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Produk pencernaan tubuh disalurkan dan dikeluarkan oleh ginjal. Berkurangnya fungsi ginjal akan mengganggu keseimbangan tubuh sehingga menyebabkan penumpukan produk limbah terutama urea (yang menyebabkan uremia), gangguan keseimbangan cairan, serta kelebihan cairan dan elektrolit. Pasien yang menjalani terapi hemodialisa dapat mengalami efek samping psikis dan fisik. Tujuan penelitian adalah untuk mengetahui hubungan depresi dengan kelelahan pada pasien yang menjalani hemodialisa. Dalam studi cross-sectional ini, 43 peserta dipilih secara acak. Kuesioner untuk mengukur tingkat kelelahan menggunakan Fatigue Severity Scale (FSS) dan Beck Depression Inventory (BDI) untuk menilai gejala depresi. Penelitian ini menggunakan uji non parametrik dengan Spearman Rank. Hasil penelitian menjelaskan bahwa 14 responden yang menjalani hemodialisis mengalami depresi ringan dan kelelahan. Dari hasil tersebut diperoleh nilai signifikansi sebesar 0,005 dan nilai korelasi Sperma sebesar 0,422. Kesimpulannya, data menunjukkan adanya korelasi positif dengan kekuatan sedang antara tingkat kelelahan dan depresi yang dialami pasien hemodialisa. Hal ini menunjukkan bahwa semakin pasien yang menjalani hemodialisa mengalami kelelahan, maka semakin besar pula kemungkinan mereka mengalami depresi. Hasil penelitian ini dijadikan evidence based dalam melakukan intervensi dalam menangani pasien dengan gagal ginjal kronik yang mengalami fatigue serta depresi pada saat menjalani hemodialisa.

Meskipun dalam undang-undang sudah disebutkan perkawinan yang sah adalah perkawinan yang dilakukan menurut agama dan kepercayaannya masing-masing dan dicatatkan, dalam kenyataannya di masyarakat masih ada pasangan suanmi istri yang melangsungkan perkawinan tidak dicatatkan, mereka melakukan perkawinan sesuai dengan syarat dan ketentuan agama yang berlaku tetapi tidak dicatatkan, sehingga perkawinannya sah menurut agama tetapi tidak sah menurut negara. Perkawinan semacam ini biasa dikenal dengan perkawinan siri. Kedudukan anak yang lahir dalam perkawinan yang tidak dicatatkan sebagai anak luar kawin. jika kemudian orang tuanya mencatatkan perkawinannya bagaimanakah kedudukan anak yang dilahirkan dalam perkawinan tersebut. Penelitian ini merupakan penelitian hukum normatif. Bahan hukum yang digunakan adalah bahan hukum primer. Berdasarkan hasil penelitian dapat disimpulkan kedudukan anak yang lahir dalam perkawinan orang tuanya yang tidak dicatatkan dalam Undang-undang Nomo 1 Tahun 1974 termasuk anak Luar kawin karena dianggap tidak lahir dalam perkawinan yang sah. Namun, kalau kemudian orang tuanya melangsungkan perkawinan dengan dicatatkan sesuai Pasal 2 Undang-undang Nomor 1 Tahumn 1974, anak tersebut kemudian kedudukannya dapat berubah menjadi anak sah, dengan mengajukan penetapan ke Pangadilan Agama, hakim akan mengabulkan permohonan asal usul anak sebagai anak sah orangtuanya sepanjang perkawinan Siri yang telah berlangsung telah dilakukan sah menurut agama. Sebagaimana dalam Penetapan Nomor 1/Pdt.P/2023/PA.Mgl.

