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1. The Efficacy, Feasibility And Acceptability Of A Remotely Accessible Use Of CIRCuiTS, A Computerized Cognitive Remediation Therapy Program For Schizophrenia: A Pilot Study

Author

Palumbo D, Mucci A, Giordano GM, Piegari G, Aiello C, Pietrafesa D, Annarumma N, Chieffi M, Cella M, and Galderisi S

Subjects
cognition, cognitive training, metacognition, real-life functioning., Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Davide Palumbo,1 Armida Mucci,1 Giulia Maria Giordano,1 Giuseppe Piegari,1 Carmen Aiello,1 Daria Pietrafesa,1 Nicola Annarumma,1 Marcello Chieffi,1 Matteo Cella,2 Silvana Galderisi1 1Department of Psychiatry, University of Campania Luigi Vanvitelli, Naples, Italy; 2Institute of Psychiatry, Psychology and Neuroscience (ioppn), King’s College London, London, UKCorrespondence: Armida MucciDepartment of Psychiatry, University of Campania Luigi Vanvitelli, L.go Madonna delle Grazie 1, 80138 Naples, ItalyTel +39-81-5665153Email armida.mucci@gmail.comIntroduction: The Computerized Interactive Remediation of Cognition – Training for Schizophrenia (CIRCuiTS) is a form of cognitive remediation therapy developed to target neurocognitive and metacognitive deficits of people with schizophrenia, which have a detrimental impact on real-life functioning. The English version of CIRCuiTS demonstrated good acceptability and feasibility. A recent randomized controlled trial provided evidence that the program improves memory and functioning, and that the impact on functional outcome is mediated by metacognition. The next steps in the development of CIRCuiTS include both: 1) the translation and adaptation of the program in different cultural settings; and 2) the demonstration of feasibility, acceptability and effectiveness of a standardized method to administer CIRCuiTS remotely.Purpose: To implement the CIRCuiTS Italian version and to assess acceptability, feasibility and efficacy of a standardized method to administer CIRCuiTS remotely.Methods: Participants were assessed at baseline and received up to 40 CIRCuiTS therapy sessions, three times a week, for about 1 hr over a three-month period. Participants were reassessed post-treatment.Results: The program demonstrated good feasibility and high acceptability when assessed by the number of dropouts and evaluation of patients’ satisfaction. Participants improved in learning, speed of processing, working memory and executive control. They showed a reduction in disorganization and improvement in self-esteem, functional capacity, and real-life functioning.Conclusion: In this study, a standardized protocol for using CIRCuiTS from home was implemented. The first set of data showed in the paper is encouraging. The proposed procedure could lead to a dropout reduction while maintaining the efficacy of the program.Keywords: cognition, cognitive training, metacognition, real-life functioning

Published
2019

3. Ordered magnetic fields around the 3C 84 central black hole

Author

Paraschos, G. F., Kim, J. -Y., Wielgus, M., Röder, J., Krichbaum, T. P., Ros, E., Agudo, I., Myserlis, I., Moscibrodzka, M., Traianou, E., Zensus, J. A., Blackburn, L., Chan, C. -K., Issaoun, S., Janssen, M., Johnson, M. D., Fish, V. L., Akiyama, K., Alberdi, A., Alef, W., Algaba, J. C., Anantua, R., Asada, K., Azulay, R., Bach, U., Baczko, A. -K., Ball, D., Baloković, M., Barrett, J., Bauböck, M., Benson, B. A., Bintley, D., Blundell, R., Bouman, K. L., Bower, G. C., Boyce, H., Bremer, M., Brinkerink, C. D., Brissenden, R., Britzen, S., Broderick, A. E., Broguiere, D., Bronzwaer, T., Bustamante, S., Byun, D. -Y., Carlstrom, J. E., Ceccobello, C., Chael, A., Chang, D. O., Chatterjee, K., Chatterjee, S., Chen, M. T., Chen, Y., Cheng, X., Cho, I., Christian, P., Conroy, N. S., Conway, J. E., Cordes, J. M., Crawford, T. M., Crew, G. B., Cruz-Osorio, A., Cui, Y., Dahale, R., Davelaar, J., De Laurentis, M., Deane, R., Dempsey, J., Desvignes, G., Dexter, J., Dhruv, V., Doeleman, S. S., Dougal, S., Dzib, S. A., Eatough, R. P., Emami, R., Falcke, H., Farah, J., Fomalont, E., Ford, H. A., Foschi, M., Fraga-Encinas, R., Freeman, W. T., Friberg, P., Fromm, C. M., Fuentes, A., Galison, P., Gammie, C. F., García, R., Gentaz, O., Georgiev, B., Goddi, C., Gold, R., Gómez-Ruiz, A. I., Gómez, J. L., Gu, M., Gurwell, M., Hada, K., Haggard, D., Haworth, K., Hecht, M. H., Hesper, R., Heumann, D., Ho, L. C., Ho, P., Honma, M., Huang, C. L., Huang, L., Hughes, D. H., Ikeda, S., Impellizzeri, C. M. V., Inoue, M., James, D. J., Jannuzi, B. T., Jeter, B., Jaing, W., Jiménez-Rosales, A., Jorstad, S., Joshi, A. V., Jung, T., Karami, M., Karuppusamy, R., Kawashima, T., Keating, G. K., Kettenis, M., Kim, D. -J., Kim, J., Kino, M., Koay, J. Y., Kocherlakota, P., Kofuji, Y., Koch, P. M., Koyama, S., Kramer, C., Kramer, J. A., Kramer, M., Kuo, C. -Y., La Bella, N., Lauer, T. R., Lee, D., Lee, S. -S., Leung, P. K., Levis, A., Li, Z., Lico, R., Lindahl, G., Lindqvist, M., Lisakov, M., Liu, J., Liu, K., Liuzzo, E., Lo, W. -P., Lobanov, A. P., Loinard, L., Lonsdale, C. J., Lowitz, A. E., Lu, R. -S., MacDonald, N. R., Mao, J., Marchili, N., Markoff, S., Marrone, D. P., Marscher, A. P., Martí-Vidal, I., Matsushita, S., Matthews, L. D., Medeiros, L., Menten, K. M., Michalik, D., Mizuno, I., Mizuno, Y., Moran, J. M., Moriyama, K., Mulaudzi, W., Müller, C., Müller, H., Mus, A., Musoke, G., Nadolski, A., Nagai, H., Nagar, N. M., Nakamura, M., Narayanan, G., Natarajan, I., Nathanail, A., Fuentes, S. Navarro, Neilsen, J., Neri, R., Ni, C., Noutsos, A., Nowak, M. A., Oh, J., Okino, H., Olivares, H., Ortiz-León, G. N., Oyama, T., Özel, F., Palumbo, D. C. M., Park, J., Parsons, H., Patel, N., Pen, U. -L., Piétu, V., Plambeck, R., PopStefanija, A., Porth, O., Pötzl, F. M., Prather, B., Preciado-López, J. A., Psaltis, D., Pu, H. -Y., Ramakrishnan, V., Rao, R., Rawlings, M. G., Raymond, A. W., Rezzolla, L., Ricarte, A., Ripperda, B., Roelofs, F., Rogers, A., Romero-Cañizales, C., Roshanineshat, A., Rottmann, H., Roy, A. L., Ruiz, I., Ruszczyk, C., Rygl, K. L. J., Sánchez, S., Sánchez-Argüelles, D., Sánchez-Portal, M., Sasada, M., Satapathy, K., Savolainen, T., Schloerb, F. P., Schonfeld, J., Schuster, K., Shao, L., Shen, Z., Small, D., Sohn, B. W., SooHoo, J., Salas, L. D. Sosapanta, Souccar, K., Sun, H., Tazaki, F., Tetarenko, A. J., Tiede, P., Tilanus, R. P. J., Titus, M., Torne, P., Toscano, T., Trent, T., Trippe, S., Turk, M., van Bemmel, I., van Langevelde, H. J., van Rossum, D. R., Vos, J., Wagner, J., Ward-Thompson, D., Wardle, J., Washington, J. E., Weintroub, J., Wharton, R., Wiik, K., Witzel, G., Wondrak, M. F., Wong, G. N., Wu, Q., Yadlapalli, N., Yamaguchi, P., Yfantis, A., Yoon, D., Young, A., Young, K., Younsi, Z., Yu, W., Yuan, F., Yuan, Y. -F., Zhang, S., Zhao, G. Y., and Zhao, S. -S.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies
Abstract

