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Contains fulltext : 292749.pdf (Publisher’s version ) (Open Access), BACKGROUND: Partial breast irradiation (PBI) is standard of care in low-risk breast cancer patients after breast-conserving surgery (BCS). Pre-operative PBI can result in tumor downstaging and more precise target definition possibly resulting in less treatment-related toxicity. This study aims to assess the pathologic complete response (pCR) rate one year after MR-guided single-dose pre-operative PBI in low-risk breast cancer patients. METHODS: The ABLATIVE-2 trial is a multicenter prospective single-arm trial using single-dose ablative PBI in low-risk breast cancer patients. Patients ≥ 50 years with non-lobular invasive breast cancer ≤ 2 cm, grade 1 or 2, estrogen receptor-positive, HER2-negative, and tumor-negative sentinel node procedure are eligible. A total of 100 patients will be enrolled. PBI treatment planning will be performed using a radiotherapy planning CT and -MRI in treatment position. The treatment delivery will take place on a conventional or MR-guided linear accelerator. The prescribed radiotherapy dose is a single dose of 20 Gy to the tumor, and 15 Gy to the 2 cm of breast tissue surrounding the tumor. Follow-up MRIs, scheduled at baseline, 2 weeks, 3, 6, 9, and 12 months after PBI, are combined with liquid biopsies to identify biomarkers for pCR prediction. BCS will be performed 12 months after radiotherapy or after 6 months, if MRI does not show a radiologic complete response. The primary endpoint is the pCR rate after PBI. Secondary endpoints are radiologic response, toxicity, quality of life, cosmetic outcome, patient distress, oncological outcomes, and the evaluation of biomarkers in liquid biopsies and tumor tissue. Patients will be followed up to 10 years after radiation therapy. DISCUSSION: This trial will investigate the pathological tumor response after pre-operative single-dose PBI after 12 months in patients with low-risk breast cancer. In comparison with previous trial outcomes, a longer interval between PBI and BCS of 12 months is exp

Revista oficial de la Asociación Española de Teledetección, [EN] The MWR builds, together with the SRAL altimeter, the S3 topography mission. The MWR, developed by EADS CASA Espacio as prime contractor, provides information for tropospheric path correction of SRAL measurements. MWR data can also be used for determining surface emissivity and soil moisture over land, surface energy budget investigations and ice characterization. The MWR instrument is a Noise Injection Radiometer (NIR), working at two frequencies (23.8/36.5 GHz), embarking a dual frequency horn antenna pointing to the cold sky for embedded autonomous calibration., [ES] El radiómetro MWR, desarrollado por EADS CASA Espacio, constituye la misión topográfica de Sentinel-3 (S3) junto al radar altímetro SRAL. Su función es la entrega de información auxiliar para la corrección troposférica de las medidas del SRAL. Sus datos también pueden servir para caracterizar magnitudes físicas del suelo y la criosfera, así como para la evaluación de balances energéticos. El MWR es un radiómetro de inyección de ruido (NIR) que funciona a dos frecuencias (23,8 y 36,5 GHz) e incorpora una bocina para la obtención de la temperatura de brillo del cielo como medio de calibración autónoma.

R-Albuterol (levalbuterol) is a drug used for asthma therapy and some formulations of it are in solid dosage forms. The aim of this work was to describe and characterize two polymorphic modifications of R-albuterol sulfate by means of typical structure-sensitive analytical techniques such as X-ray powder diffraction, FT-IR spectroscopy, visual and microscopic inspection, and DSC. Substantial differences were observed between the solid-state properties of the crystals, confirming the existence of at least two polymorphic forms for R-albuterol sulfate: Form I and Form II., Fil: Palacios, M.A. Agencia Córdoba Ciencia SE, Unidad CEPROCOR, Santa Maria de Punilla 5164, Cordoba, Argentina, Fil: Cuffini, S. Agencia Córdoba Ciencia SE, Unidad CEPROCOR, Santa Maria de Punilla 5164, Cordoba, Argentina, Fil: Badini, R. Agencia Córdoba Ciencia SE, Unidad CEPROCOR, Santa Maria de Punilla 5164, Cordoba, Argentina, Fil: Karlsson, A. Facultad de Ciencias Exactas Físicas y Naturales, Universidad Nacional de Córdoba, 5000 Córdoba, Vélez Sarsfield 298, Argentina, Fil: Palacios, S.M. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina

In chlorophyll biosynthesis protochlorophyllide reductase (POR) catalyzes the light-driven reduction of protochlorophyllide (Pchlide) to chlorophyllide, providing a rare opportunity to trap and characterize catalytic intermediates at low temperatures. Moreover, the presence of a chlorophyll-like molecule allows the use of EPR, electron nuclear double resonance, and Stark spectroscopies, previously used for the analysis of photosynthetic systems, to follow catalytic events in the active site of POR. Different models involving the formation of either radical species or charge transfer complexes have been proposed for the initial photochemical step, which forms a nonfluorescent intermediate absorbing at 696 nm (A

We have modeled steady-state spectra and energy-transfer dynamics in the peripheral plant light-harvesting complex LHCII using new structural data (Liu, Z.; Yan, H.; Wang, K.; Kuang, T.; Zhang, J.; Gui, L.; An, X.; Chang, W. Nature. 2004, 428, 287). The dynamics of the chlorophyll (Chl) b→Chl a transfer and decay of selectively excited "bottleneck" Chl a and b states have been studied by femtosecond pump-probe spectroscopy. We propose an exciton model of the LHCII trimer (with specific site energies) which allows a simultaneous quantitative fit of the absorption, linear-dichroism, steady-state fluorescence spectra, and transient absorption kinetics upon excitation at different wavelengths. In the modeling we use the experimental exciton-phonon spectral density and modified Redfield theory. We have found that fast b→a transfer is determined by a good connection of the Chls b to strongly coupled Chl a clusters, i.e., a610-a611-a612 trimer and a602-a603 and a613-a614 dimers. Long-lived components of the energy-transfer kinetics are determined by a quick population of red-shifted Chl b605 and blue-shifted Chl a604 followed by a very slow (3 ps for b605 and 12 ps for a604) flow of energy from these monomeric bottleneck sites to the Chl a clusters. The dynamics within the Chl a region is determined by fast (with time constants down to sub-100 fs) exciton relaxation within the a610-a611-o612 trimer, slower 200-300 fs relaxation within the a602-a603 and a613-a614 dimers, even slower 300-800 fs migration between these clusters, and very slow transfer from a604 to the quasi-equilibrated a sites. The final equilibrium is characterized by predominant population of the a610-a611-a612 cluster (mostly the a610 site). The location of this cluster on the outer side of the LHCII trimer probably provides a good connection with the other subunits of PSII. © 2005 American Chemical Society.