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Alloyed triple half-Heusler Ti(Fe0.5+xCo0.25Cu0.25−x)Sb with intrinsically low thermal conductivity have been successfully designed and synthesized based on a valence balanced strategy.

Photochromic hexaarylbiimidazoles (HABIs) enable reversible transformation between HABI and triphenylimidazole radicals (TPIRs) upon UV light irradiation, which have been applied in photo-patterning, super-resolution imaging, photoinduced self-healing materials and photomechanical hydrogels. Here, we designed and prepared a novel kind of polyurethane (PU) photoresist based on photo-cleavable HABI cross-linkers (HABI-PU), linear PU backbone and additive tert-butylhydroquinone (TBHQ) radical quencher. Upon UV light irradiation, the C-N bond inside HABI unit is broken, causing the transformation of HABI into two TPIRs which are subsequently quenched by TBHQ. Therefore, the cross-linking points of HABI-PU in UV irradiation area were broken, forming flexible PU polymer chains with declined molecular weight, which can be dissolved in developer. HABI-PU films show excellent photosensitivity as a positive photoresist in photolithography. The reaction mechanism between HABI and TBHQ was studied by UV-vis absorption spectra, electron paramagnetic resonance (EPR), mass spectra and nuclear magnetic resonance spectra. The lithographic patterns were characterized through metallurgical microscope and scanning electron microscope with a resolution at about 5 µm.

The ability to effectively detect bacterial infection in human tissues is important for the timely treatment of the infection. However, traditional techniques fail to visualize bacterial species adhered to host cells

To compare clinical effect of Kirschner wire radial sector fixation and bilateral ulnar radial cross fixation in treating supracondylar fracture of humerus in children after closed reduction.From March 2017 to December 2018, 60 children with supracondylar fracture of humerus treated with closed reduction and Kirschner wire fixation were analyzed retrospectively, and divided into two groups according to different needling methods. Thirty patients in radial three needles fan fixation group (group A), including 19 males and 11 females, aged from 2 to 10 years old with an average of (5.00±2.10) years old, 21 patients were typeⅡ and 9 patients were typeⅢ according to Gartland classification. Thirty patients in cross fixationwith 3 needles on both ulnar and radial side group(group B), including 22 males and 8 females, aged from 1 to 9 years old with an average of(5.13±2.08) years old, 19 patients were typeⅡand 11 patients were typeⅢ. Healing time of fracture, postoperative complications, elbow flexion and extension activity, forearm rotation activity recovery, elbow carrying angle and angle loss after operation between two groups were observed and compared. Mayo Elbow function score at the final following up was used to evaluate clinical efficacy.All patients were followed up, while there were no significant difference in follow-up time and fracture healing time between two groups (Closed reduction and Kirschner wire at the early stage of fracture has advantages of less trauma, easy reduction, stable fixation, and early functional exercise. The risk of iatrogenic ulnar nerve injury caused by fan-shaped fixation of three radial needles is less than that of cross fixation of three radial needles.

This paper conducts an experimental study on the variable modulus foundation for frame-tube structure. The base reactions are measured and its correlation with deformation characteristic is analyzed. The following conclusions are summarized: (1) soil cement (volume ratio is 1:4) is used to strengthen the foundation soil at core tube area. The ratio of moduli of foundation soils at core tube area and external frame column is 2.23. The vertical deflections of medial axis and diagonal are 0.08‰ and 0.1‰. (2) Under the working loads, the base reaction at core tube area is highest and distributed uniformly. The base reaction at the area between the core tube and the external frame column decreases gradually. The overall distribution of base reaction shows a basin shape. (3) The ratio of foundation modulus at core tube area and external frame column area is 2.35. The ratio of base reactions at these two parts is 3.31, which shows a good correlation with the foundation modulus.

Composite foundation can be designed as long and short piles that lie on different bearing strata with high bearing capacities. Researches have shown that for foundation with sufficient stiffness, the ratio of the thickness of cushion to pile diameter (thickness-diameter ratio) plays an important role on the exertion of bearing capacities of pile and soil between piles. Traditional method just applies equal thickness-diameter ratio to design composite foundation with long and short piles, which hinders the exertion of bearing capacity of composite foundation. To overcome this defect, this paper studies the relations between thickness-diameter ratio and the exertions of bearing capacities of pile and soil between piles. The design method of thickness-diameter ratio for composite foundation with long and short piles is also proposed in this study.

