118 results on '"Pursell, Zachary F"'
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2. Altered dNTP pools accelerate tumor formation in mice.
3. RNA-mediated double-strand break repair by end-joining mechanisms.
4. Comprehensive Analysis of Hypermutation in Human Cancer
5. Light-strand bias and enriched zones of embedded ribonucleotides are associated with DNA replication and transcription in the human-mitochondrial genome
6. 2167. Mutational Signature Analysis to Predict Drug-resistant Pseudomonas aeruginosa
7. 2769. Treatment of Hypermutator Pseudomonas aeruginosa Induces Multidrug Resistance but Can Be Targeted by Combination Therapy
8. DNA Precursor Asymmetries in Mammalian Tissue Mitochondria and Possible Contribution to Mutagenesis through Reduced Replication Fidelity
9. Replication DNA polymerases, genome instability and cancer therapies
10. Light-strand bias and enriched zones of embedded ribonucleotides are associated with DNA replication and transcription in the human-mitochondrial genome.
11. Data from Cancers from Novel Pole-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
12. Supplementary Table S3 from Cancers from Novel Pole-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
13. Supplementary Data Figures 1-8 from Cancers from Novel Pole-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
14. Supplementary Data from Cancers from Novel Pole-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
15. RNA-mediated double-strand break repair in human cells
16. The role of the Pseudomonas aeruginosa hypermutator phenotype on the shift from acute to chronic virulence during respiratory infection
17. Abstract 1297: Chemotherapy-induced senescence activates robust, parallel programs of immune checkpoint expression that can be targeted with immunotherapy
18. Abstract 1504: Mouse model and human patient data suggest critical roles for Pten and p53 in suppressing POLE mutant tumor development
19. Yeast DNA Polymerase ε Participates in Leading-Strand DNA Replication
20. Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development
21. Mouse model and human patient data suggest critical roles for Pten and p53 in suppressing POLE mutant tumor development
22. DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells.
23. Yeast DNA polymerase [epsilon] participates in leading-strand DNA replication
24. DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells
25. Cancers from Novel Pole-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
26. Mechanisms for High Fidelity DNA Replication
27. DNA Polymerase ε: A Polymerase of Unusual Size (and Complexity)
28. The high fidelity and unique error signature of human DNA polymerase ε
29. POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status
30. Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase γ replication fidelity
31. Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase ϵ
32. Bright G-Quadruplex Nanostructures Functionalized with Porphyrin Lanterns
33. POLE proofreading defects: Contributions to mutagenesis and cancer
34. Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair
35. Author response: Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair
36. In colonic ρ0 (rho0) cells reduced mitochondrial function mediates transcriptomic alterations associated with cancer
37. Abstract B09: DNA polymerase mutations trigger rapid onset of ultra-hypermutant malignant brain tumors in children with biallelic mismatch repair deficiency
38. Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA
39. Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication
40. DNA polymerase ε and its roles in genome stability
41. Mismatch Repair Balances Leading and Lagging Strand DNA Replication Fidelity
42. Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε
43. Human Pol ɛ-dependent replication errors and the influence of mismatch repair on their correction
44. Yeast DNA polymerase epsilon participates in leading-strand DNA replication.
45. Regulation of B family DNA polymerase fidelity by a conserved active site residue : characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon.
46. Human DNA Polymerase ϵ Is Able to Efficiently Extend from Multiple Consecutive Ribonucleotides
47. Mismatch Repair Balances Leading and Lagging Strand DNA Replication Fidelity
48. An active site mutant allele of human Pol ε is a mutator in vitro and in vivo
49. Mismatch Repair–Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase ε
50. Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.
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