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448 results on '"Perotti, C"'

9. Involvement of miRNAs as a response to extracorporeal photopheresis in the control of bronchiolitis obliterans syndrome

Author

Bozzini, S, primary, Del Fante, C, additional, Morosini, M, additional, Bagnera, C, additional, Berezhinskiy, H O, additional, Auner, S, additional, Pandolfi, L, additional, Della Zoppa, M, additional, Perotti, C, additional, Hoetzenecker, K, additional, Jaksch, P, additional, Benazzo, A, additional, and Meloni, F, additional

Published
2022
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11. CFU-GM Growth from Peripheral Blood Stem Cells (PBSC) Before and After Cryopreservation : Comparison with Bone Marrow Cells

Author

Bonfichi, M., Brera, C., Balduini, A., Alessandrino, E. P., Bernasconi, P., Troletti, D., Boni, M., Castagnola, C., Brusamolino, E., Pagnucco, G., Perotti, C., Salvaneschi, L., Bernasconi, C., Abraham, Nader G., editor, Asano, Shigetaka, editor, Brittinger, Günther, editor, Maestroni, Georges J. M., editor, and Shadduck, Richard K., editor

Published
1996
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15. Impact of in-hospital intravenous iron supplementation on red blood cell transfusions: experience from an Internal Medicine Unit

Author

Bergamaschi G., Livraghi A., Aronico N., Barteselli C., Bonadeo E., Del Rio V., Gabba M., Gentile L., Mengoli C., Perotti C., Di Sabatino A., Bergamaschi, G., Livraghi, A., Aronico, N., Barteselli, C., Bonadeo, E., Del Rio, V., Gabba, M., Gentile, L., Mengoli, C., Perotti, C., and Di Sabatino, A.

Subjects
Anemia, Iron-Deficiency, Iron, Dietary Supplements, Aftercare, Humans, Iron Deficiencies, Erythrocyte Transfusion, Maltose, Ferric Compounds, Hospitals, Patient Discharge, Retrospective Studies
Abstract

BACKGROUND: Pharmacological treatment of iron deficiency anaemia can reduce red blood cell (RBC) transfusions. Intravenous iron provides a more effective and quicker correction of iron deficiency anaemia than oral iron, and third-generation high-dose intravenous iron formulations allow the complete correction of iron deficiency with just one or two drug infusions, thus facilitating iron supplementation therapy and reducing transfusion requirement. MATERIAL AND METHODS: In an observational, retrospective study we compared RBC transfusion requirement during hospitalisation and within 3 months of hospital discharge in 88 patients with iron deficiency anaemia treated with high-dose ferric carboxymaltose and in 85 patients treated with ferric gluconate while hospitalised in the Internal Medicine unit of our Institution. RESULTS: Ferric carboxymaltose reduced the number of RBC units given to each transfused patient during hospitalisation (1.81±0.84 vs 2.39±1.49, p=0.011). At hospital discharge, fewer ferric carboxymaltose patients were prescribed home therapy with iron. No differences between treatment groups were observed in the proportion of patients or the number of RBC units transfused within 3 months of discharge. At one month from discharge, however, only 2 ferric carboxymaltose patients had been transfused compared with 7 ferric gluconate patients (p=0.078). Patients transfused post-discharge were more likely to have an underlying malignancy and/or higher serum creatinine concentrations. DISCUSSION: Treatment with ferric carboxymaltose reduced the number of RBC units per transfused patient. Larger studies are required to define risk factors associated with post-discharge transfusion requirement and to establish if home therapy with iron will reduce subsequent transfusions in patients treated with ferric carboxymaltose.

Published
2021

21. Effect of High-Titer Convalescent Plasma on Progression to Severe Respiratory Failure or Death in Hospitalized Patients with COVID-19 Pneumonia: A Randomized Clinical Trial

