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2 results on '"Oullai A"'

2. Optic neuritis in lung adenocarcinoma: A challenging diagnosis

Author

Anouk Goudsmit, Mariana Brandao, Ali Oullai, Dan Engelman, Nathalie Ghorra, Tarik Daif, Tom Buelens, and Anne-Pascale Meert

Subjects
Pulmonary and Respiratory Medicine, COVID-19 Vaccines, Optic Neuritis, Lung Neoplasms, Hydrolases, Immunoglobulin G, Humans, COVID-19, Nerve Tissue Proteins, Adenocarcinoma of Lung, Microtubule-Associated Proteins
Abstract

Optic neuritis with CRMP-5 IgG is a paraneoplastic inflammation of the optic nerve associated with lung cancer, mostly small-cell lung cancer. We present the case of a patient with lung adenocarcinoma who developed progressive bilateral visual loss a few months after immune-chemotherapy with pembrolizumab and after Covid-19 vaccination. Positive CRMP-5 IgG were detected in blood sample and complete work-up - including brain MRI - did not show any progression. High dose systemic corticoids were administered with transient improving, followed by intravenous immunoglobulins, methotrexate and rituximab but despite negativization of CRMP-5 IgG, the patient had a progressive visual loss.

Published
2022

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