Background: The number of dysmenorrhea in Indonesia is 64,25%. About 54,98% had primary dysmenorrhea, and 9,36% had secondary dysmenorrhea. The continuity of abdominal muscle contraction causes the pain of dysmenorrhea during the menstrual period. A combination of gentle massage and linalool in aromatherapy will stimulate the hypothalamus to produce endorphin hormones to reduce the tension of the uterus’s muscle due to the menstrual. Objective: To know the effect of combining petrissage massage with Cananga aromatherapy for dysmenorrhea in teenage girls at senior high school. Methods: This research used Pre Experimental method with one group pretest-postest approach. The population for this study is 540 people. The sampling technique used a rule of thumb by the number of 30 people of teenage girls at the high school. A parametric test and paired t-test processed the data. Result: After giving intervention was available, 28 respondents (93%) with dysmenorrhea reduced, and 2 respondents (7%) remained dysmenorrhea. The analysis result was obtained with a p = 0,000 (p

This literature study intends to dissect the literature on how the effect of good corporate governance mechanism on financial distress in a company. In CG Asian Watch 2020, Indonesia is ranked last among the 12 countries in Asia. In CG Asian Watch 2020, Indonesia is ranked last among the 12 countries in Asia. This shows that good corporate governance in Indonesia is still relatively weak, so it is interesting to study further. The method used in this research is qualitative research with a literature study technique using 18 articles. Good corporate governance variables in this literature study involve managerial ownership; independent commissioners; audit committees; institutional ownership; the board of directors; and firm size. This article attempts to describe the results of previous research on the role of good corporate governance to prevent financial distress. The results of the study indicate that there is an influence of good corporate governance on the company's financial distress, both positive and negative. Keywords: corporate governance; good corporate governance, financial distress ABSTRAK Studi literatur ini mempunyai tujuan untuk untuk membedah literatur tentang pengaruh dari GCG (Good Corporate Governance) terhadap financial distress pada perusahaan. Dalam CG Asian Watch 2020, Indonesia berada pada peringkat paling akhir diantara 12 negara di Asia. Berdasarkan hal tersebut dapat diketahui bahwa penerapann GCG di Indonesia masih tergolong lemah sehingga menarik untuk dikaji lebih dalam. Peneliti menggunakan pendekatan kualitatif dengan metode studi literatur yang sumber dari 18 artikel. Variabel GCG dalam penelitian ini terdiri dari komisaris independent, kepemilikan manajerial, komite audit, kepemilikan institusional, dewan direksi dan ukuran perusahaan. Artikel ini berusaha untuk menggambarkan hasil-hasil penelitian terdahulu mengenai peran good corporate governance sebagai upaya untuk mencegah terjadinya permasalahan kesulitan keuangan IFinacial Distress). Hasil penelitian yang dilakukan oleh peneliti menunjukan bahwa bahwa terdapat pengaruh good corporate governance terhadap financial distress perusahaan baik secara positif maupun negatif. Kata Kunci: tata kelola perusahaan, tata kelola perusahaan yang baik, kesulitan keuangan

Tissue sealant is a material that is used as an adhesive to bond two tissue surfaces used during surgery. Chitosan and alginate are natural macromolecules used to manufacture hydrogels as tissue sealants because these two materials can strengthen bonds and the mechanical properties of tissue sealants. Irgacure® 2959, as a photo-initiator, can strengthen the cross-linking between chitosan-alginate to produce a tissue sealant with good mechanical strength. Therefore, this study aims to determine the effect of adding Irgacure® 2959 to chitosan-alginate hydrogel with different concentrations as a tissue sealant designed for the colon. The experimental design used a completely randomized design (CRD) with the addition of Irgacure® 2959 0; 1; 2; 3; 4%. The characteristics of the hydrogel as a tissue covering observed in this study include the degree of swelling, water resistance, simulated adhesion, degree of crystallinity, and ability to inhibit bacteria. The results of this study showed that the addition of 4% Irgacure® 2959 reduced the degree of swelling, increased the hydrogel's resistance to water, and increased adhesion. The interaction of chitosan and alginate with the addition of Irgacure® 2959 produces cross-links, as evidenced by a degree of crystallinity of 26.21%. Based on these results, the chitosan-alginate hydrogel with the addition of Irgacure® 2959 showed good potential in tissue sealant formulations, even though the inhibition of bacteria in all treatments showed low results, namely < 5 mm.