Based on theoretical analysis and experimental result, the principle as well as the interaction between pile and soil, the design parameters of composite foundation with cement-fly ash-gravel piles (CFG piles for short) are optimized, which are pile length, pile diameter, pile spacing, pile strength and thickness of cushion layer, in order to put forward the reasonable design parameters for reaching economic and reasonable target. Through the optimized analysis, it is put forward that bearing stratum of pile tip should select a relatively better soil layer, the diameter of CFG pile is usually appropriately to select between 350mm and 500mm, it is usually appropriately to select larger pile spacing under the permissible range between 3d and 5d being ruled by standard, it is appropriately to enlarge the pile diameter to reduce the requirement of pile strength in high rise and super high rise building which requiring bearing capacity of single pile is high, and the thickness of cushion layer is appropriately to select between 0.4 and 0.6 times of the pile diameter.

The reduced stiffness method had been adopted to evaluate the material nonlinearity characteristics of reinforced concrete structures to be in compliance with concrete structure standards of the United States, New Zealand and Canada. Concrete structure design code in China also accepts the reduced stiffness method as a supplementary method of considering the second-order effects problem. However, the concrete structure with specially shaped columns code of China still use amplified coefficients of eccentricity to consider nonlinearity characteristics of reinforced concrete structure with special shaped columns. Based on the numerical integral method, a flexural stiffness reduction factor is proposed to consider characteristics of material nonlinearity and geometrical nonlinearity of reinforced concrete columns with equiaxial T shaped section.

The performances of automobiles rely on the engine in high extent, plus connecting rods are the main part of the engine, whose work environment is poorer and pressure is complex. In order to decrease the inertial force and add the span life of the engine, the weight of connecting rods is as litter as possible. Conventional design method is mainly dependent on experience. By means of soft ware of ANSYS, connecting rods are optimized when the structure of connecting rod is simplified, such as big end hole being a whole and taking no account of the interaction between bearing and bush. 45steel is chosen as a material and it must meet tensile strength, lower yield strength, impact toughness, and so on. The new connecting rod can save the material, compared with the conventional connecting rods.

The purpose of this paper is used Ansys to simulate the temperature field of laser brazing by FEM. The 3-D solid elements are used in FEM model, and nonlinear factors of temperature-dependent material properties are considered. The surface temperature grades have been attained, and the brazing experiment have been conducted, the results show that the wetting of Ni-Cr alloy to diamond is good. This study is useful for selecting reasonable processing parameters on laser brazing.

The recent sporadic infections of humans in China with previously unrecognized avian influenza A virus of the H7N9 subtype (A(H7N9)) have caused concern. The aim is to find out the epidemiological and molecular analysis of the PB1-F2 proteins in H7N9 influenza viruses, in Jiangsu province. Sequences were obtained from GISAID database. Data were analyzed by using Molecular Evolutionary Genetics Analysis software and Bayesian Markov chain Monte Carlo method. From March 1, 2013, to May 31, 2014, 53 patients were confirmed to be infected with the H7N9 virus; one was a retrospective case in Jiangsu province. 38 sequences of PB1 in H7N9 of Jiangsu were obtained from the GISAID online and were then divided into three lineages. Of these sequences, 4 sequences and 3 sequences encode an N-terminally truncated PB1-F2 (52aa)polypeptide and C-terminally truncated PB1-F2 (76aa) polypeptide, respectively. The remaining sequences encode a full-length PB1-F2 (90aa). We estimated a mean evolutionary rate of 3.053 × 10−3 subs/site/year (95% HPD: 2.021 × 10−3–4.051 × 10−3). The site-by-site analysis of selection pressure analysis revealed positively and negatively (12, 3), respectively, selected sites. Influenza A (H7N9) virus adapting into new host, PB1-F2 of H7N9, might be faced with higher selection pressures.

OBJECTIVE: To test the hypothesis that locally directed gene transfer of human vascular endothelial growth factor 165 (hVEGF165) is able to passivate hepatic venous metallic stents by accelerating endo­thelialization and augmenting the biocompatibility of endovascular stents. METHODS: Complexes of pAdtrackCMV-hVEGF165 and lipofectamine were smeared homogeneously on the surface of the stents coated with poly-L-lysine. Bare stents were used as controls. All stents were implanted into the right hepatic vein by transjugular intrahepatic venous stent deployment. RESULTS: At the end of the first week after implantation, green fluorescence and the expression of the hVEGF165 gene were detected in the transferred stent vessels of the treated group, but were not detected in the control group. Scanning electron microscopy revealed that the endothelialization of stents was more pronounced in the treated group than that in the control group. At the end of the eighth week after implantation, quantitative angiography analysis showed the internal diameter of the stent was significantly greater in the treated group than in the control group. The de novo intima, their mean areas and percentage cross-sectional area narrowing in the treated group were significantly less than those in the control group. Immunohistochemical analysis indicated that the proliferation of vascular smooth muscle cells was more active in the control group than that in the treated group. CONCLUSION: Local gene transfer of hVEGF165 can passivate endovascular stents by accelerating stent endothelialization and enhancing their biocompatibility in the hepatic vein, resulting in a reduction of thrombus formation and attenuation of intimal hyperplasia.

