Author: "Panigada, M" / Publication Year Range: Last 50 years - Searchworks@Jio Institute Digital Library Search Results

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179 results on '"Panigada, M"'

1. OP0073 UNRAVELING PATHOPHYSIOLOGY AND HEMATOPOIESIS OF VEXAS SYNDROME BY MULTI-OMICS ANALYSIS AND TARGETED GENE EDITING

Author: Campochiaro, C., primary, Molteni, R., additional, Pacini, G., additional, Fiumara, M., additional, Tomelleri, A., additional, Diral, E., additional, Stefanoni, D., additional, Varesi, A., additional, Weber, A., additional, Alfieri, R., additional, Albano, L., additional, Panigada, M., additional, Cantoni, E., additional, Canarutto, D., additional, Bassoricci, L., additional, Quaranta, P., additional, ’alessandro, A. D, additional, Matucci-Cerinic, M., additional, DI Micco, R., additional, Aiuti, A., additional, Ciceri, F., additional, Merelli, I., additional, Dagna, L., additional, Scala, S., additional, Cenci, S., additional, Naldini, L., additional, Ferrari, S., additional, and Cavalli, G., additional
Published: 2024
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2. Pathophysiological Correlations Between Unmatched V/Q Units Assessed by Electrical Impedance Tomography and Biomarkers, Respiratory Mechanics, Chest CT Scan and Lactates Inards

Author: Spinelli, E., primary, Perez, J., additional, Chiavieri, V., additional, Leali, M., additional, Mansour, N., additional, Vaira, V., additional, Panigada, M., additional, and Mauri, T., additional
Published: 2024
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3. Correction: Epidemiology and outcomes of early-onset AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights from two prospective global cohort studies (Critical Care, (2023), 27, 1, (3), 10.1186/s13054-022-04294-5)

Author: McNicholas B. A., Mcnicholas, B, Rezoagli, E, Simpkin, A, Khanna, S, Suen, J, Yeung, P, Brodie, D, Bassi, G, Pham, T, Bellani, G, Fraser, J, Laffey, J, Al-Dabbous, T, Alfoudri, H, Shamsah, M, Alhadad, Q, Hanan, M, Elapavaluru, S, Berg, A, Horn, C, Abdelhalim, A, Amer, A, Elnaggar, C, Hassan, A, Abdelaziz, A, Abdelhalim, M, Orabi, Y, Alaraji, Z, Muhaisen, M, Almasri, L, Mustafa, D, Hamdan, S, Al-Saba'a, Y, Dalloul, Z, Alkahlout, M, Jaber, H, Aldabbourosama, O, Hussein, A, Emad, Z, Khaled, S, Mohamed, N, Hassanin, E, Hamdi, A, Ragab, A, Azizeldin, M, Mayasi, Y, Schroll, S, Meyer, D, Velazco, J, Ploskanych, L, Fikes, W, Bagewadi, R, Dao, M, White, H, Laviena, A, Ehlers, A, Shalabi-McGuire, M, Witt, T, Grazioli, L, Lorini, L, Grandin, E, Nunez, J, Reyes, T, O'Briain, D, Hunter, S, Ramanan, M, Affleck, J, Veerendra, H, Rai, S, Russell-Brown, J, Nourse, M, Joseph, M, Mitchell, B, Tenzer, M, Abe, R, Cho, H, Jeong, I, Rahman, N, Kakar, V, Sun, H, Hanley, A, Brozzi, N, Mehkri, O, Krishnan, S, Duggal, A, Houltham, S, Graf, J, Diaz, R, Orrego, R, Delgado, C, Gonzalez, J, Sanchez, M, Piagnerelli, M, Sarrazin, J, Zabert, G, Espinosa, L, Delgado, P, Delgado, V, Rincon, D, Yanten, A, Duque, M, Abouelmagd, K, Elhazmi, A, Al-Hudaib, A, Javidfar, J, Callahan, M, Dong, A, D'Orleans, C, Taufik, M, Wardoyo, E, Gunawan, M, Trisnaningrum, N, Irawany, V, Rayhan, M, Panigada, M, Pesenti, A, Zanella, A, Grasselli, G, Colombo, S, Martinet, C, Florio, G, Antonelli, M, Carelli, S, Grieco, D, Asaki, M, Hoshino, K, Salazar, L, Monsalve, M, Cosgrave, D, Atif, M, Qutishat, F, Laffey, C, Van Der Walt, M, Mccaffrey, J, Bone, A, Hakeem, Y, Winearls, J, Tallott, M, Thomson, D, Joubert, I, Arnold-Day, C, Piercy, J, van Zyl Smit, R, Miller, M, Seymour, L, van Heyningen, F, Teyangesikayi, G, Fredericks, D, Hssain, A, Aliudin, J, Alqahtani, A, Mohamed, K, Mohamed, A, Tan, D, Villanueva, J, Zaqout, A, Kurtzman, E, Ademi, A, Dobrita, A, El Aoudi, K, Segura, J, Giwangkancana, G, Ohshimo, S, Osatnik, J, Joosten, A, Torres, A, Yang, M, Motos, A, Luna, C, Arancibia, F, Williams, V, Noel, A, Luque, N, Fantini, M, Garcia, R, Alvarez, E, Greti, A, Ceccato, A, Sanchez, A, Vazquez, A, Roche-Campo, F, Franch-Llasat, D, Tuazon, D, Amato, M, Cassimiro, L, Pola, F, Ribeiro, F, Fonseca, G, Dalton, H, Desai, M, Osborn, E, Deeb, H, Arcadipane, A, Martucci, G, Panarello, G, Vitiello, S, Bianco, C, Occhipinti, G, Rossetti, M, Cuffaro, R, Cho, S, Whitman, G, El Sayed, M, Mokhtar, W, El-Shenawy, E, Shimizu, H, Moriyama, N, Kim, J, Kitamura, N, Gebauer, J, Yokoyama, T, Al-Fares, A, Buabbas, S, Alamad, E, Alawadhi, F, Alawadi, K, Khalefa, M, Al Ajeel, N, Aly, M, Al-Saleh, A, Naanouh, A, Elshourbgy, A, Gad, M, Elrazaz, R, Khadadah, I, Almumin, A, Altarakma, H, Albannay, H, Alsaleh, M, Radwan, M, Saadallah, I, Tanaka, H, Hashimoto, S, Yamazaki, M, Oh, T, Epler, M, Forney, C, Kruse, L, Feister, J, Williamson, J, Grobengieser, K, Gnall, E, Golden, S, Caroline, M, Shapiro, T, Karaj, C, Thome, L, Sher, L, Vanderland, M, Welch, M, Mcdermott, S, Brain, M, Mineall, S, Unwin, M, Chen, L, Trezise, T, Mckeon, L, Kimura, D, Brazzi, L, Sales, G, Montrucchio, G, Ogston, T, Nagpal, D, Fischer, K, Lorusso, R, van Bussell, B, De Piero, M, Mariani, S, Rangappa, R, Shetty, R, Rai, P, Ganesan, A, Esperatti, M, Fuentes, N, Gonzalez, M, Carton, E, Sen, A, Palacios, A, Rainey, D, Samoukoviv, G, Campisi, J, Durham, L, Neumann, E, Seefeldt, C, Falcucci, O, Emmrich, A, Guy, J, Johns, C, Potzner, K, Zimmermann, C, Espinal, A, Buchtele, N, Schwameis, M, Korhnfehl, A, Brock, R, Staudinger, T, Stecher, S, Barnikel, M, Anton, S, Pawlikowski, A, Zaaqoq, A, Galloway, L, Merley, C, Nichol, A, Csete, M, Quesada, L, Saba, I, Kasugai, D, Hiraiwa, H, Tanaka, T, Marwali, E, Purnama, Y, Dewayanti, S, Ardiyan, Juzar, D, Siagian, D, Chen, Y, Ogino, M, Nasa, P, Matthew, C, Majeed, N, Ratsep, I, Post, A, Sillaots, P, Krund, A, Lehiste, M, Lepik, T, Manetta, F, Mihelis, E, Sarmiento, I, Narasimhan, M, Varrone, M, Komats, M, Garcia-Diaz, J, Harmon, C, Satyapriya, S, Bhatt, A, Mokadam, N, Uribe, A, Gonzalez, A, Shi, H, Mckeown, J, Pasek, J, Fiorda, J, Echeverria, M, Moreno, R, Zakhary, B, Cavana, M, Cucino, A, Foti, G, Giani, M, Fumagalli, B, Chiumello, D, Castagna, V, Dell'Amore, A, Navalesi, P, Shum, H, Vuysteke, A, Usman, A, Acker, A, Smood, B, Mergler, B, Sertic, F, Subramanian, M, Sperry, A, Rizer, N, Burhan, E, Rasmin, M, Akmal, E, Sitompul, F, Lolong, N, Naivedh, B, Erickson, S, Barrett, P, Dean, D, Daugherty, J, Loforte, A, Khan, I, Quraishi, M, Desantis, O, So, D, Kandamby, D, Mandei, J, Natanael, H, Yudhalantang, E, Lantang, A, Wijaya, S, Jung, A, Ng, G, Ng, W, Ng, P, Fang, S, Tabah, A, Ratcliffe, M, Duroux, M, Alajeeli, A, Tarhabat, A, Adachi, S, Nakao, S, Blanco, P, Prieto, A, Sanchez, J, Nicholson, M, Butt, W, Serratore, A, Delzoppo, C, Janin, P, Yarad, E, Totaro, R, Coles, J, Pujo, B, Balk, R, Vissing, A, Kapania, E, Hays, J, Fox, S, Yantosh, G, Mishin, P, Yuliarto, S, Santoso, K, Djajalaksana, S, Fatoni, A, Fukuda, M, Liu, K, Pelosi, P, Battaglini, D, Jimenez, J, Bastos, D, Gaiao, S, Rusmawatiningtyas, D, Cho, Y, Lee, S, Kawasaki, T, Munshi, L, Sakiyalak, P, Nitayavardhana, P, Elagili, M, Salem, T, Seitz, T, Arora, R, Kent, D, Marino, D, Parwar, S, Cheng, A, Miller, J, Fujitani, S, Shimizu, N, Madhok, J, Owyang, C, Buscher, H, Reynolds, C, Maasikas, O, Aleksanbeljantsev, Mihnovits, V, Akimoto, T, Aizawa, M, Horibe, K, Onodera, R, Hodgson, C, Burrell, A, Young, M, George, T, Shekar, K, Mcguinness, N, Irvine, L, Flynn, B, Endo, T, Sugiyama, K, Shimizu, K, Fan, E, Exconde, K, Ichiba, S, Binnawara, M, Lussier, L, Lotz, G, Malfertheiner, M, Maier, L, Dreier, E, Kusumastuti, N, Mccloskey, C, Dabaliz, A, Elshazly, T, Smith, J, Szuldrzynski, K, Bielanski, P, Wille, K, Murthy, S, Parhar, K, Fiest, K, Codan, C, Shahid, A, Fayed, M, Evans, T, Gutierrez, A, Song, T, Rose, R, Bennett, S, Richardson, D, Peek, G, Arora, L, Rappapport, K, Rudolph, K, Sibenaller, Z, Stout, L, Walter, A, Herr, D, Vedadi, N, Bartlett, R, Thompson, S, Hoffman, J, Ying, X, Williams, B, Sanchez, E, Akwani, C, Kennedy, R, Elhadi, M, Griffee, M, Mone, M, Ciullo, A, Kida, Y, Roca, R, Riera, J, Contreras, S, Alegre, C, Kay, C, Fischer, I, Renner, E, Taniguci, H, Lee, J, Plotkin, D, Citarella, B, Merson, L, Hartley, E, Lubis, B, Ikeyama, T, Alhamad, A, Fathi, M, Hadhoud, M, Alhouri, H, Mechi, A, Alyasiri, M, Elsaid, M, Shahla, H, Bhaskar, B, Jung, J, Mcguinness, S, Eastwood, G, Marta, S, Guarracino, F, Gerle, S, Coxon, E, Claro, B, Eleisawy, M, Osama, H, Loverde, D, Patil, N, Parrini, V, Mcbride, A, Negaard, K, Ratsch, A, Uribe, J, Peris, A, Sanders, M, Emerson, D, Kamal, M, Faida, H, Povoa, P, Francis, R, Cherif, A, Joseph, S, Di Nardo, M, Heard, M, Kyle, K, Blackwell, R, Ouyahia, A, Biston, P, Jeong, H, Smith, R, Prawira, Y, Garcia, A, Salterain, N, Meyns, B, Elnasser, M, Moreno, M, Walia, R, Mehta, A, Schweda, A, Williams, M, Emadamkhatirah, Kim, K, Assad, A, Giraldo, E, Karolak, W, Balik, M, Pocock, E, Gajkowski, E, Masafumi, K, Barrett, N, Takeyama, Y, Park, S, Amin, F, Andriyani, F, Sudakevych, S, Schnur, J, Vera, M, Cornejo, R, Schwarz, P, Mardini, A, de Paula, T, Neto, A, Villoldo, A, Colafranceschi, A, Iglesias, A, Granjean, J, Melro, L, Romualdo, G, Gaia, D, Souza, H, Galas, F, Mendiluce, R, Sosa, A, Martinez, I, Kurosawa, H, Almoshantaf, M, Salgado, J, Hugi-Mayr, B, Charbonneau, E, Barzilai, V, Monteiro, V, de Souza, R, Harper, M, Siddig, N, Suzuki, H, Adams, C, Brieva, J, Khamees, A, Graige, F, Supriatna, M, Nyale, G, Eltatar, F, Fatani, J, Baeissa, H, Masri, A, Rabie, A, Hui, M, Yamane, M, Jung, H, Margaret, A, Nacpil, N, Ruck, K, Bakken, R, Jara, C, Felton, T, Tharwat, S, Berra, L, Shah, B, Chakraborty, A, Cardona, M, Capatos, G, Akkanti, B, Orija, A, Jain, H, Ito, A, Muftah, M, Housni, B, Aldhalia, A, Low, S, Iihara, K, Chavez, J, Ramanathan, K, Naidoo, K, Seppelt, I, Vandyk, M, Macdonald, S, Hafez, W, Mcgregor, R, Siebenaler, T, Flynn, H, Lofton, K, Aokage, T, Kvirkvelia, B, Shigemitsu, K, Moscatelli, A, Fiorentino, G, Baumgaertel, M, Mba, S, Assy, J, Hutahaean, A, Roush, H, Sichting, K, Alessandri, F, Burns, D, Alkhubouli, T, Nasrallah, A, Salt, G, Garabedian, C, Millar, J, Sim, M, Mattke, A, Mcauley, D, Tadili, J, Frenzel, T, Bar-Lavie, Y, Ortiz, A, Stone, J, Attokaran, A, Farquharson, M, Patel, B, Gunning, D, Baillie, K, Adem, S, Watson, P, Tamai, K, Sajinadiyasa, G, Kanyawati, D, Salgado, M, Sassine, A, Yudo, B, Mccaul, S, Lee, B, Afek, A, Iwashita, Y, Fadlalmola, H, Semedi, B, Mansour, N, Metiva, J, Van Belle, N, Martin-Loeches, I, Al-Sadawi, M, Kirakli, C, Shimaa, A, Abdurraouf, A, Ivatt, L, Moharam, S, Woon, C, Kang, H, Smith, T, James, E, Al-Rawas, N, Almjersah, A, Iwasaki, Y, Ashour, H, Embarek, H, King-Chung, K, Gudzenko, V, Taccone, F, Perdhana, F, Lamarche, Y, Ribeiro, J, Bradic, N, Van den Bossche, K, Lansink, O, Singh, G, Debeuckelaere, G, Stelfox, H, Yi, C, Elia, J, Tribble, T, Shankar, S, Padmanabhan, R, Hallinan, B, Paoletti, L, Leyva, Y, Fykuda, T, Badulak, J, Koch, J, Janowaik, L, Hackman, A, Hernandez, D, Osofsky, J, Donadello, K, Lawang, A, Fine, J, Davidson, B, Abdehaleem, I, McNicholas B. A., Rezoagli E., Simpkin A. J., Khanna S., Suen J. Y., Yeung P., Brodie D., Bassi G. L., Pham T., Bellani G., Fraser J. F., Laffey J., Al-Dabbous T., Alfoudri H., Shamsah M., Alhadad Q., Hanan M., Elapavaluru S., Berg A., Horn C., Abdelhalim A. R. M. E., Amer A. E., Elnaggar C. O. R., Hassan A. A., Abdelaziz A., Abdelhalim M., Orabi Y. S. S. A., Alaraji Z. A., Muhaisen M. R., Almasri L., Mustafa D., Hamdan S., Al-Saba'a Y., Dalloul Z., Alkahlout M., Jaber H., Aldabbourosama O., Hussein A. A. R. M., Emad Z. K., Khaled S., Mohamed N., Hassanin E., Hamdi A., Ragab A., Azizeldin M. G., Mayasi Y., Schroll S., Meyer D., Velazco J., Ploskanych L., Fikes W., Bagewadi R., Dao M., White H., Laviena A. B., Ehlers A., Shalabi-McGuire M., Witt T., Grazioli L., Lorini L., Grandin E. W., Nunez J., Reyes T., O'Briain D., Hunter S., Ramanan M., Affleck J., Veerendra H. H., Rai S., Russell-Brown J., Nourse M., Joseph M., Mitchell B., Tenzer M., Abe R., Cho H. J., Jeong I. S., Rahman N., Kakar V., Sun H., Hanley A., Brozzi N., Mehkri O., Krishnan S., Duggal A., Houltham S., Graf J., Diaz R., Orrego R., Delgado C., Gonzalez J., Sanchez M. S., Piagnerelli M., Sarrazin J. V., Zabert G., Espinosa L., Delgado P., Delgado V., Rincon D. F. B., Yanten A. M. M., Duque M. B., Abouelmagd K., Elhazmi A., Al-Hudaib A., Javidfar J., Callahan M., Dong A., D'Orleans C. C., Taufik M. A., Wardoyo E. Y., Gunawan M., Trisnaningrum N. S., Irawany V., Rayhan M., Panigada M., Pesenti A., Zanella A., Grasselli G., Colombo S., Martinet C., Florio G., Antonelli M., Carelli S., Grieco D. L., Asaki M., Hoshino K., Salazar L., Monsalve M. A. M., McNicholas B., Cosgrave D., Atif M., Qutishat F., Laffey C., Van Der Walt M., McCaffrey J., Bone A., Hakeem Y., Winearls J., Tallott M., Thomson D., Joubert I., Arnold-Day C., Piercy J., van Zyl Smit R., Miller M., Seymour L., van Heyningen F., Teyangesikayi G., Fredericks D., Hssain A. A., Aliudin J., Alqahtani A. -R., Mohamed K., Mohamed A., Tan D., Villanueva J., Zaqout A., Kurtzman E., Ademi A., Dobrita A., El Aoudi K., Segura J., Giwangkancana G., Ohshimo S., Osatnik J., Joosten A., Torres A., Yang M., Motos A., Luna C., Arancibia F., Williams V., Noel A., Luque N., Fantini M., Garcia R. N. J., Alvarez E. C., Greti A., Ceccato A., Sanchez A., Vazquez A. L., Roche-Campo F., Franch-Llasat D., Tuazon D., Amato M., Cassimiro L., Pola F., Ribeiro F., Fonseca G., Dalton H., Desai M., Osborn E., Deeb H., Arcadipane A., Martucci G., Panarello G., Vitiello S., Bianco C., Occhipinti G., Rossetti M., Cuffaro R., Cho S. -M., Whitman G., El Sayed M., Mokhtar W., El-Shenawy E., Shimizu H., Moriyama N., Kim J. -B., Kitamura N., Gebauer J., Yokoyama T., Al-Fares A., Buabbas S., Alamad E., Alawadhi F., Alawadi K., Khalefa M. A., Al Ajeel N. A. A., Aly M. F., Al-Saleh A., Naanouh A., Elshourbgy A. M., Gad M. Y., ElRazaz R. M., Khadadah I., Almumin A. M., Altarakma H., Albannay H., Alsaleh M. K., Radwan M. S. A., Saadallah I. A., Tanaka H., Hashimoto S., Yamazaki M., Oh T. -H., Epler M., Forney C., Kruse L., Feister J., Williamson J., Grobengieser K., Gnall E., Golden S., Caroline M., Shapiro T., Karaj C., Thome L., Sher L., Vanderland M., Welch M., McDermott S., Brain M., Mineall S., Unwin M., Chen L., Trezise T., McKeon L., Kimura D., Brazzi L., Sales G., Montrucchio G., Ogston T., Nagpal D., Fischer K., Lorusso R., van Bussell B., De Piero M. E., Mariani S., Rangappa R., Shetty R. M., Rai P. S., Ganesan A., Esperatti M., Fuentes N. A., Gonzalez M. E., Carton E. G., Sen A., Palacios A., Rainey D., Samoukoviv G., Campisi J., Durham L., Neumann E., Seefeldt C., Falcucci O., Emmrich A., Guy J., Johns C., Potzner K., Zimmermann C., Espinal A., Buchtele N., Schwameis M., Korhnfehl A., Brock R., Staudinger T., Stecher S. -S., Barnikel M., Anton S., Pawlikowski A., Zaaqoq A., Galloway L. A., Merley C., Nichol A., Csete M., Quesada L., Saba I., Kasugai D., Hiraiwa H., Tanaka T., Marwali E., Purnama Y., Dewayanti S. R., Juzar D. A., Siagian D., Chen Y. -S., Ogino M., Nasa P., Matthew C., Majeed N. A., Ratsep I., Post A. -M., Sillaots P., Krund A., Lehiste M. -H., Lepik T., Manetta F., Mihelis E., Sarmiento I. C., Narasimhan M., Varrone M., Komats M., Garcia-Diaz J., Harmon C., Satyapriya S. V., Bhatt A., Mokadam N. A., Uribe A., Gonzalez A., Shi H., McKeown J., Pasek J., Fiorda J., Echeverria M., Moreno R., Zakhary B., Cavana M., Cucino A., Foti G., Giani M., Fumagalli B., Chiumello D., Castagna V., Dell'Amore A., Navalesi P., Shum H. -P., Vuysteke A., Usman A., Acker A., Smood B., Mergler B., Sertic F., Subramanian M., Sperry A., Rizer N., Burhan E., Rasmin M., Akmal E., Sitompul F., Lolong N., Naivedh B., Erickson S., Barrett P., Dean D., Daugherty J., Loforte A., Khan I., Quraishi M. A., DeSantis O., So D., Kandamby D., Mandei J. M., Natanael H., YudhaLantang E., Lantang A., Wijaya S. O., Jung A., Ng G., Ng W. Y., Ng P. Y., Fang S., Tabah A., Ratcliffe M., Duroux M., Alajeeli A., Tarhabat A., Adachi S., Nakao S., Blanco P., Prieto A., Sanchez J., Nicholson M., Butt W., Serratore A., Delzoppo C., Janin P., Yarad E., Totaro R., Coles J., Pujo B., Balk R., Vissing A., Kapania E., Hays J., Fox S., Yantosh G., Mishin P., Yuliarto S., Santoso K. H., Djajalaksana S., Fatoni A. Z., Fukuda M., Liu K., Pelosi P., Battaglini D., Jimenez J. F. M., Bastos D., Gaiao S., Rusmawatiningtyas D., Cho Y. -J., Lee S. H., Kawasaki T., Munshi L., Sakiyalak P., Nitayavardhana P., Elagili M. B., Salem T. A. A., Seitz T., Arora R., Kent D., Marino D., Parwar S., Cheng A., Miller J., Fujitani S., Shimizu N., Madhok J., Owyang C., Buscher H., Reynolds C., Maasikas O., AleksanBeljantsev, Mihnovits V., Akimoto T., Aizawa M., Horibe K., Onodera R., Hodgson C., Burrell A., Young M., George T., Shekar K., McGuinness N., Irvine L., Flynn B., Endo T., Sugiyama K., Shimizu K., Fan E., Exconde K., Ichiba S., Binnawara M., Lussier L., Lotz G., Malfertheiner M., Maier L., Dreier E., Kusumastuti N. P., McCloskey C., Dabaliz A. -A., Elshazly T. B., Smith J., Szuldrzynski K. S., Bielanski P., Wille K., Murthy S., Parhar K. K. S., Fiest K. M., Codan C., Shahid A., Fayed M., Evans T., Garcia R., Gutierrez A., Song T., Rose R., Bennett S., Richardson D., Peek G., Arora L., Rappapport K., Rudolph K., Sibenaller Z., Stout L., Walter A., Herr D., Vedadi N., Bartlett R., Thompson S., Hoffman J., Ying X., Williams B., Sanchez E., Akwani C., Kennedy R., Elhadi M., Griffee M., Mone M., Ciullo A., Kida Y., Roca R. F., Riera J. I., Contreras S., Alegre C., Kay C., Fischer I., Renner E., Taniguci H., Lee J., Plotkin D., Citarella B. W., Merson L., Hartley E., Lubis B., Ikeyama T., Alhamad A., Fathi M., Hadhoud M. M., Alhouri H., Mechi A., Alyasiri M. S., Elsaid M. Z. A., Shahla H., Bhaskar B., Jung J. -S., McGuinness S., Eastwood G., Marta S. R., Guarracino F., Gerle S., Coxon E., Claro B., Eleisawy M., Osama H., Loverde D., Patil N., Parrini V., McBride A., Negaard K., Ratsch A., Uribe J. D., Peris A., Sanders M., Emerson D., Kamal M., Faida H., Povoa P., Francis R., Cherif A., Joseph S., Di Nardo M., Heard M., Kyle K., Blackwell R. A., Ouyahia A., Biston P., Jeong H. W., Smith R., Prawira Y., Garcia A. H., Salterain N., Meyns B., Elnasser M., Moreno M., Walia R., Mehta A., Schweda A., Williams M., EmadAmkhatirah, Kim K. H., Assad A., Giraldo E., Karolak W., Balik M., Pocock E., Gajkowski E., Masafumi K., Barrett N., Takeyama Y., Park S., Amin F., Andriyani F. M., Sudakevych S., Schnur J., Vera M., Cornejo R., Schwarz P., Mardini A. C., de Paula T., Neto A. S., Villoldo A., Colafranceschi A. S., Iglesias A. U., Granjean J., Melro L. M. G., Romualdo G. F., Gaia D., Souza H., Galas F., Mendiluce R. M., Sosa A., Martinez I., Kurosawa H., Almoshantaf M. B., Salgado J., Hugi-Mayr B., Charbonneau E., Barzilai V. S., Monteiro V., de Souza R. R., Harper M., Siddig N., Suzuki H., Adams C., Brieva J., Khamees A., Graige F., Supriatna M., Nyale G., Eltatar F. S., Fatani J., Baeissa H., Masri A. A. L., Rabie A., Hui M. Y., Yamane M., Jung H., Margaret A. 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A., Aliudin J., Alqahtani A. -R., Mohamed K., Mohamed A., Tan D., Villanueva J., Zaqout A., Kurtzman E., Ademi A., Dobrita A., El Aoudi K., Segura J., Giwangkancana G., Ohshimo S., Osatnik J., Joosten A., Torres A., Yang M., Motos A., Luna C., Arancibia F., Williams V., Noel A., Luque N., Fantini M., Garcia R. N. J., Alvarez E. C., Greti A., Ceccato A., Sanchez A., Vazquez A. L., Roche-Campo F., Franch-Llasat D., Tuazon D., Amato M., Cassimiro L., Pola F., Ribeiro F., Fonseca G., Dalton H., Desai M., Osborn E., Deeb H., Arcadipane A., Martucci G., Panarello G., Vitiello S., Bianco C., Occhipinti G., Rossetti M., Cuffaro R., Cho S. -M., Whitman G., El Sayed M., Mokhtar W., El-Shenawy E., Shimizu H., Moriyama N., Kim J. -B., Kitamura N., Gebauer J., Yokoyama T., Al-Fares A., Buabbas S., Alamad E., Alawadhi F., Alawadi K., Khalefa M. A., Al Ajeel N. A. A., Aly M. F., Al-Saleh A., Naanouh A., Elshourbgy A. M., Gad M. Y., ElRazaz R. M., Khadadah I., Almumin A. M., Altarakma H., Albannay H., Alsaleh M. K., Radwan M. S. A., Saadallah I. A., Tanaka H., Hashimoto S., Yamazaki M., Oh T. -H., Epler M., Forney C., Kruse L., Feister J., Williamson J., Grobengieser K., Gnall E., Golden S., Caroline M., Shapiro T., Karaj C., Thome L., Sher L., Vanderland M., Welch M., McDermott S., Brain M., Mineall S., Unwin M., Chen L., Trezise T., McKeon L., Kimura D., Brazzi L., Sales G., Montrucchio G., Ogston T., Nagpal D., Fischer K., Lorusso R., van Bussell B., De Piero M. E., Mariani S., Rangappa R., Shetty R. M., Rai P. S., Ganesan A., Esperatti M., Fuentes N. A., Gonzalez M. E., Carton E. G., Sen A., Palacios A., Rainey D., Samoukoviv G., Campisi J., Durham L., Neumann E., Seefeldt C., Falcucci O., Emmrich A., Guy J., Johns C., Potzner K., Zimmermann C., Espinal A., Buchtele N., Schwameis M., Korhnfehl A., Brock R., Staudinger T., Stecher S. -S., Barnikel M., Anton S., Pawlikowski A., Zaaqoq A., Galloway L. A., Merley C., Nichol A., Csete M., Quesada L., Saba I., Kasugai D., Hiraiwa H., Tanaka T., Marwali E., Purnama Y., Dewayanti S. R., Juzar D. A., Siagian D., Chen Y. -S., Ogino M., Nasa P., Matthew C., Majeed N. A., Ratsep I., Post A. -M., Sillaots P., Krund A., Lehiste M. -H., Lepik T., Manetta F., Mihelis E., Sarmiento I. C., Narasimhan M., Varrone M., Komats M., Garcia-Diaz J., Harmon C., Satyapriya S. V., Bhatt A., Mokadam N. A., Uribe A., Gonzalez A., Shi H., McKeown J., Pasek J., Fiorda J., Echeverria M., Moreno R., Zakhary B., Cavana M., Cucino A., Foti G., Giani M., Fumagalli B., Chiumello D., Castagna V., Dell'Amore A., Navalesi P., Shum H. -P., Vuysteke A., Usman A., Acker A., Smood B., Mergler B., Sertic F., Subramanian M., Sperry A., Rizer N., Burhan E., Rasmin M., Akmal E., Sitompul F., Lolong N., Naivedh B., Erickson S., Barrett P., Dean D., Daugherty J., Loforte A., Khan I., Quraishi M. A., DeSantis O., So D., Kandamby D., Mandei J. M., Natanael H., YudhaLantang E., Lantang A., Wijaya S. O., Jung A., Ng G., Ng W. Y., Ng P. Y., Fang S., Tabah A., Ratcliffe M., Duroux M., Alajeeli A., Tarhabat A., Adachi S., Nakao S., Blanco P., Prieto A., Sanchez J., Nicholson M., Butt W., Serratore A., Delzoppo C., Janin P., Yarad E., Totaro R., Coles J., Pujo B., Balk R., Vissing A., Kapania E., Hays J., Fox S., Yantosh G., Mishin P., Yuliarto S., Santoso K. H., Djajalaksana S., Fatoni A. Z., Fukuda M., Liu K., Pelosi P., Battaglini D., Jimenez J. F. M., Bastos D., Gaiao S., Rusmawatiningtyas D., Cho Y. -J., Lee S. H., Kawasaki T., Munshi L., Sakiyalak P., Nitayavardhana P., Elagili M. B., Salem T. A. A., Seitz T., Arora R., Kent D., Marino D., Parwar S., Cheng A., Miller J., Fujitani S., Shimizu N., Madhok J., Owyang C., Buscher H., Reynolds C., Maasikas O., AleksanBeljantsev, Mihnovits V., Akimoto T., Aizawa M., Horibe K., Onodera R., Hodgson C., Burrell A., Young M., George T., Shekar K., McGuinness N., Irvine L., Flynn B., Endo T., Sugiyama K., Shimizu K., Fan E., Exconde K., Ichiba S., Binnawara M., Lussier L., Lotz G., Malfertheiner M., Maier L., Dreier E., Kusumastuti N. P., McCloskey C., Dabaliz A. -A., Elshazly T. B., Smith J., Szuldrzynski K. S., Bielanski P., Wille K., Murthy S., Parhar K. K. S., Fiest K. M., Codan C., Shahid A., Fayed M., Evans T., Garcia R., Gutierrez A., Song T., Rose R., Bennett S., Richardson D., Peek G., Arora L., Rappapport K., Rudolph K., Sibenaller Z., Stout L., Walter A., Herr D., Vedadi N., Bartlett R., Thompson S., Hoffman J., Ying X., Williams B., Sanchez E., Akwani C., Kennedy R., Elhadi M., Griffee M., Mone M., Ciullo A., Kida Y., Roca R. F., Riera J. I., Contreras S., Alegre C., Kay C., Fischer I., Renner E., Taniguci H., Lee J., Plotkin D., Citarella B. W., Merson L., Hartley E., Lubis B., Ikeyama T., Alhamad A., Fathi M., Hadhoud M. M., Alhouri H., Mechi A., Alyasiri M. S., Elsaid M. Z. A., Shahla H., Bhaskar B., Jung J. -S., McGuinness S., Eastwood G., Marta S. R., Guarracino F., Gerle S., Coxon E., Claro B., Eleisawy M., Osama H., Loverde D., Patil N., Parrini V., McBride A., Negaard K., Ratsch A., Uribe J. D., Peris A., Sanders M., Emerson D., Kamal M., Faida H., Povoa P., Francis R., Cherif A., Joseph S., Di Nardo M., Heard M., Kyle K., Blackwell R. A., Ouyahia A., Biston P., Jeong H. W., Smith R., Prawira Y., Garcia A. H., Salterain N., Meyns B., Elnasser M., Moreno M., Walia R., Mehta A., Schweda A., Williams M., EmadAmkhatirah, Kim K. H., Assad A., Giraldo E., Karolak W., Balik M., Pocock E., Gajkowski E., Masafumi K., Barrett N., Takeyama Y., Park S., Amin F., Andriyani F. M., Sudakevych S., Schnur J., Vera M., Cornejo R., Schwarz P., Mardini A. C., de Paula T., Neto A. S., Villoldo A., Colafranceschi A. S., Iglesias A. U., Granjean J., Melro L. M. G., Romualdo G. F., Gaia D., Souza H., Galas F., Mendiluce R. M., Sosa A., Martinez I., Kurosawa H., Almoshantaf M. B., Salgado J., Hugi-Mayr B., Charbonneau E., Barzilai V. S., Monteiro V., de Souza R. R., Harper M., Siddig N., Suzuki H., Adams C., Brieva J., Khamees A., Graige F., Supriatna M., Nyale G., Eltatar F. S., Fatani J., Baeissa H., Masri A. A. L., Rabie A., Hui M. Y., Yamane M., Jung H., Margaret A. M., Nacpil N., Ruck K., Bakken R., Jara C., Felton T., Tharwat S., Berra L., Shah B., Chakraborty A., Cardona M., Capatos G., Akkanti B., Orija A., Jain H., Ito A., Muftah M., Housni B., Aldhalia A., Low S., Iihara K., Chavez J., Ramanathan K., Naidoo K., Seppelt I., VanDyk M., MacDonald S., Hafez W., McGregor R., Siebenaler T., Flynn H., Lofton K., Aokage T., Kvirkvelia B., Shigemitsu K., Moscatelli A., Fiorentino G., Baumgaertel M., Mba S. E., Assy J., Hutahaean A., Roush H., Sichting K. A., Alessandri F., Burns D., Alkhubouli T. H., Nasrallah A., Salt G., Garabedian C. P., Millar J., Sim M., Mattke A., McAuley D., Tadili J., Frenzel T., Bar-Lavie Y., Ortiz A. B., Stone J., Attokaran A., Farquharson M., Patel B., Gunning D., Baillie K., Adem S., Watson P., Tamai K., Sajinadiyasa G. K., Kanyawati D., Salgado M., Sassine A., Yudo B., McCaul S., Lee B., Lee S. M., Afek A., Iwashita Y., Fadlalmola H., Semedi B. P., Mansour N. M., Metiva J., Van Belle N., Martin-Loeches I., Al-Sadawi M., Kirakli C., Shimaa A. -T., Abdurraouf A., Ivatt L., Moharam S., Woon C. Y., Kang H. M., Smith T., James E., Al-Rawas N., Almjersah A., Iwasaki Y., Ashour H., Embarek H., King-Chung K. C., Gudzenko V., Taccone F., Perdhana F., Lamarche Y., Ribeiro J. M., Bradic N., Van den Bossche K., Lansink O., Singh G., Debeuckelaere G., Stelfox H. T., Yi C., Elia J., Tribble T., Shankar S., Padmanabhan R., Hallinan B., Paoletti L., Leyva Y., Fykuda T., Badulak J., Koch J., Janowaik L., Hackman A., Hernandez D., Osofsky J., Donadello K., Lawang A., Fine J., Davidson B., Vazquez A. O. R., and Abdehaleem I.
Abstract: Following publication of the original article [1], the authors identified that the collaborating authors part of the collaborating author group CCCC Consortium was missing. The collaborating author group is available and included as Additional file 1 in this article.
Published: 2023