Hydrogel is a three-dimensional network of hydrophilic polymers widely used in the biomedical field, one of which is a tissue sealant. The material that can be used in the manufacture of hydrogels is chitosan. The ability of chitosan in the formation of hydrogel is still limited by its swelling and adhesive properties, so it requires other materials such as crosslinkers, one of which is kappa-carrageenan which can stabilize and increase the viscosity of the hydrogel. The addition of Irgacure® 2959 as a photo-initiator to the hydrogel can produce free radicals that can bind to the active group of the polymer. This study aims to determine the effect of adding Irgacure® 2959 in the manufacture of hydrogel based on a chitosan-kappa-carrageenan solution formulated as a colon tissue adhesive. The treatments given were the addition of Irgacure® 2959 as much as 0%, 1%, 2%, 3%, and 4%. The characteristics of the hydrogel tested qualitatively (simulation adhesion test), degree of swelling, resistance to water, degree of crystallinity, and ability to inhibit bacterial growth. The addition of Irgacure® 2959 did not show significantly different results from the control that indicating it cannot increase the crosslinking between chitosan and kappa-carrageenan. This is predicted due to the presence of steric hindrance from kappa-carrageenan, causing very limited crosslinking due to the molecular size difference between chitosan and kappa-carrageenan. Further, it is necessary to optimize the ratio of the chitosan and kappa-carrageenan to get the balance ratio that supports the occurrence of cross-linking.

Abstrak. Salah satu kawasan sentra budidaya ikan yang ada di Kabupaten Banyumas, adalah Desa Jipang Kecamatan Karanglewas. Kawasan ini merupakan daerah potensial untuk dilakukan budidaya diakrenakan ketersediaan air sebagai media utama kegiatan budidaya ikan yang sangat mutlak dibutuhkan. Salah satu kelompok budidaya ikan adalah kelompok Lele Gaul dengan luas lahan budiaya Lele Gaul 720 m2. Tujuan kegiatan ini adalah peningkatan kompetensi pembuatan pakan ikan serta dapat meningkatkan produksi penjualan ikan. Metode pendekatan yang dilakukan dalam kegiatan ini adalah pendekatan partisipatif (PRA/Participatory Rural Appraisal) dengan cara sosialisasi dan penyuluhan tentang teknologi pembuatan pakan ikan, pelatihan dan bimbingan teknis secara langsung tentang pembuatan formulasi pakan dan melakukan perhitungan hasil produksi budidaya ikan selama 1 siklus. Hasil dari pengabdian ini adalah mitra mengetahui teknologi pembuatan pakan dengan menggunakan bahan-bahan yang tersedia dan melimpah sehingga dapat mengurangi pengeluaran produksi dalam budidaya ikan.

The coronavirus outbreak (COVID-19) has raised questions about changes in subsequent environmental effects, mainly forest and land fires. This paper evaluates the implementation of land and forest fire management policies in Indonesia during the COVID-19 pandemic, particularly in 2020. A qualitative approach was conducted in policy implementation analysis based on George Edward III's theory by looking at bureaucratic structure, resources, communication, and disposition factors. The research focused on the operational work of the Forest and Land Fire Brigade, known as Manggala Agni, in Indonesia. The results showed that the collaborative work of Manggala Agni and the other forest and land fire task forces successfully reduced the hotspots; hence there was a significant decrease in the burned area. It is also inseparable from climatic factors. During this period there was no haze disaster although the task of controlling forest and land fires still encountered several obstacles during the pandemic. This is because of training, technology transfer, budget support, and synergy between stakeholders and Manggala Agni’s team members, so a significant reduction in forest and land fires during 2020 can be achieved.