It is of great importance to know the endogenous mechanism in burn-induced organ injuries, not only for the understanding of pathophysiological processes after burn, but also for guiding the clinical treatment. Recent studies have widened and deepened our scope and understanding of secondary injuries to various organs. However, a unanimous understanding of molecular pathway involved in all burn-induced organ injuries has not been attained. Relatively, the mechanism of endogenous cellular injuries as a result of burn injury could be regarded as a common one to explain the causation of cellular injury, and to guide the prevention and treatment for the burn-induced complications using cytoprotection strategy. This review summarized four aspects of the mechanism of endogenous cellular injuries, including cellular injuries induced by ischemic/hypoxic-oxidative stress, excessive inflammatory factors released by inflammatory cells, immunosuppression caused by suppression of function of adaptive immune cells, and dysfunction of important supportive cells of various organs.

In epidemiological studies, tuberculosis (TB) appears intimately with vitamin D insufficiency whereas its relationship with vitamin D receptor (VDR) polymorphism caused by radical difference remains unspecified. This study aimed to investigate the relationship between vitamin D genetic polymorphism and tuberculosis in Han ethnic group.Meta-analysis was adopted in the synthetic quantitative analysis of documents home and abroad on the relationship between vitamin D genetic polymorphisms and tuberculosis, which were openly published during June 2000 to January 2010. Random effect model and fixed effect model analyses were used to calculate the incorporated odds ratio (OR) based on the heterogeneity test data.A total of 6 eligible studies were included in this analysis. The FokI-ff genotype showed a significant marginal association (Fixed effect model: OR 1.91, 95%CI 1.44-2.52; Random effect model: OR 1.91, 95%CI 0.94-3.88), yet TaqI polymorphisms was not significantly related to TB.The interaction between FoKI genotype polymorphism and TB observed demonstrates that vitamin D deficiency might exist as a risk factor during the development of TB in Han ethnic group and more evidences needed to validate the conclusion.

Objective To study the core message awareness of tuberculosis(TB) prevention and treatment among the primary and middle school students in rural areas of northern Jiangsu Province and to relevant influencing factors. To evaluate the intervention effects of different methods of health education on Tuberculosis, and provide a health education method which take the best effect. Methods Ten primary and middle schools were selected by stratified random sampling in rural areas of northern Jiangsu Province. There were 6 000 students to finish the questionnaires including the general information, knowledge, attitude, practice of TB prevention and treatment. 100 students per school and three primary and three middle schools were selected by multistage cluster sampling in three rural areas of northern Jiangsu Province. The interviews were divided into two intervention groups (comprehensive intervention and General intervention) and one control group. Results The general awareness rates of core messages on TB were 35.4%. The results of the multiple linear regression analysis showed that sex, age, father education, family type, and family income were significantly associated with increased knowledge scores. The awareness rates of the TB core information of comprehensive intervention group, the general intervention group and the control group were 90.5%, 81.5% and 60.4% after intervention. Conclusion Knowledge on tuberculosis prevention and control should be improved among the primary and middle school students in rural areas of northern Jiangsu Province. Compared with the general intervention group, comprehensive intervention education on TB was suitable for the primary school students in rural areas of northern Jiangsu Province.

[Objective] To understand the deaf-mute high school students' health knowledge and health habits, investigate the influencing factors of health knowledge and health habits for formulating intervention measures. [Methods] A self-designed questionnaire was independently filled by 250 senior high school students at a deaf-mute school. [Results] The awareness rate of health knowledge was 62.9% while the behavior forming rate was 52.8%. The influencing factors of health knowledge were cognitive of the social environment, the school environment, the way of knowledge accepted, and age. The influencing factors of health habits were level of father's educational, grade. [Conclusion] The awareness rate of health knowledge and the formation rate of health habits of the deaf-mute high school students were all at a low level. We should strengthen home-school co-education and concern the health problems of deaf-mute students further.

