688 results on '"Puel J"'
Search Results
2. Etat des lieux de la connaissance du grand public et des soignants français concernant le virus respiratoire syncitial (VRS) et autres virus respiratoires
- Author
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Puel, J., primary, Sosnowiez, K., additional, Sotto, A., additional, and Loubet, P., additional
- Published
- 2024
- Full Text
- View/download PDF
3. Acufeni soggettivi invalidanti
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Londero, A., Nicolas-Puel, C., Puel, J.-L., and Loche, V.
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- 2020
- Full Text
- View/download PDF
4. Existence of standing waves for the complex Ginzburg-Landau equation
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Cipolatti, R., Dickstein, F., and Puel, J. P
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Mathematics - Analysis of PDEs - Abstract
We prove the existence of non-trivial standing wave solutions of the complex Ginzburg-Landau equation $\phi_t - e^{i\theta}(\rho I- \Delta) \varphi - e^{i\gamma} |\phi |^\alpha \varphi =0 $ in $\Rn$, where $(N-2)\alpha <4$, $\theta ,\gamma \in (-\pi /2,\pi /2)$ and $\rho >0$. Analogous result is obtained in a ball $\Omega \in\Rn$ for $\rho >-\lambda_1$, where $\lambda_1$ is the first eigenvalue of the Laplace operator with Dirichlet boundary conditions.
- Published
- 2014
5. Apparecchi acustici convenzionali
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Ceccato, J.-C., Bourien, J., Venail, F., and Puel, J.-L.
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- 2017
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- View/download PDF
6. Validation of the French-language version of the OTOSPEECH automated scoring software package for speech audiometry
- Author
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Venail, F., Legris, E., Vaerenberg, B., Puel, J.-L., Govaerts, P.J., and Ceccato, J.C.
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- 2016
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- View/download PDF
7. Notation automatisée des réponses en audiométrie vocale : validation en langue française du logiciel OTOSPEECH
- Author
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Venail, F., Legris, E., Vaerenberg, B., Puel, J.-L., Govaerts, P.J., and Ceccato, J.-C.
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- 2016
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- View/download PDF
8. Thérapeutique de l'oreille interne
- Author
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Teissier, N., primary, Parodi, M., additional, Leruez-Ville, M., additional, Loundon, N., additional, Venail, F., additional, Puel, J.-L., additional, Denoyelle, F., additional, and El-Amraoui, A., additional
- Published
- 2018
- Full Text
- View/download PDF
9. Identification of coronary thrombus after myocardial infarction by intracoronary ultrasound compared with histology of tissues sampled by atherectomy.
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Chemarin-Alibelli, MJ, Pieraggi, MT, Elbaz, M, Carrié, D, Fourcade, J, Puel, J, and Tobis, J
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Coronary Vessels ,Humans ,Coronary Thrombosis ,Myocardial Infarction ,Coronary Angiography ,Ultrasonography ,Interventional ,Atherectomy ,Coronary ,Sensitivity and Specificity ,Adult ,Aged ,Middle Aged ,Female ,Male ,Ultrasonography ,Interventional ,Atherectomy ,Coronary ,Cardiovascular System & Hematology ,Cardiorespiratory Medicine and Haematology - Abstract
This study compares the ability of intracoronary ultrasound (ICUS) to identify thrombus by means of actual criteria, with the histologic studies of tissues removed by directional atherectomy in patients treated previously with thrombolytic therapy. Coronary angiography and intravascular ultrasound imaging were performed before atherectomy in 34 patients who had received intravenous thrombolytic therapy for acute myocardial infarction a mean of 6 days before. The lesion morphology and the percentage of stenosis were defined on the angiogram. The ultrasound characteristics of the narrowing were described as intraluminal thrombus, mural thrombus, mixed plaque, and dense plaque. Thirty patients were studied. Thrombus was suspected in 8 patients on angiography. By ICUS, the presence of thrombus was predicted in 21 patients. Histologic studies of excised tissues found thrombus in 20 of the 30 patients. When ICUS was compared with histology, the true-positive rate was 80% and the false-positive rate was 50%; the true-negative rate was 50% and the false-negative rate was 20%. The correlation between observers was high. These observations suggest that ICUS may be useful in identifying fresh thrombus. The findings of this study help to confirm the criteria for diagnosing intraluminal thrombus by ICUS imaging.
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- 1996
10. Plaque rupture and morphological characteristics of the culprit lesion in acute coronary syndromes without significant angiographic lesion: Analysis by intravascular ultrasound
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Ouldzein, H., Elbaz, M., Roncalli, J., Cagnac, R., Carrié, D., Puel, J., and Alibelli-Chemarin, M.-J.
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- 2012
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11. On the equilibrium electrostatic potential and light-induced charge redistribution in halide perovskite structures
- Author
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Regaldo, D, Bojar, A, Dunfield, Dunfield, S.P., Lopez-Varo, P., Frégnaux, M., Dufoulon, V., Zhang, S.-T., Alvarez, J., Berry, J. J., Puel, J.-B., Schulz, P., and Kleider, J.-P.
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defects, drift-diffusion modeling, heterojunction, perovskite solar cell, photoemission spectroscopy, surface photovoltage - Abstract
Lead halide perovskites are semiconductor materials which are employed as nonintentionally doped absorbers inserted between two selective carrier transport layers (SCTL), realizing a p-i-n or n-i-p heterojunction. In our study, we have developed and investigated a lateral device, based on methylammonium lead iodide (MAPbI3) in which the p-i-n heterojunction develops in the horizontal direction. Our research suggests that the effective doping level in the MAPbI3film should be very low, below 1012 cm−3. Along the vertical direction, this doping level is not enough to screen the electric field of the buried heterojunction with the SCTL. The perovskite work function is therefore affected by the work function of the SCTL underneath. From drift-diffusion simulations, we show that intrinsic perovskite-SCTL structures develop mV range surface photovoltages (SPVs) under continuous illumination. However, perovskite-SCTL structures can develop SPVs of hundreds of mV, as confirmed by our measurements. We therefore analyzed the compatibility between low doping and low defect densities in the perovskite layer and such high SPV values using numerical modeling. It is shown that these high SPV values could originate from electronic processes due to large band offsets in the buried perovskite-SCTL heterojunctions, or at the SCTL-transparent conductive oxide (TCO) buried heterojunction. However, such electronic processes can hardly explain the long SPV persistence after switching off the illumination.
- Published
- 2021
12. Controllability of a multi-dimensional system of schrödinger equations: Application to a system of plate and beam equations
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Puel, J. P., Zuazua, E., Thoma, M., editor, Wyner, W., editor, Davisson, L. D., editor, MacFarlane, A. G. J., editor, Kwakernaak, H., editor, Massey, J. L., editor, Tsypkin, Ya Z., editor, Viterbi, A. J., editor, Curtain, R. F., editor, Bensoussan, A., editor, and Lions, J. L., editor
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- 1993
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13. Occurrence of Viruses in Human Stools in the Ahaggar (Algeria)
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Puel, J. M. L., Orillac, M. S., Bauriaud, R. M., Boughermouh, R., and Akacem, O.
- Published
- 1982
14. On the Equilibrium Electrostatic Potential and Light-Induced Charge Redistribution in Halide Perovskite Structures
- Author
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Regaldo, D., Bojar, A., Dunfield, S.P., Lopez-Varo, P., Frégnaux, M., Dufoulon, V., Zhang, S.-T., Alvarez, J., Berry, J.J., Puel, J.-B., Schulz, P., and Kleider, J.-P.