Dalam dunia pendidikan, kemajuan teknologi informasi sangat bermanfaat dalam kegiatan pembelajaran. Sumber informasi konvensional dalam bentuk buku yang tersedia belum dapat memenuhi dan memberikan kepuasan bagi peserta didik untuk mendapatkan informasi dan pengetahuan sebagai referensi belajar. Selain itu, ketersediaan buku yang yang masih terbatas atau belum memadai. e-Book dapat menjadi salah satu solusi dalam menumbuhkan budaya literasi digital di dunia pendidikan. Dengan berbagai daya tarik dan keunggulan dari e-Book, diharapkan dapat menumbuhkan minat membaca sehingga mampu meningkatkan kemampuan literasi masyarakat Indonesia. Kegiatan ini bertujuan untuk membantu meningkatkan dan mengembangkan ketrampilan para pendidik dalam penyusunan media pembelajaran berbentuk digital guna meningkatkan kualitas pembelajaran bagi para peserta didik, selain itu juga sebagai upaya meningkatkan literasi digital di lingkungan sekolah. Metode pelaksanaan kegiatan yang dilakukan adalah sosialisasi, pelatihan, dan diskusi. Kesimpulan dari pelaksanaan kegiatan pengabdian kepada masyarakat ini yaitu masih rendahnya minat membaca para siswa terhadap materi pelajaran, keterbatasan informasi bagi para pendidik atau guru terkait penggunaan teknologi dalam pembuatan media pembelajaran digital, dan budaya literasi digital yang masih rendah. Kegiatan pengabdian kepada masyarakat yang telah dilakukan, diharapkan dapat meningkatkan dan mengembangkan ketrampilan para pendidik dalam penyusunan media pembelajaran berbentuk digital guna meningkatkan kualitas pembelajaran bagi para peserta didik, meningkatkan literasi digital di lingkungan sekolah, menumbuhkan minat membaca sehingga mampu meningkatkan kemampuan literasi masyarakat Indonesia pada umumnya, memberikan kontribusi pada bidang pendidikan dalam memfasilitasi sarana kegiatan belajar mengajar yang dilakukan baik secara online maupun secara offline, dan membantu Pemerintah dalam upaya meningkatkan budaya melek literasi digital.

TRANSFER OF ARTEMIA SP HATCHING TECHNOLOGY FOR FISH LARVA FEED IN KARYA MULYA 2 FISH CULTIVATION GROUP, PASIR LOR VILLAGE, BANYUMAS REGENCY. This community service aims to improve skills and knowledge about hatching Artemia sp as fish larvae feed through technology transfer to the Karya Mulya 2 fish cultivation group. The method used is “Participatory Rural Appraisal” which is to increase community participation and increase community involvement which is carried out through counseling, direct demonstrations and technical guidance. Technical guidance training activities include the preparation of tools in the form of aerators, aerator hoses, buckets and mixing spoons. Preparation of materials in the form of water, salt and cysts of Artemia sp. Followed by the practice of incubating Artemia sp and Harvesting Artemia sp. The results of this community service can improve the skills and knowledge of the Karya Mulya 2 fish farming group to apply simple Artemia sp hatching technology as feed to increase the growth of fish larvae.

During the Covid-19 pandemic, policies are needed in order to help economic recovery for society. This service opens public access to the policy of developing Village Seed Gardens (KBD), as an alternative to economic and environmental improvements. By using the Participatory Action Research (PAR) method with the main pillars of research, action, and participation. Partners involved in this program are seven villages in Lubuk Dalam District, Siak Regency, Riau. The results achieved were the form of community accessibility to government policies, community involvement in transformative activities to improve the economy and environment, which were obtained through assisting the development of KBD in seven villages that could independently produce thousands of seedlings for the surrounding community. Apart from economic recovery as a short-term benefit, also has long-term benefits for environmental restoration by changing degraded land to be more productive.

