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Objective The aim of this study was to document the association between pancreatic agenesis or hypoplasia and multicystic renal dysplasia related to transcription factor 2 (TCF2) or hepatocyte nuclear factor 1 beta mutations. Methodology We describe the phenotype of the pancreas and the kidneys from three fetuses heterozygous for a mutation of TCF2. Cases Case 1 had bilateral hyperechogenic, multicystic kidneys, bilateral clubfoot and pancreatic agenesis. Case 2 had two enlarged polycystic kidneys, anamnios and pancreatic agenesis. Case 3 had multicystic renal dysplasia, oligohydramnios and hypoplasia of the tail of the pancreas. Conclusion TCF2 mutations are frequently discovered in fetuses presenting with bilateral hyperechogenic kidneys. The association between pancreatic agenesis and a TCF2 mutation has not previously been reported. TCF2 deficiency in mice leads to pancreatic agenesis, suggesting that the gene is essential for pancreatic development. Our observations indicate the importance of visualizing the pancreas during ultrasound examinations if renal malformations are discovered. © 2013 John Wiley & Sons, Ltd.

The aim of this study was to document the association between pancreatic agenesis or hypoplasia and multicystic renal dysplasia related to transcription factor 2 (TCF2) or hepatocyte nuclear factor 1 beta mutations.We describe the phenotype of the pancreas and the kidneys from three fetuses heterozygous for a mutation of TCF2.Case 1 had bilateral hyperechogenic, multicystic kidneys, bilateral clubfoot and pancreatic agenesis. Case 2 had two enlarged polycystic kidneys, anamnios and pancreatic agenesis. Case 3 had multicystic renal dysplasia, oligohydramnios and hypoplasia of the tail of the pancreas.TCF2 mutations are frequently discovered in fetuses presenting with bilateral hyperechogenic kidneys. The association between pancreatic agenesis and a TCF2 mutation has not previously been reported. TCF2 deficiency in mice leads to pancreatic agenesis, suggesting that the gene is essential for pancreatic development. Our observations indicate the importance of visualizing the pancreas during ultrasound examinations if renal malformations are discovered.

International audience; OBJECTIVE: To assess the efficacy of medical abortion performed according to a single protocol from 12 through 14 weeks. STUDY DESIGN: Retrospective observational study of medical abortions from 12 through 14 weeks performed from January 2007 through March 2009. The protocol combined 600 mg de mifepristone orally, followed 48 h later by 400 μg of misoprostol, administered orally, and repeated after 3h, four times a day (during two days), if patient did not begin to abort. Outcome measures were the abortion rate, the rate of complication, the rate of manual uterine revision or vacuum aspiration, the time of expulsion and the misoprostol dose. RESULTS: The study included 126 medical abortions. The abortion rate was 98% and the secondary manual revision or vacuum aspiration rate was 41%. The mean time to expulsion was 10.4 (±8.8)h, and the mean misoprostol dose 1040 (±420) μg. Higher parity was significantly correlated with shorter time to expulsion (P=0.02). CONCLUSION: Medical abortion was consistently effective from 12 through 14 weeks but with high rate of secondary manual revision or vacuum aspiration.

International audience; OBJECTIVE: To evaluate prenatal management and to define the criteria of gravity for accurate assessment of the renal and overall prognosis of fetuses presenting malformations of the urinary tract. METHODS: We carried out a retrospective study of 127 cases of urinary tract malformation. We carried out descriptive statistical and univariate analyses as a function of severity criteria and the outcome of pregnancy. RESULTS: One-third of fetuses presented associated extrarenal malformations and 10% of the karyotypes were abnormal. There were more abortions in case of decrease in amniotic fluid volume (p < 0.001), extent of renal damage (p < 0.05), presence of associated extrarenal malformations (p < 0.05), early diagnosis of the malformation (p < 0.001) and presence of chromosomal syndrome (p = 0.01). In our study, there was an excellent correlation between prenatal data and pathological findings for the fetus following abortions for medical reasons or obtained during the surveillance of live-born children. Fetal biochemistry made very little contribution. CONCLUSION: In cases of urinary tract malformation, this work confirms the need for regular and frequent ultrasound scans, checking for the echographic factors indicative of gravity and for adapted karyotyping. It also demonstrates that pluridisciplinary management is necessary for the prenatal evaluation of renal and overall fetal prognosis.

International audience; Semantic interoperability, a prerequisite to eHealth projects, relies on sharing both information and knowledge models between information systems. Two of the standards of information models are HL7 v3 and the European norm, EN13606/OpenEHR. The paper compares both standards on a fragment of the prenatal medical record, the APGAR score. Two factors are compared: the formal representation of both information models, and the binding to knowledge models. The HL7v3 perinatality DMIM specification and the OpenEHR APGAR archetype were used. HL7v3 appears to be more formal than OpenEHR and able to represent in an easier way the clinical context. For both standards, the binding to reference terminologies such as LOINC is poor. We provide recommendations to improve the standards.

International audience; Il s'agit de l'introduction à "Diversité culturelle et figures de l'hétérogénéité" (L'Harmattan, 2013) écrite en collaboration avec Susana Villavicencio. Les auteurs soulignent le rôle que joua l'hétérogénéité interne dans la constitution de l'ouvrage, et l'absence de paradigme qui caractérise le champ de tensions qu'est la diversité; ils indiquent que les travaux effectués se subdivisent en quatre types d'approches: Généalogie de la notion de diversité; Figures et paradigmes de la diversité; Lieux et paradigmes politiques de la diversité; Devenir corps de la diversité.

Ouvrage composé et publié dans le cadre du Programme ECOS/MINCyt A08H03 Diversité culturelle, citoyenneté et démocratie en Argentine et en France; les défis de l'intégration et les figures politiques, juridiques et esthétiques de l'hétérogénéité, 2009-2012, co-dirigé par Georges Navet (Paris 8) et Susana Villavicencio (Université de Buenos Aires); International audience; Réunis dans l'horizon d'un projet universitaire de coopération entre l'Argentine et la France, les auteurs ont pris appui sur leur propre diversité interne et sur les rapports pratiques qu'elle induisait entre eux, pour explorer plusieurs figures (esthétiques, juridiques et politiques) de l'hétérogénéité dans l'optique générale d'un espace démocratique résolument moderne.

International audience; L'auteur revient d'abord sur le concept de rationalisation de Hobbes à Max Weber. Puis il centre son intérêt sur une affaire où est bel et bien en cause la diversité, en étudiant les discours des divers protagonistes, celui du directeur de l'entreprise, celui de la personne directement concernée, celui du public, aboutissant ainsi à une analyse des logiques économico-sociales, éthico-nationales, et juridico-politiques qui sont aux prises dans le cas considéré.