- Subjects
Perovskites and Other Non-Silicon Materials and Devices, Multijunctions/Tandems ,Perovskites - Abstract
38th European Photovoltaic Solar Energy Conference and Exhibition; 389-394, Lead halide perovskites are a class of semiconductor materials which are employed as non-intentionally doped absorbers inserted between two selective carrier transport layers (SCTL), realizing a p-i-n or n-i-p heterojunction. In our study, we have developed and investigated a lateral device, based on methylammonium lead iodide (MAPbI3) in which the p-i-n heterojunction develops in the horizontal direction. Our research suggests that the effective doping level in the MAPbI3 film should be very low, below 1012 cm-3. Along the vertical direction, this doping level is not enough to screen the electric field of the buried heterojunction with the SCTL. The perovskite work function is therefore affected by the work function of the SCTL underneath. From drift-diffusion simulations we show that intrinsic perovskite-SCTL structures develop mV range surface photovoltages (SPVs) under continuous illumination. However, perovskite-SCTL structures can develop SPVs of hundreds of mV, as confirmed by our measurements. We therefore analyzed the compatibility between low doping and low defect densities in the perovskite layer and such high SPV values using numerical modelling. It is shown that these high SPV values could originate from electronic processes due to large band offsets in the buried perovskite-SCTL heterojunctions, or at the SCTL - transparent conductive oxide (TCO) buried heterojunction. However, such electronic processes can hardly explain the long SPV persistence after switching off the illumination, which could be a sign that light-induced physicochemical processes are at work.
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- 2021
- Full Text
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15. Cost Assessment of Future Tandem Perovskite-Silicon Modules and LCOE Comparison to Silicon Technologies in Europe
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Moreno Castillo, C., Woodhouse, M., Puel, J.-B., Julien, A., Oberbeck, L., and Grand, P.P.
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Costs, Economics, Finance and Markets ,Finance, Markets and Policies - Abstract
38th European Photovoltaic Solar Energy Conference and Exhibition; 1637-1641, Tandem perovskite-silicon (TPS) photovoltaic (PV) technology is a promising pathway for achieving higher efficiencies than those of single-junction crystal-silicon (c-Si) technologies. In this work, a techno-economic assessment of a TPS module is performed considering a viable large-scale manufacturing process for two future scenarios in 2025 and 2030 which allowed us to identify the main cost drivers of the tandem module cost. Furthermore, to analyse the performance of tandem module-based utility-scale PV systems and understand their competitiveness in Europe, the levelized cost of electricity was compared to passivated emitter and rear cell as well as silicon heterojunction based PV systems. The aim of this work is to provide a cost and performance guidance for TPS modules which could contribute to future PV energy systems.
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- 2021
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16. Assessing Plausible Environmental Implications of a Ground-Mounted Perovskite/Si Tandem PV System
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Salas-Redondo, C., Blanco, C.-F., Puel, J.-B., Julien, A., Soumane, F., Cucurachi, S., Peijnenburg, W.J.G.M., and Oberbeck, L.
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Sustainability and Recycling ,Photovoltaic Modules and BoS Components - Abstract
38th European Photovoltaic Solar Energy Conference and Exhibition; 704-707, We have previously reported a comprehensive life cycle assessment (LCA) for large area (> 2 m²) perovskite/Si tandem solar modules with 30% power conversion efficiency (PCE), 30 years lifetime and an annual degradation of 0.5%, manufactured in a gigawatt-sized industrial scale production plant. We did an extensive compilation of the life cycle inventory (LCI) thanks to direct contacts with equipment manufacturers, who provided the required data to deliver a perspective to real-life conditions. In the present study, we prepared an updated LCA that includes an upgraded LCI as well as the addition of the end-of-life (EoL) stage and the comparison of electricity mix scenarios at the production stage. These scenarios are essential in a near future where renewable energies are expected to have a larger contribution in the global energy mix. The key result found in this work is the relevance of the performance and reliability of the photovoltaic (PV) system to achieve lower environmental impacts. We tested different assumptions using a detailed yield model for the PV system which considered optimistic, realistic, and pessimistic degradation rates, lifetime and PCE, among other parameters to investigate this matter. In a realistic scenario, we observed that for all the impacts assessed, the perovskite/Si tandem based system shows a decrease of between 30-45% in the contributions to each impact category, compared to the Si-module based reference PV system. Moreover, contemplating different EoL scenarios permits to address strategic methodologies to implement a circular economy in the life cycle of the tandem system. Finally, the analysis anticipating future electricity mix scenarios allows to define conditions to achieve further decreases of the environmental impacts.
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- 2021
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17. High Rate of Hepatitis C Virus Clearance in Hemodialysis Patients after Interferon-α Therapy
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Izopet, J., Rostaing, L., Moussion, F., Alric, L., Dubois, M., That, H. Ton, Payen, J. L., Duffaut, M., Durand, D., Sue, J. M., and Puel, J.
- Published
- 1997
18. Clinical and angiographic results of angioplasty with a paclitaxel-eluting stent for unprotected left main coronary artery disease (a study of 101 consecutive patients)
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Cherradi, R., Ouldzein, H., Zouaoui, W., Elbaz, M., Puel, J., and Carrié, D.
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- 2008
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19. Evaluation of in-stent restenosis in proximal coronary arteries with multidetector computed tomography (MDCT)
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Chabbert, V., Carrie, D., Bennaceur, M., Maupas, E., Lauwers, V., Mhem, M., Lhermusier, T., Elbaz, M., Joffre, F., Rousseau, H., and Puel, J.
- Published
- 2007
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20. Coxsackie adenovirus receptor and ανβ3/ανβ5 integrins in adenovirus gene transfer of rat cochlea
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Venail, F, Wang, J, Ruel, J, Ballana, E, Rebillard, G, Eybalin, M, Arbones, M, Bosch, A, and Puel, J-L
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- 2007
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21. Localization of energy and localized controllability
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Chaves-Silva, F.W., primary, Puel, J.-P., additional, and Santos, M.C., additional
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- 2021
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22. Existence of bounded solutions for nonlinear elliptic equations in unbounded domains
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Dall’aglio, A., De Cicco, V., Giachetti, D., and Puel, J. -P.
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- 2004
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23. Pre-Hospital Fibrinolysis Followed by Angioplasty or Primary Angioplasty in Acute Myocardial Infarction: The Long-Term Clinical Outcome
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Roncalli, J., Brunelle, F., Galinier, M., Carrié, D., Fourcade, J., Elbaz, M., Gaston, J.P., Charpentier, S., Puel, J., and Fauvel, J.M.
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- 2003
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24. Determination of HCV Genotype Using Two Antibody Assays and Genome Typing
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Sandres, K., Dubois, M., Pasquier, C., Puel, J., and Izopet, J.
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- 2001
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25. Fisiología de la audición
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Nouvian, R., Malinvaud, D., Van den Abbeele, T., Puel, J.-L., Bonfils, P., and Avan, P.