3C84 is a nearby radio source with a complex total intensity structure, showing linear polarisation and spectral patterns. A detailed investigation of the central engine region necessitates the use of VLBI above the hitherto available maximum frequency of 86GHz. Using ultrahigh resolution VLBI observations at the highest available frequency of 228GHz, we aim to directly detect compact structures and understand the physical conditions in the compact region of 3C84. We used EHT 228GHz observations and, given the limited (u,v)-coverage, applied geometric model fitting to the data. We also employed quasi-simultaneously observed, multi-frequency VLBI data for the source in order to carry out a comprehensive analysis of the core structure. We report the detection of a highly ordered, strong magnetic field around the central, SMBH of 3C84. The brightness temperature analysis suggests that the system is in equipartition. We determined a turnover frequency of $\nu_m=(113\pm4)$GHz, a corresponding synchrotron self-absorbed magnetic field of $B_{SSA}=(2.9\pm1.6)$G, and an equipartition magnetic field of $B_{eq}=(5.2\pm0.6)$G. Three components are resolved with the highest fractional polarisation detected for this object ($m_\textrm{net}=(17.0\pm3.9)$%). The positions of the components are compatible with those seen in low-frequency VLBI observations since 2017-2018. We report a steeply negative slope of the spectrum at 228GHz. We used these findings to test models of jet formation, propagation, and Faraday rotation in 3C84. The findings of our investigation into different flow geometries and black hole spins support an advection-dominated accretion flow in a magnetically arrested state around a rapidly rotating supermassive black hole as a model of the jet-launching system in the core of 3C84. However, systematic uncertainties due to the limited (u,v)-coverage, however, cannot be ignored., Comment: 15 pages, 6 figures, published in A&A

Published
2024
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4. SoCIAL – training cognition in schizophrenia: a pilot study

Author

Palumbo D, Mucci A, Piegari G, D'Alise V, Mazza A, and Galderisi S

Subjects
Cognitive Remediation, Psychiatric Rehabilitation, Negative symptoms, Avolition, MATRICS Consensus Cognitive Battery (MCCB)., Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Davide Palumbo,* Armida Mucci,* Giuseppe Piegari, Valentina D’Alise, Annapaola Mazza, Silvana Galderisi Department of Psychiatry, University of Campania Luigi Vanvitelli, Naples, Italy *These authors contributed equally to this work Abstract: The purpose of this pilot study was to assess the efficacy of a new social cognition (SC) remediation intervention, the Social Cognition Individualized Activities Lab (SoCIAL), for subjects with schizophrenia. The training includes a module for emotion recognition and one for theory of mind. A comparison with a validated cognitive remediation intervention, the Social Skills And Neurocognitive Individualized Training (SSANIT), was conducted to verify the efficacy of the SoCIAL in improving SC. Ten stabilized patients with schizophrenia accepted to participate. Five patients were randomized to SoCIAL and five to SSANIT. The SoCIAL intervention includes individual sessions of neurocognitive individualized training (NIT) and group sessions of SC training. SSANIT includes individual sessions of NIT and group sessions of social skills individualized training. The interventions were matched for the overall treatment duration (20 weeks) and for the frequency of the sessions (two times a week, one for SoCIAL or social skills individualized training and one for NIT, with a duration of 80 minutes for each session). Results showed a significant treatment effect (effect size: Cohen’s d 0.32) on the primary outcome; in fact, only the SoCIAL intervention improved theory of mind. Patients receiving the SoCIAL intervention also showed an improvement of avolition. These preliminary findings support further development of the SoCIAL and suggest that cognitive remediation should include an SC module. Keywords: cognitive remediation, psychiatric rehabilitation, negative symptoms, avolition, MATRICS consensus cognitive battery, MCCB