4. Association of ventilator-free days with respiratory physiotherapy in critically ill patients with Coronavirus Disease 2019 (COVID-19) during the first pandemic wave. A propensity score-weighted analysis

Author: Privitera, E, Gambazza, S, Rossi, V, Santambrogio, M, Binda, F, Tarello, D, Caiffa, S, Turrin, V, Casagrande, C, Battaglini, D, Panigada, M, Fumagalli, R, Pelosi, P, Grasselli, G, Privitera E., Gambazza S., Rossi V., Santambrogio M., Binda F., Tarello D., Caiffa S., Turrin V., Casagrande C., Battaglini D., Panigada M., Fumagalli R., Pelosi P., Grasselli G., Privitera, E, Gambazza, S, Rossi, V, Santambrogio, M, Binda, F, Tarello, D, Caiffa, S, Turrin, V, Casagrande, C, Battaglini, D, Panigada, M, Fumagalli, R, Pelosi, P, Grasselli, G, Privitera E., Gambazza S., Rossi V., Santambrogio M., Binda F., Tarello D., Caiffa S., Turrin V., Casagrande C., Battaglini D., Panigada M., Fumagalli R., Pelosi P., and Grasselli G.
Abstract: Background: Respiratory physiotherapy is reported as safe and feasible in mechanically ventilated patients with severe Coronavirus Disease (COVID-19) admitted to Intensive Care Unit (ICU), but the short-term benefits remain unclear. Methods: We performed a retrospective observational study in four ICUs in Northern Italy. All patients with COVID-19 admitted to ICU and under invasive mechanical ventilation (MV) between March 1st and May 30th, 2020, were enrolled into the study. Overlap weighting based on the propensity score was used to adjust for confounding in the comparison of patients who had or had not been treated by physiotherapists. The primary outcome was the number of days alive and ventilator-free (VFDs). The secondary outcomes were arterial partial pressure of oxygen (PaO2)/fraction of inspired oxygen (FiO2) ratio (P/F) at ICU discharge, ICU length of stay, ICU and hospital mortality, and survival at 90 days. The trial protocol was registered on clinicaltrials.gov (NCT 05067907). Results: A total of 317 patients were included in the analysis. The median VFDs was 18 days [interquartile range (IQR) 10; 24] in patients performing physiotherapy and 21 days (IQR 0; 26) in the group without physiotherapy [incidence rate ratio (IRR) 0.86, 95% confidence interval (CI): 0.78; 0.95]. The chance of 0 VFDs was lower for patients treated by physiotherapists compared to those who were not [odds ratio (OR) = 0.36, 95% CI: 0.18–0.71]. Survival at 90 days was 96.0% in the physiotherapy group and 70.6% in patients not performing physiotherapy [hazard ratio (HR) = 0.14, 95% CI: 0.03–0.71]. Number of VFDs was not associated with body mass index (BMI), sex, or P/F at ICU admission for individuals with at least 1 day off the ventilator. Conclusion: In patients with COVID-19 admitted to ICU during the first pandemic wave and treated by physiotherapists, the number of days alive and free from MV was lower compared to patients who did not perform respiratory physiotherapy. Surviva
Published: 2022

5. Myelomonocytic cells in giant cell arteritis activate trained immunity programs sustaining inflammation and cytokine production

Author: Cantoni, E, Merelli, I, Stefanoni, D, Tomelleri, A, Campochiaro, C, Giordano, V, Panigada, M, Baldissera, E, Merlo Pich, L, Natoli, V, Ziogas, A, Domínguez-Andrés, J, De Luca, G, Mazza, D, Zambrano, S, Gnani, D, Ferrarini, M, Ferrero, E, Agresti, A, Vergani, B, Leone, B, Cenci, S, Ravelli, A, Matucci-Cerinic, M, D'Alessandro, A, Joosten, L, Dagna, L, Netea, M, Molteni, R, Cavalli, G, Cantoni, Eleonora, Merelli, Ivan, Stefanoni, Davide, Tomelleri, Alessandro, Campochiaro, Corrado, Giordano, Vito, Panigada, Maddalena, Baldissera, Elena M, Merlo Pich, Laura, Natoli, Valentina, Ziogas, Athanasios, Domínguez-Andrés, Jorge, De Luca, Giacomo, Mazza, Davide, Zambrano, Samuel, Gnani, Daniela, Ferrarini, Marina, Ferrero, Elisabetta, Agresti, Alessandra, Vergani, Barbara, Leone, Biagio Eugenio, Cenci, Simone, Ravelli, Angelo, Matucci-Cerinic, Marco, D'Alessandro, Angelo, Joosten, Leo A B, Dagna, Lorenzo, Netea, Mihai G, Molteni, Raffaella, Cavalli, Giulio, Cantoni, E, Merelli, I, Stefanoni, D, Tomelleri, A, Campochiaro, C, Giordano, V, Panigada, M, Baldissera, E, Merlo Pich, L, Natoli, V, Ziogas, A, Domínguez-Andrés, J, De Luca, G, Mazza, D, Zambrano, S, Gnani, D, Ferrarini, M, Ferrero, E, Agresti, A, Vergani, B, Leone, B, Cenci, S, Ravelli, A, Matucci-Cerinic, M, D'Alessandro, A, Joosten, L, Dagna, L, Netea, M, Molteni, R, Cavalli, G, Cantoni, Eleonora, Merelli, Ivan, Stefanoni, Davide, Tomelleri, Alessandro, Campochiaro, Corrado, Giordano, Vito, Panigada, Maddalena, Baldissera, Elena M, Merlo Pich, Laura, Natoli, Valentina, Ziogas, Athanasios, Domínguez-Andrés, Jorge, De Luca, Giacomo, Mazza, Davide, Zambrano, Samuel, Gnani, Daniela, Ferrarini, Marina, Ferrero, Elisabetta, Agresti, Alessandra, Vergani, Barbara, Leone, Biagio Eugenio, Cenci, Simone, Ravelli, Angelo, Matucci-Cerinic, Marco, D'Alessandro, Angelo, Joosten, Leo A B, Dagna, Lorenzo, Netea, Mihai G, Molteni, Raffaella, and Cavalli, Giulio
Abstract: Objective: Trained immunity (TI) is a de facto memory program of innate immune cells, characterized by immunometabolic and epigenetic changes sustaining enhanced production of cytokines. TI evolved as a protective mechanism against infections; however, inappropriate activation can cause detrimental inflammation and might be implicated in the pathogenesis of chronic inflammatory diseases. In this study, we investigated the role of TI in the pathogenesis of giant cell arteritis (GCA), a large-vessel vasculitis characterized by aberrant macrophage activation and excess cytokine production. Methods: Monocytes from GCA patients and from age- and sex-matched healthy donors were subjected to polyfunctional studies, including cytokine production assays at baseline and following stimulation, intracellular metabolomics, chromatin immunoprecipitation-qPCR, and combined ATAC/RNA sequencing. Immunometabolic activation (i.e. glycolysis) was assessed in inflamed vessels of GCA patients with FDG-PET and immunohistochemistry (IHC), and the role of this pathway in sustaining cytokine production was confirmed with selective pharmacologic inhibition in GCA monocytes. Results: GCA monocytes exhibited hallmark molecular features of TI. Specifically, these included enhanced IL-6 production upon stimulation, typical immunometabolic changes (e.g. increased glycolysis and glutaminolysis) and epigenetic changes promoting enhanced transcription of genes governing pro-inflammatory activation. Immunometabolic changes of TI (i.e. glycolysis) were a feature of myelomonocytic cells in GCA lesions and were required for enhanced cytokine production. Conclusions: Myelomonocytic cells in GCA activate TI programs sustaining enhanced inflammatory activation with excess cytokine production.
Published: 2023

6. Long-Term Impact in Intensive Care Survivors of Coronavirus Disease-19 (AFTERCOR Study): Preliminary 3-Month Analysis After ICU Discharge

Author: Wildi, K., primary, LiBassi, G., additional, McNicholas, B., additional, Rainieri, F., additional, Forsyth, S., additional, Cho, S.-M., additional, Motos, A., additional, Cabrera, R., additional, Barnett, A., additional, Panigada, M., additional, Colombo, S., additional, Matsuoka, A., additional, Ohshimo, S., additional, Bandera, A., additional, Laffey, J.G., additional, Muscatello, A., additional, Sheehan, J., additional, Battaglini, D., additional, Robba, C., additional, Torres, A., additional, Roche-Campo, F., additional, Luna, C.M., additional, Hodgson, C.L., additional, Burrell, A., additional, Buscher, H., additional, Salazar, L., additional, Mendoza Monsalve, M., additional, Chia, Y.W., additional, Dalton, H.J., additional, Choi, H.A., additional, Suen, J., additional, and Fraser, J., additional
Published: 2022
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7. Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis

Author: Bassi, G. Li, Gibbons, K., Suen, J.Y., Dalton, H.J., White, N., Corley, A., Shrapnel, S., Hinton, S., Forsyth, S., Laffey, J.G., Fan, E., Fanning, J.P., Panigada, M., Bartlett, R., Brodie, D., Burrell, A., Chiumello, D., Elhazmi, A., Esperatti, M., Grasselli, G., Hodgson, C., Ichiba, S., Luna, C., Marwali, E., Merson, L., Murthy, S., Nichol, A., Ogino, M., Pelosi, P., Torres, A. Cedillo, Frenzel, T., Ng, P.Y., Fraser, J.F., Bassi, G. Li, Gibbons, K., Suen, J.Y., Dalton, H.J., White, N., Corley, A., Shrapnel, S., Hinton, S., Forsyth, S., Laffey, J.G., Fan, E., Fanning, J.P., Panigada, M., Bartlett, R., Brodie, D., Burrell, A., Chiumello, D., Elhazmi, A., Esperatti, M., Grasselli, G., Hodgson, C., Ichiba, S., Luna, C., Marwali, E., Merson, L., Murthy, S., Nichol, A., Ogino, M., Pelosi, P., Torres, A. Cedillo, Frenzel, T., Ng, P.Y., and Fraser, J.F.
Abstract: Contains fulltext : 252076.pdf (Publisher’s version ) (Open Access), BACKGROUND: The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate in COVID-19 patients with moderate-to-severe ARDS the impact of early use of NMBAs on 90-day mortality, through propensity score (PS) matching analysis. METHODS: We analyzed a convenience sample of patients with COVID-19 and moderate-to-severe ARDS, admitted to 244 intensive care units within the COVID-19 Critical Care Consortium, from February 1, 2020, through October 31, 2021. Patients undergoing at least 2 days and up to 3 consecutive days of NMBAs (NMBA treatment), within 48 h from commencement of IMV were compared with subjects who did not receive NMBAs or only upon commencement of IMV (control). The primary objective in the PS-matched cohort was comparison between groups in 90-day in-hospital mortality, assessed through Cox proportional hazard modeling. Secondary objectives were comparisons in the numbers of ventilator-free days (VFD) between day 1 and day 28 and between day 1 and 90 through competing risk regression. RESULTS: Data from 1953 patients were included. After propensity score matching, 210 cases from each group were well matched. In the PS-matched cohort, mean (± SD) age was 60.3 ± 13.2 years and 296 (70.5%) were male and the most common comorbidities were hypertension (56.9%), obesity (41.1%), and diabetes (30.0%). The unadjusted hazard ratio (HR) for death at 90 days in the NMBA treatment vs control group was 1.12 (95% CI 0.79, 1.59, p = 0.534). After adjustment for smoking habit and critical therapeutic covariates, the HR was 1.07 (95% CI 0.72, 1.61, p = 0.729). At 28 days, VFD were 16 (IQR 0-25) and 25 (IQR 7-26) in the NMBA treatment and control groups, respectively (sub-hazard ratio 0.82, 95% CI 0.67, 1.00, p = 0.055). At 90 days, VFD were 77 (IQR 0-87) and 87 (IQR 0-88) (sub-hazard ratio 0.86 (95% CI 0.69, 1.07; p = 0.177). CONCLUSIONS: In p
Published: 2022

8. ESICM LIVES 2016: part one: Milan, Italy. 1-5 October 2016

Author: Bos, L., Schouten, L., van Vught, L., Wiewel, M., Ong, D., Cremer, O., Artigas, A., Martin-Loeches, I., Hoogendijk, A., van der Poll, T., Horn, J., Juffermans, N., Schultz, M., de Prost, N., Pham, T., Carteaux, G., Dessap, A. Mekontso, Brun-Buisson, C., Fan, E., Bellani, G., Laffey, J., Mercat, A., Brochard, L., Maitre, B., Howells, P. A., Thickett, D. R., Knox, C., Park, D. P., Gao, F., Tucker, O., Whitehouse, T., McAuley, D. F., Perkins, G. D., Pham, T., Laffey, J., Bellani, G., Fan, E., Pisani, L., Roozeman, J. P., Simonis, F. D., Giangregorio, A., Schouten, L. R., Van der Hoeven, S. M., Horn, J., Neto, A. Serpa, Festic, E., Dondorp, A. M., Grasso, S., Bos, L. D., Schultz, M. J., Koster-Brouwer, M., Verboom, D., Scicluna, B., van de Groep, K., Frencken, J., Schultz, M., van der Poll, T., Bonten, M., Cremer, O., Ko, J. I., Kim, K. S., Suh, G. J., Kwon, W. Y., Kim, K., Shin, J. H., Ranzani, O. T., Prina, E., Menendez, R., Ceccato, A., Mendez, R., Cilloniz, C., Gabarrus, A., Ferrer, M., Torres, A., Urbano, A., Zhang, L. A., Swigon, D., Pike, F., Parker, R. S., Clermont, G., Scheer, C., Kuhn, S. O., Modler, A., Vollmer, M., Fuchs, C., Hahnenkamp, K., Rehberg, S., Gründling, M., Taggu, A., Darang, N., Öveges, N., László, I., Tánczos, K., Németh, M., Lebák, G., Tudor, B., Érces, D., Kaszaki, J., Huber, W., Trásy, D., Molnár, Z., Ferrara, G., Edul, V. S. Kanoore, Canales, H. S., Martins, E., Canullán, C., Murias, G., Pozo, M. O., Eguillor, J. F. Caminos, Buscetti, M. G., Ince, C., Dubin, A., Aya, H. D., Rhodes, A., Fletcher, N., Grounds, R. M., Cecconi, M., Jacquet-Lagrèze, M., Riche, M., Schweizer, R., Portran, P., Fornier, W., Lilot, M., Neidecker, J., Fellahi, J. L., Escoresca-Ortega, A., Gutiérrez-Pizarraya, A., Charris-Castro, L., Corcia-Palomo, Y., Fernandez-Delgado, E., Garnacho-Montero, J., Roger, C., Muller, L., Elotmani, L., Lipman, J., Lefrant, J. Y., Roberts, J. A., Muñoz-Bermúdez, R., Samper, M., Climent, C., Vasco, F., Sara, V., Luque, S., Campillo, N., Cerrato, S. Grau, Masclans, J. R., Alvarez-Lerma, F., Brugger, S. Carvalho, Jimenez, G. Jimenez, Torner, M. Miralbés, Cabello, J. Trujillano, Garrido, B. Balsera, Casals, X. Nuvials, Gaite, F. Barcenilla, Vidal, M. Vallverdú, Martínez, M. Palomar, Gusarov, V., Shilkin, D., Dementienko, M., Nesterova, E., Lashenkova, N., Kuzovlev, A., Zamyatin, M., Demoule, A., Carreira, S., Lavault, S., Palancca, O., Morawiec, E., Mayaux, J., Arnulf, I., Similowski, T., Rasmussen, B. S., Maltesen, R. G., Hanifa, M., Pedersen, S., Kristensen, S. R., Wimmer, R., Panigada, M., Bassi, G. Li, Ranzani, O. T., Kolobow, T., Zanella, A., Cressoni, M., Berra, L., Parrini, V., Kandil, H., Salati, G., Livigni, S., Amatu, A., Andreotti, A., Tagliaferri, F., Moise, G., Mercurio, G., Costa, A., Vezzani, A., Lindau, S., Babel, J., Cavana, M., Consonni, D., Pesenti, A., Gattinoni, L., Torres, A., Mansouri, P., Zand, F., Zahed, L., Dehghanrad, F., Bahrani, M., Ghorbani, M., Cambiaghi, B., Moerer, O., Mauri, T., Kunze-Szikszay, N., Ritter, C., Pesenti, A., Quintel, M., Vilander, L. M., Kaunisto, M. A., Vaara, S. T., Pettilä, V., Mulier, J. L. G. Haitsma, Rozemeijer, S., Spoelstra-de Man, A. M. E., Elbers, P. E., Tuinman, P. R., de Waard, M. C., Oudemans-van Straaten, H. M., Liberatore, A. M. A., Souza, R. B., Martins, A. M. C. R. P. F., Vieira, J. C. F., Koh, I. H. J., Martínez, M. Galindo, Sánchez, R. Jiménez, Gascón, L. Martínez, Mulero, M. D. Rodríguez, Freire, A. Ortín, Muñoz, A. Ojados, Acebes, S. Rebollo, Martínez, Á. Fernández, Aliaga, S. Moreno, Para, L. Herrera, Payá, J. Murcia, Mulero, F. Rodríguez, Guerci, P., Ince, Y., Heeman, P., Ergin, B., Ince, C., Uz, Z., Massey, M., Ince, Y., Papatella, R., Bulent, E., Guerci, P., Toraman, F., Ince, C., Longbottom, E. R., Torrance, H. D., Owen, H. C., Hinds, C. J., Pearse, R. M., O’Dywer, M. J., Trogrlic, Z., van der Jagt, M., Lingsma, H., Ponssen, H. H., Schoonderbeek, J. F., Schreiner, F., Verbrugge, S. J., Duran, S., van Achterberg, T., Bakker, J., Gommers, D. A. M. P. J., Ista, E., Krajčová, A., Waldauf, P., Duška, F., Shah, A., Roy, N., McKechnie, S., Doree, C., Fisher, S., Stanworth, S. J., Jensen, J. F., Overgaard, D., Bestle, M. H., Christensen, D. F., Egerod, I., Pivkina, A., Gusarov, V., Zhivotneva, I., Pasko, N., Zamyatin, M., Jensen, J. F., Egerod, I., Bestle, M. H., Christensen, D. F., Alklit, A., Hansen, R. L., Knudsen, H., Grode, L. B., Overgaard, D., Hravnak, M., Chen, L., Dubrawski, A., Clermont, G., Pinsky, M. R., Parry, S. M., Knight, L. D., Connolly, B. C., Baldwin, C. E., Puthucheary, Z. 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L., Mebazaa, A., Hartmann, J., Harm, S., and Weber, V.
Published: 2016
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9. Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis

