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86 pags., 49 figs., 24 tabs. NASA’s Mars 2020 (M2020) rover mission includes a suite of sensors to monitor current environmental conditions near the surface of Mars and to constrain bulk aerosol properties from changes in atmospheric radiation at the surface. The Mars Environmental Dynamics Analyzer (MEDA) consists of a set of meteorological sensors including wind sensor, a barometer, a relative humidity sensor, a set of 5 thermocouples to measure atmospheric temperature at ∼1.5 m and ∼0.5 m above the surface, a set of thermopiles to characterize the thermal IR brightness temperatures of the surface and the lower atmosphere. MEDA adds a radiation and dust sensor to monitor the optical atmospheric properties that can be used to infer bulk aerosol physical properties such as particle size distribution, non-sphericity, and concentration. The MEDA package and its scientific purpose are described in this document as well as how it responded to the calibration tests and how it helps prepare for the human exploration of Mars. A comparison is also presented to previous environmental monitoring payloads landed on Mars on the Viking, Pathfinder, Phoenix, MSL, and InSight spacecraft. This work has been funded by the Spanish Ministry of Economy and Competitiveness, through the projects No. ESP2014-54256-C4-1-R (also -2-R, -3-R and -4-R) and AYA2015-65041-P; Ministry of Science, Innovation and Universities, projects No. ESP2016-79612-C3-1-R (also -2-R and -3-R), ESP2016-80320-C2-1-R, RTI2018-098728-B-C31 (also -C32 and -C33) and RTI2018-099825-B-C31; Instituto Nacional de Técnica Aeroespacial; Ministry of Science and Innovation’s Centre for the Development of Industrial Technology; Grupos Gobierno Vasco IT1366-19; and European Research Council Consolidator Grant no 818602. The US co-authors performed their work under sponsorship from NASA’s Mars 2020 project, from the Game Changing Development program within the Space Technology Mission Directorate and from the Human Exploration and Operations Directorate.

Highly sensitive next-generation sequencing (NGS) platforms applied to preimplantation genetic testing for aneuploidy (PGT-A) allow the classification of mosaicism in trophectoderm biopsies. However, the incidence of mosaicism reported by these tests can be affected by a wide number of analytical, biological, and clinical factors. With the use of a proprietary algorithm for automated diagnosis of aneuploidy and mosaicism, we retrospectively analyzed a large series of 115,368 trophectoderm biopsies from 27,436 PGT-A cycles to determine whether certain biological factors and in vitro fertilization (IVF) practices influence the incidence of overall aneuploidy, whole uniform aneuploidy, mosaicism, and TE biopsies with only segmental aneuploidy. Older female and male patients showed higher rates of high-mosaic degree and whole uniform aneuploidies and severe oligozoospermic patients had higher rates of mosaicism and only segmental aneuploidies. Logistic regression analysis identified a positive effect of female age but a negative effect of embryo vitrification on the incidence of overall aneuploid embryos. Female age increased whole uniform aneuploidy rates but decreased only segmental aneuploidy and mosaicism, mainly low-mosaics. Conversely, higher ovarian response decreased whole uniform aneuploidy rates but increased only segmental aneuploidies. Finally, embryo vitrification decreased whole uniform aneuploidy rates but increased mosaicism, mainly low-mosaics, compared to PGT-A cycles with fresh oocytes. These results could be useful for clinician's management of the IVF cycles.

Upprättat; 2014; 20150629 (ninhul)

Upprättat; 2014; 20150629 (ninhul)

Upprättat; 2014; 20150629 (ninhul)

In this work, false positive rate of an arrayCGH platform for its use in day-3 single-blastomere analysis was calculated. For this purpose, 38 embryos diagnosed as abnormal on day-3 by FISH were re-biopsied on day-4. Single-cell day-4 arrayCGH diagnosis was then performed. A successful amplification was obtained in 97.4 % (37/38) of the day-4 cells analysed by arrayCGH. Day-3 FISH and day-4 arrayCGH diagnosis were concordant in 35/37 cases. The two discordant embryos were spread and all the cells from each embryo were re-analysed by FISH on day 5. The same error rate (2.7 %) for day-3 FISH and day-4 arrayCGH was obtained when comparing day-5 FISH re-analysis. After this pre-clinical phase, the platform was used for day-3 arrayCGH clinical application in 320 patients (1,760 embryos). Day-3 amplification rate was 98.6 %. An optimal reproductive outcome was obtained when applying arrayCGH to a clinical program: clinical pregnancy rate per cycle of 38.4 % and 60.3 % per transference were obtained, with an implantation rate of 53.5 %. Overall miscarriage rate was 10.6 %. Additionally, day-5 FISH re-analysis was performed in 42 of the embryos from the clinical phase, obtaining a concordance rate of 97.6 % with day-3 arrayCGH.