Published
2017

6. A Rapid Procedure to Reconstruct S/N Curve by Using Harmonic Components of Thermal Signal

Author

De Finis, R., Palumbo, D., Galietti, U., Zimmerman, Kristin B., Series Editor, Franck, Christian, editor, Kasza, Karen, editor, Estrada, Jon, editor, De Finis, Rosa, editor, Ólafsson, Geir, editor, Gururaja, Suhasini, editor, Furmanski, Jevan, editor, Forster, Aaron, editor, Kolluru, Pavan, editor, Prime, Mike, editor, Berfield, Tom, editor, and Aydiner, Cahit, editor

Published
2024
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9. Early regression index (ERI) on MR images as response predictor in esophageal cancer treated with neoadjuvant chemo-radiotherapy: Interim analysis of the prospective ESCAPE trial

Author

Fiorino, C., Palumbo, D., Mori, M., Palazzo, G., Pellegrini, A.E., Albarello, L., Belardo, A., Canevari, C., Cossu, A., Damascelli, A., Elmore, U., Mazza, E., Pavarini, M., Passoni, P., Puccetti, F., Slim, N., Steidler, S., Del Vecchio, A., Di Muzio, N.G., Chiti, A., Rosati, R., and De Cobelli, F.

Published
2024
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11. The Role of Adaptive Ray Tracing in Analyzing Black Hole Structure

Author

Gelles, Z., Prather, B. S., Palumbo, D. C. M., Johnson, M. D., Wong, G. N., and Georgiev, B.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The recent advent of the Event Horizon Telescope (EHT) has made direct imaging of supermassive black holes a reality. Simulated images of black holes produced via general relativistic ray tracing and radiative transfer provide a key counterpart to these observational efforts. Black hole images have a wide range of physically interesting image structures, ranging from extremely fine scales in their lensed "photon rings" to the very large scales in their relativistic jets. The multi-scale nature of the black hole system is therefore suitable for a multi-scale approach to generating simulated images that capture all key elements of the system. Here, we present a prescription for adaptive ray tracing, which enables efficient computation of extremely high resolution images of black holes. Using the polarized ray-tracing code ipole, we image a combination of semi-analytic and GRMHD models, and we show that images can be reproduced with mean squared error of less than 0.1% even after tracing 12x fewer rays. We then use adaptive ray tracing to explore properties of the photon ring. We illustrate the behavior of individual subrings in GRMHD simulations, and we explore their signatures in interferometric visibilities., Comment: 17 pages, 12 figures. Published in ApJ on May 3, 2021

Published
2021
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12. SYMBA: An end-to-end VLBI synthetic data generation pipeline

Author

Roelofs, F., Janssen, M., Natarajan, I., Deane, R., Davelaar, J., Olivares, H., Porth, O., Paine, S. N., Bouman, K. L., Tilanus, R. P. J., van Bemmel, I. M., Falcke, H., Akiyama, K., Alberdi, A., Alef, W., Asada, K., Azulay, R., Baczko, A., Ball, D., Baloković, M., Barrett, J., Bintley, D., Blackburn, L., Boland, W., Bower, G. C., Bremer, M., Brinkerink, C. D., Brissenden, R., Britzen, S., Broderick, A. E., Broguiere, D., Bronzwaer, T., Byun, D., Carlstrom, J. E., Chael, A., Chan, C., Chatterjee, S., Chatterjee, K., Chen, M., Chen, Y., Cho, I., Christian, P., Conway, J. E., Cordes, J. M., Crew, G. B., Cui, Y., De Laurentis, M., Dempsey, J., Desvignes, G., Dexter, J., Doeleman, S. S., Eatough, R. P., Fish, V. L., Fomalont, E., Fraga-Encinas, R., Friberg, P., Fromm, C. M., Gómez, J. L., Galison, P., Gammie, C. F., García, R., Gentaz, O., Georgiev, B., Goddi, C., Gold, R., Gu, M., Gurwell, M., Hada, K., Hecht, M. H., Hesper, R., Ho, L. C., Ho, P., Honma, M., Huang, C. L., Huang, L., Hughes, D. H., Ikeda, S., Inoue, M., Issaoun, S., James, D. J., Jannuzi, B. T., Jeter, B., Jiang, W., Johnson, M. D., Jorstad, S., Jung, T., Karami, M., Karuppusamy, R., Kawashima, T., Keating, G. K., Kettenis, M., Kim, J., Kino, M., Koay, J. Yi, Koch, P. M., Koyama, S., Kramer, M., Kramer, C., Krichbaum, T. P., Kuo, C., Lauer, T. R., Lee, S., Li, Y., Li, Z., Lindqvist, M., Lico, R., Liu, K., Liuzzo, E., Lo, W., Lobanov, A. P., Loinard, L., Lonsdale, C., Lu, R., MacDonald, N. R., Mao, J., Markoff, S., Marrone, D. P., Marscher, A. P., Martí-Vidal, I., Matsushita, S., Matthews, L. D., Medeiros, L., Menten, K. M., Mizuno, Y., Mizuno, I., Moran, J. M., Moriyama, K., Moscibrodzka, M., Müller, C., Nagai, H., Nagar, N. M., Nakamura, M., Narayan, R., Narayanan, G., Neri, R., Ni, C., Noutsos, A., Okino, H., Ortiz-León, G. N., Oyama, T., Özel, F., Palumbo, D. C. M., Patel, N., Pen, U., Pesce, D. W., Piétu, V., Plambeck, R., PopStefanija, A., Prather, B., Preciado-López, J. A., Psaltis, D., Pu, H., Ramakrishnan, V., Rao, R., Rawlings, M. G., Raymond, A. W., Rezzolla, L., Ripperda, B., Rogers, A., Ros, E., Rose, M., Roshanineshat, A., Rottmann, H., Roy, A. L., Ruszczyk, C., Ryan, B. R., Rygl, K. L. J., Sánchez, S., Sánchez-Arguelles, D., Sasada, M., Savolainen, T., Schloerb, F. Peter, Schuster, K., Shao, L., Shen, Z., Small, D., Sohn, B. Won, SooHoo, J., Tazaki, F., Tiede, P., Titus, M., Toma, K., Torne, P., Trent, T., Trippe, S., Tsuda, S., van Langevelde, H. J., van Rossum, D. R., Wagner, J., Wardle, J., Ward-Thompson, D., Weintroub, J., Wex, N., Wharton, R., Wielgus, M., Wong, G. N., Wu, Q., Young, A., Young, K., Younsi, Z., Yuan, F., Yuan, Y., Zensus, J. A., Zhao, G., Zhao, S., and Zhu, Z.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Realistic synthetic observations of theoretical source models are essential for our understanding of real observational data. In using synthetic data, one can verify the extent to which source parameters can be recovered and evaluate how various data corruption effects can be calibrated. These studies are important when proposing observations of new sources, in the characterization of the capabilities of new or upgraded instruments, and when verifying model-based theoretical predictions in a comparison with observational data. We present the SYnthetic Measurement creator for long Baseline Arrays (SYMBA), a novel synthetic data generation pipeline for Very Long Baseline Interferometry (VLBI) observations. SYMBA takes into account several realistic atmospheric, instrumental, and calibration effects. We used SYMBA to create synthetic observations for the Event Horizon Telescope (EHT), a mm VLBI array, which has recently captured the first image of a black hole shadow. After testing SYMBA with simple source and corruption models, we study the importance of including all corruption and calibration effects. Based on two example general relativistic magnetohydrodynamics (GRMHD) model images of M87, we performed case studies to assess the attainable image quality with the current and future EHT array for different weather conditions. The results show that the effects of atmospheric and instrumental corruptions on the measured visibilities are significant. Despite these effects, we demonstrate how the overall structure of the input models can be recovered robustly after performing calibration steps. With the planned addition of new stations to the EHT array, images could be reconstructed with higher angular resolution and dynamic range. In our case study, these improvements allowed for a distinction between a thermal and a non-thermal GRMHD model based on salient features in reconstructed images., Comment: 20 pages, 15 figures, accepted for publication in A&A