Author: Li Bassi, G., Gibbons, K., Suen, J. Y., Dalton, H. J., White, N., Corley, A., Shrapnel, S., Hinton, S., Forsyth, S., Laffey, J. G., Fan, E., Fanning, J. P., Panigada, M., Bartlett, R., Brodie, D., Burrell, A., Chiumello, D., Elhazmi, A., Esperatti, M., Grasselli, G., Hodgson, C., Ichiba, S., Luna, C., Marwali, E., Merson, L., Murthy, S., Nichol, A., Ogino, M., Pelosi, P., Torres, A., P. Y., Ng, Fraser, J. F., Al-Dabbous, T., Alfoudri, H., Shamsah, M., Elapavaluru, S., Berg, A., Horn, C., Mayasi, Y., Schroll, S., Meyer, D., Velazco, J., Ploskanych, L., Fikes, W., Bagewadi, R., Dao, M., White, H., Ehlers, A., Shalabi-McGuire, M., Witt, T., Grazioli, L., Lorini, L., Grandin, E. W., Nunez, J., Reyes, T., Obriain, D., Hunter, S., Ramanan, M., Affleck, J., Veerendra, H. H., Rai, S., Russell-Brown, J., Nourse, M., Joseph, M., Mitchell, B., Tenzer, M., Abe, R., Cho, H. J., Jeong, I. S., Rahman, N., Kakar, V., Brozzi, N., Mehkri, O., Krishnan, S., Duggal, A., Houltham, S., Graf, J., Diaz, R., Orrego, R., Delgado, C., Gonzalez, J., Sanchez, M. S., Piagnerelli, M., Sarrazin, J. V., Zabert, A. /P. G., Espinosa, L., Delgado, P., Delgado, V., Rincon, D. F. B., Yanten, A. M. M., Duque, M. B., Al-Hudaib, A., Callahan, M., Taufik, M. A., Wardoyo, E. Y., Gunawan, M., Trisnaningrum, N. S., Irawany, V., Rayhan, M., Pesenti, A., Zanella, A., Leone, M., Coppola, S., Colombo, S., Antonelli, M., Carelli, S., Grieco, D. L., Asaki, M., Hoshino, K., Salazar, L., Duarte, L., Laffey, J., Mcnicholas, B., Cosgrave, D., Mccaffrey, J., Bone, A., Hakeem, Y., Winearls, J., Tallott, M., Thomson, D., Arnold-Day, C., Cupido, J., Fanie, Z., Miller, M., Seymore, L., van Straaten, D., Hssain, A. A., Aliudin, J., Alqahtani, A. -R., Mohamed, K., Mohamed, A., Tan, D., Villanueva, J., Zaqout, A., Kurtzman, E., Ademi, A., Dobrita, A., El Aoudi, K., Segura, J., Giwangkancana, G., Ohshimo, S., Hitoshi, S., Osatnik, J., Joosten, A., Yang, M., Motos, A., Arancibia, F., Williams, V., Noel, A., Luque, N., Trung, T. H., Yacoub, S., Fantini, M., Garcia, R. N. J., Alvarez, E. C., Greti, A., Ceccato, A., Sanchez, A., Vazquez, A. L., Roche-Campo, F., Franch-Llasat, D., Tuazon, D., Amato, M., Cassimiro, L., Pola, F., Ribeiro, F., Fonseca, G., Dalton, H., Desai, M., Osborn, E., Deeb, H., Arcadipane, A., Martucci, G., Panarello, G., Vitiello, C., Bianco, C., Occhipinti, G., Rossetti, M., Cuffaro, R., Cho, S. -M., Shimizu, H., Moriyama, N., Kim, J. -B., Kitamura, N., Gebauer, J., Yokoyama, T., Al-Fares, A., Buabbas, S., Alamad, E., Alawadhi, F., Alawadi, K., Tanaka, H., Hashimoto, S., Yamazaki, M., T. -H., Oh, Epler, M., Forney, C., Kruse, L., Feister, J., Williamson, J., Grobengieser, K., Gnall, E., Golden, S., Caroline, M., Shapiro, T., Karaj, C., Thome, L., Sher, L., Vanderland, M., Welch, M., Mcdermott, S., Brain, M., Mineall, S., Kimura, D., Brazzi, L., Sales, G., Ogston, T., Nagpal, D., Fischer, K., Lorusso, R., Rangappa, R., Appu, A., Carton, E. G., Sen, A., Palacios, A., Rainey, D., Samoukoviv, G., Campisi, J., Durham, L., Neumann, E., Seefeldt, C., Falcucci, O., Emmrich, A., Guy, J., Johns, C., Potzner, K., Zimmermann, C., Espinal, A., Buchtele, N., Schwameis, M., Stecher, S. -S., Singh, D., Barnikel, M., Arenz, L., Zaaqoq, A., Galloway, L. A., Merley, C., Csete, M., Quesada, L., Saba, I., Kasugai, D., Hiraiwa, H., Tanaka, T., Purnama, Y., Dewayanti, S. R., Ardiyan, Juzar, D. A., Siagian, D., Chen, Y. -S., Ratsep, I., Oigus, G., Erikson, K., Post, A. -M., Enneveer, L., Sillaots, P., Manetta, F., Mihelis, E., Sarmiento, I. C., Narasimhan, M., Varrone, M., Komats, M., Garcia-Diaz, J., Harmon, C., Satyapriya, S. V., Bhatt, A., Mokadam, N. A., Uribe, A., Gonzalez, A., Shi, H., Mckeown, J., Pasek, J., Fiorda, J., Echeverria, M., Moreno, R., Zakhary, B., Cavana, M., Cucino, A., Foti, G., Giani, M., Russotto, V., Castagna, V., Dellamore, A., Navalesi, P., Shum, H. -P., Vuysteke, A., Usman, A., Acker, A., Smood, B., Mergler, B., Sertic, F., Subramanian, M., Sperry, A., Rizer, N., Burhan, E., Rasmin, M., Akmal, E., Sitompul, F., Lolong, N., Naivedh, B., Erickson, S., Barrett, P., Dean, D., Daugherty, J., Loforte, A., Khan, I., Abraar Quraishi, M., Desantis, O., So, D., Kandamby, D., Mandei, J. M., Natanael, H., Yudhalantang, E., Lantang, A., Wijaya, S. O., Jung, A., Ng, G., W. Y., Ng, Fang, S., Tabah, A., Ratcliffe, M., Duroux, M., Adachi, S., Nakao, S., Blanco, P., Prieto, A., Sanchez, J., Nicholson, M., Butt, W., Serratore, A., Delzoppo, C., Janin, P., Yarad, E., Totaro, R., Coles, J., Pujo, B., Balk, R., Vissing, A., Kapania, E., Hays, J., Fox, S., Yantosh, G., Mishin, P., Yuliarto, S., Hari Santoso, K., Djajalaksana, S., Fatoni, A. Z., Fukuda, M., Liu, K., Battaglini, D., Jimenez, J. F. M., Bastos, D., Gaiao, S., Rusmawatiningtyas, D., Buchner, J., Cho, Y. -J., Lee, S. H., Kawasaki, T., Munshi, L., Sakiyalak, P., Nitayavardhana, P., Seitz, T., Arora, R., Kent, D., Marino, D., Parwar, S., Cheng, A., Miller, J., Fujitani, S., Shimizu, N., Madhok, J., Owyang, C., Buscher, H., Reynolds, C., Maasikas, O., Beljantsev, A., Mihnovits, V., Akimoto, T., Aizawa, M., Horibe, K., Onodera, R., Young, M., George, T., Shekar, K., Mcguinness, N., Irvine, L., Flynn, B., Endo, T., Sugiyama, K., Shimizu, K., Exconde, K., Lussier, L., Lotz, G., Malfertheiner, M., Maier, L., Dreier, E., Kusumastuti, N. P., Mccloskey, C., Dabaliz, A. -A., Elshazly, T. B., Smith, J., Szuldrzynski, K. S., Bielanski, P., Wille, K., Parhar, K. K. S., Fiest, K. M., Codan, C., Shahid, A., Fayed, M., Evans, T., Garcia, R., Gutierrez, A., Song, T., Rose, R., Bennett, S., Richardson, D., Peek, G., Arora, L., Rappapport, K., Rudolph, K., Sibenaller, Z., Stout, L., Walter, A., Herr, D., Vedadi, N., Thompson, S., Sindt, L., Rajnic, S., Ewald, C., Hoffman, J., Ying, X., Kennedy, R., Griffee, M., Ciullo, A., Kida, Y., Roca, R. F., Riera, J. I., Contreras, S., Alegre, C., Kay, C., Fischer, I., Renner, E., Taniguci, H., Fraser, J., Bassi, G. L., Suen, J., Barnett, A., Pearse, I., Abbate, G., Hassan, H., Heinsar, S., Karnik, V. A., Ki, K., Oneill, H. F., Obonyo, N., Pimenta, L. P., Reid, J. D., Sato, K., Vuorinen, A., Wildi, K. S., Wood, E. S., Yerkovich, S., Lee, J., Plotkin, D., Citarella, B. W., Hartley, E., Lubis, B., Ikeyama, T., Bhaskar, B., Jung, J. -S., Mcguinness, S., Eastwood, G., Marta, S. R., Guarracino, F., Gerle, S., Coxon, E., Claro, B., Loverde, D., Patil, N., Parrini, V., Mcbride, A., Negaard, K., Ratsch, A., Abdelaziz, A., Uribe, J. D., Peris, A., Sanders, M., Emerson, D., Kamal, M., Povoa, P., Francis, R., Cherif, A., Joseph, S., Di Nardo, M., Heard, M., Kyle, K., Blackwell, R. A., Biston, P., Jeong, H. W., Smith, R., Prawira, Y., Montrucchio, G., Garcia, A. H., Salterain, N., Meyns, B., Moreno, M., Walia, R., Mehta, A., Schweda, A., Supriatna, M., Kirakli, C., Williams, M., Kim, K. H., Assad, A., Giraldo, E., Karolak, W., Balik, M., Pocock, E., Gajkowski, E., Masafumi, K., Barrett, N., Takeyama, Y., Park, S., Amin, F., Andriyani, F. M., Sudakevych, S., Vera, M., Cornejo, R., Schwarz, P., Mardini, A. C., de Paula, T., Neto, A. S., Villoldo, A., Colafranceschi, A. S., Iglesias, A. U., Granjean, J., Melro, L. M. G., Romualdo, G. F., Gaia, D., Souza, H., Galas, F., Mendiluce, R. M., Sosa, A., Martinez, I., Kurosawa, H., Salgado, J., Hugi-MayrCharbonneau, B. E., Barzilai, V. S., Monteiro, V., de Souza, R. R., Harper, M., Suzuki, H., Adams, C., Brieva, J., Nyale, G., Eltatar, F. S., Fatani, J., Baeissa, H., Masri, A. A., Rabie, A., Hui, M. Y., Yamane, M., Jung, H., Margaret, A. M., Nacpil, N., Ruck, K., Bakken, R., Jara, C., Felton, T., Berra, L., Shah, B., Chakraborty, A., Cardona, M., Capatos, G., Akkanti, B., Orija, A., Jain, H., Ito, A., Housni, B., Low, S., Iihara, K., Chavez, J., Ramanathan, K., Zabert, G., Naidoo, K., Seppelt, I., Vandyk, M., Macdonald, S., Mcgregor, R., Siebenaler, T., Flynn, H., Lofton, K., Aokage, T., Shigemitsu, K., Moscatelli, A., Fiorentino, G., Baumgaertel, M., Mba, S. E., Assy, J., Hutahaean, A., Roush, H., Sichting, K. A., Alessandri, F., Burns, D., Salt, G., Garabedian, C. P., Millar, J., Sim, M., Mattke, A., Mcauley, D., Tadili, J., Frenzel, T., Bar-Lavie, Y., Ortiz, A. B., Stone, J., Attokaran, A., Farquharson, M., Patel, B., Gunning, D., Baillie, K., Watson, P., Tamai, K., Sajinadiyasa, G. K., Kanyawati, D., Salgado, M., Sassine, A., Yudo, B., Mccaul, S., Lee, B., Lee, S. M., Afek, A., Iwashita, Y., Semedi, B. P., Metiva, J., Van Belle, N., Martin-Loeches, I., Ivatt, L., Woon, C. Y., Kang, H. M., Smith, T., James, E., Al-Rawas, N., Iwasaki, Y., King-Chung, K. C., Gudzenko, V., Hugi-Mayr, B., Taccone, F., Perdhana, F., Lamarche, Y., Ribeiro, J. M., Bradic, N., Van den Bossche, K., Lansink, O., Singh, G., Debeuckelaere, G., Stelfox, H. T., Yi, C., Elia, J., Tribble, T., Shankar, S., Padmanabhan, R., Hallinan, B., Paoletti, L., Leyva, Y., Fykuda, T., Badulak, J., Koch, J., Hackman, A., Janowaik, L., Hernandez, D., Osofsky, J., Donadello, K., Lawang, A., Fine, J., Davidson, B., Vazquez, A. O. R., COVID-19 Critical Care Consortium, and Consortium, COVID-19 Critical Care
Subjects: Male, Respiratory Distress Syndrome, COVID-19, Intensive care unit, Mechanical ventilation, Neuromuscular blocking agent, SARS-CoV-2, Aged, Female, Humans, Intensive Care Units, Middle Aged, Propensity Score, Respiration, Artificial, Neuromuscular Blocking Agents, Respiration, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Settore MED/41 - Anestesiologia, Critical Care and Intensive Care Medicine, COVID-19 Drug Treatment, Artificial, Human medicine
Abstract: Background The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate in COVID-19 patients with moderate-to-severe ARDS the impact of early use of NMBAs on 90-day mortality, through propensity score (PS) matching analysis. Methods We analyzed a convenience sample of patients with COVID-19 and moderate-to-severe ARDS, admitted to 244 intensive care units within the COVID-19 Critical Care Consortium, from February 1, 2020, through October 31, 2021. Patients undergoing at least 2 days and up to 3 consecutive days of NMBAs (NMBA treatment), within 48 h from commencement of IMV were compared with subjects who did not receive NMBAs or only upon commencement of IMV (control). The primary objective in the PS-matched cohort was comparison between groups in 90-day in-hospital mortality, assessed through Cox proportional hazard modeling. Secondary objectives were comparisons in the numbers of ventilator-free days (VFD) between day 1 and day 28 and between day 1 and 90 through competing risk regression. Results Data from 1953 patients were included. After propensity score matching, 210 cases from each group were well matched. In the PS-matched cohort, mean (± SD) age was 60.3 ± 13.2 years and 296 (70.5%) were male and the most common comorbidities were hypertension (56.9%), obesity (41.1%), and diabetes (30.0%). The unadjusted hazard ratio (HR) for death at 90 days in the NMBA treatment vs control group was 1.12 (95% CI 0.79, 1.59, p = 0.534). After adjustment for smoking habit and critical therapeutic covariates, the HR was 1.07 (95% CI 0.72, 1.61, p = 0.729). At 28 days, VFD were 16 (IQR 0–25) and 25 (IQR 7–26) in the NMBA treatment and control groups, respectively (sub-hazard ratio 0.82, 95% CI 0.67, 1.00, p = 0.055). At 90 days, VFD were 77 (IQR 0–87) and 87 (IQR 0–88) (sub-hazard ratio 0.86 (95% CI 0.69, 1.07; p = 0.177). Conclusions In patients with COVID-19 and moderate-to-severe ARDS, short course of NMBA treatment, applied early, did not significantly improve 90-day mortality and VFD. In the absence of definitive data from clinical trials, NMBAs should be indicated cautiously in this setting.
Published: 2022
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10. Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease.

Author: Molteni, R., Biavasco, R., Stefanoni, D., Nemkov, T., Dominguez Andres, J., Arts, R.J.W., Merelli, I., Mazza, D., Zambrano, S., Panigada, M., Cantoni, E., Tengesdal, I.W., Maksud, P., Piras, F., Cesana, D., Cassina, L., Distefano, G., Loffreda, A., Gnani, D., Luca, G. De, Tomelleri, A., Campochiaro, C., Joosten, L.A.B., Dinarello, C.A., Kajaste-Rudnitski, A., Haroche, J., Cardaci, S., Cenci, S., Dagna, L., Doglioni, C., Ferrarini, M., Ferrero, E., Boletta, A., d'Alessandro, A., Montini, E., Netea, M.G., Cavalli, G.C., Molteni, R., Biavasco, R., Stefanoni, D., Nemkov, T., Dominguez Andres, J., Arts, R.J.W., Merelli, I., Mazza, D., Zambrano, S., Panigada, M., Cantoni, E., Tengesdal, I.W., Maksud, P., Piras, F., Cesana, D., Cassina, L., Distefano, G., Loffreda, A., Gnani, D., Luca, G. De, Tomelleri, A., Campochiaro, C., Joosten, L.A.B., Dinarello, C.A., Kajaste-Rudnitski, A., Haroche, J., Cardaci, S., Cenci, S., Dagna, L., Doglioni, C., Ferrarini, M., Ferrero, E., Boletta, A., d'Alessandro, A., Montini, E., Netea, M.G., and Cavalli, G.C.
Abstract: Item does not contain fulltext, Trained immunity (TI) is a proinflammatory program induced in monocyte/macrophages upon sensing of specific pathogens and is characterized by immunometabolic and epigenetic changes that enhance cytokine production. Maladaptive activation of TI (ie, in the absence of infection) may result in detrimental inflammation and development of disease; however, the exact role and extent of inappropriate activation of TI in the pathogenesis of human diseases is undetermined. In this study, we uncovered the oncogene-induced, maladaptive induction of TI in the pathogenesis of a human inflammatory myeloid neoplasm (Erdheim-Chester disease, [ECD]), characterized by the BRAFV600E oncogenic mutation in monocyte/macrophages and excess cytokine production. Mechanistically, myeloid cells expressing BRAFV600E exhibit all molecular features of TI: activation of the AKT/mammalian target of rapamycin signaling axis; increased glycolysis, glutaminolysis, and cholesterol synthesis; epigenetic changes on promoters of genes encoding cytokines; and enhanced cytokine production leading to hyperinflammatory responses. In patients with ECD, effective therapeutic strategies combat this maladaptive TI phenotype; in addition, pharmacologic inhibition of immunometabolic changes underlying TI (ie, glycolysis) effectively dampens cytokine production by myeloid cells. This study revealed the deleterious potential of inappropriate activation of TI in the pathogenesis of human inflammatory myeloid neoplasms and the opportunity for inhibition of TI in conditions characterized by maladaptive myeloid-driven inflammation.
Published: 2021

11. An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients.

Author: Li Bassi, G, Suen, JY, Dalton, HJ, White, N, Shrapnel, S, Fanning, JP, Liquet, B, Hinton, S, Vuorinen, A, Booth, G, Millar, JE, Forsyth, S, Panigada, M, Laffey, J, Brodie, D, Fan, E, Torres, A, Chiumello, D, Corley, A, Elhazmi, A, Hodgson, C, Ichiba, S, Luna, C, Murthy, S, Nichol, A, Ng, PY, Ogino, M, Pesenti, A, Trieu, HT, Fraser, JF, COVID-19 Critical Care Consortium, Li Bassi, G, Suen, JY, Dalton, HJ, White, N, Shrapnel, S, Fanning, JP, Liquet, B, Hinton, S, Vuorinen, A, Booth, G, Millar, JE, Forsyth, S, Panigada, M, Laffey, J, Brodie, D, Fan, E, Torres, A, Chiumello, D, Corley, A, Elhazmi, A, Hodgson, C, Ichiba, S, Luna, C, Murthy, S, Nichol, A, Ng, PY, Ogino, M, Pesenti, A, Trieu, HT, Fraser, JF, and COVID-19 Critical Care Consortium
Abstract: BACKGROUND: Heterogeneous respiratory system static compliance (CRS) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported in previous small-case series or studies conducted at a national level. METHODS: We designed a retrospective observational cohort study with rapid data gathering from the international COVID-19 Critical Care Consortium study to comprehensively describe CRS-calculated as: tidal volume/[airway plateau pressure-positive end-expiratory pressure (PEEP)]-and its association with ventilatory management and outcomes of COVID-19 patients on mechanical ventilation (MV), admitted to intensive care units (ICU) worldwide. RESULTS: We studied 745 patients from 22 countries, who required admission to the ICU and MV from January 14 to December 31, 2020, and presented at least one value of CRS within the first seven days of MV. Median (IQR) age was 62 (52-71), patients were predominantly males (68%) and from Europe/North and South America (88%). CRS, within 48 h from endotracheal intubation, was available in 649 patients and was neither associated with the duration from onset of symptoms to commencement of MV (p = 0.417) nor with PaO2/FiO2 (p = 0.100). Females presented lower CRS than males (95% CI of CRS difference between females-males: - 11.8 to - 7.4 mL/cmH2O p < 0.001), and although females presented higher body mass index (BMI), association of BMI with CRS was marginal (p = 0.139). Ventilatory management varied across CRS range, resulting in a significant association between CRS and driving pressure (estimated decrease - 0.31 cmH2O/L per mL/cmH20 of CRS, 95% CI - 0.48 to - 0.14, p < 0.001). Overall, 28-day ICU mortality, accounting for the competing risk of being discharged within the period, was 35.6% (SE 1.7). Cox proportional hazard analysis demonstrated that CRS (+ 10 mL/cm H2O) was only associated with being discharge from the ICU within 28 days (HR 1.14, 95% CI 1.02-1.
Published: 2021

12. Monitoring anticoagulation during Extra-Corporeal Membrane Oxygenation (ECMO) in patients with acute respiratory failure: PO 024

Author: Passamonti, S M, Panigada, M P, Artoni, A, Mietto, C, Bucciarelli, P, and Martinelli, I
Published: 2013

13. Changes in computed tomography and ventilation/perfusion mismatch with positive end-expiratory pressure

Author: Karbing, DS, Panigada, M, Bottino, N, Spinelli, E, Protti, A, Rees', SE, and Gattinoni, L
Published: 2014
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14. Can Ventilator Associated Pneumonia Cause Acute Respiratory Distress Syndrome? An Observational Study

Author: Barbeta, E.R., primary, Ceccato, A., additional, Motos, A., additional, Lopez, R., additional, Bueno, L., additional, Mellado, R., additional, Ferrando, C., additional, Ferrer, M., additional, Palomque, A., additional, Albacar, N., additional, Panigada, M., additional, Li Bassi, G., additional, and Torres, A., additional
Published: 2020
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15. Monitoring anticoagulation during extracorporeal membrane oxygenation in patients with acute respiratory failure

Author: Panigada, M, Mietto, C, Pagan, F, Bogno, L, Berto, V, and Gattinoni, L
Published: 2013
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16. Urokinase-induced fibrinolysis in thromboelastography (UKIF-TEG) to assess fibrinolysis in critically ill patients

Author: Zacchetti, L, Panigada, M, Cressoni, M, Marchesi, T, and Gattinoni, L
Published: 2013
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17. 37th International Symposium on Intensive Care and Emergency Medicine (part 1 of 3)

Author: Karavana, V., Smith, I., Kanellis, G., Sigala, I., Kinsella, T., Zakynthinos, S., Liu, L., Chen, J., Zhang, X., Liu, A., Guo, F., Liu, S., Yang, Y., Qiu, H., Grimaldi, D. G., Kaya, E., Acicbe, O., Kayaalp, I., Asar, S., Dogan, M., Eren, G., Hergunsel, O., Pavelescu, D., Grintescu, I., Mirea, L., Guanziroli, M., Gotti, M., Marino, A., Cressoni, M., Vergani, G., Chiurazzi, C., Chiumello, D., Gattinoni, L., Spano, S., Massaro, F., Moustakas, A., Johansson, S., Larsson, A., Perchiazzi, G., Zhang, X. W., Guo, F. M., Chen, J. X., Xue, M., Qiu, H. B., Yang, L., Fister, M., Knafelj, R., Suzer, M. A., Kavlak, M. E., Atalan, H. K., Gucyetmez, B., Cakar, N., Weller, D., Grootendorst, A. F., Dijkstra, A., Kuijper, T. M., Cleffken, B. I., Regli, A., De Keulenaer, B., Van Heerden, P., Hadfield, D., Hopkins, P. A., Penhaligon, B., Reid, F., Hart, N., Rafferty, G. F., Grasselli, G., Mauri, T., Lazzeri, M., Carlesso, E., Cambiaghi, B., Eronia, N., Maffezzini, E., Bronco, A., Abbruzzese, C., Rossi, N., Foti, G., Bellani, G., Pesenti, A., Bassi, G. Li, Panigada, M., Ranzani, O., Kolobow, T., Zanella, A., Berra, L., Parrini, V., Kandil, H., Salati, G., Livigni, S., Amatu, A., Girardis, M., Barbagallo, M., Moise, G., Mercurio, G., Costa, A., Vezzani, A., Lindau, S., Babel, J., Cavana, M., Torres, A., Ranzani, O. T., Umbrello, M., Taverna, M., Formenti, P., Mistraletti, G., Vetrone, F., Baisi, A., Garnero, A. G., Novotni, D. N., Arnal, J. A., Urner, M., Fan, E., Dres, M., Vorona, S., Brochard, L., Ferguson, N. D., Goligher, E. C., Leung, C., Joynt, G., Wong, W., Lee, A., Gomersall, C., Poels, S., Casaer, M., Schetz, M., Van den Berghe, G., Meyfroidt, G., Holzgraefe, B., Von Kobyletzki, L. B., Cianchi, G., Becherucci, F., Batacchi, S., Cozzolino, M., Franchi, F., Di Valvasone, S., Ferraro, M. C., Peris, A., Phiphitthanaban, H., Wacharasint, P., Wongsrichanalai, V., Lertamornpong, A., Pengpinij, O., Wattanathum, A., Oer-areemitr, N., Boddi, M., Cappellini, E., Ciapetti, M., Di Lascio, G., Bonizzoli, M., Lazzeri, C., Katsin, M. L., Hurava, M. Y., Dzyadzko, A. M., Hermann, A., Schellongowski, P., Bojic, A., Riss, K., Robak, O., Lamm, W., Sperr, W., Staudinger, T., Buoninsegni, L. Tadini, Parodo, J., Ottaviano, A., Cecci, L., Corsi, E., Ricca, V., de Garibay, A. 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G., Lund, I., Frithiof, R., Nichols, A., Pentakota, S., Kodali, B., Pranskunas, A., Kiudulaite, I., Simkiene, J., Damanskyte, D., Pranskuniene, Z., Arstikyte, J., Vaitkaitis, D., Pilvinis, V., Brazaitis, M., Pool, R., Haugaa, H., Botero, A., Escobar, D., Maberry, D., Tønnessen, T., Zuckerbraun, B., Pinsky, M., Gomez, H., Lyons, H., Trimmings, A., Domizi, R., Scorcella, C., Damiani, E., Pierantozzi, S., Tondi, S., Monaldi, V., Carletti, A., Zuccari, S., Adrario, E., Pelaia, P., Donati, A., Kazune, S., Grabovskis, A., Volceka, K., Rubins, U., Bol, M., Suverein, M., Delnoij, T., Driessen, R., Heines, S., Delhaas, T., Vd Poll, M., Sels, J., Jozwiak, M., Chambaz, M., Sentenac, P., Richard, C., Monnet, X., Teboul, J. L., Bitar, Z., Maadarani, O., Al Hamdan, R., Huber, W., Malbrain, M., Chew, M., Mallat, J., Tagami, T., Hundeshagen, S., Wolf, S., Mair, S., Schmid, R., Aron, J., Adlam, M., Dua, G., Mu, L., Chen, L., Yoon, J., Clermont, G., Dubrawski, A., Duhailib, Z., Al Assas, K., Shafquat, A., Salahuddin, N., Donaghy, J., Morgan, P., Valeanu, L., Stefan, M., Provenchere, S., Longrois, D., Shaw, A., Mythen, M. G., Shook, D., Hayashida, D., Munson, S. H., Sawyer, A., Mariyaselvam, M., Blunt, M., Young, P., Nakwan, N., Khwannimit, B., Checharoen, P., Berger, D., Moller, P., Bloechlinger, S., Bloch, A., Jakob, S., Takala, J., Van den Brule, J. M., Stolk, R., Vinke, E., Van Loon, L. M., Pickkers, P., Van der Hoeven, J. G., Kox, M., Hoedemaekers, C. W., Werner-Moller, P., Bertini, P., Guarracino, F., Colosimo, D., Gonnella, S., Brizzi, G., Mancino, G., Baldassarri, R., Pinsky, M. R., Amitrano, D., Goslar, T., Stajer, D., Radsel, P., De Vos, R., Dijk, N. 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T., Musaeva, T., Horst, S., Lipcsey, M., Kawati, R., Pikwer, A., Rasmusson, J., Castegren, M., Shilova, A., Yafarova, A., Gilyarov, M., Stojiljkovic, D. L. Loncar, Ulici, A., Reidt, S., Lam, T., Jancik, J., Ragab, D., Taema, K., Farouk, W., Saad, M., Liu, X., Uber, A., Montissol, S., Donnino, M., Andersen, L. W., Perlikos, F., Lagiou, M., Papalois, A., Kroupis, C., Toumpoulis, I., Carter, D., Sardo, S., Landoni, G., Kongsayreepong, S., Sungsiri, R., Wongsripunetit, P., Marchio, P., Guerra-Ojeda, S., Gimeno-Raga, M., Mauricio, M. D., Valles, S. L., Aldasoro, C., Jorda, A., Aldasoro, M., Vila, J. M., Borg, U. B., Neitenbach, A. M., García, M., González, P. Guijo, Romero, M. Gracia, Orduña, P. Saludes, Cano, A. Gil, Rhodes, A., Grounds, R. M., Cecconi, M., Lee, C., Hatib, F., Jian, Z., Rinehart, J., De Los Santos, J., Canales, C., Cannesson, M., García, M. I. Monge, Scheeren, T., Chantziara, V., Vassi, A., Michaloudis, G., Sanidas, E., Golemati, S., Bateman, R. M., Mokhtar, A., Omar, W., Aziz, K. Abdel, El Azizy, H., Nielsen, D. L. Lykke, Holler, J. G., Lassen, A., Eriksson, M., Strandberg, G., Capoletto, C., Nakamura, R., Risk, S., Park, C., Dias, F., D’Arrigo, N., Fortuna, F., Redaelli, S., Zerman, L., Becker, L., Serrano, T., Cotes, L., Ramos, F., Fadel, L., Coelho, F., Mendes, C., Real, J., Pedron, B., Kuroki, M., Costa, E., and Azevedo, L.
Subjects: Critical Care and Intensive Care Medicine, Meeting Abstracts
Published: 2017

