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Your search keyword '"Pinaire, Megan"' showing total 17 results
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17 results on '"Pinaire, Megan"'

9. Connectivity Patterns Evoked by Fearful Faces Demonstrate Reduced Flexibility Across a Shared Dimension of Adolescent Anxiety and Depression

Author

Hubbard, Nicholas A., primary, Auerbach, Randy P., additional, Siless, Viviana, additional, Lo, Nicole, additional, Frosch, Isabelle R., additional, Clark, Danielle E., additional, Jones, Robert, additional, Kremens, Rebecca, additional, Pinaire, Megan, additional, Vaz-DeSouza, Flavia, additional, Ghosh, Satrajit S., additional, Henin, Aude, additional, Hofmann, Stefan G., additional, Pizzagalli, Diego A., additional, Rosso, Isabelle M., additional, Yendiki, Anastasia, additional, Whitfield-Gabrieli, Susan, additional, and Gabrieli, John D. E., additional

Published
2022
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11. sj-pdf-1-cpx-10.1177_21677026221079628 – Supplemental material for Connectivity Patterns Evoked by Fearful Faces Demonstrate Reduced Flexibility Across a Shared Dimension of Adolescent Anxiety and Depression

Author

Hubbard, Nicholas A., Auerbach, Randy P., Siless, Viviana, Lo, Nicole, Frosch, Isabelle R., Clark, Danielle E., Jones, Robert, Kremens, Rebecca, Pinaire, Megan, Vaz-DeSouza, Flavia, Ghosh, Satrajit S., Henin, Aude, Hofmann, Stefan G., Pizzagalli, Diego A., Rosso, Isabelle M., Yendiki, Anastasia, Whitfield-Gabrieli, Susan, and Gabrieli, John D. E.

Subjects
FOS: Psychology, 170199 Psychology not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-cpx-10.1177_21677026221079628 for Connectivity Patterns Evoked by Fearful Faces Demonstrate Reduced Flexibility Across a Shared Dimension of Adolescent Anxiety and Depression by Nicholas A. Hubbard, Randy P. Auerbach, Viviana Siless, Nicole Lo, Isabelle R. Frosch, Danielle E. Clark, Robert Jones, Rebecca Kremens, Megan Pinaire, Flavia Vaz-DeSouza, Satrajit S. Ghosh, Aude Henin, Stefan G. Hofmann, Diego A. Pizzagalli, Isabelle M. Rosso, Anastasia Yendiki, Susan Whitfield-Gabrieli and John D. E. Gabrieli in Clinical Psychological Science

Published
2022
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12. Image acquisition and quality assurance in the Boston Adolescent Neuroimaging of Depression and Anxiety study

Author

Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Harvard University--MIT Division of Health Sciences and Technology, Martinos Imaging Center (McGovern Institute for Brain Research at MIT), McGovern Institute for Brain Research at MIT, Siless, Viviana, Hubbard, Nicholas A, Jones, Robert, Wang, Jonathan, Lo, Nicole, Bauer, Clemens CC, Goncalves, Mathias, Frosch, Isabelle, Norton, Daniel, Vergara, Genesis, Conroy, Kristina, De Souza, Flavia Vaz, Rosso, Isabelle M, Wickham, Aleena Hay, Cosby, Elizabeth Ann, Pinaire, Megan, Hirshfeld-Becker, Dina, Pizzagalli, Diego A, Henin, Aude, Hofmann, Stefan G, Auerbach, Randy P, Ghosh, Satrajit, Gabrieli, John, Whitfield-Gabrieli, Susan, Yendiki, Anastasia, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Harvard University--MIT Division of Health Sciences and Technology, Martinos Imaging Center (McGovern Institute for Brain Research at MIT), McGovern Institute for Brain Research at MIT, Siless, Viviana, Hubbard, Nicholas A, Jones, Robert, Wang, Jonathan, Lo, Nicole, Bauer, Clemens CC, Goncalves, Mathias, Frosch, Isabelle, Norton, Daniel, Vergara, Genesis, Conroy, Kristina, De Souza, Flavia Vaz, Rosso, Isabelle M, Wickham, Aleena Hay, Cosby, Elizabeth Ann, Pinaire, Megan, Hirshfeld-Becker, Dina, Pizzagalli, Diego A, Henin, Aude, Hofmann, Stefan G, Auerbach, Randy P, Ghosh, Satrajit, Gabrieli, John, Whitfield-Gabrieli, Susan, and Yendiki, Anastasia

Abstract

© 2020 The Authors The Connectomes Related to Human Diseases (CRHD) initiative was developed with the Human Connectome Project (HCP) to provide high-resolution, open-access, multi-modal MRI data to better understand the neural correlates of human disease. Here, we present an introduction to a CRHD project, the Boston Adolescent Neuroimaging of Depression and Anxiety (BANDA) study, which is collecting multimodal neuroimaging, clinical, and neuropsychological data from 225 adolescents (ages 14–17), 150 of whom are expected to have a diagnosis of depression and/or anxiety. Our transdiagnostic recruitment approach samples the full spectrum of depressed/anxious symptoms and their comorbidity, consistent with NIMH Research Domain Criteria (RDoC). We focused on an age range that is critical for brain development and for the onset of mental illness. This project sought to harmonize imaging sequences, hardware, and functional tasks with other HCP studies, although some changes were made to canonical HCP methods to accommodate our study population and questions. We present a thorough overview of our imaging sequences, hardware, and scanning protocol. We detail similarities and differences between this study and other HCP studies. We evaluate structural-, diffusion-, and functional-image-quality measures that may be influenced by clinical factors (e.g., disorder, symptomatology). Signal-to-noise and motion estimates from the first 140 adolescents suggest minimal influence of clinical factors on image quality. We anticipate enrollment of an additional 85 participants, most of whom are expected to have a diagnosis of anxiety and/or depression. Clinical and neuropsychological data from the first 140 participants are currently freely available through the National Institute of Mental Health Data Archive (NDA).