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- 2006
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26. HIV Infection and Long‐Term Residual Cardiovascular Risk After Acute Coronary Syndrome
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Boccara, Franck, primary, Mary‐Krause, Murielle, additional, Potard, Valérie, additional, Teiger, Emmanuel, additional, Lang, Sylvie, additional, Hammoudi, Nadjib, additional, Chauvet, Marion, additional, Ederhy, Stéphane, additional, Dufour‐Soulat, Laurie, additional, Ancedy, Yann, additional, Nhan, Pascal, additional, Adavane, Saroumadi, additional, Steg, Ph. Gabriel, additional, Funck‐Brentano, Christian, additional, Costagliola, Dominique, additional, Cohen, Ariel, additional, Weber, S., additional, Wahbi, K., additional, Beaufils, P., additional, Henri, P., additional, Sideris, G., additional, Thomas, D., additional, Montalescot, G., additional, Beygui, F., additional, Meuleman, C., additional, Janower, S., additional, Raoux, F., additional, Dufaitre, G., additional, Benyounes, N., additional, Michel, P. L., additional, Petillon, B., additional, Hammoudi, N., additional, Gueret, P., additional, Dubois‐Rande, J. L., additional, Teiger, E., additional, Lim, P., additional, Slama, M., additional, Colin, P., additional, Saudubray, C., additional, Dubourg, O., additional, Milleron, O., additional, Gallet, B., additional, Duclos, F., additional, Godard, S., additional, Fuchs, L., additional, Dormagen, V., additional, Lewy, P., additional, Cattan, S., additional, Nallet, O., additional, Grollier, G., additional, Shayne, J., additional, Wolf, J. E., additional, Cottin, Y., additional, Machecourt, J., additional, Bouvaist, H., additional, Finet, G., additional, De Breyne, B., additional, Trochu, J. N., additional, Baudouy, M., additional, Ferrari, E., additional, Benhamou, M., additional, Allal, J., additional, Coisne, D., additional, Le Breton, H., additional, Bedossa, M., additional, Puel, J., additional, Elbaz, M., additional, Larifla, L., additional, Matheron, S., additional, Landman, R., additional, Fremont, G., additional, Spiridon, G., additional, Blanche, P., additional, Morini, J. P., additional, Sicard, D., additional, Zeller, V., additional, Batisse, D., additional, Clevenbergh, P., additional, Cessot, G., additional, Dohin, E., additional, Valantin, M. A., additional, Khelifa, S., additional, Girard, P. M., additional, Lallemand, F., additional, Lefebvre, B., additional, Laporte, J. P., additional, Meynard, J. L., additional, Bideault, H., additional, Picard, O., additional, Meyohas, M. C., additional, Campa, P., additional, Tredup, J., additional, Fonquernie, L., additional, Raguin, G., additional, Molina, J. M., additional, Furco, A., additional, Gharakanian, S., additional, Vincensini, J. P., additional, Guiard‐Schmid, J. B., additional, Pialoux, G., additional, Cardon, B., additional, Lascaux, A. S., additional, Chaix, F., additional, Lesprit, P., additional, Fior, R., additional, Boue, F., additional, Dupont, C., additional, Bellier, C., additional, Blanc, A., additional, Lambert, T., additional, Touahri, T., additional, Force, G., additional, de Truchis, P., additional, Compagnucci‐Seguenot, M. A., additional, Cahitte, I., additional, Roudière, L., additional, Techer, M. E., additional, Thelpin, P., additional, Troisvallets, D., additional, Lepretre, A., additional, Echard, M., additional, Le Mercier, Y., additional, Houlbert, D., additional, Dargere, S., additional, Bazin, C., additional, Verdon, R., additional, De Goer, B., additional, Duong, M., additional, Chavanet, P., additional, Gozlan, E., additional, Leclercq, P., additional, Brunel‐Dal Mas, F., additional, Durant, J., additional, Heudier, P., additional, Brunet‐François, C., additional, Le Moal, G., additional, Chapplin, J. M., additional, Arvieux, C., additional, Chaumentin, G., additional, Guerin, B., additional, Bonnet, E., additional, Poinsignon, Y., additional, Boulard, F., additional, De Lacroix, I., additional, Goerger‐Sow, M. T., additional, Kirstetter, M., additional, Volstein, M., additional, Laylavoix, F., additional, Copin, X., additional, and Ceppi, C., additional
- Published
- 2020
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27. Acúfenos subjetivos invalidantes
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Londero, A., primary, Nicolas-Puel, C., additional, Puel, J.-L., additional, and Loche, V., additional
- Published
- 2020
- Full Text
- View/download PDF
28. Boundary null controllability as the limit of internal controllability: The heat case
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Chaves-Silva, F.W., primary, Puel, J.-P., additional, and Santos, M.C., additional
- Published
- 2020
- Full Text
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29. Boundary Controllability of a Stationary Stokes System with Linear Convection Observed on an Interior Curve
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Osses, A. and Puel, J. P.
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- 1998
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30. Predictors of infarct artery patency after prehospital thrombolysis: the multicentre, prospective, observational OPTIMAL study
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Bongard, V, Puel, J, Savary, D, Belle, L, Charpentier, S, Cottin, Y, Soulat, L, Elbaz, M, Miljkovic, D, and Steg, Ph G
- Published
- 2009
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31. Protection cardiovasculaire du coronarien et du diabétique: l’important, c’est la dose
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Charpentier, G., Puel, J., and Steg, P.-G.
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- 2005
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32. Angioplastie primaire à long terme : quel bénéfice des endoprothèses ?
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Roncalli, J., Galinier, M., Fourcade, J., Carrié, D., Puel, J., and Fauvel, J.M.
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- 2005
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33. Global existence for the full von Kármán system
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Puel, J. P. and Tucsnak, M.
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- 1996
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34. Differential expression of PKC beta II in the rat organ of Corti
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Ladrech, S., Wang, J., Boukhaddaoui, H., Puel, J. L., Eybalin, M., and Lenoir, M.
- Published
- 2007
35. Synaptic connections and putative functions of the dopaminergic innervation of the guinea pig cochlea
- Author
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d'Aldin, C., Eybalin, M., Puel, J. -L., Charachon, G., Ladrech, S., Renard, N., and Pujol, R.
- Published
- 1995
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36. The Inner Hair Cell Afferent/Efferent Synapses Revisited: A Basis for New Therapeutic Strategies
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Puel, J.-L., primary, Ruel, J., additional, Guitton, M., additional, and Pujol, R., additional
- Published
- 2002
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37. Scores pronostiques pour la revascularisation des myocardiopathies ischémiques
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Roncalli, J, Richez, F, Galinier, M, Fourcade, J, Cérène, A, Fournial, G, Marco, J, Bounhoure, J.P, Puel, J, and Fauvel, J.M
- Published
- 2004
- Full Text
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38. Glutamate transporters in the guinea-pig cochlea: partial mRNA sequences, cellular expression and functional implications
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Rebillard, G., Ruel, J., Nouvian, R., Saleh, H., Pujol, R., Dehnes, Y., Raymond, J., Puel, J. L., and Devau, G.
- Published
- 2003
39. Relationship between atrial septum abnormalities (FOP and ASIA) and atrial vulnerability in young patients with ischaemic stroke: a prospective study
- Author
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Albucher, J. F., Somody, E., Prouteau, N., Puel, J., Guiraud-Chaumeil, B., Delay, M., and Chollet, F.
- Published
- 2001
40. FACT : registre national français des syndromes coronaires aigus.: Étude particulière des centres hospitaliers généraux français
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Dujardin, J.-J, Steg, P.-G, Puel, J, Montalescot, G, Ravaud, P, Goldstein, P, Jullien, G, Chevalier, B, Monassier, J.-P, Huynh-Ba, O, and Kempf, C
- Published
- 2003
- Full Text
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41. Assessment of a hepatitis C virus antibody assay in saliva for epidemiological studies
- Author
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Bello, P. -Y., Pasquier, C., Gourney, P., Puel, J., and Izopet, J.
- Published
- 1998
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42. Cochlear Effects of Mesna Application into the Middle Ear
- Author
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VINCENTI, V., MONDAIN, M., PASANISI, E., PIAZZA, F., PUEL, J.-L., BACCIU, S., QUARANTA, N., UZIEL, A., and ZINI, C.
- Published
- 1999
43. Decay of HIV-1 DNA in patients receiving suppressive antiretroviral therapy
- Author
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Izopet, J., Salama, G., Pasquier, C., Sandres, K., Marchou, B., Massip, P., and Puel, J.
- Subjects
HIV (Viruses) -- Physiological aspects ,HIV infection -- Drug therapy ,Health - Abstract
New AIDS drugs are needed to eradicate the virus that hides out inside cells. Aggressive therapy can suppress the virus in the bloodstream, but residual virus still exists inside cells. Researchers measured this residual virus inside the blood cells of 10 HIV patients who were on aggressive drug therapy and had undetectable blood levels of HIV. After one year of treatment, the level of HIV inside the blood cells had decreased, but it was always detectable.