18. Intensive care unit patients with lower respiratory tract nosocomial infections: The ENIRRIs project

Author: De Pascale, G. Ranzani, O.T. Nseir, S. Chastre, J. Welte, T. Antonelli, M. Navalesi, P. Garofalo, E. Bruni, A. Coelho, L.M. Skoczynski, S. Longhini, F. Taccone, F.S. Grimaldi, D. Salzer, H.J.F. Lange, C. Froes, F. Artigas, A. Díaz, E. Vallés, J. Rodríguez, A. Panigada, M. Comellini, V. Fasano, L. Soave, P.M. Spinazzola, G. Luyt, C.-E. Alvarez-Lerma, F. Marin, J. Masclans, J.R. Chiumello, D. Pezzi, A. Schultz, M. Mohamed, H. Van Der Eerden, M. Hoek, R.A.S. Gommers, D.A.M.P.J. Di Pasquale, M. Civljak, R. Kutleša, M. Bassetti, M. Dimopoulos, G. Nava, S. Rios, F. Zampieri, F.G. Povoa, P. Bos, L.D. Aliberti, S. Torres, A. Martín-Loeches, I.
Abstract: The clinical course of intensive care unit (ICU) patients may be complicated by a large spectrum of lower respiratory tract infections (LRTI), defined by specific epidemiological, clinical and microbiological aspects. A European network for ICU-related respiratory infections (ENIRRIs), supported by the European Respiratory Society, has been recently established, with the aim at studying all respiratory tract infective episodes except community-acquired ones. A multicentre, observational study is in progress, enrolling more than 1000 patients fulfilling the clinical, biochemical and radiological findings consistent with a LRTI. This article describes the methodology of this study. A specific interest is the clinical impact of non- ICU-acquired nosocomial pneumonia requiring ICU admission, non-ventilator-associated LRTIs occurring in the ICU, and ventilator-associated tracheobronchitis. The clinical meaning of microbiologically negative infectious episodes and specific details on antibiotic administration modalities, dosages and duration are also highlighted. Recently released guidelines address many unresolved questions which might be answered by such large-scale observational investigations. In light of the paucity of data regarding such topics, new interesting information is expected to be obtained from our network research activities, contributing to optimisation of care for critically ill patients in the ICU. © ERS 2017.
Published: 2017

19. Applicability and safety of the lateral-Trendelenburg position for the prevention of ventilator-associated pneumonia

Author: Li Bassi, G., primary, Panigada, M., additional, Zanella, A., additional, Ranzani, O., additional, Cressoni, M., additional, Berra, L., additional, Parrini, V., additional, Kandil, H., additional, Salati, G., additional, Livigni, S., additional, Amatu, A., additional, Girardis, M., additional, Barbagallo, M., additional, Moise, G., additional, Mercurio, G., additional, Costa, A., additional, Vezzani, A., additional, Lindau, S., additional, Babel, J., additional, Cavana, M., additional, and Torres, A., additional
Published: 2018
Full Text: View/download PDF

20. Intensive care unit patients with lower respiratory tract nosocomial infections: The ENIRRIs project

Author: de Pascale, G. (Gennaro), Ranzani, O.T. (Otavio T.), Nseir, S. (Saad), Chastre, J. (Jean), Welte, T. (Tobias), Antonelli, M. (Massimo), Navalesi, P., Garofalo, E. (Eugenio), Bruni, A. (Andrea), Coelho, L.M. (Luis Miguel), Skoczyński, S. (Szymon), Longhini, F. (Federico), Taccone, F.S. (Fabio), Grimaldi, D. (David), Salzer, H.J.F. (Helmut J. F.), Lange, C. (Christoph), Froes, F. (Filipe), Artigas, A. (Antonio), Díaz, E. (Emili), Vallés, J. (Jordi), Rodriguez, A.H., Panigada, M. (Mauro), Comellini, V. (Vittoria), Fasano, L. (Luca), Soave, P.M. (Paolo M.), Spinazzola, G. (Giorgia), Luyt, C.-E. (Charles-Edouard), Alvarez-Lerma, F. (Francisco), Marin, J. (Judith), Masclans, J.R. (Joan Ramon), Chiumello, D. (Davide), Pezzi, A. (Angelo), Schultz, M.J. (Marcus), Mohamed, H. (Hafiz), Eerden, M. (Menno) van der, Hoek, R.A.S. (Roger A. S.), Gommers, D.A.M.P.J. (Diederik), di Pasquale, M. (Marta), Civljak, R. (Rok), Kutleša, M. (Marko), Bassetti, M. (Matteo), Dimopoulos, G. (George), Nava, S. (Stefano), Rios, F. (Fernando), Zampieri, F.G. (Fernando G.), Povoa, P. (Pedro), Bos, L.D. (Lieuwe D.), Aliberti, S. (Stefano), Torres, A., Martin-Loeches, I., de Pascale, G. (Gennaro), Ranzani, O.T. (Otavio T.), Nseir, S. (Saad), Chastre, J. (Jean), Welte, T. (Tobias), Antonelli, M. (Massimo), Navalesi, P., Garofalo, E. (Eugenio), Bruni, A. (Andrea), Coelho, L.M. (Luis Miguel), Skoczyński, S. (Szymon), Longhini, F. (Federico), Taccone, F.S. (Fabio), Grimaldi, D. (David), Salzer, H.J.F. (Helmut J. F.), Lange, C. (Christoph), Froes, F. (Filipe), Artigas, A. (Antonio), Díaz, E. (Emili), Vallés, J. (Jordi), Rodriguez, A.H., Panigada, M. (Mauro), Comellini, V. (Vittoria), Fasano, L. (Luca), Soave, P.M. (Paolo M.), Spinazzola, G. (Giorgia), Luyt, C.-E. (Charles-Edouard), Alvarez-Lerma, F. (Francisco), Marin, J. (Judith), Masclans, J.R. (Joan Ramon), Chiumello, D. (Davide), Pezzi, A. (Angelo), Schultz, M.J. (Marcus), Mohamed, H. (Hafiz), Eerden, M. (Menno) van der, Hoek, R.A.S. (Roger A. S.), Gommers, D.A.M.P.J. (Diederik), di Pasquale, M. (Marta), Civljak, R. (Rok), Kutleša, M. (Marko), Bassetti, M. (Matteo), Dimopoulos, G. (George), Nava, S. (Stefano), Rios, F. (Fernando), Zampieri, F.G. (Fernando G.), Povoa, P. (Pedro), Bos, L.D. (Lieuwe D.), Aliberti, S. (Stefano), Torres, A., and Martin-Loeches, I.
Abstract: The clinical course of intensive care unit (ICU) patients may be complicated by a large spectrum of lower respiratory tract infections (LRTI), defined by specific epidemiological, clinical and microbiological aspects. A European network for ICU-related respiratory infections (ENIRRIs), supported by the European Respiratory Society, has been recently established, with the aim at studying all respiratory tract infective episodes except community-acquired ones. A multicentre, observational study is in progress, enrolling more than 1000 patients fulfilling the clinical, biochemical and radiological findings consistent with a LRTI. This article describes the methodology of this study. A specific interest is the clinical impact of non- ICU-acquired nosocomial pneumonia requiring ICU admission, non-ventilator-associated LRTIs occurring in the ICU, and ventilator-associated tracheobronchitis. The clinical meaning of microbiologically negative infectious episodes and specific details on antibiotic administration modalities, dosages and duration are also highlighted. Recently released guidelines address many unresolved questions which might be answered by such large-scale observational investigations. In light of the paucity of data regarding such topics, new interesting information is expected to be obtained from our network research activities, contributing to optimisation of care for critically ill patients in the ICU.
Published: 2017
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21. Albumin replacement in patients with severe sepsis or septic shock

Author: Gattinoni L, Caironi P, Pesenti A, Fumagalli R, Tognoni G, Romero M, Latini R, Masson S, Vincent JL, Suter PM, Valsecchi MG, Santosuosso A, Cavana M, Ortu A, Gabini R, Perno S, Anelli A, Amoruso R, Ferraris S, Borelli M, Massei R, Riva I, Poli G, Papagni G, Bortone F, Mamprin F, Keim R, Brivio M, Colageo U, Mimii EP, Sangiorgi G, Siniscalchi A, Pierucci E, Giovannitti A, Gentile C, Pascucci F, Antonini B, Zummo U, Valsecchi R, Cerisara M, Trezzi T, Dossena A, Ribola A, Tamayo L, Zoppellari R, Volta CA, Mangani V, Fanfani E, Chelazzi C, Bartoli T, Parrini V, Oggioni R, Fedele A, Molin A, Berri C, Guarino A, Isetta M, Bonfiglio M, Tissino F, Silvestri L, Milanesi M, Sbrana G, Motta E, Iannaco I, Casadio MC, Pasetti GS, Palandini A, Cascione C, Puscio D, Cellai F, Boccalatte D, Silvestri S, Fausto CI, Lupo V, Zompanti V, Iacobone E, Gattari D, Ronzoni G, Beck E, Francesconi S, Colombo R, Raimondi F, Castelli A, De Gasperi A, Radrizzani D, Ferla LE, Giudici R, Bellato V, Bordone G, Gavazzeni V, Lesmo A, Ripamonti D, Vesconi S, Papoff A, Rossi A, Noto A, Pezzi A, Zanforlin G, Kandil H, Ballotta A, Bettini F, Vaghi GM, Rossi S, Pessina C, Casagrande D, Trivellato A, Costagli V, Moise G, Furla M, Marelli S, Caspani L, Panigada M, Bruzzone P, Isgrò S, Abbruzzese C, Tagliabue P, Solca M, Bonazzi M, Cattaneo A, Rossi N, Andreoni P, Pasetto A, Girardis M, Barbieri E, Piazza O, Zagara G, Bono M, Galzerano A, Garzilli T, Dentini N, Bindi M, Biancofiore G, Mercante WP, Disconzi MM, Todesco N, Lunardi S, Sani E, Carli M, Bracciotti G, Gori V, Braccini P, Maggio G, Braschi A, Bottazzi A, Iotti G, Nicora B, Salati G, Salsi P, Antonelli M, Pennisi MA, Bello G, Caccese R, D'Ambrosio M, Rocco M, Sanseverino M, Gatta A, Nastasi M, Corsi A, Facondini F, Franchi F, Mongelli P, Ferrario M, Carulli F, Del Curto S, Schiappacasse G, Dalpiaz C, Armani S, Verderosa I, Marzullo A, Tonetti F, De Piero ME, Livigni S, Fiore G, Cerutti A, Erbetta S, Napolitano R, Pastorelli M, Bona F, Debernardi F, Gallo M, Segala V, Parigi L, Perzolla D, Marson F, Chiarandini P, Cammarano C, Sermann G, De Lucia S, Frigerio A, Distaso F, Franco R, Bossi E, Laudi C, De Nardin M, Violo T, Lazzari F, Vestali A, Della Mora E, Polati E, Martini A, Cristallini S, Totaro C, Milan B, Dan M, Ruberti S, Danzi V., GIARRATANO, Antonino, RAINERI, Santi Maurizio, CORTEGIANI, Andrea, Caironi, P, Tognoni, G, Masson, S, Fumagalli, R, Pesenti, A, Romero, M, Fanizza, C, Caspani, L, Faenza, S, Grasselli, G, Iapichino, G, Antonelli, M, Parrini, V, Fiore, G, Latini, R, Gattinoni, L, Caironi P, Tognoni G, Masson S, Fumagalli R, Pesenti A, Romero M, Fanizza C, Caspani L, Faenza S, Grasselli G, Iapichino G, Antonelli M, Parrini V, Fiore G, Latini R, Gattinoni L, Vincent JL, Suter PM, Valsecchi MG, Santosuosso A, Cavana M, Ortu A, Gabini R, Perno S, Anelli A, Amoruso R, Ferraris S, Borelli M, Massei R, Riva I, Poli G, Papagni G, Bortone F, Mamprin F, Keim R, Brivio M, Colageo U, Mimii EP, Sangiorgi G, Siniscalchi A, Pierucci E, Giovannitti A, Gentile C, Pascucci F, Antonini B, Zummo U, Valsecchi R, Cerisara M, Trezzi T, Dossena A, Ribola A, Tamayo L, Zoppellari R, Volta CA, Mangani V, Fanfani E, Chelazzi C, Bartoli T, Oggioni R, Fedele A, Molin A, Berri C, Guarino A, Isetta M, Bonfiglio M, Tissino F, Silvestri L, Milanesi M, Sbrana G, Motta E, Iannaco I, Casadio MC, Pasetti GS, Palandini A, Cascione C, Puscio D, Cellai F, Boccalatte D, Silvestri S, Fausto CI, Lupo V, Zompanti V, Iacobone E, Gattari D, Ronzoni G, Beck E, Francesconi S, Colombo R, Raimondi F, Castelli A, De Gasperi A, Radrizzani D, Ferla LE, Giudici R, Bellato V, Bordone G, Gavazzeni V, Lesmo A, Ripamonti D, Vesconi S, Papoff A, Rossi A, Noto A, Pezzi A, Zanforlin G, Kandil H, Ballotta A, Bettini F, Vaghi GM, Rossi S, Pessina C, Casagrande D, Trivellato A, Costagli V, Moise G, Furla M, Marelli S, Panigada M, Bruzzone P, Isgrò S, Abbruzzese C, Tagliabue P, Solca M, Bonazzi M, Cattaneo A, Rossi N, Andreoni P, Pasetto A, Girardis M, Barbieri E, Piazza O, Giarratano A, Raineri SM, Cortegiani A, Zagara G, Bono M, Galzerano A, Garzilli T, Dentini N, Bindi M, Biancofiore G, Mercante WP, Disconzi MM, Todesco N, Lunardi S, Sani E, Carli M, Bracciotti G, Gori V, Braccini P, Maggio G, Braschi A, Bottazzi A, Iotti G, Nicora B, Salati G, Salsi P, Pennisi MA, Bello G, Caccese R, D'Ambrosio M, Rocco M, Sanseverino M, Gatta A, Nastasi M, Corsi A, Facondini F, Franchi F, Mongelli P, Ferrario M, Carulli F, Del Curto S, Schiappacasse G, Dalpiaz C, Armani S, Verderosa I, Marzullo A, Tonetti F, De Piero ME, Livigni S, Cerutti A, Erbetta S, Napolitano R, Pastorelli M, Bona F, Debernardi F, Gallo M, Segala V, Parigi L, Perzolla D, Marson F, Chiarandini P, Cammarano C, Sermann G, De Lucia S, Frigerio A, Distaso F, Franco R, Bossi E, Laudi C, De Nardin M, Violo T, Lazzari F, Vestali A, Della Mora E, Polati E, Martini A, Cristallini S, Totaro C, Milan B, Dan M, Ruberti S, and Danzi V
Subjects: Male, medicine.medical_specialty, ALBUMIN, SEPSIS, SEVERE SEPSIS, SEPTIC SHOCK, Sepsi, Serum albumin, Settore MED/41 - Anestesiologia, Aged, Albumins, Female, Humans, Isotonic Solutions, Middle Aged, Rehydration Solutions, Sepsis, Serum Albumin, Shock, Septic, Survival Rate, Treatment Outcome, Intensive care, medicine, albumin replacement, Survival rate, Isotonic Solution, Medicine (all), SEPSIS, biology, business.industry, Septic shock, Rehydration Solution, Septic, Albumin, SEPTIC SHOCK, Organ dysfunction, Shock, General Medicine, medicine.disease, Surgery, Anesthesia, Relative risk, biology.protein, medicine.symptom, business, Human
Abstract: BACKGROUND: Although previous studies have suggested the potential advantages of albumin administration in patients with severe sepsis, its efficacy has not been fully established. METHODS: In this multicenter, open-label trial, we randomly assigned 1818 patients with severe sepsis, in 100 intensive care units (ICUs), to receive either 20% albumin and crystalloid solution or crystalloid solution alone. In the albumin group, the target serum albumin concentration was 30 g per liter or more until discharge from the ICU or 28 days after randomization. The primary outcome was death from any cause at 28 days. Secondary outcomes were death from any cause at 90 days, the number of patients with organ dysfunction and the degree of dysfunction, and length of stay in the ICU and the hospital. RESULTS: During the first 7 days, patients in the albumin group, as compared with those in the crystalloid group, had a higher mean arterial pressure (P = 0.03) and lower net fluid balance (P
Published: 2014

22. Epithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesis

Author: Guttinger M, Sutti F, Panigada M, Porcellini S, Merati B, Mariani M, Teesalu T, Grassi F., CONSALEZ , GIAN GIACOMO, Guttinger, M, Sutti, F, Panigada, M, Porcellini, S, Merati, B, Mariani, M, Teesalu, T, Consalez, GIAN GIACOMO, and Grassi, F.
Published: 1998

23. Mmot1, a new helix-loop-helix transcription factor gene displaying a sharp antero-posterior expression boundary in the embryonic mouse brain

Author: MALGARETTI N, POZZOLI O, BOSETTI A, CORRADI A, CIARMATORI S, PANIGADA M, BIANCHI, MARCO EMILIO, MARTINEZ S, CONSALEZ , GIAN GIACOMO, Malgaretti, N, Pozzoli, O, Bosetti, A, Corradi, A, Ciarmatori, S, Panigada, M, Bianchi, MARCO EMILIO, Martinez, S, and Consalez, GIAN GIACOMO
Published: 1997

24. Simulation-based training of extracorporeal membrane oxygenation during H1N1 influenza pandemic: the Italian experience

Author: Brazzi, L, Lissoni, A, Panigada, M, Bottino, N, Patroniti, N, Pappalardo, F, Gattinoni, L, PATRONITI, NICOLO' ANTONINO, Gattinoni, L., Brazzi, L, Lissoni, A, Panigada, M, Bottino, N, Patroniti, N, Pappalardo, F, Gattinoni, L, PATRONITI, NICOLO' ANTONINO, and Gattinoni, L.
Abstract: On November 2009, the Italian health authorities set up a network of selected intensive care unit (ICU) centers (ECMOnet) to prepare for the treatment of the sickest patients of influenza A (H1N1) by means of extracorporeal membrane oxygenation (ECMO). To quickly and efficaciously train all the physicians working in the ICUs of the ECMOnet on ECMO use, we decided to take advantages of the opportunity provided by simulation technology. Simulation proved efficacious in providing adequate training and education to participants as confirmed by the survival results obtained by the group of ICUs of the ECMOnet. Our experience supports the use of simulation as a valuable alternative to animal laboratory sessions proposed by traditional ECMO training programs providing participants with cognitive, technical, and behavioral skills and allowing a proficient transfer of those skills to the real medical domain.
Published: 2012

25. Alternative approaches to ventilator associated pneumonia prevention. The authors reply

Author: Berra, L, Pinciroli, R, Panigada, M, Zanella, A, Cressoni, M, Li, B, BERRA, LORENZO, PINCIROLI, RICCARDO, ZANELLA, ALBERTO, Li, Bassi G., Berra, L, Pinciroli, R, Panigada, M, Zanella, A, Cressoni, M, Li, B, BERRA, LORENZO, PINCIROLI, RICCARDO, ZANELLA, ALBERTO, and Li, Bassi G.
Published: 2012

26. Ventilator settings in acute respiratory failure/acute respiratory distress syndrome

Author: Luca Brazzi, Bottino, N., Eccher, G., Panigada, M., and Gattinoni, L.
Subjects: Positive-Pressure Respiration, Respiratory Distress Syndrome, Tidal Volume, Humans, Respiratory Insufficiency, Respiration, Artificial
Published: 2000

27. Different initiation of pre-TCR and gamma delta TCR signalling

Author: Saint-Ruf, C., Panigada, M., Azogui, O., Debey, P., von Boehmer, H., Grassi, F., Laboratoire associé dynamique nucleaire et développement, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration
Subjects: [SDV] Life Sciences [q-bio], T-CELL RECEPTOR, [SDV]Life Sciences [q-bio], BIOLOGIE CELLULAIRE, ComputingMilieux_MISCELLANEOUS, TCR
Abstract: International audience
Published: 2000

28. [The sigh in ARDS (acute respiratory distress syndrome)]

Author: Pelosi P, Bottino N, Panigada M, Eccher G, and Luciano Gattinoni
Subjects: Respiratory Distress Syndrome, Newborn, Acute Disease, Infant, Newborn, Respiratory Mechanics, Humans
Abstract: We studied 10 consecutive, sedated and paralyzed patients with Acute Respiratory Distress Syndrome (ARDS). The entire study lasted 4 hours, divided in 3 periods: 2 hours of recommended ventilation [lung protective strategy, LPS, i.e., ventilation with low tidal volume (8 mL/kg), limiting the plateau at 35 cm H2O, together with high positive end-expiratory pressure (PEEP)], 1 hour of sigh (LPS with 3 consecutive sighs/min at 45 cm H2O plateau pressure), and 1 hour of LPS. Total minute ventilation, PEEP, FiO2 and mean airway pressure were kept constant. The introduction of sighs induced a consistent recruitment and PaO2 improvement, and a decrease in venous admixture and PaCO2. Interrupting sighs and resuming LPS led to a progressive derecruitment, and all the physiological variables returned to baseline. Derecruitment was higher in patients with higher PaCO2 and lower VA/Q ratio. We conclude that: 1) LPS alone does not provide full lung recruitment and best oxygenation in ARDS; 2) application of sigh may provide pressure enough to recruit and volume enough to prevent reabsorption atelectasis.
Published: 1999

29. The rationale for the prone position in patients with acute respiratory distress syndrome

Author: Pelosi, P, Brazzi, Luca, Bottino, N, Panigada, M, Eccher, Lg, Resta, M, and Gattinoni, L.
Published: 1999

30. Relazione tra pressione idrostatica e pressione pleurica nel polmone con ARDS: studio sperimentale

Author: Eccher, G, Bottino, N, Panigada, M, Brazzi, Luca, Pelosi, P, Mckibben, A, Adams, A, Goldner, M, Marini, Jj, and Gattinoni, L.
Published: 1999

31. Distribuzione dell’edema in un modello sperimentale di ARDS (Acute Respiratory Distress Syndrome)

Author: Eccher, G, Bottino, N, Panigada, M, Brazzi, Luca, Pelosi, P, Mckibben, A, Adams, A, Goldner, M, Marini, Jj, and Gattinoni, L.
Published: 1999

32. The prone position

Author: Pelosi, P, Brazzi, Luca, Panigada, M, Bottino, N, Eccher, Lmg, and Gattinoni, L.
Published: 1999

33. Effects of different continuous positive airway pressure devices and periodic hyperinflations on respiratory function.

Author: Pelosi P, Chiumello D, Calvi E, Taccone P, Bottino N, Panigada M, Cadringher P, Gattinoni L, Pelosi, P, Chiumello, D, Calvi, E, Taccone, P, Bottino, N, Panigada, M, Cadringher, P, and Gattinoni, L
Published: 2001
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34. The effect of time to therapeutic hypothermia on survival after cardiac arrest

Author: Alongi, Salvatore, primary, De Chiara, S., additional, Bottino, N., additional, Nicolini, R., additional, Tosini, C., additional, Savioli, M., additional, Panigada, M., additional, Caspani, M.L., additional, and Gattinoni, L., additional
Published: 2008
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35. Bacterial colonization of the respiratory tract following tracheal intubation—Effect of gravity: An experimental study*

Author: Panigada, M., primary, Berra, L., additional, Greco, G., additional, Stylianou, M., additional, and Kolobow, T., additional
Published: 2003
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36. In vitro study of a new vaporization humidifying device: DAR HC 2000®

Author: Bottino, N, primary, Chiaravalli, L, additional, Panigada, M, additional, Carrieri, F, additional, Allegritti, E, additional, Pelosi, P, additional, and Gattinoni, L, additional
Published: 2000
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37. Effects of artificial changes in chest wall compliance on respiratory mechanics and gas exchange in patients with acute lung injury (ALI)

Author: Bottino, N, primary, Panigada, M, additional, Chiumello, D, additional, Pelosi, P, additional, and Gattinoni, L, additional
Published: 2000
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38. Thromboelastography-guided thrombolysis during ECMO: a case report.

Author: L'Acqua, C, Passamonti, S M, Spinelli, E, Gattinoni, L, and Panigada, M
Published: 2014

39. Inhibition of human platelet aggregation by parathyroid hormone. Is cyclic AMP implicated?

Author: Benigni, Ariela, Livio, Manuela, Dodesini, Patrizia, Schieppati, Arrigo, Panigada, Mario, Mecca, Giuliano, de Gaetano, Giovanni, Remuzzi, Giuseppe, Benigni, A, Livio, M, Dodesini, P, Schieppati, A, Panigada, M, Mecca, G, de Gaetano, G, and Remuzzi, G
Published: 1985
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40. Edge effects in glass-passivated collector-base junctions of high-voltage transistors.

Author: Savini, A., Dallago, E., Felici, M., Panigada, M., and Versiglia, F.
Published: 1982
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41. GKLF in thymus epithelium as a developmentally regulated element of thymocyte-stroma cross-talk

Author: Panigada, M., Porcellini, S., Sutti, F., Doneda, L., Pozzoli, O., Consalez, G. G., Guttinger, M., and Grassi, F.
Published: 1999
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42. Mmot1, a new helix-loop-helix transcription factor gene displaying a sharp expression boundary in the embryonic mouse brain.