Published
2020
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13. Application of thermal methods for characterization of steel welded joints

Author

Palumbo D. and Galietti U.

Subjects
Physics, QC1-999
Abstract

Despite the large number of proposals in the field of fatigue prediction of welded joints, a globally accepted and unified theory, which applies easily to any load condition, does not exist. Real life components, indeed, differ in geometry and/or type of load from the structural design for which they are regarded by Standards, so that a lot of precautionary safety factors are used that lead to an underestimation of the actual fatigue life of joints. Infrared thermography has a great potential in this field, both from structural and thermomechanical points of view. It enables a full field stress analysis with a sufficient spatial resolution so that the complexity of the stress state at the weld toe and its time evolution are taken into account, emphasizing anomalies that may predict structural failure. A new methods for evaluation fatigue limit damage is presented in this paper and in particular interesting results derived from analysis of the evolution of thermoelastic signal phase. Variations in the value of signal phase indicate a not elastic behaviour and plastic dissipation in the material.

Published
2010
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14. Thermoelastic stress analysis of titanium components and simultaneous assessment of residual stress

Author

Palumbo D. and Galietti U.

Subjects
Physics, QC1-999
Abstract

The thermoelastic effect describes a linear relationship between change in body temperature and state of stress in the presence of adiabatic conditions. This approach considers the material properties constant with temperature, which is not correct for all materials. Experimental results and a review of the theory, especially for the titanium and some alloys of aluminium, have shown that the thermoelastic signal is also dependent of mean stress of the material. The use of titanium in various fields of application makes interesting use of thermoelastic technique as full field stress analysis technique. However, it is necessary to make a correction of the measure in relation to the mean stress. The possibility to measure the mean stress allows also an evaluation of residual stresses on the surface of titanium components.

Published
2010
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15. Design and Operation of a Windowless Gas Target Internal to a Solenoidal Magnet for Use with a Megawatt Electron Beam

Author

Lee, S., Corliss, R., Friščić, I., Alarcon, R., Aulenbacher, S., Balewski, J., Benson, S., Bernauer, J. C., Bessuille, J., Boyce, J., Coleman, J., Douglas, D., Epstein, C. S., Fisher, P., Frierson, S., Garçon, M., Grames, J., Hasell, D., Hernandez-Garcia, C., Ihloff, E., Johnston, R., Jordan, K., Kazimi, R., Kelsey, J., Kohl, M., Liyanage, A., McCaughan, M., Milner, R. G., Moran, P., Nazeer, J., Palumbo, D., Poelker, M., Randall, G., Steadman, S. G., Tennant, C., Tschalär, C., Vidal, C., Vogel, C., Wang, Y., and Zhang, S.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

A windowless hydrogen gas target of nominal thickness $10^{19}$ cm$^{-2}$ is an essential component of the DarkLight experiment, which is designed to utilize the megawatt electron beam at an Energy Recovery Linac (ERL). The design of such a target is challenging because the pressure drops by many orders of magnitude between the central, high-density section of the target and the surrounding beamline, resulting in laminar, transitional, and finally molecular flow regimes. The target system was assembled and operated at Jefferson Lab's Low Energy Recirculator Facility (LERF) in 2016, and subsequently underwent several revisions and calibration tests at MIT Bates in 2017. The system at dynamic equilibrium was simulated in COMSOL to provide a better understanding of its optimal operation at other working points. We have determined that a windowless gas target with sufficiently high density for DarkLight's experimental needs is feasible in an ERL environment., Comment: 11 pages, 14 figures; v2: minor improvements; v3: author list updated; v4: minor revision

Published
2019
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17. One-year survival and Quality of Life of first wave COVID-19 invasively ventilated patients in Lombardy, Italy