- Published
- 1998
44. Selective Glutamate Antagonists Block the Excitotoxicity Caused Either by Glutamate Agonists or by Ischemia
- Author
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Puel, J.-L., primary and Pujol, R., additional
- Published
- 1992
- Full Text
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45. Erratum Erratum to “Effects of a dopaminergic agonist in the guinea pig cochlea” [Hear. Res. 90 (1995) 202-211]1
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dʼAldin, C., Puel, J-L., Leducq, R., Crambes, O., Eybalin, M., and Pujol, R.
- Published
- 1997
- Full Text
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46. Protecting HIV databases
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Korber, B. T. M., Learn, G., Mullins, J. I., Hahn, B. H., Wolinsky, S., Briant, L., Puel, J., Wade, C. M., Brown, A. J. Leigh, and Guyader, M.
- Published
- 1995
47. Interventional treatment in diabetics in the era of drug-eluting stents and compliance to the ESC guidelines: lessons learned from the Euro Heart Survey Programme
- Author
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Onuma Y., Kukreja N., Ramcharitar S., Hochadel M., Gitt A., Serruys P., Marco J., Vahanian A., Weidinger F., Wijns W., Zeymer U., Silber S., Seabra-Gomez R., Eberli F., Manini M., Bramley C., Laforest V., Taylor C., Huber K., Backer G. D., Sirakova V., Cerbak R., Thayssen P., Aziz O. A., Tammam K., Lehto S., Delahaye F., Kobulia B., Cokkinos D., Kremastinos D., Karlocai K., Shelley E., Behar S., Maggioni A., Grabauskiene V., Deckers J., Asmussen I., Stepinska J., Goncalves L., Fonseca C., Mareev V., Vasilijevic Z., Riecansky M. I., Kenda M. F., Lopez-Sendon J. L., Rosengren A., Buser P., Okay T., Sychov O., Schofield P., Gitt A. K., Tavazzi L., Gomes R. S., de la Iglesia J. M., Wallentin L., Kearney P., McGregor K., Simoons M. L., Squibb B. -M., Lilly E., Margaryan K., Khachatryan S., Doerler J., Stocker E. -M., Altenberger I. J., Heigert M., Pichler M., Christ S. G., Glogar H., Lang I., Ingerle S., De Wilde P., de Marneffe M., Vrolix B. M., Dens J., Lierde J. V., De Wagter G. X., Carlier G. M., Weyne G. A., Legrand K. V., Doneux P., Gach O., Davin L., Mievis L. E., Massart P. -E., Holvoet N. G., Giunio L., Glavas D., Vukovic I., Markovic B., Duplancic D., Runjic F., Galic S. E., Mirat J., Kala P., Semenka J., Hlinomaz O., Petrikovits E., Widimsky B. P., Tousek P., Varvarovsky P. I., Cappelen H., Helqvist O. S., Kelbaek H., Jorgensen E., Engstrom T., Saunamaki K., Kastrup J., Clemmensen P., Hansen H., Al Abbadi M., Razek H. A., Aboul el Nasr G., Ragi H., Ibrihim B., Zarif B., el Banhawy N., Sorour K., Meguid M. A., Mahrous A., Al Khashab K. A., Ahmed Abd Elmoniem F., El Emry M., El Naggar A., Saad B. A., Laanmets P., Voitk J., Lutter P., Jarvekulg S., Jalakas M., Reinmets J., Marandi T., Peeba M., Serka T., Syvannne M., Kaihovirta E., Korpilahti H. K., Vaittinen M. -A., Bassand J. -P., Espinosa D. P., Cottin B. Y., Lhuillier I., Buffet P., Lorgis L., Machecourt D. J., Bertrand B., Serrano D., Bonnet G. J. -L., Steg M. P. G., Juliard J. -M., Farnoud R., Delarche P. N., Marco P. J., Petit F., Farah B., Carrie D., Galinier M., Puel J., Cahuzac J., Roncalli J., Tauzin S., Elbaz M., Schachinger V., Gitt F. A., am Rhein Ralf Zahn L., Fraiture B., Haetinger S., Klepzig N. H., Girth E., Hauber A., Firschke O. C., Widmaier J., Hofbauer F., Huttl S., Sechtem P. U., Parade U., Linnartz S. G., Andrianidis S., Tsiavou N., Papaioannou G., Deliargyris E., Attikis M., Alexopoulos D., Davlouros P., Tsikaderis D., Dardas P., Mezilis N., Istvan E., Zoltan B., Turgeman Y., Khaled S., Feldman A., Jafari J., Manevich I., Cafri C., Ilia R., Abu-Ful A., Yaroslavslev S., Wainstain J. M., Rosenchtein G., Sheva B., Krakover R., Yakov B., Halon D., Gruberg L., Markiewicz W., Grenadier E., Boulos M., Roguin A., Kerner A., Amikam S., Ben-Tzvi M., Rezmovitz J., Mosseri H. M., Lotan H., Varshizky B., Nassar H., Daninberg H., Rot D., Vais T., Benhorin J., Keren A., Medina A., Huri Z., Brandis J. S., Schoenmann G., Kornowski N. R., Assali A., Fuch S., Hasdai D., Brosh D., Sela O., Teplitski I., Tikva P., Eisenberg O., Banai S., Finkelstein A., Hasin Y., Aboud M., Nahir M., Qarwani D., Diab G., Meloni L., Lai G., Cadeddu M., Pirisi R., Bonechi F., Nassi F., Nieri M., Taiti A., Naldoni A., Calabro F., Achilli F., Maggiolini S., Piatti L., Tiberti G., Addamiano P., Berti S., Ravani M., Palmieri C., Trianni G., Cardullo S., Cioppa A., Rubino P., Ambrosini V., Salemme L., Sorropago G., Tesorio T., Geraci G., Scalise F., Mazzeti S., Auguadro C., Esposito G., Canali G., Caccia M. E., Ruggieri C., Benedetta B., de Cesare N., De Benedictis M., Coco T., Manzotti S., Fraz O. S., Marraccini P., Danesi A., Ricci R., Ferraironi A., Olivieri E., Chiera A., Garducci S., Grasseli D., McFadden E., Cahill N., Quinn M., Crean P., Caroll E., Foley D., O'Connor S., O'Hanlon R., Lynch B., O'Donnell S., Roy J., O'Brien D., Krastina A., Erglis A., Lawand S., Dorniak W., Klaudel J., Pawlowski K., Trenkner W., Janion M., Sadowski M., Janion-Sadowska A., Skorupa I., Bystryk L., Kern A., Janiak B., Szelemej R., Ruzyllo W., Witkowski A., Deptuch T., Maczynska-Mazuruk R., Budaj A., Cegieska K. L., Opolski G., Wilczyska J., Roik M., Kochman J., Martins D., Goncalves I. M. F. J., Pereira H., Faria H., Calisto J., Matos V., Leitao-Marques A., Costa M., Oliveira H., Mota P., Santos W., Brandao V., Caires F. G., Silva B., Teles F. R. C., Almeida M., Goncalves P., Raposo L., Mourao L., Bernardes L., Pedro P. G., Ferreira R., Conduto R., Quininha J., Patricio L., Cacela D., Goncalves J. M., de Sousa L., Adao M., Carvalho L. H. C., Romeira H., Sousa J. P., Garcia J. M. M., Silva J. C., Magalhaes D., Santos P. R., Mendes S. P. G., Pipa J., Nunes L., Ferreira P., Vinereanu D., Udroiu C., Florescu N., Parvu O., Stoicescu C., Dorobantu M., Balanescu S. M., Niculescu R., Calmac L., Marinescu M., Olinic B. D., Ober M., Homorodean C., Budurea C., Hij A., Anton F., Cluj-Napoca, Ortan F., Suciu C., Ursu M., Baba C., Targu-Mures, Dragulescu S. I., Petrescu L., Slovenski M., Gavrilescu D., Dina C., Mut B., Babic R., Colic M., Topic D., Vilarrasa J. B., Pont M. P., Martorell R. M., Rohlfs I., Moreno R. M., Irurita M., Irurita J., de Gran Canaria L. P., Cervantes C. E., Galvan T., Navarro J., Franco D., Rodriguez I. S., Ramirez V. H., Fernandes-Aviles F., Revilla A., Masson N., Dupertuis V., Kachboura S., Iyisoy