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BACKGROUND: The National Institute of Environmental Health Sciences (NIEHS) continues to prioritize research to better understand the health effects resulting from exposure to mixtures of chemical and nonchemical stressors. Mixtures research activities over the last decade were informed by expert input during the development and deliberations of the 2011 NIEHS Workshop "Advancing Research on Mixtures: New Perspectives and Approaches for Predicting Adverse Human Health Effects." NIEHS mixtures research efforts since then have focused on key themes including a) prioritizing mixtures for study, b) translating mixtures data from in vitro and in vivo studies, c) developing cross-disciplinary collaborations, d) informing component-based and whole-mixture assessment approaches, e) developing sufficient similarity methods to compare across complex mixtures, f) using systems-based approaches to evaluate mixtures, and g) focusing on management and integration of mixtures-related data. OBJECTIVES: We aimed to describe NIEHS driven research on mixtures and combined exposures over the last decade and present areas for future attention. RESULTS: Intramural and extramural mixtures research projects have incorporated a diverse array of chemicals (e.g., polycyclic aromatic hydrocarbons, botanicals, personal care products, wildfire emissions) and nonchemical stressors (e.g., socioeconomic factors, social adversity) and have focused on many diseases (e.g., breast cancer, atherosclerosis, immune disruption). We have made significant progress in certain areas, such as developing statistical methods for evaluating multiple chemical associations in epidemiology and building translational mixtures projects that include both in vitro and in vivo models. DISCUSSION: Moving forward, additional work is needed to improve mixtures data integration, elucidate interactions between chemical and nonchemical stressors, and resolve the geospatial and temporal nature of mixture exposures. Continued mixtures research will be critical to informing cumulative impact assessments and addressing complex challenges, such as environmental justice and climate change. https://doi.org/10.1289/EHP14340, Introduction Biomonitoring programs (1-3) indicate that people experience diverse chemical exposures from their use of personal care and household products, diet, lifestyle choices, occupational exposures, and incidental contact with environmental [...]

The Hurricane Weather Research and Forecasting Model (HWRF) was the flagship hurricane model at NOAA's National Centers for Environmental Prediction for 16 years and a state-of-the-art tool for tropical cyclone (TC) intensity prediction at the National Weather Service and across the globe. HWRF was a joint development between NOAA research and operations, specifically the Environmental Modeling Center and the Atlantic Oceanographic and Meteorological Laboratory. Significant support also came from the National Hurricane Center, Developmental Testbed Center, University Corporation for Atmospheric Research, universities, cooperative institutes, and the TC community. In the North Atlantic basin, where most improvement efforts focused, HWRF intensity forecast errors decreased by 45%-50% at many lead times between 2007 and 2022. These large improvements resulted from increases in horizontal and vertical resolution, as well as advances in model physics and data assimilation. HWRF intensity forecasts performed particularly well over the Gulf of Mexico in recent years, providing useful guidance for a large number of impactful landfalling hurricanes. Such advances were made possible not only by significant gains in computing but also through substantial investment from the Hurricane Forecast Improvement Program. SIGNIFICANCE STATEMENT: HWRF is considered one of the most important and successful ocean-coupled, regional numerical weather prediction models. This work documents HWRF forecast performance for TCs in the North Atlantic since its operational inception (2007-22). Track, intensity, and storm size (wind radii) forecasts all showed significant error reductions and skill improvements, including 45%-50% lower intensity errors. HWRF intensity forecasts showed marked improvement for rapid intensification events, especially in the Gulf of Mexico, where numerous impactful TCs made landfall throughout HWRF's lifetime. HWRF's impressive performance led to its expanded use as guidance for official TC forecasts and as a research tool across the TC community. These successes paved the way for NOAA's next-generation hurricane model, the Hurricane Analysis and Forecast System. KEYWORDS: Extreme events; Hurricanes/ typhoons; Tropical cyclones; Short-range prediction; Model evaluation/ performance; Numerical weather prediction/ forecasting, 1. Introduction (the rise of dynamical hurricane models at NOAA) Tropical cyclone (TC) forecast errors have markedly decreased over the past two decades, largely due to improved numerical weather prediction [...]