To compare the incidence of chromosomal abnormalities in preimplantation embryos from couples undergoing preimplantation genetic screening (PGS) after previous aneuploid miscarriage after either natural conception (NC) or assisted reproductive technology (ART) versus fertile couples who underwent PGS for sex-linked diseases as a control group.

Ponencia presentada en el VIII Congreso Internacional de Ingeniería de Proyectos celebrada en Bilbao en el año 2004 The goal of the project was to improve the design process of the products in the furniture industry. It consisted of investigating the definition of a knowledge-based model in order to assist in the design of the industrial products. Firstly, a design process analysis and redesign was made through the process modeling. From the current design process model of the studied company a new design process model was achieved. In the new process, changes and consequences of introducing a new design tool, such as Catia V5, were reflected. Improvements referring to times, workflows, reduction of mistakes and better efficiency in the product design were achieved. Then, an Informal Model was built up and developed with the product knowledge of the company. This model was the necessary way between the information that defines the product related with the company and the Formal Model, which is required for its application in computer programs for products design. Finally, through using the program Catia V5, the prototype of a model was built up. That model allowed the achievement of variations in current designs automatically, taking into account the features and limitations of itself. Those automatic designs were gotten by the user, modifying the defined variables by introducing the searched parameters. In that way, a reduction of the time needed for current design and less mistakes of any type were achieved. As a whole, the project achieved a reduction of times and mistakes, increased flexibility referred to changes in the product design and integration between the design tasks, and achieved a best product knowledge management in the company. El objetivo general de este proyecto era mejorar el proceso de diseño de los productos de la industria del mueble. Consistía en investigar en la definición de un modelo basado en el conocimiento para asistir el diseño de productos industriales. En primer lugar se realizó un análisis y rediseño del proceso de diseño actual de la empresa estudiada mediante el modelado de procesos. A partir del modelo de proceso actual se obtuvo un nuevo modelo, en el cual se analizaban y reflejaban los cambios y consecuencias en el proceso ante la implementación de una nueva herramienta de diseño, como es el Catia. Se obtuvieron mejoras en aspectos de tiempo, flujo de actividades, reducción de fallos y una mayor eficiencia en el diseño. Otro de los puntos del proyecto fue la construcción de un Modelo Informal, desarrollado con el conocimiento de producto de la empresa, el cual constituye el paso necesario entre la información que define el producto en relación con la empresa y la obtención del Modelo Formal, requerido para su aplicación en herramientas informáticas para el diseño de productos. Y por último, mediante la utilización de la aplicación Catia V5 se desarrolló un prototipo de un modelo que permite la obtención de variaciones en diseños desarrollados rutinariamente de manera automática, teniendo en cuenta las características y limitaciones del mismo. Esto se produce, cuando el usuario introduce los parámetros deseados, modificando así las variables definidas, produciendo de esta forma una reducción de tiempos y minimización en cualquier tipo de error. Con todo ello se consigue una minimización de tiempos y errores, aumentar la flexibilidad en cuanto a la introducción de cambios en el diseño, aumentar la integración entre las actividades de producción y las actividades de diseño y una mejor gestión del conocimiento del producto por parte de la organización.

This paper describes the procedure adopted by the three co-ordinators of the CLEF 2003 question answering track (ITC-irst, UNED and ILLC) to create the question set for the monolingual tasks. Despite thelittle resources available, the three groups collaborated and managed to formulate and verify a large pool of original questions posed in three different languages: Dutch, Italian and Spanish. A part of these queries was translated into English and shared between the three coordination groups. Thus, a second cross-verification wasconducted, in order to extract the queries that had an answer in all the three monolingual document collections. Finally, the result of the joint efforts was the creation of the DISEQuA (Dutch Italian Spanish English Questions and Answers) corpus, a useful and reusable resource that is freely available for the research community. Thearticle reports on the different stages of the corpus creation, from the monolingual kernels to the multilingual extension.