Author

Lorini, L, Labanca, R, Bugada, D, Cazzaniga, S, D'Amico, F, Grazioli, L, Marmiere, M, Novelli, L, Pozzi, M, Rona, R, Giani, M, Bellin, V, Lucchini, A, Raimondi, F, Rocchi, M, Salvioni, M, Foti, G, Landoni, G, Andreossi, M, Annoni, A, Azzolini, M, Baiardo Redaelli, M, Belletti, A, Belmonte, G, Benigni, A, Benini, A, Bonfanti, P, Borghi, G, Butovska, L, Cadone Ughi, E, Calabria, M, Celona, S, Ciceri, F, Consalvo, L, Farina, A, Ferlicca, D, Finazzi, S, Fominskiy, E, Grieco, S, Guzzo, F, Landini, S, Lo-Catelli, S, Lorini, A, Lorini, G, Magri, F, Manildo, E, Nava, C, Ortalda, A, Palumbo, D, Real, G, Rezoagli, E, Ripa, C, Saracino, M, Sosio, S, Trocchia, R, Villa, M, Zangrillo, A, Lorini L. F., Labanca R., Bugada D., Cazzaniga S., D'Amico F., Grazioli L., Marmiere M., Novelli L., Pozzi M., Rona R., Giani M., Bellin V., Lucchini A., Raimondi F., Rocchi M., Salvioni M. T., Foti G., Landoni G., Andreossi M., Annoni A., Azzolini M. L., Baiardo Redaelli M., Belletti A., Belmonte G., Benigni A., Benini A., Bonfanti P., Borghi G., Butovska L., Cadone Ughi E., Calabria M., Celona S., Ciceri F., Consalvo L., Farina A., Ferlicca D., Finazzi S., Fominskiy E. V., Grieco S., Guzzo F., Landini S., Lo-Catelli S., Lorini A., Lorini G., Magri F., Manildo E., Nava C., Ortalda A., Palumbo D., Real G., Rezoagli E., Ripa C., Saracino M., Sosio S., Trocchia R., Villa M., Zangrillo A., Lorini, L, Labanca, R, Bugada, D, Cazzaniga, S, D'Amico, F, Grazioli, L, Marmiere, M, Novelli, L, Pozzi, M, Rona, R, Giani, M, Bellin, V, Lucchini, A, Raimondi, F, Rocchi, M, Salvioni, M, Foti, G, Landoni, G, Andreossi, M, Annoni, A, Azzolini, M, Baiardo Redaelli, M, Belletti, A, Belmonte, G, Benigni, A, Benini, A, Bonfanti, P, Borghi, G, Butovska, L, Cadone Ughi, E, Calabria, M, Celona, S, Ciceri, F, Consalvo, L, Farina, A, Ferlicca, D, Finazzi, S, Fominskiy, E, Grieco, S, Guzzo, F, Landini, S, Lo-Catelli, S, Lorini, A, Lorini, G, Magri, F, Manildo, E, Nava, C, Ortalda, A, Palumbo, D, Real, G, Rezoagli, E, Ripa, C, Saracino, M, Sosio, S, Trocchia, R, Villa, M, Zangrillo, A, Lorini L. F., Labanca R., Bugada D., Cazzaniga S., D'Amico F., Grazioli L., Marmiere M., Novelli L., Pozzi M., Rona R., Giani M., Bellin V., Lucchini A., Raimondi F., Rocchi M., Salvioni M. T., Foti G., Landoni G., Andreossi M., Annoni A., Azzolini M. L., Baiardo Redaelli M., Belletti A., Belmonte G., Benigni A., Benini A., Bonfanti P., Borghi G., Butovska L., Cadone Ughi E., Calabria M., Celona S., Ciceri F., Consalvo L., Farina A., Ferlicca D., Finazzi S., Fominskiy E. V., Grieco S., Guzzo F., Landini S., Lo-Catelli S., Lorini A., Lorini G., Magri F., Manildo E., Nava C., Ortalda A., Palumbo D., Real G., Rezoagli E., Ripa C., Saracino M., Sosio S., Trocchia R., Villa M., and Zangrillo A.

Abstract

BACKGROUND: Lombardy was the epicenter of the first coronavirus disease 2019 (COVID-19) outbreak in western countries. The outbreak began in February 2020 and rapidly disseminated throughout the region. ICU beds were vastly insufficient and clinical knowledge of disease was poor at that time. Unfortunately, data on long-term mortality, morbidity, and Quality of Life are scarce and controversial. The aim of this study was to evaluate 1-year survival, Quality of Life, and functional recovery in patients with COVID-19 admitted to Intensive Care Units. METHODS: All COVID-19 patients invasively ventilated and successfully discharged from 3 important academic hospitals in Lombardy were evaluated. Evaluations were performed by qualified medical staff and monitoring over time was performed by telephone call. Functional, cognitive, and psychological outcomes were explored using validated questionnaires. Selected patients were offered a follow-up chest computed tomography (CT) scan. RESULTS: Four hundred twenty-seven patients were invasively ventilated and 268 (63%) were successfully discharged. Out of these 268 patients, 266 (99%) were alive at one year with no patient loss during follow-up. Very severe or severe dyspnea was reported by 7% of patients, while most patients (84%) did not experience dyspnea at rest. A small proportion of patients (17%) reported severe anxiety/depression. Good Quality of Life was reported by 64% of survivors. In patients complaining of dyspnea on exertion, fibrotic-like changes were observed at chest CT scans in 32/37 (86%) and 7/11 (63%) patients who underwent CT at 3 months and 1 year, respectively. CONCLUSIONS: COVID-19 patients discharged from the hospital after invasive ventilation had excellent one-year survival and good overall recovery and Quality of Life.

Published
2024

20. 68Ga-DOTATOC PET/MR imaging and radiomic parameters in predicting histopathological prognostic factors in patients with pancreatic neuroendocrine well-differentiated tumours

Author

Mapelli, P., Bezzi, C., Palumbo, D., Canevari, C., Ghezzo, S., Samanes Gajate, A. M., Catalfamo, B., Messina, A., Presotto, L., Guarnaccia, A., Bettinardi, V., Muffatti, F., Andreasi, V., Schiavo Lena, M., Gianolli, L., Partelli, S., Falconi, M., Scifo, P., De Cobelli, F., and Picchio, M.

Published
2022
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23. BOC.04.3: PREDICTING THE NEED FOR STEP-UP AFTER EUS-GUIDED DRAINAGE OF PERIPANCREATIC FLUID COLLECTIONS, INCLUDING QNI SCORE VALIDATION: A PROSPECTIVE COHORT STUDY

Author

Vanella, G., primary, Leone, R., additional, Dell'Anna, G., additional, Rossi, G., additional, Guazzarotti, G., additional, Palumbo, D., additional, Preatoni, P., additional, Aldrighetti, L., additional, Falconi, M., additional, Capurso, G., additional, and Arcidiacono, P.G., additional

Published
2024
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24. OC.10.4: EUS-GUIDED DRAINAGE OF POST-SURGICAL VERSUS POSTPANCREATITIS COLLECTIONS (RESPELL): A PROSPECTIVE COMPARISON OF CLINICAL PRESENTATIONS AND THERAPEUTIC OUTCOMES