The development of this conceptual model is directed to encourage consumer purchases of products where this process occurs by online. The research model developed is called a synergy factor which includes system factors, internal factors, external factors and product factors. Each of these factors has characteristics in the form of variables consisting of website aesthetics from system factors, availability of money from internal factors, word of mouth from external factors and price perception of product factors. These four elements will determine the interest that will ultimately drive the purchase. The process in this research model is not in purchases that generally occur but in impulsive purchases or purchases without planning.

This article discusses the evaluation of the Family Hope Program (PKH) in Sri Meranti Village, Rumbai District, Pekanbaru City. Since 2007 the PKH program was created and implemented, even distribution of the program remains a problem that needs to be tracked comprehensively. Sri Meranti Village is the largest recipient of aid in all Rumbai District but still not evenly distributed. This study aims to evaluate the PKH program in Sri Meranti Village, Rumbai District, Pekanbaru City. With a research question how is the implementation of the Family of Hope Program in Sri Meranti Village. The research methodology is descriptive qualitative with the selection of purposive informants and data obtained by in-depth interview techniques. Data collected in the form of primary and secondary data and analyzed ethically and emically by William Dunn's evaluation theory approach. The findings of this study are the PKH in Sri Meranti Village, Rumbai District, Pekanbaru City and the amount of aid has increased every year. However, the Sri Meranti Kelurahan community still considers aid to be uneven because there are still poor families who do not receive PKH funding.

Co-administered medicinal herbs can modify a drug’s pharmacokinetics (PK), effectiveness, and toxicity. Andrographis paniculata (Burm. f.) ethanolic extract (APE) and andrographolide (AND) (a potent CYP2C9 inducer/inhibitor) can alter the pharmacokinetic parameters of glipizide (GLZ). This study aimed to determine the potential pharmacokinetics of herb–drug interactions between GLZ and APE/AND in the plasma of normal and diabetic rats using the HPLC bioanalysis method. The glipizide bioanalytical method established with RP-HPLC/UV instrument was validated following the EMA guidelines. GLZ was administered alone and in combination with APE or AND to normal and diabetic rats. The GLZ pharmacokinetic parameters were estimated according to the correlation between concentration and sampling time using the PK solver program. A simple and rapid GLZ bioanalysis technique with a lower limit of quantitation of 25 ng/mL was developed and presented the following parameters: accuracy (error ≤ 15%), precision (CV ≤ 15%), selectivity, stability, and linearity (R2 = 0.998) at concentrations ranging 25–1500 ng/mL. APE administration significantly improved the Cmax and AUC0–t/AUC0–∞ GLZ values in normal and diabetic rats (p < 0.05). AND significantly reduced the bioavailability of GLZ in diabetic rats with small values of T 1/2, Cmax, and AUC0–t/AUC0–∞ (p < 0.05). This combination can be considered in administering medications because it can influence the pharmacological effects of GLZ.

Data menunjukkan bahwa dari tahun ke tahun Indeks Persepsi Korupsi Indonesia terus meningkat. Hal ini menunjukkan bahwa komitmen pemerintah yang direalisasikan melalui berbagai upaya dalam menangani masalah korupsi telah berada di jalur yang tepat walaupun belum optimal. Korupsi masih menjadi masalah yang serius di Indonesia karena masih dapat dilakukan oleh siapa saja, terjadi di berbagai tempat, dan dalam berbagai jenis perkara dengan jumlah yang cenderung meningkat dari tahun ke tahun. Undang-undang Nomor 30 Tahun 2002 Pasal 13 menyebutkan bahwa salah satu upaya pencegahan yang dapat dilaksanakan oleh KPK adalah menyelenggarakan program pendidikan antikorupsi pada setiap jenjang pendidikan. Hal ini menunjukkan bahwa dunia pendidikan penting dilibatkan dalam upaya pemberantasan korupsi. Penelitian ini bertujuan untuk mengembangkan media pembelajaran Pendidikan Antikorupsi berbasis multimedia untuk tingkat perguruan tinggi yang disebut MedPAK. MedPAK dikembangkan dengan mengadopsi metode Research and Development. Hasil penilaian materi pada MedPAK menunjukkan rata-rata persentase 88% sedangkan hasil penilaian media adalah sebesar 84% di mana keduanya termasuk kategori baik. Dapat disimpulkan bahwa MedPAK layak untuk digunakan.