To study the effect of hydrogen-rich saline on blood pressure and antioxidant ability of lung tissue in scalded rats following delayed resuscitation.The hydrogen-rich saline was prepared (hydrogen-saturated normal saline with hydrogen concentration of 0.6 mmol/L). Twenty SD rats were divided into hydrogen-rich saline group (HS) and normal saline group (NS) according to the random number table, with 10 rats in each group. All the rats were subjected to 30% total body surface area (TBSA) full-thickness scald. Rats in HS and NS groups were infused with hydrogen-rich saline or normal saline with one half of the total fluid replacement volume as calculated according to the Parkland formula (4 mL×kg(-1)×%TBSA(-1)) at post scald hour (PSH) 7 and one-quarter of the volume at PSH 9 and 17 respectively. The general condition of rats during the experiment was observed. The systolic pressure of rats was measured at PSH 6 and 24. All rats were sacrificed at PSH 24 to collect lung tissue for detecting superoxide dismutase (SOD) inhibition ratio and malondialdehyde (MDA) level. Data were processed with t test.All rats survived through the experiment. The systolic pressure of rats in HS group and NS group was respectively (87 ± 4) mm Hg (1 mm Hg = 0.133 kPa) and (86 ± 5) mm Hg at PSH 6, and the values were close (t = 0.213, P = 0.834); however the systolic pressure at 24 h was higher in HS group than in NS group [(124 ± 7) mm Hg vs. (115 ± 6) mm Hg, t = 2.958, P = 0.008]. SOD inhibition ratio of lung tissue in HS group [(0.465 ± 0.014)%] was higher than that in NS group [(0.358 ± 0.021)%, t = 11.767, P = 0.000]. MDA level of lung tissue in HS group [(922 ± 196) pmol/mg] was lower than that in NS group [(1118 ± 212) pmol/mg, t = -2.142, P = 0.046].Delayed resuscitation for scalded rats with hydrogen-rich saline is helpful in the recovery of systolic pressure, and it can ameliorate lung tissue injury caused by reperfusion through enhancing the effect of antioxidase.

To investigate the effectiveness of high frequency induced thermotherapy in the treatment of hepatocellular carcinoma.We included a 65 proven cases of hepatocellular carcinoma in which the diagnosis was confirmed by pathology, radio-imaging and AFP value. The patients were randomly divided into 2 group by odd or even hospitalization number. A total of 32 patients were enrolled in the TACE + PEI only group and 33 patients were enrolled in the TACE + HITT therapy group.For the 32 patients in TACE + PEI only therapy group, the 1, 2, and 3 year of survival rates were 73%, 56%, and 23%, respectively, with a median survival of 1.876 years. For patients in the therapy group, the 1, 2, and 3 year survival rates were 87%, 76%, and 51%, respectively, with a median survival of 2.134 years. Survival rate and duration in the therapy group was significantly greater in the combination therapy group compared to the control group (P0.05). There was a negative correlation between the effectiveness of combination therapy and the mortality risk (P0.05).HiTT + TACE can significantly increase survival rate and extend length of survival in patients with hepatocellular carcinoma.

This paper presents a novel teaching software, namely ISSP, based on plug-in. It can assist in exploring the concepts and arithmetic of statistical signal processing. It is based on plug-in and host framework. This consists of two host applications, one for the normal application, and the other for the Web-based applications. The host application is used as an intermediate layer between system and plug-ins. These plug-ins are designed to do the actually work while the running environment is supported by host. Specifically, most plug-ins could run on both of the host applications. In the normal host applications, the user could do with demonstration, debugging with MATLAB, visualizing all the data for plotting and composing the experiment report. This application could be used in teaching and studying statistical signal processing.