This paper provides an introduction to a new tool that is designed to provide operationally useful vulnerability information to National Weather Service (NWS) Weather Forecasting Offices (WFOs). The Brief Vulnerability Overview Tool (BVOT) is a shapefile containing local known, spatially specific, and weather-hazard-related vulnerabilities in a format that is easily integrated into the existing forecasting, warning, and decision support responsibilities and tasks of NWS WFO meteorologists. The methods for gathering vulnerability data and then building a BVOT for a WFO leverage and strengthen the relationships that NWS WFOs already have with their local emergency managers (EMs) and core partners to work together to identify operationally useful, local vulnerability knowledge. The BVOT is populated with discrete, known vulnerabilities to provide NWS meteorologists spatial situational awareness of those people, places, and things of greatest concern to their core partners. Crucially, the BVOT is a subsample of all potential vulnerabilities; its primary purpose is to make meteorologists aware of those weather-hazard-specific vulnerabilities that, as we posed to them, "keep them awake at night." Here, we describe the development of the BVOT as a social science-informed operational tool; how the BVOT methods have evolved and how it can be integrated into the culture of the NWS as a tool for building and maintaining relationships with partners; and how the BVOT is designed to be used and its impact on operational decision-making as observed in NOAA's Hazardous Weather Testbed. SIGNIFICANCE STATEMENT: Operational meteorologists in the National Weather Service often rely on everyday knowledge of vulnerabilities to shape their messaging to communities threatened by hazardous weather. This study seeks to test methods that will permit meteorologists to work with local communities and emergency managers to collect knowledge about local vulnerabilities so that they can be formally shared and integrated into everyday operations. The results of this research provide an illustrative pathway demonstrating how social science-informed research can be used to improve meteorological operations. Future work should investigate how other findings from social science can be translated into real, operational impacts. KEYWORDS: Social science; Operational forecasting; Communication/ decision-making; Decision support; Vulnerability, 1. BVOT: An inductive approach to actionable vulnerability decision support The mission of the U.S. NWS is to "provide weather, water, and climate data, forecasts, warnings, and impact-based decision support [...]

The National Oceanic and Atmospheric Administration's (NOAA) National Weather Service (NWS) has been providing national, regional, and local climate services for more than 20 years. The NWS climate services building blocks consist of service provision infrastructure, partnership and outreach, discovery of user needs and requirements, and service delivery at national, regional, local, and tribal levels. To improve services, the NWS climate services program accelerated user engagement through customer surveys, workshops, and collaborations. Since 2002, the annual Climate Prediction Applications Science Workshop has developed a community of climate information producers and users through sharing of climate science applications, decision support tools, and effective communication practices. Although NWS had been producing operational climate monitoring and prediction products for several decades, the Weather Research and Forecasting Innovation Act of 2017 (U.S. Public Law 115-25) specifically mandated that NWS deliver services at subseasonal to seasonal time scales, including periods from two weeks to two years. Looking ahead, both the Department of Commerce (DOC) and NOAA have included climate services in their new 2022-26 strategic plans, including DOC's goal to address the climate crisis through mitigation, adaptation, and resilience efforts and NOAA's initiatives to build a Climate Ready Nation (CRN). The NWS Climate Services Program supports these strategic goals and CRN initiatives through integrating climate information into Impact-based Decision Support Services, the most critical element for implementation of the NWS strategy for a Weather-Ready Nation. This includes application of state-of-the-art climate monitoring and prediction products to the most societally relevant impacts while empowering regional and local climate delivery of enhanced services. KEYWORDS: Climate; Climate records; Climate services; Decision making; History; Societal impacts, 1. History of the NWS regional and local climate services The year 2023 marked the twentieth anniversary of the regional and local climate services infrastructure established in the National Oceanic [...]

Recycling PET bottles has set a standard for other industries, but PET thermoforms are still gaining momentum. This industry segment is paving the way for a new landscape in PET [...]

The office of Governor-General, previously analysed by Sir Paul Hasluck and Sir Zelman Cowen, has evolved as part of the 'Australianisation of the Crown' since 1901. It has been consolidated [...]