Copa del Rey by studying the development of ball possessions (from start to finish) and the styles of play (attack and defense phases). The specific aim was to identify the relations between how possessions end and the style of play, as well as the relation between the duration of possession and the action of shooting and efficacy of the possession. All the matches corresponding to the Spanish Copa del Rey in basketball in the seasons 2015/2016, 2016/2017, and 2017/2018 were analyzed, comprising a total of 3,865 possessions. To this end, two groups of variables were characterized, which made it possible to define play, the development of possession (start and finish), and the style of play (attack and defense phase). An exploratory and descriptive analysis of the situational variables, development of possession, and style of play was carried out to characterize the competition. The Chi-squared test and Cramer's V coefficient were used to estimate the association among the categorical variables, interpreting the association among the categories using contingency tables. The results show a greater number of attacks in the final stages of the matches, with short possessions that end in baskets or rebounds, and positional attacks and individual half-court defenses predominating. There were more shots in positional attacks and more fouls in transitions. It also was apparent that the competition is developing from 1 year to another. The Spanish Copa del Rey competition changes from season to season, revealing slight modifications in the teams' styles of play, although there is stability in the fundamental play parameters, like the predominance of man-to-man defense, the duration of the attacks, and the use of screens. The style of play conditions the finalization of the possession., (Copyright © 2019 Ibáñez, García-Rubio, Rodríguez-Serrano and Feu.)
- Published
- 2019
- Full Text
- View/download PDF
4. [Consensus document for sepsis code implementation and development in the Community of Madrid].
- Author
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Palencia Herrejón E, González Del Castillo J, Ramasco Rueda F, Candel FJ, Sánchez Artola B, von Wernitz Teleki A, Gordo Vidal F, Roces Iglesias P, Bejarano Redondo G, Rodríguez Serrano DA, Cobo Reinoso FJ, Corral Torres E, Martí de Gracia M, and Ruiz Álvarez A
- Subjects
- Anti-Bacterial Agents therapeutic use, Biomarkers analysis, Checklist, Community-Acquired Infections diagnosis, Community-Acquired Infections therapy, Decision Making, Organizational, Early Diagnosis, Emergency Medical Services methods, Evidence-Based Medicine, Humans, Norepinephrine therapeutic use, Patient Care Team organization & administration, Spain, Vasoconstrictor Agents therapeutic use, Consensus, Cross Infection diagnosis, Cross Infection therapy, Emergency Treatment, Organ Dysfunction Scores, Sepsis diagnosis, Sepsis therapy
- Abstract
The consensus paper for the implementation and development of the sepsis code, finished in April 2017 is presented here. It was adopted by the Regional Office of Health as a working document for the implementation of the sepsis code in the Community of Madrid, both in the hospital setting (acute, middle and long-stay hospitals) and in Primary Care and Out-of-Hospital Emergency Services. It is now published without changes with respect to the original version, having only added the most significant bibliographical references. The document is divided into four parts: introduction, initial detection and assessment, early therapy and organizational recommendations. In the second to fourth sections, 25 statements or proposals have been included, agreed upon by the authors after several face-to-face meetings and an extensive "online" discussion. The annex includes nine tables that are intended as a practical guide to the activation of the sepsis code. Both the content of the recommendations and their formal writing have been made taking into account their applicability in all areas to which they are directed, which may have very different structural and functional characteristics and features, so that we have deliberately avoided a greater degree of concretion: the objective is not that the sepsis code is organized and applied identically in all of them, but that the health resources work in a coordinated manner aligned in the same direction., (©The Author 2019. Published by Sociedad Española de Quimioterapia. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)(https://creativecommons.org/licenses/by-nc/4.0/).)
- Published
- 2019
5. Initial clinical outcomes and prognostic variables in the implementation of a Code Sepsis in a high complexity University Hospital.
- Author
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Ramasco F, Figuerola A, Mendez R, Rodríguez Serrano D, von Wernitz A, Hernández-Aceituno A, Sáez C, Cardeñoso L, Martin E, García-Vázquez N, de Las Cuevas C, Pascual N, Bautista A, Jiménez D, Fernández G, Leal A, Vinuesa M, Pizarro A, di Martino M, Del Campo L, García Sanz I, Chicot M, Barrios A, and Rubio MJ
- Subjects
- APACHE, Adult, Age Factors, Aged, Aged, 80 and over, Biomarkers, Creatinine blood, Female, Hospital Mortality trends, Hospitals, University, Humans, Lactic Acid blood, Male, Middle Aged, Procalcitonin blood, Prognosis, Risk Factors, Sepsis mortality, Treatment Outcome, Clinical Protocols, Sepsis therapy
- Abstract
Objective: To assess the impact of the first months of application of a Code Sepsis in a high complexity hospital, analyzing patient´s epidemiological and clinical characteristics and prognostic factors., Methods: A long-term observational study was carried out throughout a consecutive period of seven months (February 2015 - September 2015). The relationship with mortality of risk factors, and analytic values was analyzed using uni- and multivariate analyses., Results: A total of 237 patients were included. The in-hospital mortality was 24% at 30 days and 27% at 60 days. The mortality of patients admitted to Critical Care Units was 30%. Significant differences were found between the patients who died and those who survived in mean levels of creatinine (2.30 vs 1.46 mg/dL, p <0.05), lactic acid (6.10 vs 2.62 mmol/L, p <0.05) and procalcitonin (23.27 vs 12.73 mg/dL, p<0.05). A statistically significant linear trend was found between SOFA scale rating and mortality (p<0.05). In the multivariate analysis additional independent risk factors associated with death were identified: age > 65 years (OR 5.33, p <0.05), lactic acid > 3 mmol/L (OR 5,85, p <0,05), creatinine > 1,2 mgr /dL (OR 4,54, p <0,05) and shock (OR 6,57, P <0,05)., Conclusions: The epidemiological, clinical and mortality characteristics of the patients in our series are similar to the best published in the literature. The study has identified several markers that could be useful at a local level to estimate risk of death in septic patients. Studies like this one are necessary to make improvements in the Code Sepsis programs., (©The Author 2019. Published by Sociedad Española de Quimioterapia. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)(https://creativecommons.org/licenses/by-nc/4.0/).)