ABSTRACT This study entitled “Peningkatan Hasil Belajar IPS Melalui Metode Two Stay Two Stray pada Siswa Kelas V SDN Cempaka Baru 01 Jakarta Pusat”. The subject of this research is the grade V. This study departs from the background of the results of the study subjects are still low, IPS under KKM. So author moved to find the cause and try to improve the learning outcomes through learning methods two stay two stray (tsts). As for the purpose of this research is to improve the learning outcomes of students of class V SDN Cempaka Baru 01 on social science subjects.The method used is the class action Research with two cycles of hypothesis method with two stay two stray can improve the learning results of IPS on grade V in SDN Cempaka Baru 01. The results showed that the method can improve the learning results of tsts cognitive, affective and psychomotor the students in social science subjects. The results of the student learning experience an increase in classical and individually. This is due to the use of cooperative learning model of type two stay two stray has involved students learn actively and enhance their understanding of the material being taught. In Cycle I, students who complete of 44.83%, cycle II of 93.10%. While in the realm of affective in cycle I are classical space being in the category is good enough and in cycle II are in the category either. And in the realm of psychomotor, in classical average cycle I showed enough skilled category and on cycle II shows the category of skilled. Keywords: two stay two stray, the results of the study, IPS.

property rights are material rights that are absolute. based on article 570 of the kuhpdt, property rights are rights that are fully and freely used, however, the freedom to use property rights is not unlimited, but there are limitations. the problem in this research is: how is the application of the provisions on the limitation on the use of property rights in social life in bantul regency, diy? the results showed that the application of restrictions on the use of property rights in people's lives in bantul regency can be seen in the yogyakarta state administrative court decision number 04/g/2013/ptun.yk which was corroborated by the surabaya state administrative high court decision number: 149/b/2013/pt. tun. sby. the decision was declared null and void and revoked the decree of the head of the bantul regency licensing service number: 3497/dp/001/xi/2012 concerning disturbance permits for "hikmah" chicken livestock business at the location of dusun mangir lor rt.03, sendangsari village, pajangan district, district bantul, because it contradicts article 5 paragraph (4) of bantul regency regional regulation number 6 of 2011 concerning nuisance permits, and the decree of the governor of the special region of yogyakarta number 176 of 2003 concerning standard levels of vibration, noise and odor in the province of the special region of yogyakarta and the principles general good governance especially the principle of accuracy. with the cancellation of the nuisance permit, the owner of a broiler farm business is no longer allowed to continue his livestock business, meaning that the owner cannot use his property in the form of a cage on his private land for a chicken farm business. so the use of this property is not free without limits, but there are limitations. [ABSTRACT FROM AUTHOR]

Komputer yang berguna untuk pengolahan data yang rumit di berbagai bidang, dan juga untuk sistem informasi geografis wisata kuliner yang di web di pekanbaru. Agar menjadi lebih efektif dan efisien. Data dan informasi yang sangat berharga bagi suatu organisasi atau perusahaan. Tidak ada sistem pengolahan data dan informasi geografis wisata kuliner di pekanbaru, hal itu menyebabkan orang tidak bisa mengenali wisata kuliner yang ada di Pekanbaru. Sistem informasi geografis wisata kuliner dengan menggunakan aplikasi yang dibuat bahasa pemrograman web berbasis berbasis PHP diharapkan untuk menyediakan fasilitas untuk mengenali wisata kuliner yang ada di Pekanbaru. Hal ini dapat disimpulkan bahwa aplikasi dapat membantu orang terutama orang - orang yang tinggal di Pekanbaru tahu lebih banyak tentang wisata kuliner di Pekanbaru