Published
2021

13. Connectivity Patterns Evoked by Fearful Faces Demonstrate Reduced Flexibility Across a Shared Dimension of Adolescent Anxiety and Depression

Author

Hubbard, Nicholas A., Auerbach, Randy P., Siless, Viviana, Lo, Nicole, Frosch, Isabelle R., Clark, Danielle E., Jones, Robert, Kremens, Rebecca, Pinaire, Megan, Vaz-DeSouza, Flavia, Ghosh, Satrajit S., Henin, Aude, Hofmann, Stefan G., Pizzagalli, Diego A., Rosso, Isabelle M., Yendiki, Anastasia, Whitfield-Gabrieli, Susan, and Gabrieli, John D. E.

Abstract

Adolescents experiencing anxiety or depression exhibit cognitive biases favoring the processing of negative emotional information. It remains unknown whether common neurobiological processes underlie these biases across anxiety and depression. Here, brain imaging was acquired from typical, anxious, and depressed adolescents during an emotional-interference task. Functional connectivity patterns were assessed while adolescents were cued to attend to or ignore faces. Results revealed a shared dimension of anxious and depressive symptoms was associated with reduced changes in connectivity patterns between conditions in which adolescents needed to ignore or attend to fearful faces. These findings were exclusive to fearful faces and observed only for functional connections with a primary face-representation area (fusiform gyrus). Results suggested a failure to flexibly adapt communication patterns with sensory-representation areas in the presence of negative emotional information, which may reflect a common neurobiological mechanism explaining biases favoring such information shared among adolescent anxiety and depression.

Published
2023
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14. Image acquisition and quality assurance in the Boston Adolescent Neuroimaging of Depression and Anxiety study

Author

Siless, Viviana, primary, Hubbard, Nicholas A., additional, Jones, Robert, additional, Wang, Jonathan, additional, Lo, Nicole, additional, Bauer, Clemens C.C., additional, Goncalves, Mathias, additional, Frosch, Isabelle, additional, Norton, Daniel, additional, Vergara, Genesis, additional, Conroy, Kristina, additional, De Souza, Flavia Vaz, additional, Rosso, Isabelle M., additional, Wickham, Aleena Hay, additional, Cosby, Elizabeth Ann, additional, Pinaire, Megan, additional, Hirshfeld-Becker, Dina, additional, Pizzagalli, Diego A., additional, Henin, Aude, additional, Hofmann, Stefan G., additional, Auerbach, Randy P., additional, Ghosh, Satrajit, additional, Gabrieli, John, additional, Whitfield-Gabrieli, Susan, additional, and Yendiki, Anastasia, additional

Published
2020
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16. Clinical Characteristics, Treatment Patterns, and Outcomes of Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Refractory to Covalent Bruton's Tyrosine Kinase Inhibitor (BTKi) and Exposed to B-Cell Lymphoma 2 Inhibitor (BCL2i)

Author

Lin, Kevin H., Huynh, Lynn, Yang, Xiaoqin, Zanardo, Enrico, Matay, Lisa, Pinaire, Megan, Liborski, Daria, McDonough, Mikaela M., Foreman, Jillian, Farooqui, Mohammed Z.H., De Nigris, Enrico, Gandra, Shravanthi R., Sarpong, Eric M., Duh, Mei Sheng, Brown, Jennifer R., and Davids, Matthew S

Abstract

Introduction:CLL/SLL patients who failed BTKi and are treated with BCL2i represent a growing population with few standard-of-care treatment options after discontinuing both therapies. Patients who fail both BTKi and BCL2i have poor prognosis, with a median overall survival (OS) of 3.6 months (Lew et al., Blood Advances, 2021). However, real-world evidence for these patients is limited. This study described the characteristics, treatment patterns, and outcomes of CLL/SLL patients who were relapsed or were resistant/refractory/intolerant (R/R/R/I) to BTKi and who were exposed to BCL2i. Among patients who discontinued BCL2i, responses to the treatment immediately after BCL2i were reported.

Published
2023
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17. Correlation between Real-World Progression-Free Survival (rwPFS) and Overall Survival (OS) in Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Who Relapsed or Are Refractory, Intolerant, Resistant to Treatment with a Bruton's Tyrosine Kinase Inhibitor (BTKi)

Author

Lin, Kevin H., Huynh, Lynn, Yang, Xiaoqin, Zanardo, Enrico, Matay, Lisa, Pinaire, Megan, Liborski, Daria, McDonough, Mikaela M., Foreman, Jillian, Farooqui, Mohammed Z.H., De Nigris, Enrico, Gandra, Shravanthi R., Sarpong, Eric M., Duh, Mei Sheng, Brown, Jennifer R., and Davids, Matthew S

Abstract

Introduction:Given the long maturation time of OS, PFS is often used in oncology and hematology as a surrogate for OS. However, the association between the two endpoints varies across cancer types. In CLL clinical trial populations, PFS and OS were shown to be strongly correlated in patients receiving at least two lines of therapy (LOT). The present study used real-world individual patient data to evaluate the strength of correlation between real-world PFS (rwPFS) and OS in CLL/SLL patients who relapsed or were resistant/refractory/intolerant to treatment with a covalent BTKi.

Published
2023
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