A., Erol M. K., Ongen Z., Babalik E., Oskan M., Ozdemir N., Oto A., Aytemir K., Yavuz B., Sahin M., Durna K., Aytekin V., Demiroglu C., Gulbaran M., Aytekin S., Catakoglu A. B., Ozme B., Gemici G., Feray H., Schofield P. M., Kahn S., Clarke S., Millington H., Di Mario C., Dempster D., Henderson R. A., Burton J., Falcon-Lang D., Cardiology, Onuma, Y., Kukreja, N., Ramcharitar, S., Hochadel, M., Gitt, A., Serruys, P., Marco, J., Vahanian, A., Weidinger, F., Wijns, W., Zeymer, U., Silber, S., Seabra-Gomez, R., Eberli, F., Manini, M., Bramley, C., Laforest, V., Taylor, C., Huber, K., Backer, G. D., Sirakova, V., Cerbak, R., Thayssen, P., Aziz, O. A., Tammam, K., Lehto, S., Delahaye, F., Kobulia, B., Cokkinos, D., Kremastinos, D., Karlocai, K., Shelley, E., Behar, S., Maggioni, A., Grabauskiene, V., Deckers, J., Asmussen, I., Stepinska, J., Goncalves, L., Fonseca, C., Mareev, V., Vasilijevic, Z., Riecansky, M. I., Kenda, M. F., Lopez-Sendon, J. L., Rosengren, A., Buser, P., Okay, T., Sychov, O., Schofield, P., Gitt, A. K., Tavazzi, L., Gomes, R. S., de la Iglesia, J. M., Wallentin, L., Kearney, P., Mcgregor, K., Simoons, M. L., Squibb, B. -M., Lilly, E., Margaryan, K., Khachatryan, S., Doerler, J., Stocker, E. -M., Altenberger, I. J., Heigert, M., Pichler, M., Christ, S. G., Glogar, H., Lang, I., Ingerle, S., De Wilde, P., de Marneffe, M., Vrolix, B. M., Dens, J., Lierde, J. V., De Wagter, G. X., Carlier, G. M., Weyne, G. A., Legrand, K. V., Doneux, P., Gach, O., Davin, L., Mievis, L. E., Massart, P. -E., Holvoet, N. G., Giunio, L., Glavas, D., Vukovic, I., Markovic, B., Duplancic, D., Runjic, F., Galic, S. E., Mirat, J., Kala, P., Semenka, J., Hlinomaz, O., Petrikovits, E., Widimsky, B. P., Tousek, P., Varvarovsky, P. I., Cappelen, H., Helqvist, O. S., Kelbaek, H., Jorgensen, E., Engstrom, T., Saunamaki, K., Kastrup, J., Clemmensen, P., Hansen, H., Al Abbadi, M., Razek, H. A., Aboul el Nasr, G., Ragi, H., Ibrihim, B., Zarif, B., el Banhawy, N., Sorour, K., Meguid, M. A., Mahrous, A., Al Khashab, K. A., Ahmed Abd Elmoniem, F., El Emry, M., El Naggar, A., Saad, B. A., Laanmets, P., Voitk, J., Lutter, P., Jarvekulg, S., Jalakas, M., Reinmets, J., Marandi, T., Peeba, M., Serka, T., Syvannne, M., Kaihovirta, E., Korpilahti, H. K., Vaittinen, M. -A., Bassand, J. -P., Espinosa, D. P., Cottin, B. Y., Lhuillier, I., Buffet, P., Lorgis, L., Machecourt, D. J., Bertrand, B., Serrano, D., Bonnet, G. J. -L., Steg, M. P. G., Juliard, J. -M., Farnoud, R., Delarche, P. N., Marco, P. J., Petit, F., Farah, B., Carrie, D., Galinier, M., Puel, J., Cahuzac, J., Roncalli, J., Tauzin, S., Elbaz, M., Schachinger, V., Gitt, F. A., am Rhein Ralf Zahn, L., Fraiture, B., Haetinger, S., Klepzig, N. H., Girth, E., Hauber, A., Firschke, O. C., Widmaier, J., Hofbauer, F., Huttl, S., Sechtem, P. U., Parade, U., Linnartz, S. G., Andrianidis, S., Tsiavou, N., Papaioannou, G., Deliargyris, E., Attikis, M., Alexopoulos, D., Davlouros, P., Tsikaderis, D., Dardas, P., Mezilis, N., Istvan, E., Zoltan, B., Turgeman, Y., Khaled, S., Feldman, A., Jafari, J., Manevich, I., Cafri, C., Ilia, R., Abu-Ful, A., Yaroslavslev, S., Wainstain, J. M., Rosenchtein, G., Sheva, B., Krakover, R., Yakov, B., Halon, D., Gruberg, L., Markiewicz, W., Grenadier, E., Boulos, M., Roguin, A., Kerner, A., Amikam, S., Ben-Tzvi, M., Rezmovitz, J., Mosseri, H. M., Lotan, H., Varshizky, B., Nassar, H., Daninberg, H., Rot, D., Vais, T., Benhorin, J., Keren, A., Medina, A., Huri, Z., Brandis, J. S., Schoenmann, G., Kornowski, N. R., Assali, A., Fuch, S., Hasdai, D., Brosh, D., Sela, O., Teplitski, I., Tikva, P., Eisenberg, O., Banai, S., Finkelstein, A., Hasin, Y., Aboud, M., Nahir, M., Qarwani, D., Diab, G., Meloni, L., Lai, G., Cadeddu, M., Pirisi, R., Bonechi, F., Nassi, F., Nieri, M., Taiti, A., Naldoni, A., Calabro, F., Achilli, F., Maggiolini, S., Piatti, L., Tiberti, G., Addamiano, P., Berti, S., Ravani, M., Palmieri, C., Trianni, G., Cardullo, S., Cioppa, A., Rubino, P., Ambrosini, V., Salemme, L., Sorropago, G., Tesorio, T., Geraci, G., Scalise, F., Mazzeti, S., Auguadro, C., Esposito, G., Canali, G., Caccia, M. E., Ruggieri, C., Benedetta, B., de Cesare, N., De Benedictis, M., Coco, T., Manzotti, S., Fraz, O. S., Marraccini, P., Danesi, A., Ricci, R., Ferraironi, A., Olivieri, E., Chiera, A., Garducci, S., Grasseli, D., Mcfadden, E., Cahill, N., Quinn, M., Crean, P., Caroll, E., Foley, D., O'Connor, S., O'Hanlon, R., Lynch, B., O'Donnell, S., Roy, J., O'Brien, D., Krastina, A., Erglis, A., Lawand, S., Dorniak, W., Klaudel, J., Pawlowski, K., Trenkner, W., Janion, M., Sadowski, M., Janion-Sadowska, A., Skorupa, I., Bystryk, L., Kern, A., Janiak, B., Szelemej, R., Ruzyllo, W., Witkowski, A., Deptuch, T., Maczynska-Mazuruk, R., Budaj, A., Cegieska, K. L., Opolski, G., Wilczyska, J., Roik, M., Kochman, J., Martins, D., Goncalves, I. M. F. J., Pereira, H., Faria, H., Calisto, J., Matos, V., Leitao-Marques, A., Costa, M., Oliveira, H., Mota, P., Santos, W., Brandao, V., Caires, F. G., Silva, B., Teles, F. R. C., Almeida, M., Goncalves, P., Raposo, L., Mourao, L., Bernardes, L., Pedro, P. G., Ferreira, R., Conduto, R., Quininha, J., Patricio, L., Cacela, D., Goncalves, J. M., de Sousa, L., Adao, M., Carvalho, L. H. C., Romeira, H., Sousa, J. P., Garcia, J. M. M., Silva, J. C., Magalhaes, D., Santos, P. R., Mendes, S. P. G., Pipa, J., Nunes, L., Ferreira, P., Vinereanu, D., Udroiu, C., Florescu, N., Parvu, O., Stoicescu, C., Dorobantu, M., Balanescu, S. M., Niculescu, R., Calmac, L., Marinescu, M., Olinic, B. D., Ober, M., Homorodean, C., Budurea, C., Hij, A., Anton, F., Cluj-Napoca, Ortan, F., Suciu, C., Ursu, M., Baba, C., Targu-Mures, Dragulescu, S. I., Petrescu, L., Slovenski, M., Gavrilescu, D., Dina, C., Mut, B., Babic, R., Colic, M., Topic, D., Vilarrasa, J. B., Pont, M. P., Martorell, R. M., Rohlfs, I., Moreno, R. M., Irurita, M., Irurita, J., de Gran Canaria, L. P., Cervantes, C. E., Galvan, T., Navarro, J., Franco, D., Rodriguez, I. S., Ramirez, V. H., Fernandes-Aviles, F., Revilla, A., Masson, N., Dupertuis, V., Kachboura, S., Iyisoy, A., Erol, M. K., Ongen, Z., Babalik, E., Oskan, M., Ozdemir, N., Oto, A., Aytemir, K., Yavuz, B., Sahin, M., Durna, K., Aytekin, V., Demiroglu, C., Gulbaran, M., Aytekin, S., Catakoglu, A. B., Ozme, B., Gemici, G., Feray, H., Schofield, P. M., Kahn, S., Clarke, S., Millington, H., Di Mario, C., Dempster, D., Henderson, R. A., Burton, J., and Falcon-Lang, D.