Author

Menichetti, F., Popoli, P., Puopolo, M., Alegiani, S. S., Tiseo, G., Bartoloni, A., De Socio, G., Luchi, S., Blanc, P., Puoti, M., Toschi, E., Massari, M., Palmisano, L., Marano, G., Chiamenti, M., Martinelli, L., Franchi, S., Pallotto, C., Suardi, L. R., Pasqua, B. L., Merli, M., Fabiani, P., Bertolucci, L., Borchi, B., Modica, S., Moneta, S., Marchetti, G., d'Arminio Monforte, A., Stoppini, L., Ferracchiato, N., Piconi, S., Fabbri, C., Beccastrini, E., Saccardi, R., Giacometti, A., Esperti, S., Pierotti, P., Bernini, L., Bianco, C., Benedetti, S., Lanzi, A., Bonfanti, P., Sani, S., Saracino, A., Castagna, A., Trabace, L., Lanza, M., Focosi, D., Mazzoni, A., Pistello, M., Falcone, M., Locatelli, F., Ippolito, G., Magrini, N., Bernardini, R., Brusaferro, S., De Angelis, V., Perotti, C., Remuzzi, G., De Silvestro, G., Costantini, M., Bocchino, M., De Donno, G., Francisci, D., Menichetti, F., Popoli, P., Puopolo, M., Spila Alegiani, S., Tiseo, G., Bartoloni, A., De Socio, G. V., Luchi, S., Blanc, P., Puoti, M., Toschi, E., Massari, M., Palmisano, L., Marano, G., Chiamenti, M., Martinelli, L., Franchi, S., Pallotto, C., Suardi, L. R., Luciani Pasqua, B., Merli, M., Fabiani, P., Bertolucci, L., Borchi, B., Modica, S., Moneta, S., Marchetti, G., D'Arminio Monforte, A., Stoppini, L., Ferracchiato, N., Piconi, S., Fabbri, C., Beccastrini, E., Saccardi, R., Giacometti, A., Esperti, S., Pierotti, P., Bernini, L., Bianco, C., Benedetti, S., Lanzi, A., Bonfanti, P., Sani, S., Saracino, A., Castagna, A., Trabace, L., Lanza, M., Focosi, D., Mazzoni, A., Pistello, M., Falcone, M., Menichetti, F, Popoli, P, Puopolo, M, Spila Alegiani, S, Tiseo, G, Bartoloni, A, De Socio, G, Luchi, S, Blanc, P, Puoti, M, Toschi, E, Massari, M, Palmisano, L, Marano, G, Chiamenti, M, Martinelli, L, Franchi, S, Pallotto, C, Suardi, L, Luciani Pasqua, B, Merli, M, Fabiani, P, Bertolucci, L, Borchi, B, Modica, S, Moneta, S, Marchetti, G, d'Arminio Monforte, A, Stoppini, L, Ferracchiato, N, Piconi, S, Fabbri, C, Beccastrini, E, Saccardi, R, Giacometti, A, Esperti, S, Pierotti, P, Bernini, L, Bianco, C, Benedetti, S, Lanzi, A, Bonfanti, P, Sani, S, Saracino, A, Castagna, A, Trabace, L, Lanza, M, Focosi, D, Mazzoni, A, Pistello, M, and Falcone, M

Subjects
Male, medicine.medical_specialty, Randomization, Settore MED/17 - Malattie Infettive, Population, Aged, COVID-19, Disease Progression, Female, Humans, Italy, Middle Aged, Prospective Studies, SARS-CoV-2, Severity of Illness Index, Standard of Care, Hospital Mortality, Hospitalization, Immunization, Passive, Plasma, Respiratory Insufficiency, Passive, law.invention, Randomized controlled trial, law, Internal medicine, Clinical endpoint, medicine, education, Adverse effect, education.field_of_study, business.industry, General Medicine, Odds ratio, medicine.disease, Pneumonia, Respiratory failure, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Immunization, business
Abstract

Importance: Convalescent plasma (CP) has been generally unsuccessful in preventing worsening of respiratory failure or death in hospitalized patients with COVID-19 pneumonia. Objective: To evaluate the efficacy of CP plus standard therapy (ST) vs ST alone in preventing worsening respiratory failure or death in patients with COVID-19 pneumonia. Design, setting, and participants: This prospective, open-label, randomized clinical trial enrolled (1:1 ratio) hospitalized patients with COVID-19 pneumonia to receive CP plus ST or ST alone between July 15 and December 8, 2020, at 27 clinical sites in Italy. Hospitalized adults with COVID-19 pneumonia and a partial pressure of oxygen-to-fraction of inspired oxygen (Pao2/Fio2) ratio between 350 and 200 mm Hg were eligible. Interventions: Patients in the experimental group received intravenous high-titer CP (≥1:160, by microneutralization test) plus ST. The volume of infused CP was 200 mL given from 1 to a maximum of 3 infusions. Patients in the control group received ST, represented by remdesivir, glucocorticoids, and low-molecular weight heparin, according to the Agenzia Italiana del Farmaco recommendations. Main outcomes and measures: The primary outcome was a composite of worsening respiratory failure (Pao2/Fio2 ratio

Published
2021

38. Ten Years of ECP for CLAD: A Real Life Experience

Author

Rossetti, V., primary, Righi, I., additional, Morlacchi, L., additional, Fante, C. Del, additional, Mocellin, M., additional, Ferrari, E., additional, Cattaneo, M., additional, Perotti, C., additional, Tarsia, P., additional, Rosso, L., additional, and Blasi, F., additional

Published
2020
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