Author: Malgaretti, N, Pozzoli, O, Bosetti, A, Corradi, A, Ciarmatori, S, Panigada, M, Bianchi, M E, Martinez, S, and Consalez, G G
Abstract: Several genetic factors have been proven to contribute to the specification of the metencephalic-mesencephalic territory, a process that sets the developmental foundation for prospective morphogenesis of the cerebellum and mesencephalon. However, evidence stemming from genetic and developmental studies performed in man and various model organisms suggests the contribution of many additional factors in determining the fine subdivision and differentiation of these central nervous system regions. In man, the cerebellar ataxias/aplasias represent a large and heterogeneous family of genetic disorders. Here, we describe the identification by differential screening and the characterization of Mmot1, a new gene encoding a DNA-binding protein strikingly similar to the helix-loop-helix factor Ebf/Olf1. Throughout midgestation embryogenesis, Mmot1 is expressed at high levels in the metencephalon, mesencephalon, and sensory neurons of the nasal cavity. In vitro DNA binding data suggest some functional equivalence of Mmot1 and Ebf/Olf1, possibly accounting for the reported lack of olfactory or neural defects in Ebf-/- knockout mutants. The isolation of Mmot1 and of an additional homolog in the mouse genome defines a novel, phylogenetically conserved mammalian family of transcription factor genes of potential relevance in studies of neural development and its aberrations.
Published: 1997

43. Effects of artificial changes in chest wall compliance on respiratory mechanics and gas exchange in patients with acute lung injury (ALI)

Author: Bottino, N, Panigada, M, Chiumello, D, Pelosi, P, and Gattinoni, L
Published: 1999
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44. The value of open-source clinical science in pandemic response