- Subjects
Registrie ,Male ,medicine.medical_treatment ,Angiotensin-Converting Enzyme Inhibitors ,Comorbidity ,Coronary Artery Disease ,Severity of Illness Index ,Cardiovascular Disease ,Hospital Mortality ,Registries ,Angioplasty, Balloon, Coronary ,Drug-Eluting Stents ,Middle Aged ,Clopidogrel ,Europe ,Treatment Outcome ,Drug-eluting stent ,Cardiovascular Diseases ,Practice Guidelines as Topic ,Female ,Guideline Adherence ,Inpatient ,Cardiology and Cardiovascular Medicine ,Human ,medicine.drug ,medicine.medical_specialty ,Diabetic Angiopathie ,Adrenergic beta-Antagonists ,Diabetic ,SDG 3 - Good Health and Well-being ,Internal medicine ,Diabetes mellitus ,Angioplasty ,medicine ,Humans ,Drug eluting stent ,cardiovascular diseases ,Risk factor ,Aged ,European Heart Survey ,Inpatients ,Clinical Audit ,business.industry ,Platelet Aggregation Inhibitor ,Adrenergic beta-Antagonist ,Angiotensin-Converting Enzyme Inhibitor ,Guideline ,medicine.disease ,Surgery ,Health Care Survey ,Health Care Surveys ,Conventional PCI ,Hydroxymethylglutaryl-CoA Reductase Inhibitor ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,business ,Diabetic Angiopathies ,Platelet Aggregation Inhibitors - Abstract
Aims: The objective of the study is to determine the demographics and the in-hospital outcome of diabetic and non-diabetic patients treated with percutaneous coronary interventions (PCI) in Europe, to report the type of equipment and technology used for PCI procedures in diabetics and to clarify whether the treatment of diabetic patients complies with current European Society of Cardiology (ESC) guidelines. Methods and results: A total of 14,458 patients treated with PCI were enrolled from 29 member countries of the ESC between June 2005 and January 2006. Data were collected on patient characteristics and treatment, using new Cardiology Audit and Registration Data standards. In total, 3,603 patients (24.9%) were diabetic. Diabetics were older, more often female and had a higher body mass index than non-diabetics. Diabetics had higher rates of hypercholesterolaemia and hypertension, while current smokers were more frequent in the non-diabetics. Diabetics also had significantly higher rates of previous cardiovascular events. Clopidogrel was administered only in 48.1% of diabetic patients before PCI, while IIb/IIIa inhibitors were 22.9% during PCI. At discharge, there was a major adjustment of treatment with increases in the use of Beta-blocker (80.4%), angiotensin converting enzyme inhibitor (ACEI, 71.3%) and statins (89.8%) compared with on admission (Beta-blocker 60.9%, ACEI 55.0%, statin 63.1%). Inhospital mortality was higher in diabetics (1.8% vs 1.2%) although the in-hospital MACCE rate was not significantly different (3.6% vs 3.0%, p=0.09). Conclusions: Diabetic patients treated with PCI were older with more comorbidity. According to ESC guideline, the under-usage of clopidogrel, GP IIb/IIIa inhibitors should be improved. PCI is now taken as a good opportunity to adjust the use of appropriate medication. © Europa Edition. All rights reserved.
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- 2009
48. Ezetimibe added to statin therapy after acute coronary syndromes
- Author
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Cannon, Christopher P., Blazing, Michael A., Giugliano, Robert P., Mccagg, Amy, White, Jennifer A., Theroux, Pierre, Darius, Harald, Lewis, Basil S., Ophuis, Ton Oude, Jukema, J. Wouter, De Ferrari, Gaetano M., Ruzyllo, Witold, De Lucca, Paul, Kyungah, Im, Bohula, Erin A., Reist, Craig, Wiviott, Stephen D., Tershakovec, Andrew M., Musliner, Thomas A., Braunwald, Eugene, Califf, Musliner T, Robert M., Tershakovec, A, Gurfinkel, E, Aylward, P, Tonkin, A, Maurer, G, Van de Werf, F, Nicolau, Jc, Theroux, P, Genest, J, Armstrong, P, Corbalan, R, Isaza, D, Spinar, J, Grande, P, Voitk, J, Kesaniemi, A, Bassand, Jp, Farnier, M, Darius, H, Keltai, M, Mathur, A, Mittal, S, Reddy, K, Lewis, B, De Ferrari GM, Ophuis, To, Jukema, J, White, H, Pedersen, T, Britto, F, Ruzyllo, W, Carrageta, M, Duris, T, Dalby, A, Seung, Kb, Lopez-Sendon, J, Dellborg, M, Mach, F, Guneri, S, Parkhomenko, A, Brady, A, Cannon, C, Blazing, M, Ballantyne, C, de Lemos, J, Kleiman, N, Mcguire, Dk, Centeno, E, Casalins, M, Cartasegna, L, Beltrano, Mc, Guerrero, R, Fanuele, M, Berra, F, Egido, J, Colombo, H, Dellatorre, M, Terns, P, Blumberg, E, Reges, P, Azize, G, Ramos, H, Fernandez, R, Carlessi, C, Milesi, R, Schmuck, R, Duronto, E, Procopio, G, Carlevaro, O, Maffeo, H, Beloscar, J, Viso, M, Hominal, M, Castoldi, M, Bluguermann, J, Mauro, D, Macin, S, Cocco, N, Ruiz, N, Ricart, J, Lozada, A, Nani, S, Turri, D, Fernandez, H, Caruso, O, Zarandon, R, Bono, J, Arias, V, Allall, O, Marino, J, Cusimano, S, Schygiel, P, Buzetti, C, Penaloza, N, Berli, M, Worthley, S, Roach, A, Chew, D, Wright, T, Leitch, J, Hicks, E, Rankin, J, Venn-Edmonds, C, Lehman, R, Morrison, H, Shaw, J, Mak, V, Hii, C, Smith, K, Cross, D, Lilwall, L, Nelson, G, Loxton, A, Horowitz, J, Rose, J, Steinwender, C, Leisch, F, Kammler, J, Brussee, H, Zweiker, R, Niederl, E, Weihs, W, Giorgio, G, Lang, I, Drexel, H, Zanolin, D, Hoppe, U, Atzenhofer-Baumgartner, K, Pichler, M, Hainzer, D, Eber, B, Pichler, F, Foeger, B, Wechselberger, T, Mayr, H, Hofer, J, Stockenhuber, F, Warlits, B, Huber, K, Egger, F, Weidinger, F, Ziegler, B, Jirak, P, Metzler, B, Pachinger, O, Wanitschek, M, Auer, J, Grabscheit, G, 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E., Cullen, T., Eisenberg, S., Chronos, N., Allen, R.P., Erickson, B., Mahon, K., Kirby, A., Siegel, C., Stroud, L., Johnson, J., Panchal, V., Pearson, A., Abell, T., De Gregorio, M., Boomer, L., Vahdat, O., VanNatta, B., Long, P., Chalavarya, G., Skatrud, L., Carey, C., Wright, W., Mechem, C., Matthews, B., Adams, A., Vora, K., Wead, J., Koren, M., Gregory, D., El