Author

Vanella, G., primary, Leone, R., additional, Dell'Anna, G., additional, Rossi, G., additional, Preatoni, P., additional, Guazzarotti, G., additional, Palumbo, D., additional, Aldrighetti, L., additional, Falconi, M., additional, Capurso, G., additional, and Arcidiacono, P.G., additional

Published
2024
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25. Combining transcranial magnetic stimulation with training to improve social cognition impairment in schizophrenia: a pilot randomized controlled trial

Author

Vergallito, A, Gramano, B, La Monica, K, Giuliani, L, Palumbo, D, Gesi, C, Torriero, S, Vergallito, A, Gramano, B, La Monica, K, Giuliani, L, Palumbo, D, Gesi, C, and Torriero, S

Abstract

Schizophrenia is a severe, chronic mental disorder that profoundly impacts patients’ everyday lives. The illness’s core features include positive and negative symptoms and cognitive impairments. In particular, deficits in the social cognition domain showed a tighter connection to patients’ everyday functioning than the other symptoms. Social remediation interventions have been developed, providing heterogeneous results considering the possibility of generalizing the acquired improvements in patients’ daily activities. In this pilot randomized controlled trial, we investigated the feasibility of combining fifteen daily cognitive and social training sessions with non-invasive brain stimulation to boost the effectiveness of the two interventions. We delivered intermittent theta burst stimulation (iTBS) over the left dorsolateral prefrontal cortex (DLPFC). Twenty-one patients were randomized into four groups, varying for the assigned stimulation condition (real vs. sham iTBS) and the type of cognitive intervention (training vs. no training). Clinical symptoms and social cognition tests were administered at five time points, i.e., before and after the treatment, and at three follow-ups at one, three, and six months after the treatments’ end. Preliminary data show a trend in improving the competence in managing emotion in participants performing the training. Conversely, no differences were found in pre and post-treatment scores for emotion recognition, theory of mind, and attribution of intentions scores. The iTBS intervention did not induce additional effects on individuals’ performance. The methodological approach’s novelty and limitations of the present study are discussed.

Published
2024

30. Ordered magnetic fields around the 3C 84 central black hole

Author

Paraschos, G. F., primary, Kim, J.-Y., additional, Wielgus, M., additional, Röder, J., additional, Krichbaum, T. P., additional, Ros, E., additional, Agudo, I., additional, Myserlis, I., additional, Moscibrodzka, M., additional, Traianou, E., additional, Zensus, J. A., additional, Blackburn, L., additional, Chan, C.-K., additional, Issaoun, S., additional, Janssen, M., additional, Johnson, M. D., additional, Fish, V. L., additional, Akiyama, K., additional, Alberdi, A., additional, Alef, W., additional, Algaba, J. C., additional, Anantua, R., additional, Asada, K., additional, Azulay, R., additional, Bach, U., additional, Baczko, A.-K., additional, Ball, D., additional, Baloković, M., additional, Barrett, J., additional, Bauböck, M., additional, Benson, B. A., additional, Bintley, D., additional, Blundell, R., additional, Bouman, K. L., additional, Bower, G. C., additional, Boyce, H., additional, Bremer, M., additional, Brinkerink, C. D., additional, Brissenden, R., additional, Britzen, S., additional, Broderick, A. E., additional, Broguiere, D., additional, Bronzwaer, T., additional, Bustamante, S., additional, Byun, D.-Y., additional, Carlstrom, J. E., additional, Ceccobello, C., additional, Chael, A., additional, Chang, D. O., additional, Chatterjee, K., additional, Chatterjee, S., additional, Chen, M. T., additional, Chen, Y., additional, Cheng, X., additional, Cho, I., additional, Christian, P., additional, Conroy, N. S., additional, Conway, J. E., additional, Cordes, J. M., additional, Crawford, T. M., additional, Crew, G. B., additional, Cruz-Osorio, A., additional, Cui, Y., additional, Dahale, R., additional, Davelaar, J., additional, De Laurentis, M., additional, Deane, R., additional, Dempsey, J., additional, Desvignes, G., additional, Dexter, J., additional, Dhruv, V., additional, Doeleman, S. S., additional, Dougal, S., additional, Dzib, S. A., additional, Eatough, R. P., additional, Emami, R., additional, Falcke, H., additional, Farah, J., additional, Fomalont, E., additional, Ford, H. A., additional, Foschi, M., additional, Fraga-Encinas, R., additional, Freeman, W. T., additional, Friberg, P., additional, Fromm, C. M., additional, Fuentes, A., additional, Galison, P., additional, Gammie, C. F., additional, García, R., additional, Gentaz, O., additional, Georgiev, B., additional, Goddi, C., additional, Gold, R., additional, Gómez-Ruiz, A. I., additional, Gómez, J. L., additional, Gu, M., additional, Gurwell, M., additional, Hada, K., additional, Haggard, D., additional, Haworth, K., additional, Hecht, M. H., additional, Hesper, R., additional, Heumann, D., additional, Ho, L. C., additional, Ho, P., additional, Honma, M., additional, Huang, C. L., additional, Huang, L., additional, Hughes, D. H., additional, Ikeda, S., additional, Impellizzeri, C. M. V., additional, Inoue, M., additional, James, D. J., additional, Jannuzi, B. T., additional, Jeter, B., additional, Jaing, W., additional, Jiménez-Rosales, A., additional, Jorstad, S., additional, Joshi, A. V., additional, Jung, T., additional, Karami, M., additional, Karuppusamy, R., additional, Kawashima, T., additional, Keating, G. K., additional, Kettenis, M., additional, Kim, D.-J., additional, Kim, J., additional, Kino, M., additional, Koay, J. Y., additional, Kocherlakota, P., additional, Kofuji, Y., additional, Koch, P. M., additional, Koyama, S., additional, Kramer, C., additional, Kramer, J. A., additional, Kramer, M., additional, Kuo, C.-Y., additional, La Bella, N., additional, Lauer, T. R., additional, Lee, D., additional, Lee, S.-S., additional, Leung, P. K., additional, Levis, A., additional, Li, Z., additional, Lico, R., additional, Lindahl, G., additional, Lindqvist, M., additional, Lisakov, M., additional, Liu, J., additional, Liu, K., additional, Liuzzo, E., additional, Lo, W.-P., additional, Lobanov, A. P., additional, Loinard, L., additional, Lonsdale, C. J., additional, Lowitz, A. E., additional, Lu, R.-S., additional, MacDonald, N. R., additional, Mao, J., additional, Marchili, N., additional, Markoff, S., additional, Marrone, D. P., additional, Marscher, A. P., additional, Martí-Vidal, I., additional, Matsushita, S., additional, Matthews, L. D., additional, Medeiros, L., additional, Menten, K. M., additional, Michalik, D., additional, Mizuno, I., additional, Mizuno, Y., additional, Moran, J. M., additional, Moriyama, K., additional, Mulaudzi, W., additional, Müller, C., additional, Müller, H., additional, Mus, A., additional, Musoke, G., additional, Nadolski, A., additional, Nagai, H., additional, Nagar, N. M., additional, Nakamura, M., additional, Narayanan, G., additional, Natarajan, I., additional, Nathanail, A., additional, Navarro Fuentes, S., additional, Neilsen, J., additional, Neri, R., additional, Ni, C., additional, Noutsos, A., additional, Nowak, M. A., additional, Oh, J., additional, Okino, H., additional, Olivares, H., additional, Ortiz-León, G. N., additional, Oyama, T., additional, Özel, F., additional, Palumbo, D. C. M., additional, Park, J., additional, Parsons, H., additional, Patel, N., additional, Pen, U.-L., additional, Piétu, V., additional, Plambeck, R., additional, PopStefanija, A., additional, Porth, O., additional, Pötzl, F. M., additional, Prather, B., additional, Preciado-López, J. A., additional, Psaltis, D., additional, Pu, H.-Y., additional, Ramakrishnan, V., additional, Rao, R., additional, Rawlings, M. G., additional, Raymond, A. W., additional, Rezzolla, L., additional, Ricarte, A., additional, Ripperda, B., additional, Roelofs, F., additional, Rogers, A., additional, Romero-Cañizales, C., additional, Roshanineshat, A., additional, Rottmann, H., additional, Roy, A. L., additional, Ruiz, I., additional, Ruszczyk, C., additional, Rygl, K. L. J., additional, Sánchez, S., additional, Sánchez-Argüelles, D., additional, Sánchez-Portal, M., additional, Sasada, M., additional, Satapathy, K., additional, Savolainen, T., additional, Schloerb, F. P., additional, Schonfeld, J., additional, Schuster, K., additional, Shao, L., additional, Shen, Z., additional, Small, D., additional, Sohn, B. W., additional, SooHoo, J., additional, Sosapanta Salas, L. D., additional, Souccar, K., additional, Sun, H., additional, Tazaki, F., additional, Tetarenko, A. J., additional, Tiede, P., additional, Tilanus, R. P. J., additional, Titus, M., additional, Torne, P., additional, Toscano, T., additional, Trent, T., additional, Trippe, S., additional, Turk, M., additional, van Bemmel, I., additional, van Langevelde, H. J., additional, van Rossum, D. R., additional, Vos, J., additional, Wagner, J., additional, Ward-Thompson, D., additional, Wardle, J., additional, Washington, J. E., additional, Weintroub, J., additional, Wharton, R., additional, Wiik, K., additional, Witzel, G., additional, Wondrak, M. F., additional, Wong, G. N., additional, Wu, Q., additional, Yadlapalli, N., additional, Yamaguchi, P., additional, Yfantis, A., additional, Yoon, D., additional, Young, A., additional, Young, K., additional, Younsi, Z., additional, Yu, W., additional, Yuan, F., additional, Yuan, Y.-F., additional, Zhang, S., additional, Zhao, G. Y., additional, and Zhao, S.-S., additional