- Published
- 2019
6. [Use of recombinant activated factor vii in bronchoalveolar lavage in a case of pulmonary hemorrhage].
- Author
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Rodríguez-Serrano DA, Leal-Micharet A, Rajas O, Chicot-Llano M, and García-Romero de Tejada JA
- Subjects
- Anticoagulants adverse effects, Bronchoscopy, Combined Modality Therapy, Comorbidity, Embolization, Therapeutic, Factor VIIa administration & dosage, Female, Hemoptysis diagnostic imaging, Hemoptysis etiology, Hemoptysis therapy, Hemostatic Techniques, Humans, Middle Aged, Multiple Organ Failure etiology, Pneumonia, Bacterial complications, Postoperative Hemorrhage diagnostic imaging, Postoperative Hemorrhage etiology, Postoperative Hemorrhage therapy, Pseudomonas Infections complications, Recombinant Proteins administration & dosage, Recombinant Proteins therapeutic use, Shock, Septic etiology, Tricuspid Valve Insufficiency surgery, Bronchoalveolar Lavage Fluid, Factor VIIa therapeutic use, Hemoptysis drug therapy, Postoperative Hemorrhage drug therapy
- Published
- 2015
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7. [Fever and Brugada syndrome].
- Author
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Rodríguez-Serrano DA, Chicot-Llano M, and Méndez-Fernández I
- Subjects
- Humans, Brugada Syndrome, Fever
- Published
- 2014
- Full Text
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8. [Massive intestinal ischemia].
- Author
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Hermosa-Gelbard C, Rodríguez-Serrano DA, and Calvo-Herranz E
- Subjects
- Aged, Fatal Outcome, Female, Humans, Intestines blood supply, Intestines diagnostic imaging, Ischemia diagnostic imaging, Tomography, X-Ray Computed
- Published
- 2013
- Full Text
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9. [Kounis syndrome type I].
- Author
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Rodríguez-Serrano DA, Torrejón-Pérez I, Abella-Álvarez A, and Elices A
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- Humans, Male, Middle Aged, Syndrome, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Coronary Vasospasm diagnosis, Dipyrone adverse effects, Drug Hypersensitivity diagnosis
- Published
- 2012
- Full Text
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10. [Pneumonia as a result of infection with parainfluenza virus type 4 and thrombotic thrombocytopenic purpura].
- Author
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Rodríguez-Serrano DA, Nieto-Cabrera M, Conesa J, and Culebras-López E
- Subjects
- Anti-Infective Agents therapeutic use, Antineoplastic Combined Chemotherapy Protocols adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Breast Neoplasms complications, Breast Neoplasms drug therapy, Breast Neoplasms surgery, Carcinoma, Ductal, Breast complications, Carcinoma, Ductal, Breast drug therapy, Carcinoma, Ductal, Breast surgery, Combined Modality Therapy, Fatal Outcome, Female, Humans, Immunocompromised Host, Lung Diseases, Interstitial therapy, Lung Diseases, Interstitial virology, Middle Aged, Multiple Organ Failure etiology, Pericardial Effusion etiology, Plasmapheresis, Pneumonia, Viral therapy, Pneumonia, Viral virology, Postoperative Complications virology, Purpura, Thrombotic Thrombocytopenic therapy, Rubulavirus Infections complications, Lung Diseases, Interstitial etiology, Parainfluenza Virus 4, Human isolation & purification, Pneumonia, Viral etiology, Purpura, Thrombotic Thrombocytopenic etiology, Rubulavirus Infections virology
- Published
- 2012
- Full Text
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11. [Bile duct obstruction due to non-Hodkin's lymphoma in patients with HIV infection].
- Author
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Gómez-Domínguez E, Rodríguez Serrano DA, Mendoza J, Iscar T, Sarriá C, and García-Buey L
- Subjects
- Bone Marrow pathology, Cholestasis pathology, Cholestasis surgery, Drainage methods, Fatal Outcome, Female, HIV Infections diagnosis, HIV Infections therapy, Humans, Immunohistochemistry, Lymphoma, B-Cell diagnostic imaging, Lymphoma, B-Cell therapy, Male, Middle Aged, Tomography, X-Ray Computed, Cholestasis etiology, HIV Infections complications, HIV-1 pathogenicity, Lymphoma, B-Cell complications
- Abstract
Acquired immune deficiency syndrome increases the risk of developing non-Hodgkin's B-cell lymphoma (NHL) (relative risk over 100). NHL tend to be high-grade and to affect the central nervous system and digestive tract. Biliary tract compression is usually due to external compression from enlarged lymph nodes, but is not usually the first manifestation.We describe 2 cases of bile duct obstruction secondary to NHL in patients diagnosed with HIV infection. Histological diagnosis of the lymphoma can be difficult but is necessary so that these patients do not undergo highly aggressive surgical treatment instead of chemotherapy, which currently produces the best results. Therefore, we emphasize the importance of including lymphomas in the differential diagnosis of bile duct obstruction in patients with HIV infection.
- Published
- 2003
- Full Text
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