Khadra, M., Peacock, G., Kieval, J., Barron, M., Lewis, D., Grice, R., Bobek, M., Moore, C., Nygaard, T., Fischell, T., Salman, W., Schneider, C., Muhlestein, B., Peeler, D., Chang, D., Todd, A., Chilakamarri, V., Hanley, P., Gelormini, J., Iacona, M.A., Effron, B., Mazzurco, S., Mazzella, M., Wyman, P., Orchard, R., Battin, D., Rezkalla, S., Bishop, C., Sharp, S., Gredler, F., Knap, P., Fadel, M., Saucedo, J., Keng, A., Imburgia, M., Blank, E., Effat, M., Khoury, S., Mardis, R., Baldari, D., Tafuri, L., Mascolo, R., Taylor, D., Mandviwala, M., Khan, W., Mumford, T., Mayer, N., Mitchell, B., Oliver, T., Lombardi, W., Zimmerman, T., Rohrbeck, S., Cooke, L., Craig, M., Mego, D., Griffin, B., Perez, J., LeClerc, K., Addington, J., Aboufakher, R., Ahmed, A., Westecott, B., Steel, K., Hawkins, K., Shah, A., Ward, U., McGreevy, M., Goldberg, R., Prashad, R., McDonough, C., Silver, K., Josephson, R., Witsaman, S., Labib, S., Woodhead, G., Schrank, J., Bell, K., Chandna, H., Holly, D., Bethea, C., Fife, B., Gruberg, L., Singer, A., Ramgadoo, M., Lalonde, T., Morin, R., French, W., Barillas, O., Gradner, G., Kahn, Z., Gress, J., Rocco, D., Thew, S., Stifter, W., Fisher, M., McNamara, J., Kupfer, J., Agocha, A., Cush, S., Jones, S., Whitaker, T., Stover, T., Kumkumian, G., Kent, K., Greenberg, A., Pandey, P., Pytlewski, G., Matsumura, M., Kai, W., Sameshima, S., Thomas, J., MacNicholas, D., Pillai, K., Jones, D., Navas, J.P., Laskoe, B., Patel, P., Fini, G., Minor, S., Shipwash, T., Cabrera-Santamaria, A., Rivera, E., Mincher, L., Jafar, M., Yen, M., Finkle, C., Rahimtoola, A., Severson, L., Labroo, A., Jinich, D., Tam, K., Vogel, C., Aggarwal, R., Zakhary, B., Curtis, S., Lyster, M., Humphrey, K., Lavine, P., Fujise, K., Birnbaum, Y., Allen, J., Kesselbrenner, M., Michel, K., Staniloae, C., Liu, M., Sonel, A., Macioce-Caffas, A., Amidon, T., Leggett, J., Yedinak, S., Gudmundsson, G., Sabharwal, J., Dagefoerde, N., Wu, W., Meyerrose, G., Roongsritong, C., Jenkins, L., Lieberman, S., Sokol, S., Gutierrez, C., Nelson, C., Barrett, J., Hotchkiss, D., Farley, A., Atassi, K., Christy, L., Baig, M., Di Fazio, J., Meengs, M., Thomas, K., Surmitis, J., DeVault, S., Farhat, N., Hulyalkar, A., Riddell, L., Rivera, W., Sheynberg, B., Kobayashi, J., Katsaropoulos, J., Jan, M., Krucoff, M., Paterno, C., Chandrasekaran, S., Curry, R., Cassavar, D., Wheeler, M., McGarvey, J., Schwarz, L., Miller, E., Andrea, B., Carswell, B.S., Lurie, M., Patti, J., Bowden, W., Vasiliauskas, T., Latham, R., Schwartz, B., Bradford, L., Mattleman, S., Wertheimer, J., Goulden, D., Khan, M., Hawkins, B., Ostfeld, R., Mueller, H., Ash, Y., Wilson, V., Bayer, M., Marshall, J., Dobies, D., Dawson, G., Osman, A., Saba, F., Costello, T., Fuentes, F., Underwood, C., Vijay, N., Washam, M., Dietz, W., Glasgow, B., Mukherjee, S., Hinchion, N., Speirs, S., Thornley, A., Lee, K., Movahed, M., Strootman, D., Chernick, R., Parrott, C., Flock, C., Marques, V., Syzmanski, E., Rama, P., Domingo, D., Wu, L., Bauer, B., Dionisopoulos, P., Aggarwal, A., Holcomb, R., Foster, R., Hancock, T., Hargrove, J., Fletcher, A., Stine, R., Bullivant, M., Adams, K., Lohman, J., Klepper, V., Kabour, A., Neidhardt, J., Phillips, W., Tardiff, S., Aji, J., Corut, S., Foster, G., Firek, C., St Goar, F., Sumner, R., Davis, T., Schneider, R., Schneider, W., Villa, A., Desai, V., Chhabra, A., Banks, K., Herzog, W., Burley, T., Quyyumi, A., Smiley, W., Manocha, P., Fishbein, G., Weller, C., Coffman, A., Kim, C., Kedia, A., Firth, B., Rizvi, M., Dahiya, R., Foster, B., Balcells, E., Metzger, D.C., Lester, J., Bissett, J., Fahdi, I., Sides, E.A., Azrin, M., Martin, C., Quick, A., Conaway, D., Garg, M., Schallert, G., Lancaster, L., Mckissick, S., Atieh, M., Garbarino, J., Eisenberg, D., Uusinarkaus, K., Wirtemburg, P., Ellis, J., Cristaldi, J., Berglund, R., Negus, B., Pappas, J., Rocha, R., Nguyen, T., Stone, J., Janosik, D., Labovitz, A., Elmore, N., Dave, R., Loffredo, K., Gabriel, G., Snyder, C., Ahmed, O., Stone, H., Kelley, M., Diffenback, M., Friedman, B., Zirkle, J., Severa, L., Sample, S., Dignen, K., Raisinghani, A., Ben-Yehuda, O., Ghannadian, B., Moscoso, R., Mankowski, J., Boliek, W., Rukavina, M., Davis, W., Ledbetter, S., Handel, F., Mastouri, R., Mahenthiran, J., Foltz, J., Malhotra, V., Jonas, J., Berk, M., Singh, V., Nelson, M., Elsner, G., Gall, J., Kondo, N., Frank, S., Chandraratna, P., Ranasinghe, S., Ebrahimi, R., Treadwell, M., Walters, B., Hughes, L., Kramer, J., Kumar, K., Mente, T., Lachterman, B., Schifferdecker, B., Munshi, K., Sease, D., Waldo, D., Chandler, G., Manns, D., Nahhas, A., Kamalesh, M., Williams, V., Reich, D., Desalca, M., Sharma, S., Liston, M., Gupta, K., Costa, M., Altschuller, A., Lemmertz, K., Shanes, J., Hansen, C., Therrien, M., Mendelson, R., Ramnarine, R., Myers, G., Donovan, C., Klein, M., Fine, D., Owens, S., Murray, C., Ketroser, R., Heifetz, S., Darnell, Z., Touchon, R., Taghizadeh, B., Bohle, D., Norwood, D., Forrest, T., Jackson, S., Shumate, K., Bayles, A., Masroor, M., North, W.K., Fishberg, R., Merveil-Ceneus, B., Butcher, R., Menapace, F., Kilbride, S., Ramabadran, R.S., Loukinen, K., Khalil, J., Ramabadran, R., Walsh, S., Gill, S., Cyncar, R., McLachlan, J., Surakanti, V., Rusterholtz, L., Shoukfeh, F., Stephenson, L., Tsang, M., Nolan, V., Gilchrist, I., Jefferson, D., Feldman, T., Reyes, L., Santos, R., Little, W., Wesley, D., Gharib, W., Mendell, A., Esham, G., Kakavas, P., Whitcomb, C., Book, K., Bazzi, A., Alvarez, J., Cohen, Y., Ayres, T., Rhule, V., Labib, A., Schuler, P., Zughaib, M., Telck, K., Bikkina, M., Turnbull, K., Sharma, T., Orosz, S., Shah, R., Petrino, M., Hughes, M., Hershey, J., Hudock, D., Hui, P., Von