Published
2024
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37. BOOTSTRAP-BASED MACHINE LEARNING TO ROBUSTLY CHARACTERIZE PANCREATIC NEUROENDOCRINE NEOPLASMS (PANNEN) BASED ON CT RADIOMIC FEATURES

Author

Mori, M., primary, Palumbo, D., additional, Muffatti, F., additional, Partelli, S., additional, Mushtaq, J., additional, Andreasi, V., additional, Prato, F., additional, Ubeira-Gabellini, M.G., additional, Palazzo, G., additional, Falconi, M., additional, Del Vecchio, A., additional, De Cobelli, F., additional, and Fiorino, C., additional

Published
2023
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44. Embolisation of the parenchymal tract after percutaneous portal vein catheterization: a retrospective comparison of outcomes with different techniques in two centres

Author

Marra, P, Carbone, F, Augello, L, Dulcetta, L, Muglia, R, Bonaffini, P, Della Corte, A, Steidler, S, Gusmini, S, Guazzarotti, G, Palumbo, D, Venturini, M, De Cobelli, F, Sironi, S, Marra P., Carbone F. S., Augello L., Dulcetta L., Muglia R., Bonaffini P. A., Della Corte A., Steidler S., Gusmini S., Guazzarotti G., Palumbo D., Venturini M., De Cobelli F., Sironi S., Marra, P, Carbone, F, Augello, L, Dulcetta, L, Muglia, R, Bonaffini, P, Della Corte, A, Steidler, S, Gusmini, S, Guazzarotti, G, Palumbo, D, Venturini, M, De Cobelli, F, Sironi, S, Marra P., Carbone F. S., Augello L., Dulcetta L., Muglia R., Bonaffini P. A., Della Corte A., Steidler S., Gusmini S., Guazzarotti G., Palumbo D., Venturini M., De Cobelli F., and Sironi S.