Author: Ali Abbas, Sheryl Ann Abdukahil, Nurul Najmee Abdulkadir, Ryuzo Abe, Laurent Abel, Lara Absil, Subhash Acharya, Andrew Acker, Shingo Adachi, Elisabeth Adam, Diana Adrião, Saleh Al Ageel, Shakeel Ahmed, Quratul Ain, Kate Ainscough, Tharwat Aisa, Ali Ait Hssain, Younes Ait Tamlihat, Takako Akimoto, Ernita Akmal, Eman Al Qasim, Razi Alalqam, Tanvir Alam, Tala Al-dabbous, Senthilkumar Alegesan, Cynthia Alegre, Marta Alessi, Beatrice Alex, Kévin Alexandre, Abdulrahman Al-Fares, Huda Alfoudri, Imran Ali, Naseem Ali Shah, Kazali Enagnon Alidjnou, Jeffrey Aliudin, Qabas Alkhafajee, Clotilde Allavena, Nathalie Allou, Aneela Altaf, João Alves, João Melo Alves, Rita Alves, Maria Amaral, Nur Amira, Heidi Ammerlaan, Phoebe Ampaw, Roberto Andini, Claire Andrejak, Andrea Angheben, François Angoulvant, Séverine Ansart, Sivanesen Anthonidass, Massimo Antonelli, Carlos Alexandre Antunes de Brito, Kazi Rubayet Anwar, Ardiyan Apriyana, Yaseen Arabi, Irene Aragao, Rajeshwari Arali, Francisco Arancibia, Carolline Araujo, Antonio Arcadipane, Patrick Archambault, Lukas Arenz, Jean-Benoît Arlet, Christel Arnold-Day, Ana Aroca, Lovkesh Arora, Rakesh Arora, Elise Artaud-Macari, Diptesh Aryal, Motohiro Asaki, Angel Asensio, Elizabeth Ashley, Muhammad Ashraf, Sheharyar Ashraf, Mohammad Asim, Jean Baptiste Assie, Amirul Asyraf, Anika Atique, AM Udara Lakshan Attanyake, Johann Auchabie, Hugues Aumaitre, Adrien Auvet, Laurène Azemar, Cecile Azoulay, Benjamin Bach, Delphine Bachelet, Claudine Badr, Nadia Baig, J. Kenneth Baillie, J Kevin Baird, Erica Bak, Agamemnon Bakakos, Nazreen Abu Bakar, Andriy Bal, Mohanaprasanth Balakrishnan, Valeria Balan, Firouzé Bani-Sadr, Renata Barbalho, Nicholas Yuri Barbosa, Wendy S. Barclay, Saef Umar Barnett, Michaela Barnikel, Helena Barrasa, Audrey Barrelet, Cleide Barrigoto, Marie Bartoli, Cheryl Bartone, Joaquín Baruch, Mustehan Bashir, Romain Basmaci, Muhammad Fadhli Hassin Basri, Diego Bastos, Denise Battaglini, Jules Bauer, Diego Fernando Bautista Rincon, Denisse Bazan Dow, Alexandra Bedossa, Ker Hong Bee, Sylvie Behilill, Albertus Beishuizen, Aleksandr Beljantsev, David Bellemare, Anna Beltrame, Beatriz Amorim Beltrão, Marine Beluze, Nicolas Benech, Lionel Eric Benjiman, Dehbia Benkerrou, Suzanne Bennett, Luís Bento, Jan-Erik Berdal, Delphine Bergeaud, Hazel Bergin, José Luis Bernal Sobrino, Giulia Bertoli, Lorenzo Bertolino, Simon Bessis, Adam Betz, Sybille Bevilcaqua, Karine Bezulier, Amar Bhatt, Krishna Bhavsar, Isabella Bianchi, Claudia Bianco, Farah Nadiah Bidin, Moirangthem Bikram Singh, Felwa Bin Humaid, Mohd Nazlin Bin Kamarudin, François Bissuel, Patrick Biston, Laurent Bitker, Pablo Blanco-Schweizer, Catherine Blier, Frank Bloos, Mathieu Blot, Lucille Blumberg, Filomena Boccia, Laetitia Bodenes, Alice Bogaarts, Debby Bogaert, Anne-Hélène Boivin, Pierre-Adrien Bolze, François Bompart, Aurelius Bonfasius, Diogo Borges, Raphaël Borie, Hans Martin Bosse, Elisabeth Botelho-Nevers, Lila Bouadma, Olivier Bouchaud, Sabelline Bouchez, Dounia Bouhmani, Damien Bouhour, Kévin Bouiller, Laurence Bouillet, Camile Bouisse, Anne-Sophie Boureau, John Bourke, Maude Bouscambert, Aurore Bousquet, Jason Bouziotis, Bianca Boxma, Marielle Boyer-Besseyre, Maria Boylan, Fernando Augusto Bozza, Matthew Brack, Axelle Braconnier, Cynthia Braga, Timo Brandenburger, Filipa Brás Monteiro, Luca Brazzi, Dorothy Breen, Patrick Breen, Stephen Brett, Kathy Brickell, Tessa Broadley, Alex Browne, Shaunagh Browne, Nicolas Brozzi, Marjolein Brusse-Keizer, Nina Buchtele, Christian Buesaquillo, Polina Bugaeva, Marielle Buisson, Erlina Burhan, Aidan Burrell, Ingrid G. Bustos, Denis Butnaru, André Cabie, Susana Cabral, Eder Caceres, Cyril Cadoz, Mia Callahan, Kate Calligy, Jose Andres Calvache, João Cam, Valentine Campana, Paul Campbell, Josie Campisi, Cecilia Canepa, Mireia Cantero, Pauline Caraux-Paz, Sheila Cárcel, Chiara Simona Cardellino, Filipa Cardoso, Filipe Cardoso, Nelson Cardoso, Sofia Cardoso, Simone Carelli, Nicolas Carlier, Thierry Carmoi, Gayle Carney, Chloe Carpenter, Inês Carqueja, Marie-Christine Carret, François Martin Carrier, Ida Carroll, Gail Carson, Ed Carton, Maire-Laure Casanova, Mariana Cascão, Siobhan Casey, José Casimiro, Bailey Cassandra, Silvia Castañeda, Nidyanara Castanheira, Guylaine Castor-Alexandre, Henry Castrillón, Ivo Castro, Ana Catarino, François-Xavier Catherine, Paolo Cattaneo, Roberta Cavalin, Giulio Giovanni Cavalli, Alexandros Cavayas, Adrian Ceccato, Minerva Cervantes-Gonzalez, Anissa Chair, Catherine Chakveatze, Adrienne Chan, Meera Chand, Christelle Chantalat Auger, Jean-Marc Chapplain, Julie Chas, Mobin Chaudary, Jonathan Samuel Chávez Iñiguez, Anjellica Chen, Yih-Sharng Chen, Matthew Pellan Cheng, Antoine Cheret, Thibault Chiarabini, Julian Chica, Suresh Kumar Chidambaram, Leong Chin-Tho, Catherine Chirouze, Davide Chiumello, Hwa Jin Cho, Sung-Min Cho, Bernard Cholley, Marie-Charlotte Chopin, Ting Soo Chow, Yock Ping Chow, Hiu Jian Chua, Jonathan Chua, Jose Pedro Cidade, José Miguel Cisneros Herreros, Barbara Wanjiru Citarella, Anna Ciullo, Emma Clarke, Jennifer Clarke, Rolando Claure Del Granado, Sara Clohisey, J. Perren Cobb, Necsoi Coca, Cassidy Codan, Caitriona Cody, Alexandra Coelho, Megan Coles, Gwenhaël Colin, Michael Collins, Sebastiano Maria Colombo, Pamela Combs, Jennifer Connolly, Marie Connor, Anne Conrad, Sofía Contreras, Elaine Conway, Graham S. Cooke, Mary Copland, Hugues Cordel, Amanda Corley, Sarah Cormican, Sabine Cornelis, Alexander Daniel Cornet, Arianne Joy Corpuz, Andrea Cortegiani, Grégory Corvaisier, Emma Costigan, Camille Couffignal, Sandrine Couffin-Cadiergues, Roxane Courtois, Stéphanie Cousse, Rachel Cregan, Charles Crepy D'Orleans, Sabine Croonen, Gloria Crowl, Jonathan Crump, Claudina Cruz, Juan Luis Cruz Berm, Jaime Cruz Rojo, Marc Csete, Alberto Cucino, Ailbhe Cullen, Caroline Cullen, Matthew Cummings, Gerard Curley, Elodie Curlier, Colleen Curran, Paula Custodio, Ana da Silva Filipe, Charlene Da Silveira, Al-Awwab Dabaliz, Andrew Dagens, Darren Dahly, Heidi Dalton, Jo Dalton, Seamus Daly, Federico D'Amico, Nick Daneman, Corinne Daniel, Emmanuelle A Dankwa, Jorge Dantas, Frédérick D’Aragon, Mark de Boer, Gillian de Loughry, Diego de Mendoza, Etienne De Montmollin, Rafael Freitas de Oliveira França, Ana Isabel de Pinho Oliveira, Rosanna De Rosa, Thushan de Silva, Peter de Vries, Jillian Deacon, David Dean, Alexa Debard, Bianca DeBenedictis, Marie-Pierre Debray, Nathalie DeCastro, William Dechert, Lauren Deconninck, Romain Decours, Eve Defous, Isabelle Delacroix, Eric Delaveuve, Karen Delavigne, Nathalie M. Delfos, Ionna Deligiannis, Andrea Dell'Amore, Christelle Delmas, Pierre Delobel, Corine Delsing, Elisa Demonchy, Emmanuelle Denis, Dominique Deplanque, Pieter Depuydt, Mehul Desai, Diane Descamps, Mathilde Desvallée, Santi Dewayanti, Alpha Diallo, Sylvain Diamantis, André Dias, Priscila Diaz, Rodrigo Diaz, Juan Jose Diaz Diaz, Kévin Didier, Jean-Luc Diehl, Wim Dieperink, Jérôme Dimet, Vincent Dinot, Fara Diop, Alphonsine Diouf, Yael Dishon, Devika Dixit, Félix Djossou, Annemarie B. Docherty, Helen Doherty, Arjen M Dondorp, Andy Dong, Christl A. Donnelly, Maria Donnelly, Chloe Donohue, Sean Donohue, Yoann Donohue, Ciara Doran, Peter Doran, Céline Dorival, Eric D'Ortenzio, James Joshua Douglas, Renee Douma, Nathalie Dournon, Triona Downer, Joanne Downey, Mark Downing, Tom Drake, Aoife Driscoll, Murray Dryden, Claudio Duarte Fonseca, Vincent Dubee, François Dubos, Alexandre Ducancelle, Toni Duculan, Susanne Dudman, Abhijit Duggal, Paul Dunand, Jake Dunning, Mathilde Duplaix, Emanuele Durante-Mangoni, Lucian Durham III, Bertrand Dussol, Juliette Duthoit, Xavier Duval, Anne Margarita Dyrhol-Riise, Sim Choon Ean, Marco Echeverria-Villalobos, Siobhan Egan, Carla Eira, Mohammed El Sanharawi, Subbarao Elapavaluru, Brigitte Elharrar, Jacobien Ellerbroek, Philippine Eloy, Tarek Elshazly, Iqbal Elyazar, Isabelle Enderle, Tomoyuki Endo, Chan Chee Eng, Ilka Engelmann, Vincent Enouf, Olivier Epaulard, Martina Escher, Mariano Esperatti, Hélène Esperou, Marina Esposito-Farese, João Estevão, Manuel Etienne, Nadia Ettalhaoui, Anna Greti Everding, Mirjam Evers, Isabelle Fabre, Marc Fabre, Amna Faheem, Arabella Fahy, Cameron J. Fairfield, Zul Fakar, Pedro Faria, Ahmed Farooq, Jeremy J. Farrar, Nataly Farshait, Hanan Fateena, Arie Zainul Fatoni, Karine Faure, Raphaël Favory, Mohamed Fayed, Niamh Feely, Laura Feeney, Jorge Fernandes, Marília Fernandes, Susana Fernandes, François-Xavier Ferrand, Eglantine Ferrand Devouge, Joana Ferrão, Mário Ferraz, Benigno Ferreira, Sílvia Ferreira, Ricard Ferrer-Roca, Nicolas Ferriere, Céline Ficko, Claudia Figueiredo-Mello, Juan Fiorda, Thomas Flament, Clara Flateau, Tom Fletcher, Letizia Lucia Florio, Brigid Flynn, Deirdre Flynn, Claire Foley, Jean Foley, Victor Fomin, Tatiana Fonseca, Patricia Fontela, Simon Forsyth, Denise Foster, Giuseppe Foti, Erwan Fourn, Robert A. Fowler, Dr Marianne Fraher, Diego Franch-Llasat, Christophe Fraser, John F. Fraser, Marcela Vieira Freire, Ana Freitas Ribeiro, Caren Friedrich, Ricardo Fritz, Stéphanie Fry, Nora Fuentes, Masahiro Fukuda, Valérie Gaborieau, Rostane Gaci, Massimo Gagliardi, Jean-Charles Gagnard, Nathalie Gagné, Amandine Gagneux-Brunon, Sérgio Gaião, Linda Gail Skeie, Phil Gallagher, Elena Gallego Curto, Carrol Gamble, Yasmin Gani, Arthur Garan, Rebekha Garcia, Noelia García Barrio, Julia Garcia-Diaz, Esteban Garcia-Gallo, Navya Garimella, Denis Garot, Valérie Garrait, Basanta Gauli, Nathalie Gault, Aisling Gavin, Anatoliy Gavrylov, Alexandre Gaymard, Johannes Gebauer, Eva Geraud, Louis Gerbaud Morlaes, Nuno Germano, praveen kumar ghisulal, Jade Ghosn, Marco Giani, Carlo Giaquinto, Jess Gibson, Tristan Gigante, Morgane Gilg, Elaine Gilroy, Guillermo Giordano, Michelle Girvan, Valérie Gissot, Judy Gitahi, Gezy Giwangkancana, Daniel Glikman, Petr Glybochko, Eric Gnall, Geraldine Goco, François Goehringer, Siri Goepel, Jean-Christophe Goffard, Jin Yi Goh, Jonathan Golob, Rui Gomes, Kyle Gomez, Joan Gómez-Junyent, Marie Gominet, Alicia Gonzalez, Patricia Gordon, Anthony Gordon, Isabelle Gorenne, Laure Goubert, Cécile Goujard, Tiphaine Goulenok, Margarite Grable, Jeronimo Graf, Edward Wilson Grandin, Pascal Granier, Giacomo Grasselli, Lorenzo Grazioli, Christopher A. Green, Courtney Greene, William Greenhalf, Segolène Greffe, Domenico Luca Grieco, Matthew Griffee, Fiona Griffiths, Ioana Grigoras, Albert Groenendijk, Anja Grosse Lordemann, Heidi Gruner, Yusing Gu, Fabio Guarracino, Jérémie Guedj, Martin Guego, Dewi Guellec, Anne-Marie Guerguerian, Daniela Guerreiro, Romain Guery, Anne Guillaumot, Laurent Guilleminault, Maisa Guimarães de Castro, Thomas Guimard, Marieke Haalboom, Daniel Haber, Hannah Habraken, Ali Hachemi, Nadir Hadri, Olena Haidash, Saeeda Haider, Fakhir Haidri, Sheeba Hakak, Adam Hall, Matthew Hall, Sophie Halpin, Ansley Hamer, Raph Hamers, Rebecca Hamidfar, Terese Hammond, Lim Yuen Han, Rashan Haniffa, Kok Wei Hao, Hayley Hardwick, Ewen M. Harrison, Janet Harrison, Samuel Bernard Ekow Harrison, Alan Hartman, Junaid Hashmi, Madiha Hashmi, Muhammad Hayat, Ailbhe Hayes, Leanne Hays, Jan Heerman, Lars Heggelund, Ross Hendry, Martina Hennessy, Aquiles Henriquez, Maxime Hentzien, Fivzia Herekar, Jaime Hernandez-Montfort, Daniel Herr, Andrew Hershey, Liv Hesstvedt, Astarini Hidayah, Dawn Higgins, Eibhilin Higgins, Grainne HigginsOKeeffe, Rita Hinchion, Samuel Hinton, Hiroaki Hiraiwa, Hikombo Hitoto, Antonia Ho, Yi Bin Ho, Alexandre Hoctin, Isabelle Hoffmann, Wei Han Hoh, Oscar Hoiting, Rebecca Holt, Jan Cato Holter, Peter Horby, Juan Pablo Horcajada, Koji Hoshino, Kota Hoshino, Ikram Houas, Catherine L. Hough, Stuart Houltham, Jimmy Ming-Yang Hsu, Jean-Sébastien Hulot, Iqbal Hussain, Samreen Ijaz, Hajnal-Gabriela Illes, Patrick Imbert, Mohammad Imran, Rana Imran Sikander, Hugo Inácio, Carmen Infante Dominguez, Yun Sii Ing, Elias Iosifidis, Mariachiara Ippolito, Sarah Isgett, Palliya Guruge Pramodya Ishani Ishani, Tiago Isidoro, Nadiah Ismail, Margaux Isnard, Junji Itai, Asami Ito, Daniel Ivulich, Danielle Jaafar, Salma Jaafoura, Julien Jabot, Clare Jackson, Nina Jamieson, Pierre Jaquet, Waasila Jassat, Coline Jaud-Fischer, Stéphane Jaureguiberry, Jeffrey Javidfar, Issrah Jawad, Denise Jaworsky, Devachandran Jayakumar, Florence Jego, Anilawati Mat Jelani, Synne Jenum, Ruth Jimbo-Sotomayor, van der Palen Job, Ong Yiaw Joe, Ruth N. Jorge García, Cédric Joseph, Mark Joseph, Swosti Joshi, Mercé Jourdain, Philippe Jouvet, Jennifer June, Anna Jung, Hanna Jung, Dafsah Juzar, Ouifiya Kafif, Florentia Kaguelidou, Neerusha Kaisbain, Thavamany Kaleesvran, Sabina Kali, Alina Kalicinska, Smaragdi Kalomoiri, Saima Kamal, Muhammad Aisar Ayadi Kamaluddin, Zul Amali Che Kamaruddin, Nadiah Kamarudin, Darshana Hewa Kandamby, Chris Kandel, Kong Yeow Kang, Ravi Kant, Darakhshan Kanwal, Dyah Kanyawati, Bipin Karki, Pratap Karpayah, Todd Karsies, Christiana Kartsonaki, Daisuke Kasugai, Anant Kataria, Kevin Katz, Aasmine Kaur, Simreen Kaur Johal, Tatsuya Kawasaki, Christy Kay, Hannah Keane, Seán Keating, Paul Kellam, Andrea Kelly, Aoife Kelly, Claire Kelly, Niamh Kelly, Sadie Kelly, Yvelynne Kelly, Maeve Kelsey, Ryan Kennedy, Kalynn Kennon, Maeve Kernan, Younes Kerroumi, Sharma Keshav, Evelyne Kestelyn, Imrana Khalid, Osama Khalid, Antoine Khalil, Coralie Khan, Irfan Khan, Sushil Khanal, Michelle E Kho, Denisa Khoo, Ryan Khoo, Saye Khoo, Nasir Khoso, Khor How Kiat, Yuri Kida, Peter Kiiza, Anders Benjamin Kildal, Jae Burm Kim, Antoine Kimmoun, Detlef Kindgen-Milles, Alexander King, Nobuya Kitamura, Paul Klenerman, Rob Klont, Gry Kloumann Bekken, Stephen Knight, Robin Kobbe, Chamira Kodippily, Malte Kohns Vasconcelos, Sabin Koirala, Mamoru Komatsu, Volkan Korten, Caroline Kosgei, Arsène Kpangon, Karolina Krawczyk, Sudhir Krishnan, Vinothini Krishnan, Oksana Kruglova, Ashok Kumar, Deepali Kumar, Ganesh Kumar, Mukesh Kumar, Pavan Kumar Vecham, Dinesh Kuriakose, Ethan Kurtzman, Neurinda Permata Kusumastuti, Demetrios Kutsogiannis, Galyna Kutsyna, Konstantinos Kyriakoulis, Marie Lachatre, Marie Lacoste, John G. Laffey, Marie Lagrange, Fabrice Laine, Olivier Lairez, Sanjay Lakhey, Antonio Lalueza, Marc Lambert, François Lamontagne, Marie Langelot-Richard, Vincent Langlois, Eka Yudha Lantang, Marina Lanza, Cédric Laouénan, Samira Laribi, Delphine Lariviere, Stéphane Lasry, Naveed Latif, Odile Launay, Didier Laureillard, Yoan Lavie-Badie, Andy Law, Cassie Lawrence, Teresa Lawrence, Minh Le, Clément Le Bihan, Cyril Le Bris, Georges Le Falher, Lucie Le Fevre, Quentin Le Hingrat, Marion Le Maréchal, Soizic Le Mestre, Gwenaël Le Moal, Vincent Le Moing, Hervé Le Nagard, Paul Le Turnier, Ema Leal, Marta Leal Santos, Biing Horng Lee, Heng Gee Lee, James Lee, Su Hwan Lee, Todd C. Lee, Yi Lin Lee, Gary Leeming, Bénédicte Lefebvre, Laurent Lefebvre, Benjamin Lefevre, Sylvie LeGac, Jean-Daniel Lelievre, François Lellouche, Adrien Lemaignen, Véronique Lemee, Anthony Lemeur, Gretchen Lemmink, Ha Sha Lene, Jenny Lennon, Rafael León, Marc Leone, Michela Leone, Quentin Lepiller, François-Xavier Lescure, Olivier Lesens, Mathieu Lesouhaitier, Amy Lester-Grant, Bruno Levy, Yves Levy, Claire Levy-Marchal, Katarzyna Lewandowska, Erwan L'Her, Gianluigi Li Bassi, Janet Liang, Ali Liaquat, Geoffrey Liegeon, Kah Chuan Lim, Wei Shen Lim, Chantre Lima, Bruno Lina, Lim Lina, Andreas Lind, Guillaume Lingas, Sylvie Lion-Daolio, Samantha Lissauer, Keibun Liu, Marine Livrozet, Patricia Lizotte, Antonio Loforte, Navy Lolong, Leong Chee Loon, Diogo Lopes, Dalia Lopez-Colon, Anthony L. Loschner, Paul Loubet, Bouchra Loufti, Guillame Louis, Silvia Lourenco, Lara Lovelace-Macon, Lee Lee Low, Marije Lowik, Jia Shyi Loy, Jean Christophe Lucet, Carlos Lumbreras Bermejo, Carlos M. Luna, Olguta Lungu, Liem Luong, Nestor Luque, Dominique Luton, Nilar Lwin, Ruth Lyons, Olavi Maasikas, Oryane Mabiala, Samual MacDonald, Sarah MacDonald, Moïse Machado, Gabriel Macheda, Juan Macias Sanchez, Jai Madhok, Guillermo Maestro de la Calle, Rafael Mahieu, Sophie Mahy, Ana Raquel Maia, Lars S. Maier, Mylène Maillet, Thomas Maitre, Maximilian Malfertheiner, Nadia Malik, Paddy Mallon, Fernando Maltez, Denis Malvy, Victoria Manda, Jose M. Mandei, Laurent Mandelbrot, Frank Manetta, Kishore Mangal, Julie Mankikian, Edmund Manning, Aldric Manuel, Ceila Maria Sant`Ana Malaque, Daniel Marino, Flávio Marino, Samuel Markowicz, Charbel Maroun Eid, Ana Marques, Catherine Marquis, Brian Marsh, Laura Marsh, Megan Marshal, John Marshall, Celina Turchi Martelli, Dori-Ann Martin, Emily Martin, Guillaume Martin-Blondel, Alessandra Martinelli, Ignacio Martin-Loeches, Martin Martinot, Alejandro Martin-Quiros, Ana Martins, João Martins, Nuno Martins, Caroline Martins Rego, Gennaro Martucci, Olga Martynenko, Eva Miranda Marwali, Marsilla Marzukie, Juan Fernado Masa Jimenez, David Maslove, Phillip Mason, Sabina Mason, Sobia Masood, Basri Mat Nor, Moshe Matan, Henrique Mateus Fernandes, Meghena Mathew, Daniel Mathieu, Mathieu Mattei, Romans Matulevics, Laurence Maulin, Michael Maxwell, Javier Maynar, Thierry Mazzoni, Lisa Mc Sweeney, Lorraine McAndrew, Colin McArthur, Aine McCarthy, Anne McCarthy, Colin McCloskey, Rachael McConnochie, Sherry McDermott, Sarah E. McDonald, Aine McElroy, Samuel McElwee, Victoria McEneany, Natalie McEvoy, Allison McGeer, Chris McKay, Johnny McKeown, Kenneth A. McLean, Paul McNally, Bairbre McNicholas, Elaine McPartlan, Edel Meaney, Cécile Mear-Passard, Maggie Mechlin, Maqsood Meher, Omar Mehkri, Ferruccio Mele, Luis Melo, Kashif Memon, Joao Joao Mendes, Ogechukwu Menkiti, Kusum Menon, France Mentré, Alexander J. Mentzer, Emmanuelle Mercier, Noémie Mercier, Antoine Merckx, Mayka Mergeay-Fabre, Blake Mergler, Laura Merson, António Mesquita, Osama Metwally, Agnès Meybeck, Dan Meyer, Alison M. Meynert, Vanina Meysonnier, Amina Meziane, Mehdi Mezidi, Giuliano Michelagnoli, Céline Michelanglei, Isabelle Michelet, Efstathia Mihelis, Vladislav Mihnovit, Hugo Miranda-Maldonado, Nor Arisah Misnan, Nik Nur Eliza Mohamed, Tahira Jamal Mohamed, Asma Moin, David Molina, Elena Molinos, Brenda Molloy, Mary Mone, Agostinho Monteiro, Claudia Montes, Giorgia Montrucchio, Sarah Moore, Shona C. Moore, Lina Morales Cely, Lucia Moro, Diego Rolando Morocho Tutillo, Ben Morton, Catherine Motherway, Ana Motos, Hugo Mouquet, Clara Mouton Perrot, Julien Moyet, Caroline Mudara, Aisha Kalsoom Mufti, Ng Yong Muh, Dzawani Muhamad, Jimmy Mullaert, Fredrik Muller, Karl Erik Müller, Daniel Munblit, Syed Muneeb, Nadeem Munir, Laveena Munshi, Aisling Murphy, Lorna Murphy, Marlène Murris, Srinivas Murthy, Himed Musaab, Gugapriyaa Muyandy, Dimitra Melia Myrodia, Namra N, Dave Nagpal, Alex Nagrebetsky, Mangala Narasimhan, Nageswaran Narayanan, Rashid Nasim Khan, Alasdair Nazerali-Maitland, Nadège Neant, Holger Neb, Nikita A Nekliudov, Erni Nelwan, Raul Neto, Emily Neumann, Bernardo Neves, Pauline Yeung Ng, Anthony Nghi, Duc Nguyen, Orna Ni Choileain, Niamh Ni Leathlobhair, Alistair Nichol, Prompak Nitayavardhana, Stephanie Nonas, Nurul Amani Mohd Noordin, Marion Noret, Nurul Faten Izzati Norharizam, Lisa Norman, Alessandra Notari, Mahdad Noursadeghi, Karolina Nowicka, Adam Nowinski, Saad Nseir, Jose I Nunez, Nurnaningsih Nurnaningsih, Elsa Nyamankolly, Fionnuala O Brien, Annmarie O'Callaghan, Giovanna Occhipinti, Derbrenn OConnor, Max O'Donnell, Tawnya Ogston, Takayuki Ogura, Tak-Hyuk Oh, Sophie O'Halloran, Katie O'Hearn, Shinichiro Ohshimo, Agnieszka Oldakowska, João Oliveira, Larissa Oliveira, Piero L. Olliaro, Conar O'Neil, David S.Y. Ong, Jee Yan Ong, Wilna Oosthuyzen, Anne Opavsky, Peter Openshaw, Saijad Orakzai, Claudia Milena Orozco-Chamorro, Andrés Orquera, Jamel Ortoleva, Javier Osatnik, Linda O'Shea, Miriam O'Sullivan, Siti Zubaidah Othman, Nadia Ouamara, Rachida Ouissa, Clark Owyang, Eric Oziol, H M Upulee Pabasara, Maïder Pagadoy, Justine Pages, Amanda Palacios, Mario Palacios, Massimo Palmarini, Giovanna Panarello, Prasan Kumar Panda, Hem Paneru, Lai Hui Pang, Mauro Panigada, Nathalie Pansu, Aurélie Papadopoulos, Rachael Parke, Melissa Parker, Briseida Parra, Vieri Parrini, Taha Pasha, Jérémie Pasquier, Bruno Pastene, Fabian Patauner, Junaid Patel, Mohan Dass Pathmanathan, Luís Patrão, Patricia Patricio, Juliette Patrier, Lisa Patterson, Rajyabardhan Pattnaik, Christelle Paul, Mical Paul, Jorge Paulos, William A. Paxton, Jean-François Payen, Kalaiarasu Peariasamy, Miguel Pedrera Jiménez, Giles J. 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Thwaites, Paul Tierney, Vadim Tieroshyn, Peter S Timashev, Jean-François Timsit, Bharath Kumar Tirupakuzhi Vijayaraghavan, Noémie Tissot, Jordan Zhien Yang Toh, Maria Toki, Timo Tolppa, Kristian Tonby, Sia Loong Tonnii, Antoni Torres, Margarida Torres, Rosario Maria Torres Santos-Olmo, Hernando Torres-Zevallos, Michael Towers, Tony Trapani, Damien Traynor, Théo Treoux, Huynh Trung Trieu, Swagata Tripathy, Cécile Tromeur, Ioannis Trontzas, Tiffany Trouillon, Jeanne Truong, Christelle Tual, Sarah Tubiana, Helen Tuite, Jean-Marie Turmel, Lance C.W. Turtle, Anders Tveita, Pawel Twardowski, Makoto Uchiyama, PG Ishara Udayanga, Andrew Udy, Roman Ullrich, Zubair Umer, Alberto Uribe, Asad Usman, Cristinava Vajdovics, Luís Val-Flores, Ana Luiza Valle, Amélie Valran, Stijn Van de Velde, Marcel van den Berge, Machteld van der Feltz, Paul van der Valk, Nicky Van Der Vekens, Peter Van der Voort, Sylvie Van Der Werf, Marlice van Dyk, Laura van Gulik, Jarne Van Hattem, Steven van Lelyveld, Carolien van Netten, Gitte Van Twillert, Ilonka van Veen, Noémie Vanel, Henk Vanoverschelde, Pooja Varghese, Michael Varrone, Shoban Raj Vasudayan, Charline Vauchy, Helen Vaughan, Shaminee Veeran, Aurélie Veislinger, Sebastian Vencken, Sara Ventura, Annelies Verbon, José Ernesto Vidal, César Vieira, Deepak Vijayan, Joy Ann Villanueva, Judit Villar, Pierre-Marc Villeneuve, Andrea Villoldo, Nguyen Van Vinh Chau, Benoit Visseaux, Hannah Visser, Chiara Vitiello, Harald Vonkeman, Fanny Vuotto, Noor Hidayu Wahab, Suhaila Abdul Wahab, Nadirah Abdul Wahid, Marina Wainstein, Wan Fadzlina Wan Muhd Shukeri, Chih-Hsien Wang, Steven Anthony Webb, Jia Wei, Katharina Weil, Tan Pei Wen, Sanne Wesselius, T. Eoin West, Murray Wham, Bryan Whelan, Nicole White, Paul Henri Wicky, Aurélie Wiedemann, Surya Otto Wijaya, Keith Wille, Suzette Willems, Virginie Williams, Evert-Jan Wils, Ng Wing Yiu, Calvin Wong, Teck Fung Wong, Xin Ci Wong, Yew Sing Wong, Gan Ee Xian, Lim Saio Xian, Kuan Pei Xuan, Ioannis Xynogalas, Sophie Yacoub, Siti Rohani Binti Mohd Yakop, Masaki Yamazaki, Yazdan Yazdanpanah, Nicholas Yee Liang Hing, Cécile Yelnik, Chian Hui Yeoh, Stephanie Yerkovich, Toshiki Yokoyama, Hodane Yonis, Obada Yousif, Saptadi Yuliarto, Akram Zaaqoq, Marion Zabbe, Kai Zacharowski, Masliza Zahid, Maram Zahran, Nor Zaila Binti Zaidan, Maria Zambon, Miguel Zambrano, Alberto Zanella, Konrad Zawadka, Nurul Zaynah, Hiba Zayyad, Alexander Zoufaly, David Zucman, ESTACA'Lab ( ESTACA'Lab ), École Supérieure des Techniques Aéronautiques et de Construction Automobile (ESTACA), Laboratoire d’Ingénierie Circulation Transport et Éco-gestion des systèmes énergétiques pour les transports (LICIT-Eco7), École Nationale des Travaux Publics de l'État (ENTPE)-Université Gustave Eiffel, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University [New York], Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Department of Mathematics and Statistics, Wichita State University, Indo-French Center for Groundwater Research (IFCGR), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-National Geophysical Research Institute [Hyderabad] (NGRI), National Geophysical Research Institute [Hyderabad] (NGRI), Department of Zoology [Rawalpindi, Pakistan], Pir Mehr Ali Shah Arid Agriculture University = PMAS-Arid Agriculture University Rawalpindi (AAUR), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR - laboratoire coordonnateur), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Abbas A., Abdukahil S.A., Abdulkadir N.N., Abe R., Abel L., Absil L., Acharya S., Acker A., Adachi S., Adam E., Adriao D., Ageel S.A., Ahmed S., Ain Q., Ainscough K., Aisa T., Ait Hssain A., Ait Tamlihat Y., Akimoto T., Akmal E., Al Qasim E., Alalqam R., Alam T., Al-dabbous T., Alegesan S., Alegre C., Alessi M., Alex B., Alexandre K., Al-Fares A., Alfoudri H., Ali I., Ali Shah N., Alidjnou K.E., Aliudin J., Alkhafajee Q., Allavena C., Allou N., Altaf A., Alves J., Alves J.M., Alves R., Amaral M., Amira N., Ammerlaan H., Ampaw P., Andini R., Andrejak C., Angheben A., Angoulvant F., Ansart S., Anthonidass S., Antonelli M., Antunes de Brito C.A., Anwar K.R., Apriyana A., Arabi Y., Aragao I., Arali R., Arancibia F., Araujo C., Arcadipane A., Archambault P., Arenz L., Arlet J.-B., Arnold-Day C., Aroca A., Arora L., Arora R., Artaud-Macari E., Aryal D., Asaki M., Asensio A., Ashley E., Ashraf M., Ashraf S., Asim M., Assie J.B., Asyraf A., Atique A., Attanyake A.U.L., Auchabie J., Aumaitre H., Auvet A., Azemar L., Azoulay C., Bach B., Bachelet D., Badr C., Baig N., Baillie J.K., Baird J.K., Bak E., Bakakos A., Bakar N.A., Bal A., Balakrishnan M., Balan V., Bani-Sadr F., Barbalho R., Barbosa N.Y., Barclay W.S., Barnett S.U., Barnikel M., Barrasa H., Barrelet A., Barrigoto C., Bartoli M., Bartone C., Baruch J., Bashir M., Basmaci R., Basri M.F.H., Bastos D., Battaglini D., Bauer J., Bautista Rincon D.F., Bazan Dow D., Bedossa A., Bee K.H., Behilill S., Beishuizen A., Beljantsev A., Bellemare D., Beltrame A., Beltrao B.A., Beluze M., Benech N., Benjiman L.E., Benkerrou D., Bennett S., Bento L., Berdal J.-E., Bergeaud D., Bergin H., Bernal Sobrino J.L., Bertoli G., Bertolino L., Bessis S., Betz A., Bevilcaqua S., Bezulier K., Bhatt A., Bhavsar K., Bianchi I., Bianco C., Bidin F.N., Bikram Singh M., Bin Humaid F., Bin Kamarudin M.N., Bissuel F., Biston P., Bitker L., Blanco-Schweizer P., Blier C., Bloos F., Blot M., Blumberg L., Boccia F., Bodenes L., Bogaarts A., Bogaert D., Boivin A.-H., Bolze P.-A., Bompart F., Bonfasius A., Borges D., Borie R., Bosse H.M., Botelho-Nevers E., Bouadma L., Bouchaud O., Bouchez S., Bouhmani D., Bouhour D., Bouiller K., Bouillet L., Bouisse C., Boureau A.-S., Bourke J., Bouscambert M., Bousquet A., Bouziotis J., Boxma B., Boyer-Besseyre M., Boylan M., Bozza F.A., Brack M., Braconnier A., Braga C., Brandenburger T., Bras Monteiro F., Brazzi L., Breen D., Breen P., Brett S., Brickell K., Broadley T., Browne A., Browne S., Brozzi N., Brusse-Keizer M., Buchtele N., Buesaquillo C., Bugaeva P., Buisson M., Burhan E., Burrell A., Bustos I.G., Butnaru D., Cabie A., Cabral S., Caceres E., Cadoz C., Callahan M., Calligy K., Calvache J.A., Cam J., Campana V., Campbell P., Campisi J., Canepa C., Cantero M., Caraux-Paz P., Carcel S., Cardellino C.S., Cardoso F., Cardoso N., Cardoso S., Carelli S., Carlier N., Carmoi T., Carney G., Carpenter C., Carqueja I., Carret M.-C., Carrier F.M., Carroll I., Carson G., Carton E., Casanova M.-L., Cascao M., Casey S., Casimiro J., Cassandra B., Castaneda S., Castanheira N., Castor-Alexandre G., Castrillon H., Castro I., Catarino A., Catherine F.-X., Cattaneo P., Cavalin R., Cavalli G.G., Cavayas A., Ceccato A., Cervantes-Gonzalez M., Chair A., Chakveatze C., Chan A., Chand M., Chantalat Auger C., Chapplain J.-M., Chas J., Chaudary M., Chavez Iniguez J.S., Chen A., Chen Y.-S., Cheng M.P., Cheret A., Chiarabini T., Chica J., Chidambaram S.K., Chin-Tho L., Chirouze C., Chiumello D., Cho H.J., Cho S.-M., Cholley B., Chopin M.-C., Chow T.S., Chow Y.P., Chua H.J., Chua J., Cidade J.P., Cisneros Herreros J.M., Citarella B.W., Ciullo A., Clarke E., Clarke J., Claure Del Granado R., Clohisey S., Cobb J.P., Coca N., Codan C., Cody C., Coelho A., Coles M., Colin G., Collins M., Colombo S.M., Combs P., Connolly J., Connor M., Conrad A., Contreras S., Conway E., Cooke G.S., Copland M., Cordel H., Corley A., Cormican S., Cornelis S., Cornet A.D., Corpuz A.J., Cortegiani A., Corvaisier G., Costigan E., Couffignal C., Couffin-Cadiergues S., Courtois R., Cousse S., Cregan R., Crepy D'Orleans C., Croonen S., Crowl G., Crump J., Cruz C., Cruz Berm J.L., Cruz Rojo J., Csete M., Cucino A., Cullen A., Cullen C., Cummings M., Curley G., Curlier E., Curran C., Custodio P., da Silva Filipe A., Da Silveira C., Dabaliz A.-A., Dagens A., Dahly D., Dalton H., Dalton J., Daly S., D'Amico F., Daneman N., Daniel C., Dankwa E.A., Dantas J., D'Aragon F., de Boer M., de Loughry G., de Mendoza D., De Montmollin E., de Oliveira Franca R.F., de Pinho Oliveira A.I., De Rosa R., de Silva T., de Vries P., Deacon J., Dean D., Debard A., DeBenedictis B., Debray M.-P., DeCastro N., Dechert W., Deconninck L., Decours R., Defous E., Delacroix I., Delaveuve E., Delavigne K., Delfos N.M., Deligiannis I., Dell'Amore A., Delmas C., Delobel P., Delsing C., Demonchy E., Denis E., Deplanque D., Depuydt P., Desai M., Descamps D., Desvallee M., Dewayanti S., Diallo A., Diamantis S., Dias A., Diaz P., Diaz R., Diaz Diaz J.J., Didier K., Diehl J.-L., Dieperink W., Dimet J., Dinot V., Diop F., Diouf A., Dishon Y., Dixit D., Djossou F., Docherty A.B., Doherty H., Dondorp A.M., Dong A., Donnelly C.A., Donnelly M., Donohue C., Donohue S., Donohue Y., Doran C., Doran P., Dorival C., D'Ortenzio E., Douglas J.J., Douma R., Dournon N., Downer T., Downey J., Downing M., Drake T., Driscoll A., Dryden M., Duarte Fonseca C., Dubee V., Dubos F., Ducancelle A., Duculan T., Dudman S., Duggal A., Dunand P., Dunning J., Duplaix M., Durante-Mangoni E., Durham III L., Dussol B., Duthoit J., Duval X., Dyrhol-Riise A.M., Ean S.C., Echeverria-Villalobos M., Egan S., Eira C., El Sanharawi M., Elapavaluru S., Elharrar B., Ellerbroek J., Eloy P., Elshazly T., Elyazar I., Enderle I., Endo T., Eng C.C., Engelmann I., Enouf V., Epaulard O., Escher M., Esperatti M., Esperou H., Esposito-Farese M., Estevao J., Etienne M., Ettalhaoui N., Everding A.G., Evers M., Fabre I., Fabre M., Faheem A., Fahy A., Fairfield C.J., Fakar Z., Faria P., Farooq A., Farrar J.J., Farshait N., Fateena H., Fatoni A.Z., Faure K., Favory R., Fayed M., Feely N., Feeney L., Fernandes J., Fernandes M., Fernandes S., Ferrand F.-X., Ferrand Devouge E., Ferrao J., Ferraz M., Ferreira B., Ferreira S., Ferrer-Roca R., Ferriere N., Ficko C., Figueiredo-Mello C., Fiorda J., Flament T., Flateau C., Fletcher T., Florio L.L., Flynn B., Flynn D., Foley C., Foley J., Fomin V., Fonseca T., Fontela P., Forsyth S., Foster D., Foti G., Fourn E., Fowler R.A., Fraher D.M., Franch-Llasat D., Fraser C., Fraser J.F., Freire M.V., Freitas Ribeiro A., Friedrich C., Fritz R., Fry S., Fuentes N., Fukuda M., Gaborieau V., Gaci R., Gagliardi M., Gagnard J.-C., Gagne N., Gagneux-Brunon A., Gaiao S., Gail Skeie L., Gallagher P., Gallego Curto E., Gamble C., Gani Y., Garan A., Garcia R., Garcia Barrio N., Garcia-Diaz J., Garcia-Gallo E., Garimella N., Garot D., Garrait V., Gauli B., Gault N., Gavin A., Gavrylov A., Gaymard A., Gebauer J., Geraud E., Gerbaud Morlaes L., Germano N., ghisulal P.K., Ghosn J., Giani M., Giaquinto C., Gibson J., Gigante T., Gilg M., Gilroy E., Giordano G., Girvan M., Gissot V., Gitahi J., Giwangkancana G., Glikman D., Glybochko P., Gnall E., Goco G., Goehringer F., Goepel S., Goffard J.-C., Goh J.Y., Golob J., Gomes R., Gomez K., Gomez-Junyent J., Gominet M., Gonzalez A., Gordon P., Gordon A., Gorenne I., Goubert L., Goujard C., Goulenok T., Grable M., Graf J., Grandin E.W., Granier P., Grasselli G., Grazioli L., Green C.A., Greene C., Greenhalf W., Greffe S., Grieco D.L., Griffee M., Griffiths F., Grigoras I., Groenendijk A., Grosse Lordemann A., Gruner H., Gu Y., Guarracino F., Guedj J., Guego M., Guellec D., Guerguerian A.-M., Guerreiro D., Guery R., Guillaumot A., Guilleminault L., Guimaraes de Castro M., Guimard T., Haalboom M., Haber D., Habraken H., Hachemi A., Hadri N., Haidash O., Haider S., Haidri F., Hakak S., Hall A., Hall M., Halpin S., Hamer A., Hamers R., Hamidfar R., Hammond T., Han L.Y., Haniffa R., Hao K.W., Hardwick H., Harrison E.M., Harrison J., Harrison S.B.E., Hartman A., Hashmi J., Hashmi M., Hayat M., Hayes A., Hays L., Heerman J., Heggelund L., Hendry R., Hennessy M., Henriquez A., Hentzien M., Herekar F., Hernandez-Montfort J., Herr D., Hershey A., Hesstvedt L., Hidayah A., Higgins D., Higgins E., HigginsOKeeffe G., Hinchion R., Hinton S., Hiraiwa H., Hitoto H., Ho A., Ho Y.B., Hoctin A., Hoffmann I., Hoh W.H., Hoiting O., Holt R., Holter J.C., Horby P., Horcajada J.P., Hoshino K., Houas I., Hough C.L., Houltham S., Hsu J.M.-Y., Hulot J.-S., Hussain I., Ijaz S., Illes H.-G., Imbert P., Imran M., Imran Sikander R., Inacio H., Infante Dominguez C., Ing Y.S., Iosifidis E., Ippolito M., Isgett S., Ishani P.G.P.I., Isidoro T., Ismail N., Isnard M., Itai J., Ito A., Ivulich D., Jaafar D., Jaafoura S., Jabot J., Jackson C., Jamieson N., Jaquet P., Jassat W., Jaud-Fischer C., Jaureguiberry S., Javidfar J., Jawad I., Jaworsky D., Jayakumar D., Jego F., Jelani A.M., Jenum S., Jimbo-Sotomayor R., Job V.D.P., Joe O.Y., Jorge Garcia R.N., Joseph C., Joseph M., Joshi S., Jourdain M., Jouvet P., June J., Jung A., Jung H., Juzar D., Kafif O., Kaguelidou F., Kaisbain N., Kaleesvran T., Kali S., Kalicinska A., Kalomoiri S., Kamal S., Kamaluddin M.A.A., Kamaruddin Z.A.C., Kamarudin N., Kandamby D.H., Kandel C., Kang K.Y., Kant R., Kanwal D., Kanyawati D., Karki B., Karpayah P., Karsies T., Kartsonaki C., Kasugai D., Kataria A., Katz K., Kaur A., Kaur Johal S., Kawasaki T., Kay C., Keane H., Keating S., Kellam P., Kelly A., Kelly C., Kelly N., Kelly S., Kelly Y., Kelsey M., Kennedy R., Kennon K., Kernan M., Kerroumi Y., Keshav S., Kestelyn E., Khalid I., Khalid O., Khalil A., Khan C., Khan I., Khanal S., Kho M.E., Khoo D., Khoo R., Khoo S., Khoso N., Kiat K.H., Kida Y., Kiiza P., Kildal A.B., Kim J.B., Kimmoun A., Kindgen-Milles D., King A., Kitamura N., Klenerman P., Klont R., Kloumann Bekken G., Knight S., Kobbe R., Kodippily C., Kohns Vasconcelos M., Koirala S., Komatsu M., Korten V., Kosgei C., Kpangon A., Krawczyk K., Krishnan S., Krishnan V., Kruglova O., Kumar A., Kumar D., Kumar G., Kumar M., Kumar Vecham P., Kuriakose D., Kurtzman E., Kusumastuti N.P., Kutsogiannis D., Kutsyna G., Kyriakoulis K., Lachatre M., Lacoste M., Laffey J.G., Lagrange M., Laine F., Lairez O., Lakhey S., Lalueza A., Lambert M., Lamontagne F., Langelot-Richard M., Langlois V., Lantang E.Y., Lanza M., Laouenan C., Laribi S., Lariviere D., Lasry S., Latif N., Launay O., Laureillard D., Lavie-Badie Y., Law A., Lawrence C., Lawrence T., Le M., Le Bihan C., Le Bris C., Le Falher G., Le Fevre L., Le Hingrat Q., Le Marechal M., Le Mestre S., Le Moal G., Le Moing V., Le Nagard H., Le Turnier P., Leal E., Leal Santos M., Lee B.H., Lee H.G., Lee J., Lee S.H., Lee T.C., Lee Y.L., Leeming G., Lefebvre B., Lefebvre L., Lefevre B., LeGac S., Lelievre J.-D., Lellouche F., Lemaignen A., Lemee V., Lemeur A., Lemmink G., Lene H.S., Lennon J., Leon R., Leone M., Lepiller Q., Lescure F.-X., Lesens O., Lesouhaitier M., Lester-Grant A., Levy B., Levy Y., Levy-Marchal C., Lewandowska K., L'Her E., Li Bassi G., Liang J., Liaquat A., Liegeon G., Lim K.C., Lim W.S., Lima C., Lina B., Lina L., Lind A., Lingas G., Lion-Daolio S., Lissauer S., Liu K., Livrozet M., Lizotte P., Loforte A., Lolong N., Loon L.C., Lopes D., Lopez-Colon D., Loschner A.L., Loubet P., Loufti B., Louis G., Lourenco S., Lovelace-Macon L., Low L.L., Lowik M., Loy J.S., Lucet J.C., Lumbreras Bermejo C., Luna C.M., Lungu O., Luong L., Luque N., Luton D., Lwin N., Lyons R., Maasikas O., Mabiala O., MacDonald S., Machado M., Macheda G., Macias Sanchez J., Madhok J., Maestro de la Calle G., Mahieu R., Mahy S., Maia A.R., Maier L.S., Maillet M., Maitre T., Malfertheiner M., Malik N., Mallon P., Maltez F., Malvy D., Manda V., Mandei J.M., Mandelbrot L., Manetta F., Mangal K., Mankikian J., Manning E., Manuel A., Maria Sant`Ana Malaque C., Marino D., Marino F., Markowicz S., Maroun Eid C., Marques A., Marquis C., Marsh B., Marsh L., Marshal M., Marshall J., Martelli C.T., Martin D.-A., Martin E., Martin-Blondel G., Martinelli A., Martin-Loeches I., Martinot M., Martin-Quiros A., Martins A., Martins J., Martins N., Martins Rego C., Martucci G., Martynenko O., Marwali E.M., Marzukie M., Masa Jimenez J.F., Maslove D., Mason P., Mason S., Masood S., Mat Nor B., Matan M., Mateus Fernandes H., Mathew M., Mathieu D., Mattei M., Matulevics R., Maulin L., Maxwell M., Maynar J., Mazzoni T., Mc Sweeney L., McAndrew L., McArthur C., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S.E., McElroy A., McElwee S., McEneany V., McEvoy N., McGeer A., McKay C., McKeown J., McLean K.A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Meher M., Mehkri O., Mele F., Melo L., Memon K., Mendes J.J., Menkiti O., Menon K., Mentre F., Mentzer A.J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Merson L., Mesquita A., Metwally O., Meybeck A., Meyer D., Meynert A.M., Meysonnier V., Meziane A., Mezidi M., Michelagnoli G., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miranda-Maldonado H., Misnan N.A., Mohamed N.N.E., Mohamed T.J., Moin A., Molina D., Molinos E., Molloy B., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S., Moore S.C., Morales Cely L., Moro L., Morocho Tutillo D.R., Morton B., Motherway C., Motos A., Mouquet H., Mouton Perrot C., Moyet J., Mudara C., Mufti A.K., Muh N.Y., Muhamad D., Mullaert J., Muller F., Muller K.E., Munblit D., Muneeb S., Munir N., Munshi L., Murphy A., Murphy L., Murris M., Murthy S., Musaab H., Muyandy G., Myrodia D.M., N N., Nagpal D., Nagrebetsky A., Narasimhan M., Narayanan N., Nasim Khan R., Nazerali-Maitland A., Neant N., Neb H., Nekliudov N.A., Nelwan E., Neto R., Neumann E., Neves B., Ng P.Y., Nghi A., Nguyen D., Ni Choileain O., Ni Leathlobhair N., Nichol A., Nitayavardhana P., Nonas S., Noordin N.A.M., Noret M., Norharizam N.F.I., Norman L., Notari A., Noursadeghi M., Nowicka K., Nowinski A., Nseir S., Nunez J.I., Nurnaningsih N., Nyamankolly E., O Brien F., O'Callaghan A., Occhipinti G., OConnor D., O'Donnell M., Ogston T., Ogura T., Oh T.-H., O'Halloran S., O'Hearn K., Ohshimo S., Oldakowska A., Oliveira J., Oliveira L., Olliaro P.L., O'Neil C., Ong D.S.Y., Ong J.Y., Oosthuyzen W., Opavsky A., Openshaw P., Orakzai S., Orozco-Chamorro C.M., Orquera A., Ortoleva J., Osatnik J., O'Shea L., O'Sullivan M., Othman S.Z., Ouamara N., Ouissa R., Owyang C., Oziol E., Pabasara H.M.U., Pagadoy M., Pages J., Palacios A., Palacios M., Palmarini M., Panarello G., Panda P.K., Paneru H., Pang L.H., Panigada M., Pansu N., Papadopoulos A., Parke R., Parker M., Parra B., Parrini V., Pasha T., Pasquier J., Pastene B., Patauner F., Patel J., Pathmanathan M.D., Patrao L., Patricio P., Patrier J., Patterson L., Pattnaik R., Paul C., Paul M., Paulos J., Paxton W.A., Payen J.-F., Peariasamy K., Pedrera Jimenez M., Peek G.J., Peelman F., Peiffer-Smadja N., Peigne V., Pejkovska M., Pelosi P., Peltan I.D., Pereira R., Perez D., Periel L., Perpoint T., Pesenti A., Pestre V., Petrou L., Petrov-Sanchez V., Pettersen F.O., Peytavin G., Pharand S., Piagnerelli M., Picard W., Picone O., de Piero M., Pierobon C., Piersma D., Pimentel C., Pinto R., Pires C., Pironneau I., Piroth L., Pius R., Piva S., Plantier L., Plotkin D., Png H.S., Poissy J., Pokeerbux R., Pokorska-Spiewak M., Poli S., Pollakis G., Ponscarme D., Popielska J., Post A.-M., Postma D.F., Povoa P., Povoas D., Powis J., Prapa S., Preau S., Prebensen C., Preiser J.-C., Prinssen A., Pritchard M.G., Priyadarshani G.D.D., Proenca L., Pudota S., Puechal O., Pujo Semedi B., Pulicken M., Puntoni M., Purcell G., Quesada L., Quinones-Cardona V., Quiros Gonzalez V., Quist-Paulsen E., Quraishi M., Rabaa M., Rabaud C., Rabindrarajan E., Rafael A., Rafiq M., Ragazzo G., Rahman A.K.H.A., Rahman R.A., Rahutullah A., Rainieri F., Rajahram G.S., Rajapakse N., Ralib A., Ramakrishnan N., Ramanathan K., Ramli A.A., Rammaert B., Ramos G.V., Rana A., Rangappa R., Ranjan R., Rapp C., Rashan A., Rashan T., Rasheed G., Rasmin M., Ratsep I., Rau C., Ravi T., Raza A., Real A., Rebaudet S., Redl S., Reeve B., Rehan A., Rehman A., Reid L., Reikvam D.H., Reis R., Rello J., Remppis J., Remy M., Ren H., Renk H., Resende L., Resseguier A.-S., Revest M., Rewa O., Reyes L.F., Reyes T., Ribeiro M.I., Richardson D., Richier L., Ridzuan S.N.A.A., Riera J., Rios A.L., Rishu A., Rispal P., Risso K., Rivera Nunez M.A., Rizer N., Robb D., Robba C., Roberto A., Roberts S., Robertson D.L., Robineau O., Roche-Campo F., Rodari P., Rodeia S., Rodriguez Abreu J., Roessler B., Roger C., Roger 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P., Cisneros Herreros, J. M., Citarella, B. W., Ciullo, A., Clarke, E., Clarke, J., Claure Del Granado, R., Clohisey, S., Cobb, J. P., Coca, N., Codan, C., Cody, C., Coelho, A., Coles, M., Colin, G., Collins, M., Colombo, S. M., Combs, P., Connolly, J., Connor, M., Conrad, A., Contreras, S., Conway, E., Cooke, G. S., Copland, M., Cordel, H., Corley, A., Cormican, S., Cornelis, S., Cornet, A. D., Corpuz, A. J., Cortegiani, A., Corvaisier, G., Costigan, E., Couffignal, C., Couffin-Cadiergues, S., Courtois, R., Cousse, S., Cregan, R., Crepy D'Orleans, C., Croonen, S., Crowl, G., Crump, J., Cruz, C., Cruz Berm, J. L., Cruz Rojo, J., Csete, M., Cucino, A., Cullen, A., Cullen, C., Cummings, M., Curley, G., Curlier, E., Curran, C., Custodio, P., da Silva Filipe, A., Da Silveira, C., Dabaliz, A. -A., Dagens, A., Dahly, D., Dalton, H., Dalton, J., Daly, S., D'Amico, F., Daneman, N., Daniel, C., Dankwa, E. A., Dantas, J., D'Aragon, F., de Boer, M., de Loughry, G., de Mendoza, D., De Montmollin, E., de Oliveira Franca, R. F., de Pinho Oliveira, A. I., De Rosa, R., de Silva, T., de Vries, P., Deacon, J., Dean, D., Debard, A., Debenedictis, B., Debray, M. -P., Decastro, N., Dechert, W., Deconninck, L., Decours, R., Defous, E., Delacroix, I., Delaveuve, E., Delavigne, K., Delfos, N. M., Deligiannis, I., Dell'Amore, A., Delmas, C., Delobel, P., Delsing, C., Demonchy, E., Denis, E., Deplanque, D., Depuydt, P., Desai, M., Descamps, D., Desvallee, M., Dewayanti, S., Diallo, A., Diamantis, S., Dias, A., Diaz, P., Diaz, R., Diaz Diaz, J. J., Didier, K., Diehl, J. -L., Dieperink, W., Dimet, J., Dinot, V., Diop, F., Diouf, A., Dishon, Y., Dixit, D., Djossou, F., Docherty, A. B., Doherty, H., Dondorp, A. M., Dong, A., Donnelly, C. A., Donnelly, M., Donohue, C., Donohue, S., Donohue, Y., Doran, C., Doran, P., Dorival, C., D'Ortenzio, E., Douglas, J. 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W., Granier, P., Grasselli, G., Grazioli, L., Green, C. A., Greene, C., Greenhalf, W., Greffe, S., Grieco, D. L., Griffee, M., Griffiths, F., Grigoras, I., Groenendijk, A., Grosse Lordemann, A., Gruner, H., Gu, Y., Guarracino, F., Guedj, J., Guego, M., Guellec, D., Guerguerian, A. -M., Guerreiro, D., Guery, R., Guillaumot, A., Guilleminault, L., Guimaraes de Castro, M., Guimard, T., Haalboom, M., Haber, D., Habraken, H., Hachemi, A., Hadri, N., Haidash, O., Haider, S., Haidri, F., Hakak, S., Hall, A., Hall, M., Halpin, S., Hamer, A., Hamers, R., Hamidfar, R., Hammond, T., Han, L. Y., Haniffa, R., Hao, K. W., Hardwick, H., Harrison, E. M., Harrison, J., Harrison, S. B. E., Hartman, A., Hashmi, J., Hashmi, M., Hayat, M., Hayes, A., Hays, L., Heerman, J., Heggelund, L., Hendry, R., Hennessy, M., Henriquez, A., Hentzien, M., Herekar, F., Hernandez-Montfort, J., Herr, D., Hershey, A., Hesstvedt, L., Hidayah, A., Higgins, D., Higgins, E., Higginsokeeffe, G., Hinchion, R., Hinton, S., Hiraiwa, H., Hitoto, H., Ho, A., Ho, Y. B., Hoctin, A., Hoffmann, I., Hoh, W. H., Hoiting, O., Holt, R., Holter, J. C., Horby, P., Horcajada, J. P., Hoshino, K., Houas, I., Hough, C. L., Houltham, S., Hsu, J. M. -Y., Hulot, J. -S., Hussain, I., Ijaz, S., Illes, H. -G., Imbert, P., Imran, M., Imran Sikander, R., Inacio, H., Infante Dominguez, C., Ing, Y. S., Iosifidis, E., Ippolito, M., Isgett, S., Ishani, P. G. P. I., Isidoro, T., Ismail, N., Isnard, M., Itai, J., Ito, A., Ivulich, D., Jaafar, D., Jaafoura, S., Jabot, J., Jackson, C., Jamieson, N., Jaquet, P., Jassat, W., Jaud-Fischer, C., Jaureguiberry, S., Javidfar, J., Jawad, I., Jaworsky, D., Jayakumar, D., Jego, F., Jelani, A. M., Jenum, S., Jimbo-Sotomayor, R., Job, V. D. P., Joe, O. Y., Jorge Garcia, R. N., Joseph, C., Joseph, M., Joshi, S., Jourdain, M., Jouvet, P., June, J., Jung, A., Jung, H., Juzar, D., Kafif, O., Kaguelidou, F., Kaisbain, N., Kaleesvran, T., Kali, S., Kalicinska, A., Kalomoiri, S., Kamal, S., Kamaluddin, M. A. A., Kamaruddin, Z. A. C., Kamarudin, N., Kandamby, D. H., Kandel, C., Kang, K. 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Subjects: Biomedical Research, [SDV]Life Sciences [q-bio], Clinical science, Global Health, Corrections, Microbiology, 1117 Public Health and Health Services, 1108 Medical Microbiology, Pandemic, Economics, Humans, ISARIC Clinical Characterisation Group, Pandemics, COVID-19/epidemiology, Actuarial science, Information Dissemination, SARS-CoV-2, Comment, ISARIC, COVID-19, 1103 Clinical Sciences, Communicable Disease Control/methods, Infectious Diseases, Open source, Communicable Disease Control, Value (mathematics), Human
Abstract: International audience
Published: 2021