Bakonyi, A., Arnold, A., Kappel, D., Pennock, G., Cloud, B., Tucker, K., Harp, L., Hoover, C., Eisenhauer, M., Roth, J., Young, C., Thai, H., Escalante, A., Bautista, J., Gazmuri, R., Nyland, J., Cubeddu, L., DeFranco, A., Dias, D., Fielding, M., Reeves, R., Hermany, P., Meissner-Dengler, S., Evans, M., Flores, E., Tannenbaum, A., McGarr, K., Moran, J., Stout, E., Allred, S., Henderson, D., Crandall, L., Strote, J., Voyles, W., Robeson, D., Bedoya, R., Omar, B., Pettyjohn, F., Revere, C., Coy, K., Margolis, J., Sotolongo, C., Scheffel, M., Munir, A., Shirwany, A., Douglas, L., Girala, R., Humphreys, R., Agarwal, J., Bankowski, D., Watson, R., Bishop, B., Klementowicz, P., Blais, D., Cohen, B., Lobur, E., Dimenna, J., Dempsey, K., Izzo, M., Bondi, L., Carell, E., Eaton, C., Saltiel, F., Grewal, G., Connolly, T., Little, T., Wiegman, P., Gips, S., Held, J., Paraschos, A., Quesada, R., Goudreau, E., Sears, M., Istfan, P., Holt, S., McClung, J., Nguyen, N., Quintana, O., Gottlieb, D., Knutson, T., Barringhaus, K., Lester, F., Sullivan, P., Rodriguez-Ospina, L., Cannon, Cp, Blazing, Ma, Giugliano, Rp, Mccagg, A, White, Ja, Theroux, P, Darius, H, Lewis, B, Ophuis, To, Jukema, Jw, De Ferrari, Gm, Ruzyllo, W, De Lucca, P, Im, K, Bohula, Ea, Reist, C, Wiviott, Sd, Tershakovec, Am, Musliner, Ta, Braunwald, E, Califf, Rm, for the IMPROVE-IT, Investigator, Cianflone, D, Cardiovascular Division (SZG), Brigham and Women's Hospital [Boston], College of Information Science and Engineering, Ritsumeikan University, Montreal Heart Institute (MONTREAL HEART INSTITUTE), Laboratoire des Micro-algues toxiques, Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD), Interuniversity Cardiology Institute Netherlands, Institute of Cardiology (WARSAW - Cardiology), Institute of Cardiology, Merck Sharp & Dohme Corp., Merck & Co. Inc, DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE, Facolta' di MEDICINA e CHIRURGIA, AREA MIN. 06 - Scienze mediche, Cannon, C.P., Blazing, M.A., Giugliano, R.P., Mccagg, A., White, J.A., Lewis, B.S., Jukema, J.W., De Lucca, P., Im, K., Bohula, E.A., Reist, C., Wiviott, S.D., Tershakovec, A.M., Musliner, T.A., Braunwald, E., Califf, R.M., for the IMPROVE-IT Investigators [.., C. Rapezzi, ], Other departments, Cannon, Christopher P, Blazing, Michael A., Giugliano, Robert P., Mccagg, Amy, White, Jennifer A., Theroux, Pierre, Darius, Harald, Lewis, Basil S., Ophuis, Ton Oude, Jukema, J. Wouter, De Ferrari, Gaetano M., Ruzyllo, Witold, De Lucca, Paul, Kyungah, Im, Bohula, Erin A., Reist, Craig, Wiviott, Stephen D., Tershakovec, Andrew M., Musliner, Thomas A., Braunwald, Eugene, and Califf, Robert M.
- Subjects
Male ,Simvastatin ,acute coronary syndrome ,aged ,anticholesteremic agents ,azetidines ,cardiovascular diseases ,cholesterol, ldl ,double-blind method ,drug therapy, combination ,ezetimibe ,female ,humans ,hydroxymethylglutaryl-coa reductase inhibitors ,kaplan-meier estimate ,male ,middle aged ,simvastatin ,triglycerides ,medicine (all ,[SDV]Life Sciences [q-bio] ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Bococizumab ,Triglyceride ,chemistry.chemical_compound ,0302 clinical medicine ,Azetidine ,Cardiovascular Disease ,Anticholesteremic Agent ,Acute Coronary Syndrome ,Aged ,Anticholesteremic Agents ,Azetidines ,Cardiovascular Diseases ,Cholesterol, LDL ,Double-Blind Method ,Drug Therapy, Combination ,Female ,Humans ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Middle Aged ,Triglycerides ,030212 general & internal medicine ,Medicine (all) ,Research Support, Non-U.S. Gov't ,Hazard ratio ,General Medicine ,Acute Coronary Syndrome, Aged ,Anticholesteremic Agents, Azetidines, Cardiovascular Diseases ,Ezetimibe, Female, Humans ,Male, Middle Aged ,3. Good health ,Multicenter Study ,Editorial ,Cholesterol ,Randomized Controlled Trial ,Combination ,Ezetimibe ,lipids (amino acids, peptides, and proteins) ,Human ,medicine.drug ,medicine.medical_specialty ,Acute Coronary Syndroms ,Urology ,Acute Coronary Syndrome/drug therapy ,Anticholesteremic Agents/adverse effects ,Anticholesteremic Agents/therapeutic use ,Azetidines/adverse effects ,Azetidines/therapeutic use ,Cardiovascular Diseases/epidemiology ,Cardiovascular Diseases/mortality ,Cardiovascular Diseases/prevention & control ,Cholesterol, LDL/blood ,Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ,Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ,Simvastatin/therapeutic use ,Triglycerides/blood ,NO ,LDL ,03 medical and health sciences ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Drug Therapy ,Internal medicine ,Journal Article ,medicine ,Comparative Study ,Alirocumab ,business.industry ,PCSK9 ,ta3121 ,Lomitapide ,DOENÇAS CARDIOVASCULARES ,Endocrinology ,chemistry ,Statin Therapy ,Hydroxymethylglutaryl-CoA Reductase Inhibitor ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known.METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization (≥30 days after randomization), or nonfatal stroke. The median follow-up was 6 years.RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (PCONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit. (Funded by Merck; IMPROVE-IT ClinicalTrials.gov number, NCT00202878.).
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- 2015
49. Using RT-PCR and bDNA assays to measure non-clade B HIV-1 subtype RNA
- Author
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Pasquier, C, Sandres, K, Salama, G, Puel, J, and Izopet, J
- Published
- 1999
- Full Text
- View/download PDF
50. Effect of Visual Selective Attention on Otoacoustic Emissions
- Author
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Puel, J.-L., Rebillard, G., Bonfils, P., Pujol, R., Wilson, J. P., editor, and Kemp, D. T., editor
- Published
- 1989
- Full Text
- View/download PDF
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