Abstract

Background: Embolisation of the parenchymal tract is a key step after any other transhepatic or transplenic percutaneous portal vein catheterization since eventual venous bleeding is difficult to control and may require surgical management. Different techniques have been proposed to perform tract embolisation. The aim of this study is to compare the safety and efficacy of different techniques of haemostasis of the parenchymal tract. Materials and methods: All the interventional procedures with percutaneous transhepatic or transplenic access to the portal vein (excluding ipsilateral portal vein embolisation) from January 2010 to July 2020, in two tertiary hospitals, were retrospectively analyzed. The following data were evaluated: access site, the technique of embolisation, technical success in terms of immediate thrombosis of the tract, safety and clinical efficacy in terms of the absence of hemorrhagic and thrombotic complications. Results: One-hundred-sixty-one patients underwent 220 percutaneous transhepatic or transplenic portal vein catheterization procedures. The main indications were pancreatic islet transplantation, portal anastomotic stenosis after liver transplantation, and portal vein thrombosis recanalization. As embolic materials gelfoam was used in 105 cases, metallic micro-coils in 54 cases, and cyanoacrylic glue in 44 cases; in 17 cases the parenchymal tract was not embolized. Technical success was 98% without significant difference among groups (p-value = 0.22). Eighteen post-procedural abdominal bleedings occurred, all grade 3 and were managed conservatively; difference among groups was not significant (p-value = 0.25). We detected 12 intrahepatic portal branch thromboses not related to the embolisation technique; only one case of non-target embolisation was documented after liver tract embolisation with glue, without clinical consequences. Conclusion: Embolisation of the parenchymal tract after percutaneous portal vein catheterization is technical

Published
2022

45. 68Ga-DOTATOC PET/MR imaging and radiomic parameters in predicting histopathological prognostic factors in patients with pancreatic neuroendocrine well-differentiated tumours

Author

Mapelli, P, Bezzi, C, Palumbo, D, Canevari, C, Ghezzo, S, Samanes Gajate, A, Catalfamo, B, Messina, A, Presotto, L, Guarnaccia, A, Bettinardi, V, Muffatti, F, Andreasi, V, Schiavo Lena, M, Gianolli, L, Partelli, S, Falconi, M, Scifo, P, De Cobelli, F, Picchio, M, Mapelli P., Bezzi C., Palumbo D., Canevari C., Ghezzo S., Samanes Gajate A. M., Catalfamo B., Messina A., Presotto L., Guarnaccia A., Bettinardi V., Muffatti F., Andreasi V., Schiavo Lena M., Gianolli L., Partelli S., Falconi M., Scifo P., De Cobelli F., Picchio M., Mapelli, P, Bezzi, C, Palumbo, D, Canevari, C, Ghezzo, S, Samanes Gajate, A, Catalfamo, B, Messina, A, Presotto, L, Guarnaccia, A, Bettinardi, V, Muffatti, F, Andreasi, V, Schiavo Lena, M, Gianolli, L, Partelli, S, Falconi, M, Scifo, P, De Cobelli, F, Picchio, M, Mapelli P., Bezzi C., Palumbo D., Canevari C., Ghezzo S., Samanes Gajate A. M., Catalfamo B., Messina A., Presotto L., Guarnaccia A., Bettinardi V., Muffatti F., Andreasi V., Schiavo Lena M., Gianolli L., Partelli S., Falconi M., Scifo P., De Cobelli F., and Picchio M.

Abstract

Purpose: To explore the role of fully hybrid 68Ga-DOTATOC PET/MR imaging and radiomic parameters in predicting histopathological prognostic factors in patients with pancreatic neuroendocrine tumours (PanNETs) undergoing surgery. Methods: One hundred eighty-seven consecutive 68Ga-DOTATOC PET/MRI scans (March 2018–June 2020) performed for gastroenteropancreatic neuroendocrine tumour were retrospectively evaluated; 16/187 patients met the eligibility criteria (68Ga-DOTATOC PET/MRI for preoperative staging of PanNET and availability of histological data). PET/MR scans were qualitatively and quantitatively interpreted, and the following imaging parameters were derived: PET-derived SUVmax, SUVmean, somatostatin receptor density (SRD), total lesion somatostatin receptor density (TLSRD), and MRI-derived apparent diffusion coefficient (ADC), arterial and late enhancement, necrosis, cystic degeneration, and maximum diameter. Additionally, first-, second-, and higher-order radiomic parameters were extracted from both PET and MRI scans. Correlations with several PanNETs’ histopathological prognostic factors were evaluated using Spearman’s coefficient, while the area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to evaluate parameters’ predictive performance. Results: Primary tumour was detected in all 16 patients (15/16 by 68Ga-DOTATOC PET and 16/16 by MRI). SUVmax and SUVmean resulted good predictors of lymphnodal (LN) involvement (AUC of 0.850 and 0.783, respectively). Second-order radiomic parameters GrayLevelVariance and HighGrayLevelZoneEmphasis extracted from T2 MRI demonstrated significant correlations with LN involvement (adjusted p = 0.009), also showing good predictive performance (AUC = 0.992). Conclusion: This study demonstrates the role of the fully hybrid PET/MRI tool for the synergic function of imaging parameters extracted by the two modalities and highlights the potentiality of imaging and radiomic parameters in assessing h

Published
2022

47. The impact of a multidisciplinary team evaluation on the diagnosis and management of acute and chronic pancreatitis in a tertiary referral center

Author

Lauri, G., additional, Tacelli, M., additional, Belfiori, G., additional, Palumbo, D., additional, Aleotti, F., additional, Lanzillotta, M., additional, Ponz de Leon Pisani, R., additional, Bina, N., additional, Dell'Anna, G., additional, Zaccari, P., additional, Vanella, G., additional, Archibugi, L., additional, Balzano, G., additional, Petrone, M. C., additional, Rossi, G., additional, Tamburrino, D., additional, Mariani, A., additional, Doglioni, C., additional, Della Torre, E., additional, De Cobelli, F., additional, Falconi, M., additional, Arcidiacono, P. G., additional, Crippa, S., additional, and Capurso, G., additional

Published
2023
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48. OC.09.4 THE IMPACT OF A MULTIDISCIPLINARY TEAM EVALUATION ON THE DIAGNOSIS AND MANAGEMENT OF ACUTE AND CHRONIC PANCREATITIS IN A TERTIARY REFERRAL CENTER

Author

Lauri, G., primary, Tacelli, M., additional, Palumbo, D., additional, Aleotti, F., additional, Lanzillotta, M., additional, Ponz De Leon Pisani, R., additional, Bina, N., additional, Dell'Anna, G., additional, Zaccari, P., additional, Vanella, G., additional, Archibugi, L., additional, Balzano, G., additional, Petrone, M.C., additional, Rossi, G., additional, Tamburrino, D., additional, Mariani, A., additional, Doglioni, C., additional, Della Torre, E., additional, De Cobelli, F., additional, Falconi, M., additional, Arcidiacono, P., additional, Crippa, S., additional, and Capurso, G., additional

Published
2023
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