To evaluate the therapeutic effects and adverse effects of transarterial oily chemoembolization combined with interstitial laser thermotherapy (TOCE+ILT) in the treatment of hepatocellular carcinoma.Totally 120 patients with hepatocellular carcinoma were randomized into two groups and received interventions with TOCE+ILT or TOCE combined with percutaneous ethanol injection (TOCE+PEI). The treatment was repeated when necessary until the tumor was completely ablated, after which the therapeutic effects were evaluated and the patients were the followed up for observing long-term clinical outcome.Of the 120 patients enrolled in this observation, 105 were followed up for two years (54 in TOCE+ILT group and 51 in TOCE+PEI group). The complete tumor necrosis rate of TOCE+ILT group was significantly higher than that of the TOCE+PEI group (84.8% vs 73.9%,Chi(2)=4.405, P=0.036), and TOCE+ILT was associated with a significantly higher negative conversion rate of AFP positivity (77.8% vs 56.1%, Chi(2)=4.592, P=0.032). The 1-year survival rate were similar between two groups, but the 2-year survival rate was significantly higher in patients with TOCE+ILT (79.6% vs 60.8%, Chi(2)=4.477, P=0.034). The hepatic function was comparable between the two groups before treatment, and 1 week after treatment, the ALT level in patients undergoing TOCE+ILT was significantly lower than that in patients with TOCE+PEI (95.90-/+56.06 U/L vs 116.31-/+45.27 U/L, t=2.04, P=0.043). Post-embolization syndrome was observed in the patients in two groups, but no severe adverse events were found.TOCE+ILT has good therapeutic effects and mild side effects in the treatment of hepatocellular carcinoma.

Both transcatheter arterial chemoembolization (TACE) and percutaneous ethanol injection (PEI) are the most important and popular procedures of interventional treatment for hepatocellular carcinoma (HCC). Although the improvement of the short-term efficacy of the combination of TACE and PEI has been proved, the long-term efficacy is seldom reported so far. The purpose of this study was to evaluate the long-term efficacy of the combination of TACE and PEI for treatment of HCC.Six hundred and seventy-five patients with HCC from 2 cm to 15 cm in the greatest diameter (average 9.6 cm) were enrolled in this study. Among them, 179 were treated by a combination of TACE using the emulsion of lipiodol and anti-cancer drugs and PEI (TACE/PEI group) and 496 patients by TACE alone (TACE group). Ten patients in each group underwent resection after the final interventional treatment and the resected specimens were detected by histopathology method. The unresected patients had been followed up for 5-7 years and the 1-, 3-, 5 -, and 7-year survival rates were evaluated. The clinical data of the patients in two groups before intervention were comparable.Pathological data of two groups showed that remarkable differences were found in the mean necrosis rates (100.0+/-0.0% vs 91.5+/-7.1%, P0.05) and the complete necrosis rates of tumors (100% vs 20%, P = 0.0007), while there were no statistical significances in the extent of shrinkage of tumors after treatment between two groups. The results of follow-up showed that the 1-, 3-, 5-, and 7-year survival rates were 80.5%, 58.6%, 29.6%, 16.5% in TACE-PEI group, and 68.5%, 27.8%, 7.2%, 5.2% in TACE group, respectively. Significant differences were found between two groups (P0.01).The combination of TACE and PEI is a valuable remedy for HCC to prolong long-term survival rate.

To compare the clinical efficacy of metal versus plastic biliary stent implantation for treatment of malignant biliary obstruction.Percutaneous transhepatic implantations of self-expandable metal stent (MS, n=61) or 10F plastic stent (PS, n=34) were performed in 95 patients with malignant biliary obstruction selected from 3 hospitals of Guangdong Province. All patients were followed up until death or at least one year after the procedure. Kaplan-Meier analysis was used to compare the patients' survival and stent patency rates.The 30-day mortality rate was lower in MS group (6/61, 9.8%) than in PS group (9/34, 26.5%, P0.05). The 30-day reobstruction rate and incidence of complications were 15.0%, 16.4% in MS group and 32.4%, 29.4% in PS group, respectively (P0.01). The median patency period of the stents and median survival period of the patients were 230 d, 224 d in MS group and 90 d, 94 d in PS group, respectively (P0.01).Metal stent implantation is superior to plastic stent for treatment of malignant biliary obstruction.

To compare the efficacy of metal versus plastic biliary stent implantation in the treatment of malignant biliary obstruction.Percutaneous transhepatic self-expandable metal stent (MS, n=61) and 10F plastic stent (PS, n=34) were placed in 95 patients with malignant biliary obstruction in three hospitals of Guangdong province. All patients were followed up until death or at least one year after the procedure. Kaplan-Meier analysis was used to compare the survival of the patients and the rates of stent patency.The 30-day mortality rate was lower in the MS group (6/61, 9.8%) than in the PS group (9/34, 26.5%, P0.05). The 30-day reobstruction rate and the complication rate were 15.0%, 16.4% in the MS group and 32.4%, 29.4% in the PS group, respectively (P0.01). The median patency period of stents and median survival period of the patients were 230 days, 224 days in the MS group and 90 days, 94 days in the PS group, respectively (P0.01).Metal stent is clinically superior to plastic stent in the treatment of malignant biliary obstruction.