45. In vitrostudy of a new vaporization humidifying device: DAR HC 2000®

Author: Bottino, N, Chiaravalli, L, Panigada, M, Carrieri, F, Allegritti, E, Pelosi, P, and Gattinoni, L
Published: 1999
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46. Myelomonocytic cells in giant cell arteritis activate trained immunity programs sustaining inflammation and cytokine production

Author: Eleonora Cantoni, Ivan Merelli, Davide Stefanoni, Alessandro Tomelleri, Corrado Campochiaro, Vito Giordano, Maddalena Panigada, Elena M Baldissera, Laura Merlo Pich, Valentina Natoli, Athanasios Ziogas, Jorge Domínguez-Andrés, Giacomo De Luca, Davide Mazza, Samuel Zambrano, Daniela Gnani, Marina Ferrarini, Elisabetta Ferrero, Alessandra Agresti, Barbara Vergani, Biagio Eugenio Leone, Simone Cenci, Angelo Ravelli, Marco Matucci-Cerinic, Angelo D’Alessandro, Leo A B Joosten, Lorenzo Dagna, Mihai G Netea, Raffaella Molteni, Giulio Cavalli, Cantoni, E, Merelli, I, Stefanoni, D, Tomelleri, A, Campochiaro, C, Giordano, V, Panigada, M, Baldissera, E, Merlo Pich, L, Natoli, V, Ziogas, A, Domínguez-Andrés, J, De Luca, G, Mazza, D, Zambrano, S, Gnani, D, Ferrarini, M, Ferrero, E, Agresti, A, Vergani, B, Leone, B, Cenci, S, Ravelli, A, Matucci-Cerinic, M, D'Alessandro, A, Joosten, L, Dagna, L, Netea, M, Molteni, R, and Cavalli, G
Subjects: IL-6, trained immunity, Rheumatology, immunometabolism, Pharmacology (medical), monocyte/macrophage, epigenetic
Abstract: ObjectiveTrained immunity (TI) is a de facto memory program of innate immune cells, characterized by immunometabolic and epigenetic changes sustaining enhanced production of cytokines. TI evolved as a protective mechanism against infections; however, inappropriate activation can cause detrimental inflammation and might be implicated in the pathogenesis of chronic inflammatory diseases. In this study, we investigated the role of TI in the pathogenesis of giant cell arteritis (GCA), a large-vessel vasculitis characterized by aberrant macrophage activation and excess cytokine production.MethodsMonocytes from GCA patients and from age- and sex-matched healthy donors were subjected to polyfunctional studies, including cytokine production assays at baseline and following stimulation, intracellular metabolomics, chromatin immunoprecipitation-qPCR, and combined ATAC/RNA sequencing. Immunometabolic activation (i.e. glycolysis) was assessed in inflamed vessels of GCA patients with FDG-PET and immunohistochemistry (IHC), and the role of this pathway in sustaining cytokine production was confirmed with selective pharmacologic inhibition in GCA monocytes.ResultsGCA monocytes exhibited hallmark molecular features of TI. Specifically, these included enhanced IL-6 production upon stimulation, typical immunometabolic changes (e.g. increased glycolysis and glutaminolysis) and epigenetic changes promoting enhanced transcription of genes governing pro-inflammatory activation. Immunometabolic changes of TI (i.e. glycolysis) were a feature of myelomonocytic cells in GCA lesions and were required for enhanced cytokine production.ConclusionsMyelomonocytic cells in GCA activate TI programs sustaining enhanced inflammatory activation with excess cytokine production.
Published: 2023

47. COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Author: Abdukahil, Sheryl, Hssain, Ali, Tamlihat, Younes, Alidjnou, Kazali, de Brito, Carlos, Assie, Jean, Rincon, Diego, Humaid, Felwa, Bosse, Hans, Calvache, Jose, Carrier, François, Cavalli, Giulio, Cheng, Matthew, Cho, Hwa, Cho, Sung, Cidade, Jose, Herreros, Jose, Citarella, Barbara, Colombo, Sebastiano, Corpuz, Arianne, D’orleans, Charles, de Oliveira França, Rafael, Dewayanti, Santi, Diaz, Juan, Douglas, James, Mangoni, Emanuele, Dyrhol-Riise, Anne, Vidal, José, Sanharawi, Mohammed, Everding, Anna, Fatoni, Arie, Devouge, Eglantine, Florio, Letizia, Fonseca, Claudio, Freire, Marcela, Ribeiro, Ana, Curto, Elena, Morlaes, Louis, Grandin, Edward, Grieco, Domenico, Lordemann, Anja, Ho, Antonia, Holter, Jan, Horcajada, Juan, Dominguez, Carmen, Sotomayor, Ruth, García, Ruth, Kandamby, Darshana, Johal, Simreen, Kildal, Anders, Bekken, Gry, Vasconcelos, Malte, Vecham, Pavan, Lantang, Eka, Santos, Marta, Lee, Su, Bassi, Gianluigi, Lim, Wei, Lucet, Jean, Müller, Karl, Sanchez, Juan, Maier, Lars, Sant, Ceila, Eid, Charbel, Martelli, Celina, Rego, Caroline, Marwali, Eva, Jimenez, Juan, Maldonado, Hugo, Tutillo, Diego, Perrot, Clara, Myrodia, Dimitra, Ng, Pauline, Ng, Wing, Choileain, Orna, Oinam, Budha, Oliveira, Ana, Orozco-Chamorro, Claudia, Panda, Prasan, Reyes, Luis, Rios, Ana, Nuñez, Maria, Abreu, Julia, Holten, Aleksander, Choez, Xavier, Shum, Hoi, Mohammed, Nassima, Silva, Maria, Sin, Wai, Song, Myung, Uva, Maria, Svistunov, Magdalena, Thuy, Duong, Vijayaraghavan, Bharath, Santos-Olmo, Rosario, Trieu, Huynh, Villanueva, Joy, Abdukahil, Sheryl Ann, Abe, Ryuzo, Abel, Laurent, Absil, Lara, Acker, Andrew, Adachi, Shingo, Adam, Elisabeth, Adrião, Diana, Ainscough, Kate, Hssain, Ali Ait, Tamlihat, Younes Ait, Akimoto, Takako, Al-Dabbous, Tala, Al-Fares, Abdulrahman, Al Qasim, Eman, Alalqam, Razi, Alex, Beatrice, Alexandre, Kévin, Alfoudri, Huda, Alidjnou, Kazali Enagnon, Aliudin, Jeffrey, Allavena, Clotilde, Allou, Nathalie, Alves, João, Alves, Rita, Amaral, Maria, Ammerlaan, Heidi, Ampaw, Phoebe, Andini, Roberto, Andrejak, Claire, Angheben, Andrea, Angoulvant, François, Ansart, Séverine, Antonelli, Massimo, de Brito, Carlos Alexandre Antunes, Arabi, Yaseen, Aragao, Irene, Arcadipane, Antonio, Arenz, Lukas, Arlet, Jean-Benoît, Arnold-Day, Christel, Arora, Lovkesh, Artaud-Macari, Elise, Asensio, Angel, Assie, Jean Baptiste, Atique, Anika, Auchabie, Johann, Aumaitre, Hugues, Azemar, Laurène, Azoulay, Cécile, Bach, Benjamin, Bachelet, Delphine, Baillie, J. Kenneth, Bak, Erica, Bakakos, Agamemnon, Banisadr, Firouzé, Barbalho, Renata, Barclay, Wendy, Barnikel, Michaela, Barrelet, Audrey, Barrigoto, Cleide, Basmaci, Romain, Rincon, Diego Fernando Bautista, Bedossa, Alexandra, Behilill, Sylvie, Beljantsev, Aleksandr, Bellemare, David, Beltrame, Anna, Beluze, Marine, Benech, Nicolas, Benkerrou, Dehbia, Bennett, Suzanne, Bento, Luís, Berdal, Jan-Erik, Bergeaud, Delphine, Bertolino, Lorenzo, Bessis, Simon, Bevilcaqua, Sybille, Bhavsar, Krishna, Humaid, Felwa Bin, Bissuel, François, Biston, Patrick, Bitker, Laurent, Blanco-Schweizer, Pablo, Blot, Mathieu, Boccia, Filomena, Bogaert, Debby, Bompart, François, Booth, Gareth, Borges, Diogo, Borie, Raphaël, Bos, Jeannet, Bosse, Hans Martin, Botelho-Nevers, Elisabeth, Bouadma, Lila, Bouchaud, Olivier, Bouchez, Sabelline, Bouhmani, Dounia, Bouhour, Damien, Bouiller, Kévin, Bouillet, Laurence, Bouisse, Camille, Boureau, Anne-Sophie, Bouscambert, Maude, Bouziotis, Jason, Boxma, Bianca, Boyer-Besseyre, Marielle, Boylan, Maria, Braga, Cynthia, Brandenburger, Timo, Brazzi, Luca, Breen, Dorothy, Breen, Patrick, Brickell, Kathy, Brozzi, Nicolas, Buchtele, Nina, Buesaquillo, Christian, Bugaeva, Polina, Buisson, Marielle, Burhan, Erlina, Bustos, Ingrid, Butnaru, Denis, Cárcel, Sheila, Cabie, André, Cabral, Susana, Caceres, Eder, Callahan, Mia, Calligy, Kate, Calvache, Jose Andres, Camões, João, Campana, Valentine, Campbell, Paul, Canepa, Cecilia, Cantero, Mireia, Caraux-Paz, Pauline, Cardoso, Filipa, Cardoso, Filipe, Cardoso, Sofia, Carelli, Simone, Carlier, Nicolas, Carney, Gayle, Carpenter, Chloe, Carret, Marie-Christine, Carrier, François Martin, Carson, Gail, Casanova, Maire-Laure, Cascão, Mariana, Casimiro, José, Cassandra, Bailey, Castañeda, Silvia, Castanheira, Nidyanara, Castor-Alexandre, Guylaine, Castrillón, Henry, Castro, Ivo, Catarino, Ana, Catherine, François-Xavier, Cavalin, Roberta, Cavalli, Giulio Giovanni, Cavayas, Alexandros, Ceccato, Adrian, Cervantes-Gonzalez, Minerva, Chair, Anissa, Chakveatze, Catherine, Chan, Adrienne, Chand, Meera, Chas, Julie, Chassin, Camille, Chen, Anjellica, Chen, Yih-Sharng, Cheng, Matthew Pellan, Cheret, Antoine, Chiarabini, Thibault, Chica, Julian, Chirouze, Catherine, Chiumello, Davide, Cho, Hwa Jin, Cho, Sung Min, Cholley, Bernard, Cidade, Jose Pedro, Herreros, Jose Miguel Cisneros, Citarella, Barbara Wanjiru, Ciullo, Anna, Clarke, Jennifer, Clohisey, Sara, Codan, Cassidy, Cody, Caitriona, Coelho, Alexandra, Colin, Gwenhaël, Collins, Michael, Colombo, Sebastiano Maria, Combs, Pamela, Connelly, J., Connor, Marie, Conrad, Anne, Contreras, Sofía, Cooke, Graham, Copland, Mary, Cordel, Hugues, Corley, Amanda, Cormican, Sarah, Cornelis, Sabine, Corpuz, Arianne Joy, Corvaisier, Grégory, Couffignal, Camille, Couffin-Cadiergues, Sandrine, Courtois, Roxane, D’orleans, Charles Crepy, Croonen, Sabine, Crowl, Gloria, Crump, Jonathan, Cruz, Claudina, Csete, Marc, Cucino, Alberto, Cullen, Caroline, Cummings, Matthew, Curley, Gerard, Curlier, Elodie, Custodio, Paula, D’aragon, Frédérick, da Silva Filipe, Ana, da Silveira, Charlene, D’ortenzio, Eric, Dabaliz, Al-Awwab, Dagens, Andrew, Dalton, Heidi, Dalton, Jo, Daneman, Nick, Dankwa, Emmanuelle, Dantas, Jorge, de Castro, Nathalie, de Mendoza, Diego, de Oliveira França, Rafael Freitas, de Rosa, Rosanna, de Silva, Thushan, de Vries, Peter, Dean, David, Debray, Marie-Pierre, Dechert, William, Deconninck, Lauren, Decours, Romain, Delacroix, Isabelle, Delavigne, Karen, Deligiannis, Ionna, Dell’amore, Andrea, Delobel, Pierre, Demonchy, Elisa, Denis, Emmanuelle, Deplanque, Dominique, Depuydt, Pieter, Desai, Mehul, Descamps, Diane, Desvallée, Mathilde, Dewayanti, Santi Rahayu, Diallo, Alpha, Diamantis, Sylvain, Dias, André, Diaz, Juan Jose Diaz, Diaz, Rodrigo, Didier, Kévin, Diehl, Jean-Luc, Dieperink, Wim, Dimet, Jérôme, Dinot, Vincent, Diouf, Alphonsine, Dishon, Yael, Djossou, Félix, Docherty, Annemarie, Dong, Andy, Donnelly, Christl, Donnelly, Maria, Donohue, Chloe, Dorival, Céline, Douglas, James Joshua, Douma, Renee, Dournon, Nathalie, Downer, Triona, Downing, Mark, Drake, Tom, Dubee, Vincent, Dubos, François, Ducancelle, Alexandra, Dudman, Susanne, Dunning, Jake, Mangoni, Emanuele Durante, Duranti, Silvia, Durham, Lucian, Dussol, Bertrand, Duval, Xavier, Dyrhol-Riise, Anne Margarita, Eira, Carla, Vidal, José Ernesto, Sanharawi, Mohammed El, Elapavaluru, Subbarao, Elharrar, Brigitte, Elkheir, Natalie, Ellerbroek, Jacobien, Ellis, Rachael, Eloy, Philippine, Elshazly, Tarek, Enderle, Isabelle, Engelmann, Ilka, Enouf, Vincent, Epaulard, Olivier, Esperatti, Mariano, Esperou, Hélène, Esposito-Farese, Marina, Estevão, João, Etienne, Manuel, Ettalhaoui, Nadia, Everding, Anna Greti, Evers, Mirjam, Fabre, Isabelle, Faheem, Amna, Fahy, Arabella, Fairfield, Cameron, Faria, Pedro, Farshait, Nataly, Fatoni, Arie Zainul, Faure, Karine, Fayed, Mohamed, Feely, Niamh, Fernandes, Jorge, Fernandes, Marília, Fernandes, Susana, Ferrão, Joana, Devouge, Eglantine Ferrand, Ferraz, Mário, Ferreira, Benigno, Ferrer-Roca, Ricard, Figueiredo-Mello, Claudia, Flateau, Clara, Fletcher, Tom, Florio, Letizia Lucia, Foley, Claire, Fomin, Victor, Fonseca, Claudio Duarte, Fonseca, Tatiana, Fontela, Patricia, Forsyth, Simon, Foti, Giuseppe, Fourn, Erwan, Fowler, Rob, Franch-Llasat, Diego, Fraser, Christophe, Fraser, John, Freire, Marcela Vieira, Ribeiro, Ana Freitas, Friedrich, Caren, Fry, Stéphane, Fuentes, Nora, Fukuda, Masahiro, Gómez-Junyent, Joan, Gaborieau, Valérie, Gachet, Benoît, Gaci, Rostane, Gagliardi, Massimo, Gagnard, Jean-Charles, Gagneux-Brunon, Amandine, Gaião, Sérgio, Gallagher, Phil, Curto, Elena Gallego, Gamble, Carrol, Garan, Arthur, Garcia-Gallo, Esteban, Garcia, Rebekha, Garot, Denis, Garrait, Valérie, Gault, Nathalie, Gavin, Aisling, Gaymard, Alexandre, Gebauer, Johannes, Morlaes, Louis Gerbaud, Germano, Nuno, Ghosn, Jade, Giani, Marco, Giaquinto, Carlo, Gibson, Jess, Gigante, Tristan, Gilg, Morgane, Giordano, Guillermo, Girvan, Michelle, Gissot, Valérie, Giwangkancana, Gezy, Glikman, Daniel, Glybochko, Petr, Gnall, Eric, Goco, Geraldine, Goehringer, François, Goepel, Siri, Goffard, Jean-Christophe, Golob, Jonathan, Gorenne, Isabelle, Goujard, Cécile, Goulenok, Tiphaine, Grable, Margarite, Grandin, Edward Wilson, Granier, Pascal, Grasselli, Giacomo, Green, Christopher, Greenhalf, William, Greffe, Segolène, Grieco, Domenico Luca, Griffee, Matthew, Griffiths, Fiona, Grigoras, Ioana, Groenendijk, Albert, Lordemann, Anja Grosse, Gruner, Heidi, Gu, Yusing, Guedj, Jérémie, Guellec, Dewi, Guerguerian, Anne-Marie, Guerreiro, Daniela, Guery, Romain, Guillaumot, Anne, Guilleminault, Laurent, Guimard, Thomas, Haber, Daniel, Hakak, Sheeba, Hall, Matthew, Halpin, Sophie, Hamer, Ansley, Hamidfar, Rebecca, Hammond, Terese, Hardwick, Hayley, Harley, Kristen, Harrison, Ewen, Harrison, Janet, Hays, Leanne, Heerman, Jan, Heggelund, Lars, Hendry, Ross, Hennessy, Martina, Henriquez-Trujillo, Aquiles, Hentzien, Maxime, Hernandez-Montfort, Jaime, Hidayah, Astarini, Higgins, Dawn, Higgins, Eibhilin, Hinton, Samuel, Hipólito-Reis, Ana, Hiraiwa, Hiroaki, Hiscox, Julian, Ho, Antonia Ying Wai, Hoctin, Alexandre, Hoffmann, Isabelle, Hoiting, Oscar, Holt, Rebecca, Holter, Jan Cato, Horby, Peter, Horcajada, Juan Pablo, Hoshino, Koji, Hoshino, Kota, Hough, Catherine, Hsu, Jimmy Ming-Yang, Hulot, Jean-Sébastien, Ijaz, Samreen, Illes, Hajnal-Gabriela, Inácio, Hugo, Dominguez, Carmen Infante, Iosifidis, Elias, Irvine, Lacey, Isgett, Sarah, Isidoro, Tiago, Isnard, Margaux, Itai, Junji, Ivulich, Daniel, Jaafoura, Salma, Jabot, Julien, Jackson, Clare, Jamieson, Nina, Jaureguiberry, Stéphane, Javidfar, Jeffrey, Jean-Benoît, Zabbe, Jego, Florence, Jenum, Synne, Sotomayor, Ruth Jimbo, García, Ruth Noemí Jorge, Joseph, Cédric, Joseph, Mark, Jouvet, Philippe, Jung, Hanna, Kafif, Ouifiya, Kaguelidou, Florentia, Kali, Sabina, Kalomoiri, Smaragdi, Kandamby, Darshana Hewa, Kandel, Chris, Kant, Ravi, Kartsonaki, Christiana, Kasugai, Daisuke, Katz, Kevin, Johal, Simreen Kaur, Keating, Sean, Kelly, Andrea, Kelly, Sadie, Kennedy, Lisa, Kennon, Kalynn, Kerroumi, Younes, Kestelyn, Evelyne, Khalid, Imrana, Khalil, Antoine, Khan, Coralie, Khan, Irfan, Kho, Michelle, Khoo, Saye, Kida, Yuri, Kiiza, Peter, Kildal, Anders Benjamin, Kimmoun, Antoine, Kindgen-Milles, Detlef, Kitamura, Nobuya, Klenerman, Paul, Bekken, Gry Kloumann, Knight, Stephen, Kobbe, Robin, Vasconcelos, Malte Kohns, Korten, Volkan, Kosgei, Caroline, Krawczyk, Karolina, Vecham, Pavan Kumar, Kumar, Deepali, Kurtzman, Ethan, Kutsogiannis, Demetrios, Kyriakoulis, Konstantinos, L’her, Erwan, Lachatre, Marie, Lacoste, Marie, Laffey, John, Lagrange, Marie, Laine, Fabrice, Lambert, Marc, Lamontagne, François, Langelot-Richard, Marie, Lantang, Eka Yudha, Lanza, Marina, Laouénan, Cédric, Laribi, Samira, Lariviere, Delphine, Launay, Odile, Lavie-Badie, Yoan, Law, Andrew, Le Bihan, Clément, Le Bris, Cyril, Le Coustumier, Eve, Le Falher, Georges, Le Gac, Sylvie, Le Hingrat, Quentin, Le Maréchal, Marion, Le Mestre, Soizic, Le Moing, Vincent, Le Nagard, Hervé, Le Turnier, Paul, León, Rafael, Le, Minh, Santos, Marta Leal, Leal, Ema, Lee, James, Lee, Su Hwan, Lee, Todd, Leeming, Gary, Lefebvre, Bénédicte, Lefebvre, Laurent, Lefevre, Benjamin, Lellouche, François, Lemaignen, Adrien, Lemee, Véronique, Lemmink, Gretchen, Leone, Michela, Lepiller, Quentin, Lescure, François-Xavier, Lesens, Olivier, Lesouhaitier, Mathieu, Levy-Marchal, Claire, Levy, Bruno, Levy, Yves, Bassi, Gianluigi Li, Liang, Janet, Lim, Wei Shen, Lina, Bruno, Lind, Andreas, Lingas, Guillaume, Lion-Daolio, Sylvie, Liu, Keibun, Loforte, Antonio, Lolong, Navy, Lopes, Diogo, Lopez-Colon, Dalia, Loubet, Paul, Lucet, Jean Christophe, Luna, Carlos, Lungu, Olguta, Luong, Liem, Luton, Dominique, Lyons, Ruth, Müller, Fredrik, Müller, Karl Erik, Maasikas, Olavi, Macdonald, Sarah, Machado, Moïse, Macheda, Gabrielle, Sanchez, Juan Macias, Madhok, Jai, Mahieu, Rafael, Mahy, Sophie, Maier, Lars Siegfrid, Maillet, Mylène, Maitre, Thomas, Malfertheiner, Maximilian, Malik, Nadia, Maltez, Fernando, Malvy, Denis, Mambert, Marina, Manda, Victoria, Mandei, Jose, Manning, Edmund, Manuel, Aldric, Sant, Ceila Maria, Malaque, Ana, Marino, Flávio, de Araújo Mariz, Carolline, Eid, Charbel Maroun, Marques, Ana, Marquis, Catherine, Marsh, Brian, Marsh, Laura, Marshall, John, Martelli, Celina Turchi, Martin-Blondel, Guillaume, Martin-Loeches, Ignacio, Martin-Quiros, Alejandro, Martin, Dori-Ann, Martin, Emily, Martinot, Martin, Rego, Caroline Martins, Martins, Ana, Martins, João, Martucci, Gennaro, Marwali, Eva Miranda, Jimenez, Juan Fernado Masa, Maslove, David, Mason, Sabina, Matan, Moshe, Mathieu, Daniel, Mattei, Mathieu, Matulevics, Romans, Maulin, Laurence, Mc Evoy, Natalie, Mccarthy, Aine, Mccloskey, Colin, Mcconnochie, Rachael, Mcdermott, Sherry, Mcdonald, Sarah, Mcelwee, Samuel, Mcevoy, Natalie, Mcgeer, Allison, Mcguinness, Niki, Mclean, Kenneth, Mcnicholas, Bairbre, Meaney, Edel, Mear-Passard, Cécile, Mechlin, Maggie, Mele, Ferruccio, Menon, Kusum, Mentré, France, Mentzer, Alexander, Mercier, Noémie, Merckx, Antoine, Mergler, Blake, Merson, Laura, Mesquita, António, Meybeck, Agnès, Meynert, Alison, Meyssonnier, Vanina, Meziane, Amina, Mezidi, Medhi, Michelanglei, Céline, Mihnovitš, Vladislav, Maldonado, Hugo Miranda, Mone, Mary, Moin, Asma, Molina, David, Molinos, Elena, Monteiro, Agostinho, Montes, Claudia, Montrucchio, Giorgia, Moore, Sarah, Moore, Shona, Morales-Cely, Lina, Moro, Lucia, Tutillo, Diego Rolando Morocho, Motos, Ana, Mouquet, Hugo, Perrot, Clara Mouton, Moyet, Julien, Mullaert, Jimmy, Munblit, Daniel, Murphy, Derek, Murris, Marlène, Myrodia, Dimitra Melia, N’guyen, Yohan, Neant, Nadège, Neb, Holger, Nekliudov, Nikita, Neto, Raul, Neumann, Emily, Neves, Bernardo, Ng, Pauline Yeung, Ng, Wing Yiu, Choileain, Orna Ni, Nichol, Alistair, Nonas, Stephanie, Noret, Marion, Norman, Lisa, Notari, Alessandra, Noursadeghi, Mahdad, Nowicka, Karolina, Nseir, Saad, Nunez, Jose, Nyamankolly, Elsa, O’donnell, Max, O’hearn, Katie, O’neil, Conar, Occhipinti, Giovanna, Ogston, Tawnya, Ogura, Takayuki, Oh, Tak-Hyuk, Ohshimo, Shinichiro, Oinam, Budha Charan Singh, Oliveira, Ana Pinho, Oliveira, João, Olliaro, Piero, Ong, David, Oosthuyzen, Wilna, Openshaw, Peter, Orozco-Chamorro, Claudia Milena, Orquera, Andrés, Osatnik, Javier, Ouamara, Nadia, Ouissa, Rachida, Owyang, Clark, Oziol, Eric, Póvoas, Diana, Pagadoy, Maïder, Pages, Justine, Palacios, Mario, Palmarini, Massimo, Panarello, Giovanna, Panda, Prasan Kumar, Panigada, Mauro, Pansu, Nathalie, Papadopoulos, Aurélie, Parra, Briseida, Pasquier, Jérémie, Patauner, Fabian, Patrão, Luís, Paul, Christelle, Paul, Mical, Paulos, Jorge, Paxton, William, Payen, Jean-François, Pearse, India, Peek, Giles, Peelman, Florent, Peiffer-Smadja, Nathan, Peigne, Vincent, Pejkovska, Mare, Peltan, Ithan, Pereira, Rui, Perez, Daniel, Perpoint, Thomas, Pesenti, Antonio, Petroušová, Lenka, Petrov-Sanchez, Ventzislava, Peytavin, Gilles, Pharand, Scott, Piagnerelli, Michael, Picard, Walter, Picone, Olivier, Piel-Julian, Marie, Pierobon, Carola, Pimentel, Carlos, Piroth, Lionel, Pius, Riinu, Piva, Simone, Plantier, Laurent, Plotkin, Daniel, Poissy, Julien, Pokorska-Spiewak, Maria, Poli, Sergio, Pollakis, Georgios, Popielska, Jolanta, Postma, Douwe, Povoa, Pedro, Powis, Jeff, Prapa, Sofia, Prebensen, Christian, Preiser, Jean-Charles, Prestre, Vincent, Price, Nicholas, Prinssen, Anton, Pritchard, Mark, Proença, Lúcia, Puéchal, Oriane, Purcell, Gregory, Quesada, Luisa, Quist-Paulsen, Else, Quraishi, Mohammed, Rätsep, Indrek, Rössler, Bernhard, Rabaud, Christian, Rafiq, Marie, Ragazzo, Gabrielle, Rainieri, Fernando, Ramakrishnan, Nagarajan, Ramanathan, Kollengode, Rammaert, Blandine, Rapp, Christophe, Rasmin, Menaldi, Rau, Cornelius, Rebaudet, Stanislas, Redl, Sarah, Reeve, Brenda, Reid, Liadain, Reis, Renato, Remppis, Jonathan, Remy, Martine, Renk, Hanna, Resende, Liliana, Resseguier, Anne-Sophie, Revest, Matthieu, Rewa, Oleksa, Reyes, Luis Felipe, Richardson, David, Richardson, Denise, Richier, Laurent, Riera, Jordi, Rios, Ana Lúcia, Rishu, Asgar, Rispal, Patrick, Risso, Karine, Nuñez, Maria Angelica Rivera, Rizer, Nicholas, Roberto, André, Roberts, Stephanie, Robertson, David, Robineau, Olivier, Roche-Campo, Ferran, Rodari, Paola, Rodeia, Simão, Abreu, Julia Rodriguez, Roilides, Emmanuel, Rojek, Amanda, Romaru, Juliette, Roncon-Albuquerque, Roberto, Roriz, Mélanie, Rosa-Calatrava, Manuel, Rose, Michael, Rosenberger, Dorothea, Rossanese, Andrea, Rossignol, Bénédicte, Rossignol, Patrick, Roy, Carine, Roze, Benoît, Russell, Clark, Ryckaert, Steffi, Holten, Aleksander Rygh, Choez, Xavier Sánchez, Saba, Isabela, Sadat, Musharaf, Saidani, Nadia, Salazar, Leonardo, Sales, Gabriele, Sallaberry, Stéphane, Salvator, Hélène, Sanchez-Miralles, Angel, Sanchez, Olivier, Sancho-Shimizu, Vanessa, Sandhu, Gyan, Sandulescu, Oana, Santos, Marlene, Sarfo-Mensah, Shirley, Sarton, Benjamine, Saviciute, Egle, Savvidou, Parthena, Scarsbrook, Joshua, Schermer, Tjard, Scherpereel, Arnaud, Schneider, Marion, Schroll, Stephan, Schwameis, Michael, Scott-Brown, James, Scott, Janet, Sedillot, Nicholas, Seitz, Tamara, Semaille, Caroline, Semple, Malcolm, Senneville, Eric, Sequeira, Filipa, Sequeira, Tânia, Shadowitz, Ellen, Shamsah, Mohammad, Sharma, Pratima, Shaw, Catherine, Shaw, Victoria, Shiban, Nisreen, Shime, Nobuaki, Shimizu, Hiroaki, Shimizu, Keiki, Shrapnel, Sally, Shum, Hoi Ping, Mohammed, Nassima Si, Sigfrid, Louise, Silva, Catarina, Silva, Maria Joao, Sin, Wai Ching, Skogen, Vegard, Smith, Sue, Smood, Benjamin, Smyth, Michelle, Snacken, Morgane, So, Dominic, Solis, Monserrat, Solomon, Joshua, Solomon, Tom, Somers, Emily, Sommet, Agnès, Song, Myung Jin, Song, Rima, Song, Tae, Sonntagbauer, Michael, Soum, Edouard, Uva, Maria Sousa, Sousa, Marta, Souza-Dantas, Vicente, Sperry, Alexandra, Sriskandan, Shiranee, Staudinger, Thomas, Stecher, Stephanie-Susanne, Stienstra, Ymkje, Stiksrud, Birgitte, Streinu-Cercel, Adrian, Streinu-Cercel, Anca, Strudwick, Samantha, Stuart, Ami, Stuart, David, Sultana, Asfia, Summers, Charlotte, Svistunov, Magdalena Surovcová Andrey A., Syrigos, Konstantinos, Sztajnbok, Jaques, Szuldrzynski, Konstanty, Téoulé, François, Tabrizi, Shirin, Tagherset, Lysa, Talarek, Ewa, Taleb, Sara, Talsma, Jelmer, Le Van, Tan, Tanaka, Hiroyuki, Tanaka, Taku, Taniguchi, Hayato, Tardivon, Coralie, Tattevin, Pierre, Taufik, M. Azhari, Tedder, Richard, Teixeira, João, Tellier, Marie-Capucine, Terpstra, Pleun, Terrier, Olivier, Terzi, Nicolas, Tessier-Grenier, Hubert, Thibault, V., Thiberville, Simon-Djamel, Thill, Benoît, Thompson, A., Thompson, Shaun, Thomson, David, Thomson, Emma, Thuy, Duong Bich, Thwaites, Ryan, Timashev, Peter, Timsit, Jean-François, Vijayaraghavan, Bharath Kumar Tirupakuzhi, Toki, Maria, Tonby, Kristian, Santos-Olmo, Rosario Maria Torres, Torres, Antoni, Torres, Margarida, Trioux, Théo, Trieu, Huynh Trung, Tromeur, Cécile, Trontzas, Ioannis, Troost, Jonathan, Trouillon, Tiffany, Tual, Christelle, Tubiana, Sarah, Tuite, Helen, Turtle, Lance, Twardowski, Pawel, Uchiyama, Makoto, Ullrich, Roman, Uribe, Alberto, Usman, Asad, Val-Flores, Luís, van de Velde, Stijn, van den Berge, Marcel, van Der Feltz, Machteld, van Der Vekens, Nicky, van Der Voort, Peter, van Der Werf, Sylvie, van Dyk, Marlice, van Gulik, Laura, van Hattem, Jarne, van Lelyveld, Steven, van Netten, Carolien, Vanel, Noémie, Vanoverschelde, Henk, Vauchy, Charline, Veislinger, Aurélie, Velazco, Jorge, Ventura, Sara, Verbon, Annelies, Vieira, César, Villanueva, Joy Ann, Villar, Judit, Villeneuve, Pierre-Marc, Villoldo, Andrea, van Vinh Chau, Nguyen, Visseaux, Benoit, Visser, Hannah, Vuorinen, Aapeli, Vuotto, Fanny, Wang, Chih-Hsien, Wei, Jia, Weil, Katharina, Wesselius, Sanne, Wham, Murray, Whelan, Bryan, White, Nicole, Wiedemann, Aurélie, Wille, Keith, Wils, Evert-Jan, Xynogalas, Ioannis, Suen, Jacky, Yacoub, Sophie, Yamazaki, Masaki, Yazdanpanah, Yazdan, Yelnik, Cécile, Yerkovich, Stephanie, Yokoyama, Toshiki, Yonis, Hodane, Young, Paul, Yuliarto, Saptadi, Zabbe, Marion, Zacharowski, Kai, Zahran, Maram, Zambon, Maria, Zanella, Alberto, Zawadka, Konrad, Zayyad, Hiba, Zoufaly, Alexander, Zucman, David, Abdukahil, S. A., Abe, R., Abel, L., Absil, L., Acker, A., Adachi, S., Adam, E., Adriao, D., Ainscough, K., Hssain, A. A., Tamlihat, Y. A., Akimoto, T., Al-Dabbous, T., Al-Fares, A., Al Qasim, E., Alalqam, R., Alex, B., Alexandre, K., Alfoudri, H., Alidjnou, K. E., Aliudin, J., Allavena, C., Allou, N., Alves, J., Alves, R., Amaral, M., Ammerlaan, H., Ampaw, P., Andini, R., Andrejak, C., Angheben, A., Angoulvant, F., Ansart, S., Antonelli, M., De Brito, C. A. A., Arabi, Y., Aragao, I., Arcadipane, A., Arenz, L., Arlet, J. -B., Arnold-Day, C., Arora, L., Artaud-Macari, E., Asensio, A., Assie, J. B., Atique, A., Auchabie, J., Aumaitre, H., Azemar, L., Azoulay, C., Bach, B., Bachelet, D., Baillie, J. K., Bak, E., Bakakos, A., Banisadr, F., Barbalho, R., Barclay, W. S., Barnikel, M., Barrelet, A., Barrigoto, C., Basmaci, R., Rincon, D. F. B., Bedossa, A., Behilill, S., Beljantsev, A., Bellemare, D., Beltrame, A., Beluze, M., Benech, N., Benkerrou, D., Bennett, S., Bento, L. I., Berdal, J. -E., Bergeaud, D., Bertolino, L., Bessis, S., Bevilcaqua, S., Bhavsar, K., Humaid, F. B., Bissuel, F., Biston, P., Bitker, L., Blanco-Schweizer, P., Blot, M., Boccia, F., Bogaert, D., Bompart, F., Booth, G., Borges, D., Borie, R., Bos, J., Bosse, H. M., Botelho-Nevers, E., Bouadma, L., Bouchaud, O., Bouchez, S., Bouhmani, D., Bouhour, D., Bouiller, K., Bouillet, L., Bouisse, C., Boureau, A. -S., Bouscambert, M., Bouziotis, J., Boxma, B., Boyer-Besseyre, M., Boylan, M., Braga, C., Brandenburger, T., Brazzi, L., Breen, D., Breen, P., Brickell, K., Brozzi, N., Buchtele, N., Buesaquillo, C., Bugaeva, P., Buisson, M., Burhan, E., Bustos, I. G., Butnaru, D., Carcel, S., Cabie, A., Cabral, S., Caceres, E., Callahan, M., Calligy, K., Calvache, J. A., Camoes, J., Campana, V., Campbell, P., Canepa, C., Cantero, M., Caraux-Paz, P., Cardoso, F., Cardoso, S., Carelli, S., Carlier, N., Carney, G., Carpenter, C., Carret, M. -C., Carrier, F. 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W., Twardowski, P., Uchiyama, M., Ullrich, R., Uribe, A., Usman, A., Val-Flores, L., Van De Velde, S., Van Den Berge, M., Van Der Feltz, M., Van Der Vekens, N., Van Der Voort, P., Van Der Werf, S., Van Dyk, M., Van Gulik, L., Van Hattem, J., Van Lelyveld, S., Van Netten, C., Vanel, N., Vanoverschelde, H., Vauchy, C., Veislinger, A., Velazco, J., Ventura, S., Verbon, A., Vieira, C., Villanueva, J. A., Villar, J., Villeneuve, P. -M., Villoldo, A., Van Vinh Chau, N., Visseaux, B., Visser, H., Vuorinen, A., Vuotto, F., Wang, C. -H., Wei, J., Weil, K., Wesselius, S., Wham, M., Whelan, B., White, N., Wiedemann, A., Wille, K., Wils, E. -J., Xynogalas, I., Suen, J. Y., Yacoub, S., Yamazaki, M., Yazdanpanah, Y., Yelnik, C., Yerkovich, S., Yokoyama, T., Yonis, H., Young, P., Yuliarto, S., Zabbe, M., Zacharowski, K., Zahran, M., Zambon, M., Zanella, A., Zawadka, K., Zayyad, H., Zoufaly, A., Zucman, D., Apollo - University of Cambridge Repository, Human genetics of infectious diseases: Complex predisposition (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Department of Mathematics and Statistics, Wichita State University, Service d'Anésthésie Réanimation [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Institut Pasteur [Paris] (IP), Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), This work was supported by the Department for International Development and Wellcome Trust [215091/Z/18/Z], the Bill and Melinda Gates Foundation [OPP1209135]. Country-specific support was provided by the Canadian Institutes of Health Research Coronavirus Rapid Research Funding Opportunity [OV2170359], the Health Research Board Ireland [CTN Award 2014-012], National Institute for Health Research (NIHR) [award CO-CIN-01], the Medical Research Council (MRC) [grant MC_PC_19059], the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool in partnership with Public Health England (PHE), in collaboration with Liverpool School of Tropical Medicine and the University of Oxford [award 200907], NIHR HPRU in Respiratory Infections at Imperial College London with PHE [award 200927], Liverpool Experimental Cancer Medicine Centre [grant reference C18616/A25153], NIHR Biomedical Research Centre at Imperial College London [IS-BRC-1215-20013], EU Platform for European Preparedness Against (Re-)emerging Epidemics (PREPARE) [FP7 project 602525], National Institutes of Health (NIH) [UL1TR002240], and NIHR Clinical Research Network infrastructure support. We acknowledge the generous support of all ISARIC Partners who have contributed data and expertise to this analysis, with or without dedicated funding. The views expressed are those of the authors and not necessarily those of the funders or institutions listed above., European Project: 602525,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,PREPARE(2014), Infectious diseases, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Medical Research Council (MRC), National Institute for Health Research, UKRI MRC COVID-19 Rapid Response Call, UK Research and Innovation, and BOZEC, Erwan
Subjects: Male, Abdominal pain, Pediatrics, 030204 cardiovascular system & hematology, Logistic regression, 0302 clinical medicine, Diagnosis, wc_505, Medicine, ISARIC Clinical Characterisation Group, Prospective Studies, 030212 general & internal medicine, Child, wa_105, COVID-19, Case definition, SARS-CoV-2, Symptoms, Aged, Female, Hospitalization, Hospitals, Humans, Middle Aged, General Medicine, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, Infectious Diseases, Cohort, Vomiting, qw_160, medicine.symptom, Life Sciences & Biomedicine, Diagnosi, Human, Microbiology (medical), medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Nausea, Symptom, Age and sex, Microbiology, 1117 Public Health and Health Services, 03 medical and health sciences, Hospital, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Science & Technology, business.industry, 1103 Clinical Sciences, Prospective Studie, Observational study, wf_100, business
Abstract: Background The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P Interpretation This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men.
Published: 2021

