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Your search keyword '"Ravindran, Sundari"' showing total 17 results
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17 results on '"Ravindran, Sundari"'

1. 'Yes' to abortion but 'no' to sexual rights: the paradoxical reality of married women in rural Tamil Nadu, India

Author

Ravindran, Sundari T.K. and Balasubramanian, P.

Subjects
Tamil Nadu, India -- Social aspects, Women -- Surveys, Men -- Surveys, Reproductive rights -- Forecasts and trends, Reproductive rights -- Statistics, Abortion -- Forecasts and trends, Abortion -- Statistics, Market trend/market analysis, Family and marriage, Health, Women's issues/gender studies
Abstract

Abstract: This study in rural Tamil Nadu, India, explored the reasons why many married women in India undergo induced abortions rather than use reversible contraception to space or limit births [...]

Published
2004

11. Characterization of Hemodynamic Events Following Intravascular Infusion of Recombinant Adenovirus Reveals Possible Solutions for Mitigating Cardiovascular Responses

Author

Machemer, Todd, primary, Engler, Heidrun, additional, Tsai, Van, additional, Lee, Seoju, additional, Cannon-Carlson, Susan, additional, Voloch, Marcio, additional, Schluep, Thomas, additional, Ravindran, Sundari, additional, Vellekamp, Gary, additional, Brin, Elena, additional, Cornell, Douglas, additional, Sutjipto, Suganto, additional, Wen, Shu Fen, additional, Horn, Mark, additional, Van Rooijen, Nico, additional, Maneval, Dan, additional, Hutchins, Beth, additional, and LaFace, Drake, additional

Published
2005
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17. Determination of particle heterogeneity and stability of recombinant adenovirus by analytical ultracentrifugation in CsCl gradients.

Author

Xiaoyu Yang, Agarwala, Shilpi, Ravindran, Sundari, and Vellekamp, Gary

Subjects
*GENE therapy, *GENETIC engineering, *CHROMATOGRAPHIC analysis, *PHASE partition, *ADENOVIRUSES, *DNA viruses
Abstract

Recombinant adenoviruses (rAd), widely used as vectors for gene therapy, are generally purified by column chromatography and frequently contain empty capsids and other aberrant forms of virus particles. To determine particle heterogeneity we utilized analytical ultracentrifugation (AUC) in CsCl density gradients. Preparations of three different rAd vectors were assessed. AUC was able to resolve multiple density forms including two empty capsid types in various virus preparations. One unusual density form (form V), was noninfectious and lacked protein VI. AUC was able to quantify empty capsids and monitor their removal during process development. Their relative concentrations were reduced by either addition of an immobilized zinc affinity chromatography (IZAC) step or by extension of the infection time. The Adenovirus Reference Material (ARM), a wild-type Ad5, had 2.2% empty capsids and no other detectable minor particle forms. Finally, AUC was utilized to monitor the thermal instability of the three rAd vectors via the transformations of different density forms. The vector and empty capsids containing protein IX were more stable than those without IX. Together, these results exemplify AUC in CsCl density gradients as a valuable technique for evaluating product particle heterogeneity and stability. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97: 746–763, 2008 [ABSTRACT FROM AUTHOR]

Published
2008
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