48. A genetic vaccine encoding shared cancer neoantigens to treat tumors with microsatellite instability

Author: Valentino Ruzza, Adele Abbate, Adriano Leuzzi, Veronica Bignone, Christophe Vanhaver, Fulvia Troise, Mónica Gordón-Alonso, Anna Morena D'Alise, Irene Garzia, Pierre van der Bruggen, Maddalena Panigada, Francesca Langone, Alfredo Nicosia, Guido Leoni, Elisa Scarselli, Federica Mori, Rosa Maria Vitale, Mahesh Yadav, Maria Grazia Diodoro, Imma Fichera, Rossella Merone, Maria Teresa Catanese, Stefano Colloca, Armin Lahm, Maria De Lucia, Fabio Giovanni Tucci, Elena Di Matteo, Elisa Soprana, Gabriella Cotugno, Antonella Folgori, Antonio G. Siccardi, Leoni, G., D'Alise, A. M., Cotugno, G., Langone, F., Garzia, I., de Lucia, M., Fichera, I., Vitale, R., Bignone, V., Tucci, F. G., Mori, F., Leuzzi, A., Di Matteo, E., Troise, F., Abbate, A., Merone, R., Ruzza, V., Diodoro, M. G., Yadav, M., Gordon-Alonso, M., Vanhaver, C., Panigada, M., Soprana, E., Siccardi, A., Folgori, A., Colloca, S., van der Bruggen, P., Nicosia, A., Lahm, A., Catanese, M. T., Scarselli, E., and UCL - SSS/DDUV/GECE - Génétique cellulaire
Subjects: 0301 basic medicine, CD4-Positive T-Lymphocytes, Cancer Research, Modified vaccinia Ankara, Antigen-Presenting Cells, Colorectal Neoplasm, Biology, CD8-Positive T-Lymphocytes, Cancer Vaccines, Frameshift mutation, Neoplasm Protein, 03 medical and health sciences, Mice, 0302 clinical medicine, Immunogenicity, Vaccine, Antigen, Antigens, Neoplasm, Cell Line, Tumor, medicine, Animals, Humans, Frameshift Mutation, Gene, Antigen-Presenting Cell, Animal, Microsatellite instability, CD8-Positive T-Lymphocyte, medicine.disease, Neoplasm Proteins, 030104 developmental biology, Oncology, CD4-Positive T-Lymphocyte, 030220 oncology & carcinogenesis, Cancer research, Microsatellite, DNA mismatch repair, Female, Microsatellite Instability, Cancer vaccine, Colorectal Neoplasms, Cancer Vaccine, Human
Abstract: Tumors with microsatellite instability (MSI) are caused by a defective DNA mismatch repair system that leads to the accumulation of mutations within microsatellite regions. Indels in microsatellites of coding genes can result in the synthesis of frameshift peptides (FSP). FSPs are tumor-specific neoantigens shared across patients with MSI. In this study, we developed a neoantigen-based vaccine for the treatment of MSI tumors. Genetic sequences from 320 MSI tumor biopsies and matched healthy tissues in The Cancer Genome Atlas database were analyzed to select shared FSPs. Two hundred nine FSPs were selected and cloned into nonhuman Great Ape Adenoviral and Modified Vaccinia Ankara vectors to generate a viral-vectored vaccine, referred to as Nous-209. Sequencing tumor biopsies of 20 independent patients with MSI colorectal cancer revealed that a median number of 31 FSPs out of the 209 encoded by the vaccine was detected both in DNA and mRNA extracted from each tumor biopsy. A relevant number of peptides encoded by the vaccine were predicted to bind patient HLA haplotypes. Vaccine immunogenicity was demonstrated in mice with potent and broad induction of FSP-specific CD8 and CD4 T-cell responses. Moreover, a vaccine-encoded FSP was processed in vitro by human antigen-presenting cells and was subsequently able to activate human CD8 T cells. Nous-209 is an “off-the-shelf” cancer vaccine encoding many neoantigens shared across sporadic and hereditary MSI tumors. These results indicate that Nous-209 can induce the optimal breadth of immune responses that might achieve clinical benefit to treat and prevent MSI tumors. Significance: These findings demonstrate the feasibility of an “off-the-shelf” vaccine for treatment and prevention of tumors harboring frameshift mutations and neoantigenic peptides as a result of microsatellite instability.
Published: 2020

49. Platelet Drop and Fibrinolytic Shutdown in Patients With Sepsis

Author: Antonio Pesenti, Giovanni Salati, Roberto Latini, Fabrizio Semeraro, Luciano Gattinoni, Tommaso Tonetti, Roberto Teli, Gianni Tognoni, Mario Colucci, Mauro Panigada, Michele Isetta, Michela Magnoli, Nicola Semeraro, Concetta T. Ammollo, Serge Masson, Pietro Caironi, Semeraro F., Colucci M., Caironi P., Masson S., Ammollo C.T., Teli R., Semeraro N., Magnoli M., Salati G., Isetta M., Panigada M., Tonetti T., Tognoni G., Latini R., Pesenti A., and Gattinoni L.
Subjects: Male, medicine.medical_specialty, Plasmin, medicine.medical_treatment, 030204 cardiovascular system & hematology, Severe sepsi, Critical Care and Intensive Care Medicine, Gastroenterology, Sepsis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Albumins, Internal medicine, Septic shock, Fibrinolysis, Humans, Medicine, Fibrinolysi, Platelet, Thrombin activatable fibrinolysis inhibitor, Survival analysis, Aged, Platelet Count, business.industry, 030208 emergency & critical care medicine, Middle Aged, medicine.disease, Survival Analysis, Thrombocytopenia, 3. Good health, chemistry, Plasminogen activator inhibitor-1, Female, business, Plasminogen activator, Biomarkers, medicine.drug
Abstract: Objective Thrombocytopenia is the most common hemostatic disorder during sepsis and is associated with high mortality. We examined whether fibrinolytic changes precede incident thrombocytopenia and predict outcome in patients with severe sepsis. Design Nested study from the multicenter, randomized, controlled trial on the efficacy of albumin replacement in severe sepsis or septic shock (the Albumin Italian Outcome Sepsis trial). Setting Forty ICUs in Italy. Patients Three groups of patients were selected: 1) patients with platelet count less than or equal to 50 × 10/L at study entry (n = 85); 2) patients with baseline platelet count greater than or equal to 100 × 10/L who developed thrombocytopenia (≤ 50 × 10/L) within 28 days (n = 100); 3) patients with platelet count always more than or equal to 100 × 10/L (n = 95). Interventions Fibrinolytic variables, including fibrinolysis inhibitors and in vivo markers of plasmin generation, were measured on day 1. Measurements and main results Patients with early thrombocytopenia (group 1) and those who developed it later (group 2) had similar illness severity and 90-day mortality, whereas patients without thrombocytopenia (group 3) had milder disease and lower mortality. Fibrinolysis was markedly (and similarly) depressed in groups 1 and 2 as compared with group 3. Major fibrinolytic changes included increased levels of plasminogen activator inhibitor 1 and extensive activation/consumption of thrombin activatable fibrinolysis inhibitor. Most fibrinolytic variables were significantly associated with mortality in univariate models. However, only thrombin activatable fibrinolysis inhibitor level and in vivo markers of fibrinolysis activation, namely plasmin-antiplasmin complex, and D-dimer, were independently associated with mortality after adjustment for Simplified Acute Physiology Score-II score, sex, and platelet count. Furthermore, the coexistence of impaired fibrinolysis and low platelets was associated with an even greater mortality. Conclusions Impaired fibrinolysis, mainly driven by plasminogen activator inhibitor-1 increase and thrombin activatable fibrinolysis inhibitor activation, is an early manifestation of sepsis and may precede the development of thrombocytopenia. Thrombin activatable fibrinolysis inhibitor level, in particular, proved to be an independent predictor of mortality, which may improve risk stratification of patients with severe sepsis.
Published: 2018

50. GKLF in thymus epithelium as a developmentally regulated element of thymocyte-stroma cross-talk

Author: Francesca Sutti, G. Giacomo Consalez, Ombretta Pozzoli, Simona Porcellini, Maria Guttinger, Maddalena Panigada, Luisa Doneda, Fabio Grassi, Panigada, M, Porcellini, S, Sutti, F, Doneda, L, Pozzoli, O, Consalez, GIAN GIACOMO, Guttinger, M, and Grassi, F.
Subjects: Embryology, Time Factors, Kruppel-Like Transcription Factors, Down-Regulation, Thymus Gland, Biology, Epithelium, Cell Line, Kruppel-Like Factor 4, Mice, Ribonucleases, medicine, Transcriptional regulation, Animals, Tissue Distribution, In Situ Hybridization, Regulation of gene expression, Mice, Inbred BALB C, Immunomagnetic Separation, Reverse Transcriptase Polymerase Chain Reaction, T-cell receptor, Antibodies, Monoclonal, Gene Expression Regulation, Developmental, 3T3 Cells, Sequence Analysis, DNA, Gene rearrangement, Immunohistochemistry, Up-Regulation, Cell biology, DNA-Binding Proteins, Kinetics, Haematopoiesis, Thymocyte, medicine.anatomical_structure, Cancer research, RNA, Stromal Cells, CD8, Signal Transduction, Transcription Factors, Developmental Biology
Abstract: Gut-enriched Kruppel-like factor (GKLF) is a transcriptional regulator expressed in differentiated epithelia. We identified GKLF transcript as a regulated element in thymic epithelium of recombinase-deficient mice during thymus development induced by anti-CD3 antibody injection. This treatment recapitulates the organogenetic process depending on productive rearrangement of T cell receptor (TCR) β gene with thymocytes expansion and acquisition of the CD4+8+ double positive phenotype. In wildtype mice, GKLF is expressed very early in embryogenesis and becomes intensely up-regulated in thymus epithelium at day 18 of gestation when TCR β expressing cells have selectively expanded and express both CD4 and CD8. The results presented here suggest that thymocytes may regulate GKLF transcriptionally in the cortical epithelium at the developmental check-point controlled by TCR β gene rearrangement. Furthermore, GKLF expression in hematopoietic stroma might suggest the thus far uncharacterised participation of this factor in hematopoiesis.
Published: 1999

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